DE102018218686A1 - Device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory detection of a local biological environment - Google Patents

Abstract

The invention relates to a device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory detection of a local biological environment, with a flat, biocompatible material having a support structure and having a support structure surface to which an electrode structure is applied , which has at least two electrode elements each having a lateral spacing from one another, which together with the surface of the support structure can locally limit the biological milieu, and with an electronics unit arranged on or in the support structure, which makes electrical contact with the electrode structure and a specifiable electrical voltage between the at least one two electrode elements to form each applied as an electrode and counter electrode.

Description

Technical field

The invention relates to a device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory detection of a local biological environment.

State of the art

A central research and therapy goal in the medical field of tumor therapy as well as wound therapy is the most targeted treatment of oneself in the body through uncontrolled proliferation, i.e. Cell division, multiplying and spreading tumor cells or cells from the wound area without or largely without an associated irritation of surrounding, healthy tissue areas as well as health burden of the patient to be treated.

Tumor cells in particular are able to influence the intercellular milieu in their immediate cellular environment by metabolically changing the pH value in such a way that the body's own phagocytes, which support the immune system, e.g. the so-called macrophages, especially LAK cells, are naturally prevented from doing so To eliminate tumor cells by phagocytosis. The chemical or electrochemical change in the environment takes place through local acidification by overexpression or overactivation of the Na-H antiporter, typically up to a pH of 3.5, and the associated establishment of a pH gradient in the cellular environment around the Tumor cells.

If these tumor cells succeed in eliminating the pH gradients caused by electrochemical neutralization or by physical and / or chemical reprogramming of the tumor cells, the body's own defense mechanisms against the tumor growth can work again. The inventor has already been able to demonstrate this phenomenon and also concerns advanced immunotherapeutic approaches.

Presentation of the invention

The invention has for its object to look for suitable measures to eliminate or at least significantly weaken the pH gradient explained above, so that the explained barrier effect for the body's own cells, caused by tumor cells or caused by malignant cells and based on an acidified environmental environment, is reduced, is preferably completely eliminated. The measures required for this should only be local, i.e. without significant impairment of adjacent tissue areas and in particular without a health hazard to the patient.

The solution to the problem on which the invention is based is specified in claim 1. Features which further develop the inventive idea in an advantageous manner are the subject matter of the subclaims and the further description, in particular with reference to the exemplary embodiments.

The idea on which the invention is based provides for a local electrochemical neutralization of the acidic pH gradient in the immediate cellular environment of the tumor tissue, by attaching a device according to the solution to the tumor tissue, which is capable of producing oxygen within the extracellular fluid immediately surrounding the tumor tissue and thereby to influence local biological milieu locally. Alternatively or in combination, the device according to the solution can change or completely re-polarize the cell-specific polarity of the cell surface in the direction of more negative transmembrane potentials by means of a controlled and locally acting electrical voltage application, as a result of which a type of electrodynamic or electronic reprogramming can be achieved, which is likewise due to charge-specific blocking the sodium / proton antiporter can help break down the pH gradient.

In addition to the above-mentioned intracorporeal use of the device, the device according to the solution is also suitable for extracorporeal use for the purpose of supporting the wound healing process, in particular in the case of skin injuries. In this case, the device according to the solution is designed in the manner of a plaster adhering to the skin surface and locally covering the wound site and, in the same way, is able to influence the biological environment directly at the wound site in a manner that supports the wound healing process.

For intra- or extracorporeal application in or on a human or animal body for influencing and / or for sensory detection of a local biological medium, the device according to the solution has a flat, biocompatible material carrier structure with a carrier structure surface to which an electrode structure is attached, which has at least two electrode elements, each having a lateral spacing from one another, which are preferably elongated in the manner of unstructured or structured finger electrodes and which, together with the support structure surface, can locally limit the biological environment. Furthermore, the Carried structure an electronics unit attached, which makes electrical contact with the electrode structure and applies a predetermined electrical voltage between the at least two electrode elements to form each as an electrode and counter electrode.

The carrier substrate surface preferably has a means which directly or laterally adjoins the electrode structure and which is suitable for joining to a biological tissue surface.

