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Optimal Structure for Automatic Processing of DNA Sequences.......... SW Davies, M. Eizenman, and S. Pasupathy 1044 Instrumentation Restoration of Cardio-Circulatory Regulation by Rate-Adaptive Pacemaker Systems: The Bioengineering View of a Clinical Problem..................................................... J. Werner, M. Hexamer, M. Meine, and B. Lemke 1057 Perforated Silicon Nerve Chips with Doped Registration Electrodes: in Vitro Performance and in Vivo Operation......