DE10351469A1 - Intraocular lens with physically adhered hyaluronan layer is especially for use in cataract surgery and is stored in an aqueous hyaluronan solution - Google Patents

Intraocular lens with physically adhered hyaluronan layer is especially for use in cataract surgery and is stored in an aqueous hyaluronan solution Download PDF

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Publication number
DE10351469A1
DE10351469A1 DE10351469A DE10351469A DE10351469A1 DE 10351469 A1 DE10351469 A1 DE 10351469A1 DE 10351469 A DE10351469 A DE 10351469A DE 10351469 A DE10351469 A DE 10351469A DE 10351469 A1 DE10351469 A1 DE 10351469A1
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DE
Germany
Prior art keywords
hyaluronan
intraocular lens
solution
cataract surgery
stored
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10351469A
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German (de)
Inventor
Lydia Dr. Nachbaur
Ingeborg Fromberg
Christine Dr. Kreiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss Meditec AG
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Acri Tec GmbH
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Publication date
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Priority to DE10351469A priority Critical patent/DE10351469A1/en
Publication of DE10351469A1 publication Critical patent/DE10351469A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1691—Packages or dispensers for intraocular lenses

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

An intraocular lens for cataract surgery and especially of silicone (polyorganosiloxane) has a hyaluronan layer physically adhered to its surface. An independent claim is also included for a system comprising an aqueous hyaluronan solution in which the lens is stored.

Description

Die Erfindung betrifft eine Intraokularlinse für die Kataraktchirurgie und ein Aufbewahrungssystem hierfür.The The invention relates to an intraocular lens for cataract surgery and a storage system for this.

Bei der Kataraktchirurgie entstehen nach der Implantation der Intraokularlinse im Kapselsack des Auges häufig Trübungen der Hinterkapsel (Nachstar). Der Nachstar entsteht durch rasante Zellproliferation an der Intraokularlinsenoberfläche. Insbesondere wenn diese aus einem hydrophoben Material, wie Silikon besteht. Die Nachstarbildung erfordert eine Behandlung mit einem Nd-YAG-Laser.at Cataract surgery occurs after implantation of the intraocular lens in the capsular bag of the eye often opacities the posterior capsule (after star). The after-star is created by rapid Cell proliferation on the intraocular lens surface. Especially if this made of a hydrophobic material, such as silicone. The after-star requires treatment with an Nd-YAG laser.

Aufgabe der Erfindung ist es, bei der Kataraktchirurgie eine Reduzierung der Nachstarrate zu erreichen.task The invention is a reduction in cataract surgery to reach the Nachstarrate.

Diese Aufgabe wird erfindungsgemäß durch die Merkmale des Patentanspruches 1 oder 3 gelöst. Die Erfindung schafft eine Intraokularlinse, deren Oberfläche durch eine physikalisch haftende aus Hyaluronanschicht hydrophil ausgebildet ist und ein Aufwahrungssystem mit einer wässrigen Hyaluronatlösung, in welcher die Intraokularlinse aufbewahrt ist. Hyaluronan (Hyaluronsäure) ist ein Polysacharid (Biopolymer), welches im menschlichen und tierischen Körper, beispielsweise Bindegewebe, Gelenkflüsigkeit vorkommt.These The object is achieved by the Characteristics of claim 1 or 3 solved. The invention provides a Intraocular lens whose surface hydrophilic by a physically adherent hyaluronan layer is formed and a storage system with an aqueous Hyaluronatlösung, in which the intraocular lens is stored. Hyaluronan (hyaluronic acid) is a polysaccharide (biopolymer), which in the human and animal body, for example Connective tissue, synovial fluid occurs.

Zur Hydrophilierung der Linsenoberfläche reicht es aus, wenn die Hyaluronanschicht durch physikalische Adhäsion an der Linsenoberfläche haftet. Durch thermische Behandlung, beispielsweise Autoklavieren wird eine ausreichende physikalische Adhäsion an der Linsenoberfläche erreicht. Diese Hydrophilierung der Linsenoberfläche gewährleistet, dass die in aller Regel unmittelbar nach der Implantation an der unbehandelten Oberfläche der Intraokularlinse einsetzende Zellproliferation unterbunden wird. Auch die Aufbewahrung der Linse in einer Hyaluronan aufweisenden Lösung gewährleistet eine Hydrophilierung der Linsenoberfläche. In vorteilhafter Weise besitzt die Intraokularlinse, welche in der Hyaluronan enthaltenen Aufbewahrungslösung in Bereitschaft gehaltene wird, eine durch physikalische Adhäsion an der Linsenoberfläche haftende Hyaluronanschicht. Die Aufbewahrungslösung ist eine wässrige Lösung und kann 0,3 mg bis 0,5 mg, vorzugsweise 0,4 mg Hyaluronsäure (Natriumhyaluronat) pro 1 ml Lösung enthalten. Das Molekulargewicht des Hyaluronats (Natriumhyaluronat) kann ≥ 2,8 × 106 Dalton sein und der pH-Wert der Lösung beträgt vorzugsweise 7,0 bis 7,3. Die Aufbewahrungslösung und die Intraokularlinse befinden sich in einem geeigneten Aufbewahrungsgefäß.For hydrophilizing the lens surface, it suffices if the hyaluronan layer adheres to the lens surface by physical adhesion. By thermal treatment, for example autoclaving, sufficient physical adhesion to the lens surface is achieved. This hydrophilization of the lens surface ensures that the cell proliferation that usually begins immediately after the implantation on the untreated surface of the intraocular lens is suppressed. Also, the storage of the lens in a hyaluronan-containing solution ensures hydrophilization of the lens surface. Advantageously, the intraocular lens which is kept in standby in the storage solution containing hyaluronan has a hyaluronan layer adhered to the lens surface by physical adhesion. The storage solution is an aqueous solution and may contain from 0.3 mg to 0.5 mg, preferably 0.4 mg, of hyaluronic acid (sodium hyaluronate) per 1 ml of solution. The molecular weight of the hyaluronate (sodium hyaluronate) may be ≥ 2.8 × 10 6 daltons, and the pH of the solution is preferably 7.0 to 7.3. The storage solution and the intraocular lens are in a suitable storage container.