The electrical voltage that can be applied to the electrode structure creates an electric field between the electrode and the counterelectrode, which, depending on the field strength selected, consists of an extracellular fluid that intracorporeally surrounds both a tumor cell tissue or extracorporeally in the wound area of a skin wound and consists essentially of water and electrolytes can trigger, through which oxygen is released. If the electrical potential difference applied to the finger electrode structure is typically 1 V or more, oxygen is split off from the water portion of the extracellular fluid, which is chemically reduced and, in the case of tumor cell control, contributes to the neutralization of the locally predominant acidic environment and at least reduces the risk of inflammation in the event of wound healing .

The oxygen generated in this way starts the complete implementation of glycolysis via intrinsic cellular sensors - predominantly by means of hypoxia-induced factor, or Hif for short - so that the metabolic end products of the cell can be led to H ₂ O and CO ₂ and the pH gradients balance out.

In a preferred embodiment of the device according to the solution, the electrode structure on the carrier substrate surface is in the form of an interdigital electrode structure, which is preferably applied to the carrier structure surface in the course of a printing process.

The shape and size of both the interdigital electrode structure applied to the carrier substrate surface and the carrier structure itself depend primarily on the dimension and the spatial characteristics of the therapy area to be locally exposed to oxygen, the surface area of which ranges from a few mm ² and below to many cm ² or a few dm ² can measure. Thus, depending on the specific therapeutic conditions, the support structure surface can be flat or can take any free-form surfaces, in order to enable a surface contact between the intra- or extracorporeal surface and the support substrate surface provided with the interdigital electrode structure that is as true to the contour as possible. Particularly in the case of cleared tumor or metastatic areas, highly flexible support structures are suitable in order to establish close surface contact between the electrode structure applied to the support structure and the benign tissue areas. In these cases, the tissue areas to be treated are molded. The free-form bodies obtained are covered on the surface with the highly flexible support structure. For example, in the treatment of mostly spherical brain tumors, the more or less concave spherical resection site is covered with a spherically shaped support structure in order to get the best possible fit between the electrode structure and the surrounding benign tissue. In the case of brain tumors, in addition to the O ₂ generation, the release of electrical potentials for controlling the metabolism plays an important role.

The device according to the solution can be scaled almost arbitrarily, i.e. from the submillimeter range to large-scale dimensions that depend on the respective ergonomically predetermined conditions of the patient to be treated, such as, for example, extracorporeal skin surfaces to be treated.

The carrier structure is preferably designed in the manner of a fleece and preferably consists of a knitted fabric, braid or felt made of natural, synthetic or hollow fibers. The support structure surface of the support structure preferably has, in addition to the electrode structure applied to it, at least one additional layer, which is applied either on the electrode structure and the support structure surface or between the electrode structure and the support structure surface, is biologically compatible, antiseptic, electrically non-conductive and preferably at least one medical May contain active ingredient. This layer, which is preferably a disposable article, serves as a removable wound dressing that can be discarded after use. The thin layer in this case, designed as a wearing part, is preferably designed as a fleece with a corresponding porosity and suction force, but which at the same time is permeable to O ₂ and / or permits control or electrostatic or electrodynamic influencing of the tissue via the field gradients.

At the same time, support structures which are customary in microsystems technology lend themselves in cases in which the device according to the solution is dimensioned, for example, in the form of a microchip. In these cases, common wafer materials, preferably silicon or ceramics, are suitable as the base material for the carrier structure.

It is also conceivable to design the support structure as a body with a three-dimensional free-form surface, which can be produced, for example, by means of additive manufacturing processes. In this way, arbitrarily shaped surface shapes, for example spherical or cylindrical or the like, can be realized, which are adapted to patient-specific extra- or intracorporeal tissue shapes and thus produce ideal surface contact between the carrier substrate surface and a tissue area to be treated.

The finger electrode structure applied to the surface of the carrier structure preferably consists of a metallic, highly conductive material, such as gold, silver, platinum or palladium, however alternative electrically conductive materials can also be used, such as graphene, graphene analogues or electrically conductive biocompatible polymers.

