DE10240742A1 - Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection - Google Patents
Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection Download PDFInfo
- Publication number
- DE10240742A1 DE10240742A1 DE2002140742 DE10240742A DE10240742A1 DE 10240742 A1 DE10240742 A1 DE 10240742A1 DE 2002140742 DE2002140742 DE 2002140742 DE 10240742 A DE10240742 A DE 10240742A DE 10240742 A1 DE10240742 A1 DE 10240742A1
- Authority
- DE
- Germany
- Prior art keywords
- hollow tube
- test medium
- hollow
- hollow container
- stamp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0657—Pipetting powder
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N2033/0091—Powders
Abstract
Description
Die Erfindung betrifft eine Vorrichtung zur Aufnahme von pulverförmigen, wachsartigen und stark pastösen Untersuchungsmedien verschiedenster Herkunft und Abgabe dieser zur Durchführung instrumenteller Analytik, hauptsächlich Trennverfahren mit entsprechender Detektion, des Untersuchungsmediums und Verfahren zur Aufnahme von pulverförmigen, wachsartigen und stark pastösen Untersuchungsmedien verschiedenster Herkunft sowohl manuell als auch automatisiert einsetzbar.The invention relates to a device for powdery, waxy and very pasty Test media of various origins and delivery of these for execution instrumental analytics, mainly Separation process with appropriate detection, the test medium and method of taking powdery, waxy and strong pasty Examination media of various origins both manually and can also be used automatically.
Sollen riechende oder duftende Untersuchungsmedien auf ihren qualitativen und quantitativen Gehalt an Inhaltsstoffen, deren Zusammensetzung, das Profil der Substanzen hin untersucht werden oder ähnliche Fragestellungen geklärt werden, kommt die Analytik, bei flüchtigen und verflüchtigbaren Substanzen mit Hilfe von Trennverfahren gasförmiger Medien, zum Einsatz.Should smell or scented test media on their qualitative and quantitative content of ingredients, their composition, the profile of the substances examined be or similar Questions clarified analytics, in the case of volatile and volatile Substances with the help of separation processes of gaseous media.
Unabdingbar für den schnellen Erhalt der Ergebnisse ist dabei, die Untersuchung bereits an den festen Untersuchungsmedien durchzuführen, da diese Herangehensweise übliche aufwändige Handlingschritte wie z.B. zeitaufwändige Extraktionen mit Lösemitteln, um ein analysefähiges Medium zu erhalten, erspart. Feste Untersuchungsmedien werden dabei nach der Headspace-Methode untersucht, bei der die abgegebenen flüchtigen Substanzen, wenn nötig durch Temperatureinwirkung verstärkt, aus dem das Untersuchungsmedium umgebenden Raum, aus dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß, wenn notwendig mit Anreicherung der Substanzen, der chromatographischen Trennung zugeführt werden. Der Übergang der Substanzen aus dem festen Untersuchungsmedium in den das Untersuchungsmedium umgebenden Raum, in dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß, muss, wenn notwendig durch Temperatureinfluss angeregt, zu Gunsten des das Untersuchungsmedium umgebenden Raumes, in dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß, erfolgen. Feste Medien, die flüchtige Verbindungen enthalten, müssen so schnell wie möglich der Untersuchung zugeführt werden, um ein Verlust an Substanzen während der Vorbereitung zu verhindern. Schnelles, verlustfreies Handling bis zum Verschließen des für die Untersuchung erforderlichen mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäßes ist unabdingbar.Essential for the quick receipt of the The result is that the examination is already on the fixed examination media perform, because this approach is common complex Handling steps such as time-consuming solvent extractions, to be able to analyze To save medium. Fixed examination media are included according to the headspace method examined in which the volatile substances released, if necessary, by Temperature influence increased, from the room surrounding the test medium, from the room with a tightly closed Small septum, in relation to the amount of test media huge Sample vessel if necessary with enrichment of the substances, the chromatographic Separation fed become. The transition of Substances from the solid test medium into which the test medium surrounding space, in the small, sealed septum, in relation to to the volume of sample medium for the test medium, if necessarily stimulated by temperature influence, in favor of that Examination medium surrounding space, in which with a tightly closing septum provided small, in proportion for the amount of sample medium to be examined. Solid media, the volatile Must contain connections as quickly as possible submitted to the investigation to prevent loss of substances during preparation. fast, lossless handling until the closure of the necessary for the examination with a tight closing Small septum, in relation to the amount of test media huge Sample vessel is essential.