Durch die Erfindung wird somit ferner eine Aufbewahrungseinrichtung oder ein Aufbewahrungssystem zur Bereitstellung einer Intraokularlinse insbesondere ans Silikon geschaffen, durch die bzw. durch das bei der Kataraktchirurgie eine Reduzierung der Nachstarrate erreicht wird. Die ein- oder mehrfache Autoklavierung findet bevorzugt am Aufbewahrungssystem mit der in der Aufbewahrungslösung befindlichen Intraokularlinse statt.By The invention will thus further be a storage device or a storage system for providing an intraocular lens especially created on silicone, by or through the at Cataract surgery achieved a reduction in the Nachstarrate becomes. Single or multiple autoclaving is preferred on Storage system with the one in the storage solution Intraocular lens held.

Bei einer Bakterien-Adhäsionsstudie an Intraokularlinsen, welche mit Hyaluronan durch physikalische Adhäsion beschichtet waren, und an unbeschichteten Linsen wurde festgestellt, dass bei Implantation von mit Hyaluronan beschichteten Intraokularlinsen nach Kataraktextraktion eine Reduzierung der Nachstarrate von 50% gegenüber Intraokularlinsen ohne Hyaluronanbeschichtung erreicht wurde. Die Erfindung eignet sich vorzugsweise bei Intraokularlinsen aus Silikon, insbesondere Polydimethylsiloxan.at a bacterial adhesion study on intraocular lenses, which with hyaluronan by physical adhesion were coated, and uncoated lenses were found that at implantation of hyaluronan-coated intraocular lenses after cataract extraction a 50% reduction in the post-mortem rate across from Intraocular lenses without Hyaluronanbeschichtung was achieved. The Invention is preferably suitable for intraocular lenses made of silicone, in particular polydimethylsiloxane.

Claims (5)

Intraokularlinse für die Kataraktchirurgie, insbesondere aus Silikon (Polyorganosiloxan), gekennzeichnet durch eine hydrophile Hyaluronanschicht, welche durch physikalische Adhäsion an der Linsenoberfläche haftet.Intraocular lens for cataract surgery, in particular made of silicone (polyorganosiloxane), characterized by a hydrophilic Hyaluronan layer, which by physical adhesion to the lens surface liable. Intraokularlinse nach Anspruch 1, welche in einer Aufbewahrungslösung angeordnet ist, dadurch gekennzeichnet, dass die Aufbewahrungslösung eine Hyaluronan enthaltende Lösung ist.An intraocular lens according to claim 1, which is in a storage solution is arranged, characterized in that the storage solution a Hyaluronan containing solution is. Aufbewahrungssystem für eine Intraokularlinse, welche bei der Kataraktchirurgie implantiert wird, gekennzeichnet durch eine wässrige Hyaluronanlösung, in welcher die Intraokularlinse aufbewahrt wird.Storage system for an intraocular lens, which implanted in cataract surgery, characterized by an aqueous one Hyaluronanlösung, in which the intraocular lens is stored. Aufbewahrungssystem nach Anspruch 3, dadurch gekennzeichnet, dass die wässrige Aufbewahrungslösung 0,3 bis 0,5 mg, insbesondere 0,4 mg Hyaluronat (Natriumhyaluronat) pro 1 ml Lösung bei einem pH-Wert von 7,0 bis 7,3 enthält.Storage system according to claim 3, characterized that the watery storage solution 0.3 to 0.5 mg, especially 0.4 mg hyaluronate (sodium hyaluronate) per 1 ml of solution at a pH of 7.0 to 7.3. Aufbewahrungssystem nach Anspruch 3 oder 4, dadurch gekennzeichnet, dass das Hyaluronan ein Molekulargewicht von ≥ 2,8 × 106 Dalton aufweist.Storage system according to claim 3 or 4, characterized in that the hyaluronan has a molecular weight of ≥ 2.8 × 10 6 daltons.
DE10351469A 2003-11-04 2003-11-04 Intraocular lens with physically adhered hyaluronan layer is especially for use in cataract surgery and is stored in an aqueous hyaluronan solution Ceased DE10351469A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE10351469A DE10351469A1 (en) 2003-11-04 2003-11-04 Intraocular lens with physically adhered hyaluronan layer is especially for use in cataract surgery and is stored in an aqueous hyaluronan solution

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Application Number Priority Date Filing Date Title
DE10351469A DE10351469A1 (en) 2003-11-04 2003-11-04 Intraocular lens with physically adhered hyaluronan layer is especially for use in cataract surgery and is stored in an aqueous hyaluronan solution

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011023380A1 (en) * 2009-08-28 2011-03-03 Coronis Gmbh Intraocular lens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011023380A1 (en) * 2009-08-28 2011-03-03 Coronis Gmbh Intraocular lens

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Owner name: ACRI.TEC AG GES. F. OPHTHALMOLOGISCHE PR, DE

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Effective date: 20130724