In order to ensure that the support structure adheres as permanently as possible to a biological tissue surface, which in the above case corresponds, for example, to a tumor cell surface or skin surface, a means for joining to a biological tissue surface is provided on the support structure. For this purpose, the support structure surface is preferably provided, at least in some areas, with a biocompatible, adhesive layer, by means of which the support structure adheres flatly to the biological tissue surface. Alternatively or in combination, other joining means are also conceivable, such as mechanical fixings in the form of clips, surgical threads, etc.

The electronics unit integrated in the support structure and electrically connected to the electrode structure is used for the controlled supply of electrical voltage to the electrode structure, which can be specified precisely with regard to amount as well as time modulation. The electronic unit preferably comprises an electrical energy store in the form of a battery, a rechargeable battery or a capacitor, but it is nevertheless possible to design the electrical energy store in the form of an induction coil into which electrical signals and also energy can be coupled in contactlessly with the aid of a separate external transmitter coil.

A further preferred embodiment provides, in addition to the electronics unit, a micropump unit with at least one active substance reservoir attached to the support structure, the electronics unit being in signal exchange with the micropump unit in such a way that the micropump unit can be activated for the metered delivery of at least one stored active substance into the area of the electrode structure.

As an alternative to the integral configuration of the micropump unit and the carrier structure, it is also conceivable to design the micropump unit separately from the carrier structure and to connect it via at least one fluid line to the carrier structure for local supply and delivery of the at least one active substance into the area of the electrode structure. In this case too, the electronics unit attached to the support structure serves to control and activate the micropump unit which is formed separately from the support structure.

In a further embodiment, a gas reservoir or a gas generator in the form of a gas cell is attached directly or indirectly to the support structure and is designed and arranged in such a way that the gas reservoir or the gas cell by means of the electronics unit for the metered delivery of a stored or can be activated electrochemically generated gas in the region of the electrode structure. Any therapeutically effective gases or gases which influence the local biological milieu enclosed by the support structure and the biological tissue surface, for example oxygen, nitrogen, N ₂ O, are suitable as gases. The electrode structure applied to the support structure surface preferably has a large number of interdigital, alternating in each case and non-contact interlocking, elongated electrode elements, each of which is electrically connected at the end in the form of a counter electrode and electrode.
At least one local electrode structure is attached or introduced along at least one finger-shaped electrode or counterelectrode, which has a larger electrode surface per length dimension in the longitudinal extent than the elongated electrode element in the remaining area. In the simplest case, the at least one structure can be in the form of a bare electrode surface roughening. The structure is preferably annular, spherical, zigzag or meandering and has a smooth or roughened electrode surface. The local change in the surface geometry along at least one electrode element leads to a local change in the electrical field distribution between the electrode elements of the electrode structure, which is preferably designed as an interdigital electrode structure, which has an effect on the formation of oxygen by means of electrolysis.

In addition to the desired therapeutic goal of neutralizing the pH gradient explained by local oxygen production or supporting wound healing, the device according to the solution, with suitable control of the electrode elements applied to the surface of the support structure by the electronics unit, can also serve as a sensor device with which it is used, for example it is possible to record the pH value and / or a certain gas content, for example oxygen content, within the biological environment that is limited on one side by the support structure. A preferred embodiment variant of the device for sensory detection of the local biological environment delimited on one side by the support structure provides at least one sensor element which makes local electrical contact with at least two electrode elements serving as electrodes and counterelectrodes. Iridium oxide, palladium oxide or aluminum oxide serves as the sensor element, the electrical properties of which change depending on the pH value and / or gases present, for example O ₂ . These changes are recorded by the electronic unit using an appropriate processor. To measure oxygen, an electrical voltage of preferably about 650 mV is applied between the electrode elements.

The above-described development of the device according to the solution by providing at least one sensor element enables rule-based monitoring and adjustment of the local biological environment through controlled influence by means of controlled oxygen generation and sensory detection, for example the pH value or an oxygen content contained in the biological environment. The change between oxygen generation and measurement can be specified using one and the same electrode structure with the aid of the electronic unit, for example in the context of a sequentially changing time sequence. At the same time, it is possible to provide two separate electrode structures on the support structure, which are connected to the electronics unit, one of which is used for O ₂ generation and the other for O ₂ measurement, thereby enabling time-synchronous generation and measurement of oxygen.

The device according to the solution can be used intracorporeally and also extracorporeally. For example, the device according to the solution can be embodied as part of a plaster or in the form of a plaster, in which the surface area of the plaster that comes into direct contact with a wound site on the skin surface corresponds to the explained support structure surface to which the electrode structure is attached, which has an inner surface of the patch, ie the electronic unit integrated in the support structure in the sense explained above. The device according to the solution is able in particular to support wound healing by locally applying an electrical voltage applied between the electrode structure by means of a local production of oxygen associated therewith in the context of electrolysis within the wound secretion which is secreted by the wound. Alternatively or in combination, the plaster designed according to the solution can be supplemented with an integrally provided micropump unit or can be connected in a fluid-tight manner to a micropump unit designed separately from the plaster.

In a further preferred embodiment of the device according to the solution, the carrier substrate surface on which the electrode structure is applied is hydrophilic, i.e. the preferably fleece-like carrier structure is able to absorb the extracellular liquid, in particular water, so that the electrode elements of the electrode structure are almost completely surrounded or wetted by liquid. In this way, oxygen production is efficiently supported as part of the electrolysis.

In a further embodiment, the support structure surface on which the electrode structure is attached consists of a hydrophobic material, for example of a polyether ether ketone, through which no liquid can penetrate into the material of the support structure and thus to the electronics unit, which it would otherwise have in the case explained above Sealing liquid accordingly applies.

In a further embodiment, on and / or in the support structure, in particular in the region of the electrode structure, i.e. preferably between the electrode elements, a large number of vesicular fluid reservoirs, each filled with a gaseous or liquid fluid, the envelopes of which can be burst by applying a certain electrical voltage to the electrode structure, as a result of which the fluid pours into the biological environment. The fluid preferably contains at least one medicinal active ingredient with a therapeutic target-promoting effect.

Since electrodes in the implanted state can degrade on the surface due to the intracorporeal milieu and due to cell growth, or can literally overgrow, in a further embodiment, a further separate electrode structure is attached to the support structure in close proximity to the electrode structure, which serve as cleaning electrodes and / or as further functional electrodes , via which voltage potentials can be applied with predeterminable pulse shapes and pulse amplitudes, whose electrical fields have a cleaning effect on the electrode structure surfaces and / or have a direct influence on the electrical cell membrane potentials of directly adjacent cells.

Figure list

• 1 bevorzugte, lösungsgemäße Ausbildungsform
• 2a, b Darstellung eines intra- und extrakorporalen Einsatzzweckes der Vorrichtung,
• 3 lösungsgemäße Vorrichtung in Form eines Pflasters sowie
• 4 lösungsgemäße Vorrichtung mit Deckschicht,
• 5 alternative Ausgestaltung einer Elektrodenstruktur mit lokalen Strukturen sowie
• 6 Anordnung mit einer Vielzahl lösungsgemäßer Vorrichtungen auf einem gemeinsamen Träger.

The invention is described below without restricting the general inventive concept described by way of example using exemplary embodiments with reference to the drawing. Show it:

• 1 preferred, solution-based form of training
• 2a, b Representation of an intra- and extracorporeal purpose of the device,
• 3rd device according to the solution in the form of a plaster and
• 4th device according to the invention with a covering layer,
• 5 alternative design of an electrode structure with local structures as well
• 6 Arrangement with a plurality of devices according to the solution on a common carrier.

WAYS OF CARRYING OUT THE INVENTION, INDUSTRIAL APPLICABILITY

1 shows an embodiment according to the solution with a flat support structure 1 , preferably in the form of a fleece, consisting of a knitted fabric, braid or felt made of a natural, synthetic or hollow fiber. On the support structure surface 2nd is an electrode structure 3rd attached in the form of an interdigital electrode structure, with longitudinally interlocking, finger-like electrodes 31 and counter electrodes 32 . The electrode structure 3rd is with one in the support structure 1 integrated electronics unit 4th electrically connected, the at least one electrical energy source and the voltage potential between electrodes 31 and counter electrodes 32 the electrode structure 3rd specifiable control unit includes. Optionally, the electronics unit 4th be provided with a wireless interface via which an electrical signal and / or energy exchange to an external signal or electrical energy source is possible.

The electrode structure, which is preferably formed from a very good conductive metal 3rd is by means of a printing process on the surface of the support structure 2nd the support structure 1 upset. Of course, alternative metallic deposition processes known to those skilled in the art for producing the electrode structure are also possible 3rd applicable.

A main application of the device according to the solution relates to the intracorporeal attachment of the device to the surface 5 of a cellular tumor tissue 6 . This is in 2a illustrated. For this, the support structure surface 2nd of the carrier substrate 1 preferably on the edge by means of a biocompatible adhesive 7 on the surface 5 of the tumor tissue joined as permanently as possible. The support structure surface 2nd closes with the tumor tissue 6 a volume 8th one in which, as in the rest of the intracorporeal area, extracellular fluid is contained, which determines a local biological milieu.

Is attached to the electrode structure 3rd by means of the electronic unit 4th If an electrical voltage of at least 1 V, preferably greater than 1.1 V, is applied, the extracellular fluid near the electrode structure is electrolyzed 3rd and an associated release of oxygen. The electrodes see for the purpose of improved oxygen generation 31 the electrode structure 3rd local structures 9 before, which in the case of in 1 illustrated embodiment are annular. Alternatively, structures of this type can also take on other electrode shapes which enlarge the electrode surface.

Alternatively to that in 2 a illustrated intracorporeal application, the device according to the solution is also suitable for extracorporeal application for the purpose of supporting wound healing. In the same way, the carrier structure, which is preferably in the form of a plaster, can 1 by means of a biologically compatible adhesive adhesive 7 to the skin surface 10th be added to the wound 11 is present by the support structure 1 is preferably covered seamlessly. In the same way, wound healing is achieved by locally generating oxygen with the aid of the voltage-loaded electrode arrangement 3rd by means of electrolysis between the skin surface 10th and the support structure surface 2nd trapped extracellular fluid 12th supported.

In a further preferred embodiment the 1 illustrated device a gas reservoir 13 , preferably in the form of a gas cell, from which controlled gas, preferably oxygen, over the support structure surface 2nd , preferably in the area of the electrode structure 3rd , can be delivered.

Alternatively or in combination with the provision of a gas cell 13 within the support structure 1 can be a micropump unit 14 with at least one drug reservoir within the carrier structure 1 or attached separately to this. The active substance stored within the active substance reservoir is suitable for the particular intended use and the desired therapeutic goal, and is selected via the surface of the carrier structure 2nd , preferably in the area of the electrode arrangement 3rd to deliver.

Instead of a gas reservoir or in addition to a gas reservoir, a large number of none, bubble-like, formed fluid reservoirs can also be arranged distributed on the support structure in the region of the electrode structure, the individual ones of which Envelopes can be caused to burst by a high electrical voltage that can be briefly applied to the electrode structure, as a result of which the gaseous or liquid fluid stored in the bubble-like fluid reservoirs can pour out into the environment. Therapeutically active substances are preferably contained in the fluid.

Furthermore, an alternative development of the device provides the provision of so-called sensor elements 14 before, each between the electrodes 31 and counter electrodes 32 are arranged in a contacting manner and are used, for example, for the purpose of oxygen detection or pH value determination. The sensor elements 15 consist preferably of iridium oxide, palladium oxide or aluminum oxide.

To activate the sensor elements 15 suitable operating voltages between the electrodes 31 and counter electrodes 32 the electrode structure 3rd to apply. This is done with the help of the electronic unit 4th .

3rd illustrates an embodiment for forming the device as a plaster, the adhesive strip lying at least on both sides opposite 16 has on its surface the biologically compatible adhesive adhesive 7 is applied.

In 4th is a further training of the in 1 illustrated embodiment shown in the on the support structure surface 2nd the support structure 1 another layer 17th is applied, which can be hydrophilic or hydrophobic depending on the application. Also the additional layer 17th be designed in the form of a barrier membrane which is water-repellent but gas-permeable. Suitable materials are, for example, polyether ether ketone, hydrogels or Goretex®.