Analyseverfahren mit den entsprechenden Anreicherungstechniken sind so empfindlich, dass kleinste Untersuchungsmedienmengen ausreichen. Kleine Untersuchungsmedienmengen sind notwendig, um die Beeinflussung des Messergebnisses wie z.B. durch Oberflächenunterschiede, Unterschiede durch diffusionskontrollierte Abgabe der Substanzen in den das Untersuchungsmedium umgebenden Raum in einem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß weitestgehend auszuschließen. Für die vollständige Entfernung und Überführung der Substanzen aus dem das Untersuchungsmedium umgebenden Raum, aus dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß in das Analysengerät, wenn notwendig in mehreren Schritten, sind ebenfalls kleine Untersuchungsmedienmengen erforderlich, da die vollständige Überführung von Substanzen aus dem das Untersuchungsmedium umgebenden Raum, aus dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß bei großen Untersuchungsmedienmengen deutlich aufwändiger ist und der Übergang der Substanzen aus dem festen Untersuchungsmedium in den das Untersuchungsmedium umgebenden Raum, in dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß, wenn notwendig durch Temperatureinfluss angeregt, wesentlich weniger zu Gunsten des das Untersuchungsmedium umgebenden Raumes, in dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß, erfolgt. Das Verhältnis der Untersuchungsmedienmenge zum dem das Untersuchungsmedium umgebenden Raum, in dem mit einem dichtschließenden Septum versehenen kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß ist bei großen Untersuchungsmedienmengen ungünstiger als bei kleinen Untersuchungsmedienmengen.Analysis methods with the corresponding enrichment techniques are so sensitive that the smallest quantities of test media are sufficient. little one Quantities of test media are necessary to influence the Measurement result such as through surface differences, differences through diffusion-controlled release of the substances into the test medium surrounding space in a small, sealed septum, in relation to large sample vessel for the amount of test media excluded. For the full Removal and transfer of the Substances from the space surrounding the test medium, from which with a tight closing Small septum, in relation to the amount of test media huge Sample vessel in the Analyzer if necessary in several steps, are also small amounts of test media required because the complete transfer of Substances from the space surrounding the test medium with a tight-fitting septum provided small, in proportion for the amount of test medium large sample vessel with large amounts of test media much more complex is and the transition the substances from the solid test medium into those surrounding the test medium Space in the small, sealed with a septum, in the relationship to the volume of test medium large sample vessel, if necessarily stimulated by the influence of temperature, much less in favor of the space surrounding the test medium in which with a tight closing Small septum, in relation to the amount of test media huge Sample vessel. The relationship the quantity of examination medium to the space surrounding the examination medium, in the one with a tight closing Small septum, in relation to the amount of test media huge Sample vessel is for large quantities of test media less favorable than with small quantities of test media.
Die exakte Abmessung der Untersuchungsmedienmenge ist Voraussetzung, um quantitative Auswertungen durchzuführen und Vergleiche möglich zu machen. Reproduzierbarkeit der Untersuchungsmedienmenge ist also unabdingbar. Im allgemeinen wird dazu die Wägung der Untersuchungsmedienmenge angewandt. Bei kleinen Untersuchungsmedienmengen können dabei nur Präzisionswaagen angewandt werden, mit dem Problem des, bei der Wägung von kleinen Untersuchungsmedienmengen auftretenden, mit der Gefahr von Verlusten, langen Kontaktes zur Umgebungsluft.The exact dimension of the amount of test media is a prerequisite for carrying out quantitative evaluations and Comparisons possible close. Reproducibility of the amount of test media is therefore essential. This generally involves weighing the amount of test media applied. Small amounts of test media can be used precision scales only applied with the problem of when weighing small amounts of test media occurring, with the risk of loss, long contact with Ambient air.
Die hier vorgestellte Erfindung betrifft eine Vorrichtung und Verfahren, das die Überführung kleinster, im μg-Bereich liegende Untersuchungsmedienmengen in ein mit einem dichtschließenden Septum verschließbaren kleinen, im Verhältnis zur Untersuchungsmedienmenge großen Probengefäß in kürzester Zeit, ohne aufwändige Handlingschritte und ohne den bei der Wägung von kleinen Untersuchungsmedienmengen auftretenden, mit der Gefahr von Verlusten, langen Kontakt zur Umgebungsluft, möglich macht. Die Erfindung bietet eine Vorrichtung und Verfahren zur Aufnahme von pulverförmigen, wachsartigen und stark pastösen Untersuchungsmedien und Abgabe dieser zur Durchführung instrumenteller Analytik, hauptsächlich Trennverfahren mit entsprechender Detektion, des Untersuchungsmediums mit für die Untersuchungsmedienmenge im μg-Bereich und dem geringen Handlingaufwand hohen Präzision. Zudem wird das Untersuchungsmedium während des Handlings an der Umgebungsluft durch die Bauform und die Verwendung inerten Materials in einem zur Untersuchungsmedien menge hohen Grad von der Umgebungsluft getrennt und damit der Verlust an leichtflüchtigen Substanzen aus dem Untersuchungsmedium unterdrückt.The invention presented here relates to a device and method which allows the transfer of the smallest test medium quantities in the μg range into a small sample container, which can be closed with a tightly sealed septum, and which is large in relation to the test medium quantity, in a very short time, without complex handling steps and without the risk of loss, long contact with the ambient air that occurs when weighing small quantities of test media. The invention provides a device and method for receiving powdery, wax-like and strongly pasty test media and dispensing them for performing instrumental analysis, mainly separation methods with corresponding detection, the test medium with high precision for the test media quantity in the μg range and the low handling effort. In addition, the test medium is separated from the ambient air during handling in the ambient air by the design and the use of inert material to a high degree compared to the test media and thus the loss of volatile substances from the test medium is suppressed.
Die in
Die Ausführungsform der Vorrichtung
besteht aus einem niederdrückbaren
Druckknopf (
In der Stellung der Ausführungsform
der Vorrichtung bereit zur Aufnahme des Untersuchungsmediums wird
der aus inertem, nicht ad- bzw. absorbierendem Material bestehende
Ausschubstempel (
Der Anschlagring (
In der Stellung der Ausführungsform
der Vorrichtung bereit zur Aufnahme des Untersuchungsmediums ergibt
sich ein Hohlcontainer (
Die Variation der Position des Anschlagringes
(
Das aus inertem, nicht ad- bzw. absorbierendem
Material bestehende Hohlrohr (
Ausgehend von der Stellung der Ausführungsform
der Vorrichtung bereit zur Aufnahme des Untersuchungsmediums wird
das Untersuchungsmedium je nach Untersuchungsmediumeigenschaft nach
verschiedenen Verfahren in den Hohlcontainer (
Wachsartige sowie stark pastöse Untersuchungsmedien
werden aufgenommen, indem die Vorrichtung im Grundzustand verwendet
wird und das untere stumpfe Ende des aus inertem, nicht ad- bzw.
