DE10346751A1 - Clot lysis assay - Google Patents

Clot lysis assay Download PDF

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Publication number
DE10346751A1
DE10346751A1 DE2003146751 DE10346751A DE10346751A1 DE 10346751 A1 DE10346751 A1 DE 10346751A1 DE 2003146751 DE2003146751 DE 2003146751 DE 10346751 A DE10346751 A DE 10346751A DE 10346751 A1 DE10346751 A1 DE 10346751A1
Authority
DE
Germany
Prior art keywords
clot lysis
lysis assay
streptokinase
psac
reteplase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE2003146751
Other languages
German (de)
Inventor
Thomas Stief
Harald Renz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philipps-Universitaet Marburg 35037 Marburg De
Original Assignee
Transmit Gesellschaft fuer Technologietransfer mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transmit Gesellschaft fuer Technologietransfer mbH filed Critical Transmit Gesellschaft fuer Technologietransfer mbH
Priority to DE2003146751 priority Critical patent/DE10346751A1/en
Priority to PCT/DE2004/002224 priority patent/WO2005033711A2/en
Publication of DE10346751A1 publication Critical patent/DE10346751A1/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf eine neue Methode eines Clot-Lyse-Assays, der zur Untersuchung der Thrombolyse, insbesondere durch Urokinase (u-PA), t-PA, Streptokinase (SK), Plasminogen-Streptokinase-Aktivator-Komplex (PSAC), Reteplase (RP) oder Tenecteplase (TP), verwendet werden kann.The present invention relates to a novel method of a clot lysis assay useful in the study of thrombolysis, in particular by urokinase (u-PA), t-PA, streptokinase (SK), plasminogen streptokinase activator complex (PSAC). , Reteplase (RP) or Tenecteplase (TP) can be used.

DE2003146751 2003-10-06 2003-10-06 Clot lysis assay Withdrawn DE10346751A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE2003146751 DE10346751A1 (en) 2003-10-06 2003-10-06 Clot lysis assay
PCT/DE2004/002224 WO2005033711A2 (en) 2003-10-06 2004-10-05 Clot lysis assay

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2003146751 DE10346751A1 (en) 2003-10-06 2003-10-06 Clot lysis assay

Publications (1)

Publication Number Publication Date
DE10346751A1 true DE10346751A1 (en) 2005-04-21

Family

ID=34353347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2003146751 Withdrawn DE10346751A1 (en) 2003-10-06 2003-10-06 Clot lysis assay

Country Status (2)

Country Link
DE (1) DE10346751A1 (en)
WO (1) WO2005033711A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838529A1 (en) * 1988-11-14 1990-05-17 Behringwerke Ag GLOBALTEST FOR DETECTING THE MAIN COMPONENTS OF THE FIBRINOLYSIS SYSTEM
DE3917949A1 (en) * 1989-05-30 1991-01-24 Schering Ag New fibrin specific thrombolytic agent v-PA
DE19756773A1 (en) * 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh New procedure and diagnostic tool for hemostasis diagnostics
DE19903693A1 (en) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease for activation of coagulation factor VII
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838529A1 (en) * 1988-11-14 1990-05-17 Behringwerke Ag GLOBALTEST FOR DETECTING THE MAIN COMPONENTS OF THE FIBRINOLYSIS SYSTEM
DE3917949A1 (en) * 1989-05-30 1991-01-24 Schering Ag New fibrin specific thrombolytic agent v-PA
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis
DE19756773A1 (en) * 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh New procedure and diagnostic tool for hemostasis diagnostics
DE19903693A1 (en) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease for activation of coagulation factor VII

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BENNET,W.F.:High resolution analysis of functional determinants on human tissue-type plasminogen activator. In:J.Biol.Chem.,(1991),266 (8),S.5191-201 *
Datenband PubMed bei NCBI, Adresse www.ncbi.nlm.nih. gov Zusammenfassung zu: RHODES N.P. & WILLIAMS D.F.: Plasma recalcification as a measure of contact phase activation and heparinization efficacy after contact with biomaterials.In:Biomaterials (1994),15,(1),S.35-7 (recherchiert am 30.06.2004) *
Datenband PubMed bei NCBI,Adresse www.ncbi.nlm.nih.gov Zusammenf. zu SAKHAROV,D.V.,u.a.:Fibrin-specificity of a *
REED,G.L.,u.a.:Synergistic fibrinolysis:combined effects of plasminogen activators and an antibody that inhibits alpha 2-antiplasmin..In:Proc.Natl.Acad. Sci,USA (1990),87,(3),S.1114-8 *

Also Published As

Publication number Publication date
WO2005033711A2 (en) 2005-04-14
WO2005033711A3 (en) 2005-06-02

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8127 New person/name/address of the applicant

Owner name: PHILIPPS-UNIVERSITAET MARBURG, 35037 MARBURG, DE

8110 Request for examination paragraph 44
R016 Response to examination communication
R016 Response to examination communication
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee