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Novartis Vaccines and Diagnostics Inc
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Chiron Corp
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Publication date
Application filed by Chiron CorpfiledCriticalChiron Corp
Priority claimed from PCT/US1984/001050external-prioritypatent/WO1985000369A1/en
Publication of DE148922T1publicationCriticalpatent/DE148922T1/en
0U8922 902 750.3 (PCT/US 8 4 /01 0Γ>0) Chiron Corporation Patentansprüche0U8922 902 750.3 (PCT / US 8 4/01 0Γ> 0) Chiron Corporation patent claims1. Human-DNA-Sequenz mit einem für einen epidermalen Wachstumsfaktor
(EGF) kodierenden Abschnitt sowie mit mindestens einem mit diesem im Leseraster befindlichen Abschnitt der
flankierenden Kodierungsabschnitte.1. Human DNA sequence with one for an epidermal growth factor
(EGF) coding section as well as with at least one section of the
flanking coding sections.2. DNA-Fragment mit mindestens etwa 60 Nucleotiden, das einen
Abschnitt der DNA-Sequenz nach Anspruch 1 darstellt und eine Sequenz einschließt, die für anderes als EGF kodiert.2. DNA fragment of at least about 60 nucleotides, the one
Representing a portion of the DNA sequence of claim 1 and including a sequence encoding other than EGF.3. Funktionelles episomales Element mit einem Replikationssystem sowie einer DNA-Sequenz bzw. Fragment von mindestens 60
Nucleotiden nach Anspruch 1.3. Functional episomal element with a replication system and a DNA sequence or fragment of at least 60
Nucleotides according to claim 1.4. DNA-Sequenz mit weniger als 5000 und mehr als 159 Basenpaaren, die mindestens 50% der Nucleotide des für ein die Human-EGF-aminosäuresequenz
einschließenden Polypeptids kodierenden Gens umfaßt.4. DNA sequence with less than 5000 and greater than 159 base pairs that contain at least 50% of the nucleotides for a human EGF amino acid sequence
encoding the polypeptide encoding gene.5. DNA-Sequenz nach Anspruch 4 mit mindestens 1000 Nucleotiden in einem offenen Leserahmen.5. DNA sequence according to claim 4 with at least 1000 nucleotides in an open reading frame.6. DNA-Sequenz nach Anspruch 5, in der der offene Leserahmen einen Abschnitt der für EGF kodierenden Sequenz einschließt.6. The DNA sequence of claim 5, wherein the open reading frame includes a portion of the EGF coding sequence.
DE19849027501983-07-051984-07-02
HYBRID DNA SYNTHESIS OF THE EPIDERM GROWTH FACTOR.
PendingDE148922T1
(en)
Dna sequences encoding for human erythropoietin,vectors including it,host cells transformed by them,process for producing human erythropoietin and pharmaceutical compositions comprising it
Recombinant human basic fibroblast growth factor analogs, their production, dna sequences encoding therefor and recombinant vectors and host cells containing said dna sequences
PLASMID THE DNA ENCODING THE AMINO ACID SEQUENCE OF TCF-II CONTAINS, TRANSFORMED CELL AND PRODUCTION OF A PHYSIOLOGICALLY ACTIVE SUBSTANCE WITH THEIR USE
PHYSIOLOGICALLY ACTIVE HUMAN POLYPEPTIDE, DEOXYBROMIDRIC ACID COMPRISING A BASIC SEQUENCE CORDING THE POLYPEPTIDE, PROCESS FOR PRODUCING THE POLYPEPTIDE AND COMPOSITION CONTAINING THE SAME
USE OF DNA FRAGMENTS ENCODING A SIGNAL PEPTIDE FOR SECRETION OF MATURE PROTEINS IN RECOMBINANT YEASTS, EXPRESSION CASSETTES, TRANSFORMED YEASTS AND METHOD FOR PRODUCING THESE PROTEINS.
Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
GROWTH FACTOR, NUCLEOTIDE SEQUENCE CODING FOR THE GROWTH FACTOR EXPRESSING PLASMID, INCLUDING NUCLEOTIDE SEQUENCE, CONTAINING PLASMID PROTEIN PROCESSED IN PREPARATION OF PREPARED PREPARATION FOR PRODUCTION
HUMAN, DNA AND PLASMIDS WHICH PRODUCT POLYPEPTIDE CODE FOR THIS SEQUENCE, MICROBIOLOGICALLY WITH THE SEQUENCE MICROORGANISMS THAT CONTAIN INTERFERON AMINO ACIDS THIS GENETIC INFORMATION AND PROCESS FOR THEIR PREPARATION.
POLYPEPTIDE PRODUCED MICROBIOLOGICALLY WITH THE PROINSULIN AMINO ACID SEQUENCE OF PRIMATE, DNA AND PLASMIDS THAT CODE FOR THIS SEQUENCE, MICROORGANISMS THAT CONTAIN THIS GENETIC INFORMATION AND PROCESS FOR THEIR PREPARATION.
DNA fragments containing a regulatory region specific for lactic acid bacteria for the expression of genes which normally encode heterologous proteins.