absorbierendem Material bestehenden Hohlrohres (
Pulverförmige Untersuchungsmedien werden
aufgenommen, indem das untere stumpfe Ende des aus inertem, nicht
ad- bzw. absorbierendem Material bestehenden Hohlrohres (
Das pulverförmige, wachsartige oder stark pastöse Untersuchungsmedium
haftet, seitlich und nach oben von der Umgebungsluft abgeschirmt, nach
der Befüllung
durch Wechselwirkungen zwischen pulverförmigen, wachsartigen oder stark
pastösen
Untersuchungsmedium und der aus inertem, nicht ad- bzw. absorbierendem
Material bestehenden Innenwandung des Hohlrohres (
Die Abgabe des pulverförmigen,
wachsartigen oder stark pastösen
Untersuchungsmediums aus dem Hohlcontainer (
Die Ablage des freigewordenen pulverförmigen, wachsartigen oder stark pastösen Untersuchungsmediums erfolgt ohne langen Luftkontakt in ein mit einem dichtschließenden Septum verschließbares Analysegefäß.The deposit of the released powdery, waxy or very pasty Test medium takes place without long air contact in a a tight-fitting one Lockable septum Analysis vessel.
Die Tab. 1 zeigt die erreichbare für die Untersuchungsmedienmenge im μg-Bereich und dem geringen Handlingaufwand hohen Präzision in Form der durch Wägung kontrollierten aufgenommenen und abgegebenen Untersuchungsmedienmenge, hier als pulverförmiges Untersuchungsmedium von durch Mahlung in Pulverform überführte getrocknete Kräuter, in μg und der durch die Mehrfachbestimmung errechneten relativen Standardabweichung (RSD) zur Abschätzung der Präzision. Zur genauen Massebestimmung von pulverförmigen, wachsartigen oder stark pastösen Untersuchungsmedien ist einmal eine Wägung je pulverförmigen, wachsartigen oder stark pastösen Untersuchungsmediums als Kalibrierung notwendig.Tab. 1 shows the achievable for the Quantity of test media in the μg range and the low handling effort high precision in the form of the recorded controlled by weighing and the amount of test medium delivered, here as a powder test medium from dried powdered powder Herbs, in μg and the relative standard deviation calculated by the multiple determination (RSD) for assessment of precision. For precise mass determination of powdery, waxy or strong pasty Examination media is one weighing per powdered, waxy or very pasty Examination medium necessary as calibration.
Tab. 1 Tab. 1
Claims (24)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2002140742 DE10240742A1 (en) | 2002-08-31 | 2002-08-31 | Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2002140742 DE10240742A1 (en) | 2002-08-31 | 2002-08-31 | Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10240742A1 true DE10240742A1 (en) | 2004-03-18 |
Family
ID=31724300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2002140742 Ceased DE10240742A1 (en) | 2002-08-31 | 2002-08-31 | Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE10240742A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010115026A1 (en) * | 2009-04-02 | 2010-10-07 | Abbott Point Of Care, Inc. | Method and device for transferring biologic fluid samples |
US7903241B2 (en) | 2008-03-21 | 2011-03-08 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US7929121B2 (en) | 2008-03-21 | 2011-04-19 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
US7951599B2 (en) | 2008-03-21 | 2011-05-31 | Abbott Point Of Care, Inc. | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US7995194B2 (en) | 2008-04-02 | 2011-08-09 | Abbott Point Of Care, Inc. | Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood |
US8045165B2 (en) | 2008-03-21 | 2011-10-25 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
US8081303B2 (en) | 2008-03-21 | 2011-12-20 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US8326008B2 (en) | 2008-04-09 | 2012-12-04 | Abbott Point Of Care, Inc. | Method for measuring the area of a sample disposed within an analysis chamber |
US8472693B2 (en) | 2010-03-18 | 2013-06-25 | Abbott Point Of Care, Inc. | Method for determining at least one hemoglobin related parameter of a whole blood sample |
US8837803B2 (en) | 2009-12-31 | 2014-09-16 | Abbott Point Of Care, Inc. | Method and apparatus for determining mean cell volume of red blood cells |