In 5 is a preferred design for the design of the electrode elements 31 , 32 an electrode structure 3rd with which the generation of oxygen is particularly effective. The elongated, finger-like electrodes 31 have web-like extensions oriented transversely to their longitudinal extent 31 ' on that on a spherical or plate-shaped extension 31 " end and in bulges 32 ' open out, each along the counter electrodes 32 are attached.

Is an electrical voltage by means of the electronics unit 4th of at least 1V between the electrode 31 and counter electrode 32 applied, it forms in the presence of extracellular fluid within the bulges 32 ' Oxygen. If, on the other hand, an electrical voltage of approximately 650 mV is applied, the areas with the web-like extensions serve 31 ' as well as the bulges 32 ' as oxygen sensors.

6 shows an arrangement A that a variety of devices V in an array-like arrangement pattern, all via a data bus transmission system 18th are interconnected, in which a central processing and control unit 19th , which is preferably chip-based, is integrated. The devices V , see detailed view in 6 each have an electrode structure in a simplest embodiment 3rd comprising at least one electrode 31 and a counter electrode 32 , as well as an electronics unit 4th , and are each capable of being used separately and separately from one another in connection with extracellular fluid and depending on one between the electrodes 31 and counter electrode 32 applied electrical voltage to trigger an electrolysis process through which oxygen is released. Due to the flat arrangement of the devices V as well as the separate control of the individual devices V , ie the central processing unit 19th communicates with those in the devices V contained electronic units 4th Together or separately, an areally homogeneous or heterogeneously controllable oxygen release can be realized.

Of course, the individual devices in the data bus network can V be designed to be multifunctionally expanded in the manner explained above, for example by supplementing it with at least one sensor, for example for detecting the pH value, O ₂ content or the like. This allows the arrangement to be influenced therapeutically A Make area-specific treatments for a tissue area to be treated, ie depending on the healing or intracorporeal milieu condition, which can be detected by sensors in a surface-resolved manner, select devices V or a group of selected devices V in the arrangement A activate, for example, for the purpose of a local electrolysis process or the local release of a medium by means of a gas cell or a micropump unit which is connected to an active substance reservoir.

In one embodiment, all devices are V each on a support structure 1 applied, for example on a chip, which in turn on a carrier 1' is applied on which the devices V have a fixed spatial relative arrangement with each other.

The over the data bus transmission system 18th linked individual chips or devices 1 can be made both very small and larger area. The chip-based central processing and control unit 19th can be on a ceramic or on a fleece as a carrier 1' be applied on or in which the individual chips or devices V are let in. The data bus transmission system 18th is wired, ie the devices V are with each other and with the central processing and control unit 19th galvanically connected via electrical lines applied or integrated in the carrier. This in 6 The illustrated electrical connection pattern is only to be understood as representative of a large number of possible circuit topologies.

In a further conceivable embodiment, the electronic units have 4th of the individual devices V electrical energy sources, for example in the form of at least one interface for the wireless transmission of electrical energy or in the form of a battery or rechargeable batteries or the like. In this case it is possible instead of a line-based data bus transmission system 18th signal transmission within the data bus transmission system 18th by means of the whole arrangement A surrounding electrically conductive liquid milieus, for example. Lymph or tissue fluid. This avoids the galvanic connection lines.

For the physical education of the wearer 1' are basically the same biocompatible materials that are also suitable for the support structures 1 are suitable, as explained above.

In a further embodiment, the electrode structure 3rd and at least the electronics unit 4th any device V directly on the carrier 1' the arrangement A be upset.

Reference list

1

Support structure

1'

carrier

2nd

Support structure surface

3rd

Electrode structure

31

Electrodes

31 '

Steigeriger extension

31 "

spherical or plate-shaped extension

32

Counter electrodes

32 '

bulge

4th

Electronics unit

5

surface

6

Cellular tumor tissue

7

Biologically compatible adhesive adhesive

8th

volume

9

Local structure

10th

Skin surface

11

wound

12th

Extracellular fluid

13

Gas reservoir

14

Micropump unit

15

Sensor element

16

Adhesive strips

17th

layer

18th

Data bus transmission system

19th

Arithmetic unit

A

arrangement

V

contraption

Claims (23)

