DE112012006137T8 - Optimization of nucleation and crystallization in lyophilization using gap freezing - Google Patents

Optimization of nucleation and crystallization in lyophilization using gap freezing Download PDF

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Publication number
DE112012006137T8
DE112012006137T8 DE112012006137.3T DE112012006137T DE112012006137T8 DE 112012006137 T8 DE112012006137 T8 DE 112012006137T8 DE 112012006137 T DE112012006137 T DE 112012006137T DE 112012006137 T8 DE112012006137 T8 DE 112012006137T8
Authority
DE
Germany
Prior art keywords
nucleation
lyophilization
crystallization
optimization
freezing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE112012006137.3T
Other languages
German (de)
Other versions
DE112012006137T5 (en
Inventor
Wei-Youh Kuu
Mark J. Doty
William S. Hurst
Christine L. Rebbeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of DE112012006137T5 publication Critical patent/DE112012006137T5/en
Application granted granted Critical
Publication of DE112012006137T8 publication Critical patent/DE112012006137T8/en
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Confectionery (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
DE112012006137.3T 2012-03-28 2012-03-28 Optimization of nucleation and crystallization in lyophilization using gap freezing Expired - Fee Related DE112012006137T8 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/030854 WO2013147759A1 (en) 2012-03-28 2012-03-28 Optimization of nucleation and crystallization for lyophilization using gap freezing

Publications (2)

Publication Number Publication Date
DE112012006137T5 DE112012006137T5 (en) 2015-01-15
DE112012006137T8 true DE112012006137T8 (en) 2015-02-19

Family

ID=46001741

Family Applications (1)

Application Number Title Priority Date Filing Date
DE112012006137.3T Expired - Fee Related DE112012006137T8 (en) 2012-03-28 2012-03-28 Optimization of nucleation and crystallization in lyophilization using gap freezing

Country Status (5)

Country Link
EP (2) EP3171109B1 (en)
DE (1) DE112012006137T8 (en)
ES (1) ES2626001T3 (en)
GB (1) GB2516191A (en)
WO (1) WO2013147759A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8689460B2 (en) * 2010-09-28 2014-04-08 Baxter International Inc. Optimization of nucleation and crystallization for lyophilization using gap freezing
US20170336141A1 (en) 2014-11-14 2017-11-23 Project Pharmaceutics Gmbh Freeze drying of nested vials
BR112017016033B1 (en) * 2015-01-28 2022-05-10 Ima Life North America Inc Product condition measuring unit, method for freeze drying a product containing a frozen solvent and aseptic pharmaceutical processing system
CN107429968B (en) * 2015-01-28 2019-08-06 Ima生命北美股份有限公司 It is controlled using the processing of non-intrusion type printing product sensor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501719A (en) * 1981-05-04 1985-02-26 Marquest Medical Products, Inc. Tray apparatus for freeze-drying biologicals having a predetermined unit dosage
FR2623277B1 (en) * 1987-11-17 1990-04-27 Bioetica Sa LYOPHILIZATION METHOD AND APPARATUS COMPRISING THERMAL SHIELDING MEANS BETWEEN LYOPHILIZATION SHELVES
US8371039B2 (en) * 2009-12-30 2013-02-12 Baxter International Inc. Thermal shielding to optimize lyophilization process for pre-filled syringes or vials
US8689460B2 (en) * 2010-09-28 2014-04-08 Baxter International Inc. Optimization of nucleation and crystallization for lyophilization using gap freezing

Also Published As

Publication number Publication date
ES2626001T3 (en) 2017-07-21
GB201419097D0 (en) 2014-12-10
DE112012006137T5 (en) 2015-01-15
EP3171109A1 (en) 2017-05-24
EP3171109B1 (en) 2018-11-14
EP2831526A1 (en) 2015-02-04
GB2516191A (en) 2015-01-14
EP2831526B1 (en) 2017-02-22
WO2013147759A1 (en) 2013-10-03

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Legal Events

Date Code Title Description
R083 Amendment of/additions to inventor(s)
R082 Change of representative

Representative=s name: MUELLER-BORE & PARTNER PATENTANWAELTE PARTG MB, DE

R082 Change of representative

Representative=s name: MUELLER-BORE & PARTNER PATENTANWAELTE PARTG MB, DE

R081 Change of applicant/patentee

Owner name: BAXTER INTERNATIONAL INC., DEERFIELD, US

Free format text: FORMER OWNERS: BAXTER HEALTHCARE S.A., 8304 WALLISELLEN, CH; BAXTER INTERNATIONAL INC., DEERFIELD, ILL., US

Effective date: 20150109

Owner name: BAXTER HEALTHCARE SA, GLATTPARK, CH

Free format text: FORMER OWNERS: BAXTER HEALTHCARE S.A., 8304 WALLISELLEN, CH; BAXTER INTERNATIONAL INC., DEERFIELD, ILL., US

Effective date: 20150109

Owner name: BAXTER INTERNATIONAL INC., DEERFIELD, US

Free format text: FORMER OWNERS: BAXTER HEALTHCARE S.A., GLATTPARK, CH; BAXTER INTERNATIONAL INC., DEERFIELD, ILL., US

Effective date: 20150202

Owner name: BAXTER HEALTHCARE SA, GLATTPARK, CH

Free format text: FORMER OWNERS: BAXTER HEALTHCARE S.A., GLATTPARK, CH; BAXTER INTERNATIONAL INC., DEERFIELD, ILL., US

Effective date: 20150202

Owner name: BAXTER INTERNATIONAL INC., DEERFIELD, US

Free format text: FORMER OWNER: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC., , US

Effective date: 20150202

Owner name: BAXTER INTERNATIONAL INC., DEERFIELD, US

Free format text: FORMER OWNER: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC., , US

Effective date: 20150109

Owner name: BAXTER HEALTHCARE SA, GLATTPARK, CH

Free format text: FORMER OWNER: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC., , US

Effective date: 20150202

Owner name: BAXTER HEALTHCARE SA, GLATTPARK, CH

Free format text: FORMER OWNER: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC., , US

Effective date: 20150109

R082 Change of representative

Representative=s name: MUELLER-BORE & PARTNER PATENTANWAELTE PARTG MB, DE

Effective date: 20150109

Representative=s name: MUELLER-BORE & PARTNER PATENTANWAELTE PARTG MB, DE

Effective date: 20150202

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20150401