DE10347311A1 - Method and device for carrying out reactions - Google Patents
Method and device for carrying out reactions Download PDFInfo
- Publication number
- DE10347311A1 DE10347311A1 DE2003147311 DE10347311A DE10347311A1 DE 10347311 A1 DE10347311 A1 DE 10347311A1 DE 2003147311 DE2003147311 DE 2003147311 DE 10347311 A DE10347311 A DE 10347311A DE 10347311 A1 DE10347311 A1 DE 10347311A1
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- Prior art keywords
- reaction
- carrying
- out reactions
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- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00315—Microtiter plates
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- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
- B01J2219/00328—Movement by linear translation
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
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- G01N2035/1034—Transferring microquantities of liquid
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- General Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Crystallography & Structural Chemistry (AREA)
- Clinical Laboratory Science (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Die Erfindung betrifft eine Vorrichtung zur Durchführung von Reaktionen mit Reagenzmengen im Bereich von 0,5 bis 10 nmol, bei der die Reagenzien über Dosierstationen (5, 9, 11, 13) an Reaktionsorte (3) dosiert werden, die sich entlang einer Reaktionsstrecke (2) bewegen, wobei mindestens eine Dosierstation (5, 9, 11, 13) und eine Entnahmestelle (16) derart angeordnet sind, dass die Zeit, in der sich die Reaktionsorte (3) auf der Reaktionsstrecke (2) bewegen, mindestens der erforderlichen Reaktionszeit für einen Reaktionsschritt entspricht.The invention relates to a device for carrying out reactions with reagent amounts in the range of 0.5 to 10 nmol, in which the reagents are dosed via metering stations (5, 9, 11, 13) to reaction sites (3) which extend along a reaction path (FIG. 2), wherein at least one dosing station (5, 9, 11, 13) and a removal point (16) are arranged such that the time in which the reaction sites (3) move on the reaction path (2), at least the required Reaction time for one reaction step.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2003147311 DE10347311A1 (en) | 2003-10-08 | 2003-10-08 | Method and device for carrying out reactions |
PCT/EP2004/011291 WO2005035110A1 (en) | 2003-10-08 | 2004-10-08 | Method and device for carrying out reactions |
EP04765899A EP1673161A1 (en) | 2003-10-08 | 2004-10-08 | Method and device for carrying out reactions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2003147311 DE10347311A1 (en) | 2003-10-08 | 2003-10-08 | Method and device for carrying out reactions |
Publications (1)
Publication Number | Publication Date |
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DE10347311A1 true DE10347311A1 (en) | 2005-05-12 |
Family
ID=34428320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2003147311 Withdrawn DE10347311A1 (en) | 2003-10-08 | 2003-10-08 | Method and device for carrying out reactions |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1673161A1 (en) |
DE (1) | DE10347311A1 (en) |
WO (1) | WO2005035110A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114206891A (en) * | 2019-04-10 | 2022-03-18 | 日东电工艾维西亚有限公司 | Method and apparatus for sequential synthesis of biopolymers |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005058471A2 (en) * | 2003-12-15 | 2005-06-30 | Applera Corporation | Automated oligomer synthesis |
WO2009134821A1 (en) * | 2008-04-28 | 2009-11-05 | Douglas Machine, Inc. | High throughput screening employing combination of dispensing well plate device and array tape |
US20160018428A1 (en) | 2013-03-15 | 2016-01-21 | Douglas Scientific, LLC | Reusable belt with a matrix of wells |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5310674A (en) * | 1982-05-10 | 1994-05-10 | Bar-Ilan University | Apertured cell carrier |
WO1997019749A1 (en) * | 1995-11-27 | 1997-06-05 | Dehlinger Peter J | Method and apparatus for producing position-addressable combinatorial libraries |
WO2000040330A2 (en) * | 1998-12-30 | 2000-07-13 | Mwg - Biotech Ag | Device for carrying out chemical reactions |
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WO2000066269A1 (en) * | 1999-05-03 | 2000-11-09 | Ljl Biosystems, Inc. | Integrated sample-processing system |
WO2001077640A2 (en) * | 2000-04-05 | 2001-10-18 | Alexion Pharmaceuticals, Inc. | Methods and devices for storing and dispensing liquids |
US6841663B2 (en) * | 2001-10-18 | 2005-01-11 | Agilent Technologies, Inc. | Chemical arrays |
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2004
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WO1997019749A1 (en) * | 1995-11-27 | 1997-06-05 | Dehlinger Peter J | Method and apparatus for producing position-addressable combinatorial libraries |
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DE60000874T2 (en) * | 1999-02-16 | 2003-08-28 | Pe Corp Ny Foster City | MATRIX SYSTEM FOR STORAGE AND DELIVERY |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114206891A (en) * | 2019-04-10 | 2022-03-18 | 日东电工艾维西亚有限公司 | Method and apparatus for sequential synthesis of biopolymers |
EP3953364A4 (en) * | 2019-04-10 | 2023-01-11 | NITTO DENKO Avecia Inc. | Process and apparatus for sequential synthesis of biological polymers |
Also Published As
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WO2005035110A1 (en) | 2005-04-21 |
EP1673161A1 (en) | 2006-06-28 |
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