CN104647436A (en) * | 2015-02-11 | 2015-05-27 | 刘劲军 | Comb honey cutting tool |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3614050A1 (en) * | 1986-04-25 | 1987-10-29 | Hartwig Gerhardt | Device for inoculating a culture substrate with fungal mycelium |
DE29619444U1 (en) * | 1996-11-08 | 1997-01-09 | Canberra Packard Gmbh | Pipetting device |
US5651940A (en) * | 1995-12-26 | 1997-07-29 | Hitachi Instruments, Inc. | Sealed sample cuvette for volatile solutions |
WO1999015875A1 (en) * | 1997-09-25 | 1999-04-01 | Macquarie Research Ltd. | Apparatus for removing a sample from an array of samples and a cutting tool for use with that apparatus |
DE10011235A1 (en) * | 2000-03-08 | 2001-09-20 | Max Planck Gesellschaft | Manually-operated coring sampler for e.g. gels, tissues or vegetable matter, includes unit producing pressure or suction inside coring cutter |
-
2002
- 2002-08-31 DE DE2002140742 patent/DE10240742A1/en not_active Ceased
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3614050A1 (en) * | 1986-04-25 | 1987-10-29 | Hartwig Gerhardt | Device for inoculating a culture substrate with fungal mycelium |
US5651940A (en) * | 1995-12-26 | 1997-07-29 | Hitachi Instruments, Inc. | Sealed sample cuvette for volatile solutions |
DE29619444U1 (en) * | 1996-11-08 | 1997-01-09 | Canberra Packard Gmbh | Pipetting device |
WO1999015875A1 (en) * | 1997-09-25 | 1999-04-01 | Macquarie Research Ltd. | Apparatus for removing a sample from an array of samples and a cutting tool for use with that apparatus |
DE10011235A1 (en) * | 2000-03-08 | 2001-09-20 | Max Planck Gesellschaft | Manually-operated coring sampler for e.g. gels, tissues or vegetable matter, includes unit producing pressure or suction inside coring cutter |
Non-Patent Citations (2)
Title |
---|
JP 03-240482 A, in: Pat. Abstr. of Jp. (1991) * |
JP 08-117618 A, in: Pat. Abstr. of Jp. (1996) * |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8310659B2 (en) | 2008-03-21 | 2012-11-13 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
US7951599B2 (en) | 2008-03-21 | 2011-05-31 | Abbott Point Of Care, Inc. | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US9733233B2 (en) | 2008-03-21 | 2017-08-15 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US7929122B2 (en) | 2008-03-21 | 2011-04-19 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US8778687B2 (en) | 2008-03-21 | 2014-07-15 | Abbott Point Of Care, Inc. | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US8502963B2 (en) | 2008-03-21 | 2013-08-06 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US8045165B2 (en) | 2008-03-21 | 2011-10-25 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
US8077296B2 (en) | 2008-03-21 | 2011-12-13 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
US8081303B2 (en) | 2008-03-21 | 2011-12-20 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US8133738B2 (en) | 2008-03-21 | 2012-03-13 | Abbott Point Of Care, Inc. | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US8467063B2 (en) | 2008-03-21 | 2013-06-18 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
US8361799B2 (en) | 2008-03-21 | 2013-01-29 | Abbott Point Of Care, Inc. | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US8284384B2 (en) | 2008-03-21 | 2012-10-09 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US8310658B2 (en) | 2008-03-21 | 2012-11-13 | Abbott Point Of Care, Inc. | Method and apparatus for identifying reticulocytes within a blood sample |
US7929121B2 (en) | 2008-03-21 | 2011-04-19 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
US7903241B2 (en) | 2008-03-21 | 2011-03-08 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
US8269954B2 (en) | 2008-03-21 | 2012-09-18 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
US8221985B2 (en) | 2008-04-02 | 2012-07-17 | Abbott Point Of Care, Inc. | Self-calibrating gradient dilution in a constituent assay and gradient dilution apparatus performed in a thin film sample |
US7995194B2 (en) | 2008-04-02 | 2011-08-09 | Abbott Point Of Care, Inc. | Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood |
US8569076B2 (en) | 2008-04-02 | 2013-10-29 | Abbott Point Of Care, Inc. | Method for serologic agglutination and other immunoassays performed in a thin film fluid sample |
US8319954B2 (en) | 2008-04-02 | 2012-11-27 | Abbott Point Of Care, Inc. | Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood |
US8842264B2 (en) | 2008-04-02 | 2014-09-23 | Abbott Point Of Care, Inc. | Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood |
US9274094B2 (en) | 2008-04-02 | 2016-03-01 | Abbott Point Of Care, Inc. | Self-calibrating gradient dilution in a constitutent assay and gradient dilution apparatus performed in a thin film sample |
US8326008B2 (en) | 2008-04-09 | 2012-12-04 | Abbott Point Of Care, Inc. | Method for measuring the area of a sample disposed within an analysis chamber |
AU2010232585B2 (en) * | 2009-04-02 | 2013-03-21 | Abbott Point Of Care, Inc. | Method and device for transferring biologic fluid samples |
WO2010115026A1 (en) * | 2009-04-02 | 2010-10-07 | Abbott Point Of Care, Inc. | Method and device for transferring biologic fluid samples |
US8837803B2 (en) | 2009-12-31 | 2014-09-16 | Abbott Point Of Care, Inc. | Method and apparatus for determining mean cell volume of red blood cells |
US8472693B2 (en) | 2010-03-18 | 2013-06-25 | Abbott Point Of Care, Inc. | Method for determining at least one hemoglobin related parameter of a whole blood sample |
CN104647436A (en) * | 2015-02-11 | 2015-05-27 | 刘劲军 | Comb honey cutting tool |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0618426B1 (en) | System for dosing of liquids | |
DE1673340C3 (en) | ||
DE10240742A1 (en) | Apparatus for the delivery of sensitive material for analysis, containing volatile compounds, comprises a container sealed against the atmosphere with a plunger for ejection | |
EP2927696B1 (en) | Devices for automatically collecting samples | |
EP1726950A1 (en) | Cartridge for storing test elements | |
DE4328815A1 (en) | System for the storage of test elements | |
EP3218678B1 (en) | Dosing device | |
DE2011239A1 (en) | Device for taking up and dispensing small, precisely measured amounts of liquid | |
DE1816226C3 (en) | Reaction vessel | |
DE2642777A1 (en) | DEVICE FOR APPLYING LIQUID SAMPLES TO SURFACES | |
DE19539276C2 (en) | Device for removing and spreading liquids | |
DE2638743A1 (en) | DEVICE FOR DISPENSING BIOLOGICAL LIQUID | |
DE2245797A1 (en) | DEVICE FOR PERFORMING SATISFACTION ANALYSIS | |
DE202014100329U1 (en) | Device for the automated testing of the properties of foundry sand | |
DE2326596A1 (en) | METHOD AND DEVICE FOR DETERMINING GAS CONTENT | |
EP3620232A1 (en) | Insert for reaction vessel, reaction vessel, test system, method and use of an insert for reaction vessel for detection of gaseous substances emerging out of a sample of a substance | |
WO2003098170A1 (en) | Device for dosing substances | |
DE2603777A1 (en) | DEVICE FOR COLLECTING AND STORING BLOOD | |
DE102004047464A1 (en) | Powder dosing unit, used to form combinatorial materials libraries e.g. in pharmaceutical or chemical industry, includes tubular vessel pressed into powder packing | |
DE2627904A1 (en) | Moisture determn. in foundry sand - in which sample is compacted under standard conditions before using electrical test circuit | |
DE2945646C2 (en) | Methods and tools for placing solid or semi-solid samples in a graphite tube cuvette for flameless atomic absorption spectroscopy | |
DE10324913A1 (en) | Method and device for stool sampling | |
DE2519895A1 (en) | Determination of water content in liquids - using reagent in sealed vessel to evaporate water and noting pressure rise | |
DE202020000847U1 (en) | Device for longitudinally displacing a stamp by a defined distance, for example for producing a powder compact | |
DE102018207059A1 (en) | Closed pattern removal and sampling device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
OP8 | Request for examination as to paragraph 44 patent law | ||
8122 | Nonbinding interest in granting licenses declared | ||
8131 | Rejection |