Device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory detection of a local biological environment, with a flat, biocompatible material having a support structure that has a support structure surface on which an electrode structure is applied, at least has two electrode elements each having a lateral spacing from one another, which together with the support structure surface can locally limit the biological environment, and an electronics unit arranged on or in the support structure, which makes electrical contact with the electrode structure and a predeterminable electrical voltage between the at least two electrode elements Training applied as an electrode and counter electrode. Device after Claim 1 , characterized in that the material of the support structure is hydrophilic at least in the region of the electrode structure. Device after Claim 1 , characterized in that the material of the support structure is hydrophobic at least in the region of the electrode arrangement. Device after Claim 3 , characterized in that the material is a polyether ether ketone, on the support structure surface of which the electrode structure is attached. Device according to one of the Claims 1 to 4th , characterized in that the electrode structure is in the form of an interdigital finger electrode structure. Device according to one of the Claims 1 to 5 , characterized in that in Longitudinal extension of at least one of the electrode elements serving as an electrode or as a counterelectrode is at least one local structure which has a larger electrode surface in the longitudinal extension than the rest of the electrode element in the longitudinal extension. Device after Claim 6 , characterized in that the at least one structure is annular, spherical, zigzag or meandering and / or has a roughened surface with respect to the rest of the electrode element surface. Device according to one of the Claims 1 to 7 , characterized in that the electrode structure is applied to the support structure surface by means of a printing process. Device according to one of the Claims 1 to 8th , characterized in that the electrode structure consists of one of the following electrically conductive materials: gold, silver, platinum, palladium, graphene, graphene analogues, electrically conductive polymers. Device according to one of the Claims 1 to 9 , characterized in that the at least two electrode elements are arranged parallel or largely parallel along their longitudinal extent to each other. Device according to one of the Claims 1 to 10th , characterized in that the support structure which is designed in the manner of a fleece and consists of a knitted fabric, braid or felt made of a natural, synthetic or hollow fiber. Device according to one of the Claims 1 to 10th , characterized in that the carrier structure is designed in the manner of a chip or a printed circuit board. Device according to one of the Claims 1 to 12th , characterized in that at least one fluid reservoir, in which a gaseous or flowable medium is stored, is attached directly or indirectly to the carrier structure, and / or that at least one gas cell is attached directly or indirectly to the carrier structure. Device after Claim 13 , characterized in that the at least one fluid reservoir and / or the at least one gas cell can be activated by means of the electronics unit for the metered delivery of a fluid in the region of the electrode structure or can be released by means of an electrical voltage that can be applied between the at least two electrode elements. Device according to one of the Claims 1 to 14 , characterized in that a micropump unit with at least one drug reservoir is attached to the carrier structure or that the carrier structure is fluidically connected to at least one fluid line with a micropump unit with at least one drug reservoir such that the micropump unit by means of the electronics unit for the metered delivery of the at least one drug can be activated in the area of the electrode structure. Device according to one of the Claims 1 to 15 , characterized in that the electronic unit comprises at least one of the following functional units: microprocessor unit, interface for wireless transmission of signals and / or electrical energy, battery and / or accumulator, electrical resonant circuit with inductive receiving coil. Device according to one of the Claims 1 to 16 , characterized in that a fluidic barrier membrane is introduced on or within the support structure. Device according to one of the Claims 1 to 17th , characterized in that between the at least two electrode elements at least one sensor element is arranged and contacted with the two electrode elements, and that the at least one sensor element is connected to the electronics unit which applies a predeterminable electrical voltage to the sensor element. Device after Claim 18 , characterized in that the at least one sensor element is a pH sensor based on iridium oxide, palladium oxide, aluminum oxide. Device according to one of the Claims 1 to 19th , characterized in that the support structure surface provides, directly or indirectly adjacent to the electrode structure, a means which is suitable for joining to a biological tissue surface. Arrangement with at least two devices according to one of the Claims 1 to 20th , characterized in that the at least two devices are interconnected via a data bus transmission system. Arrangement after Claim 21 , characterized in that a plurality of the devices are arranged in rows or arrays with a fixed predetermined relative arrangement. Arrangement after Claim 21 or 22 , characterized in that the at least two Devices are arranged on a carrier on which a chip-based computing unit is attached, which communicates with the electronic unit present in each device via the data bus transmission system.

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