DE102014221853A1 - Use of an aluminum salt-free and / or aluminum zirconium salt-free cosmetic composition containing specific amino acid derivatives and proteins from legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma, for reducing and / or preventing sweat - Google Patents

Abstract

The present invention relates to the use of a cosmetic composition for reducing and / or preventing perspiration, in particular axillary sweat or perspiration of other body regions, wherein the cosmetic agent is free of aluminum-containing and / or aluminum zirconium-containing compounds and at least one specific amino acid derivative and at least one protein Legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma contains. Moreover, the present invention relates to a packaging unit as well as a non-therapeutic method for reducing transpiration of the body.

Description

The present invention relates to the use of a cosmetic composition for reducing and / or preventing perspiration, in particular axillary sweat or perspiration of other body regions, wherein the cosmetic agent is free of aluminum-containing and / or aluminum zirconium-containing compounds and at least one specific amino acid derivative and at least one protein Legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma contains.

Furthermore, the present invention relates to the use of a cosmetic composition for reducing and / or preventing perspiration, in particular axillary sweat or perspiration of other body regions, wherein the cosmetic agent is free of aluminum-containing and / or aluminum zirconium-containing compounds and at least one specific amino acid derivative and one of legumes the genus Pisum (pea) isolated, hydrolyzed protein which is optionally cationically modified contains.

Moreover, the present invention relates to a kit of parts containing a cosmetic agent (M1) with at least one antiperspirant active ingredient and at least one cosmetic agent (M2), which is free of aluminum-containing and / or aluminum zirconium-containing compounds and contains at least one specific amino acid derivative and at least one protein from legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma.

Finally, the present invention relates to a non-therapeutic cosmetic method for preventing and / or reducing perspiration of the body, in which a cosmetic agent or the cosmetic agents (M1) and (M2) of the packaging unit according to the invention is / are applied to the skin the cosmetic product is free of aluminum-containing compounds and contains at least one specific amino acid derivative and at least one protein from legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma.

Washing, cleansing and caring for one's own body is a basic human need, and modern industry is constantly trying to meet these needs of man in a variety of ways. Especially important for daily hygiene is the permanent elimination or at least reduction of body odor and underarm wetness. Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as impregnated flexible substrates (towels).

The antiperspirant cosmetic antiperspirants used in the prior art contain, in addition to at least one oil or a wax and a fragrance component or a perfume, at least one antiperspirant compound, in particular in the form of halides and / or hydroxyhalides of aluminum and / or zirconium. These antiperspirant compounds reduce sweat secretion of the body by temporarily narrowing and / or obstructing the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60 percent. On the other hand, they have an additional deodorizing effect due to their antimicrobial effect.

However, the halides and / or hydroxy halides of aluminum and / or zirconium used for antiperspirancy may, in conjunction with the acidic pH of these antiperspirants, cause unpleasant skin reactions in some users. In addition, the use of the aforementioned antiperspirant compounds can lead to staining on clothing.

There is therefore a need, instead of the previously mentioned halides and / or hydroxy halides of aluminum and / or zirconium to use other antiperspirant cosmetic agents. These antiperspirant active ingredients should have a good antiperspirant effect, good skin compatibility and easy formulatability. In addition, these antiperspirant active ingredients should have no negative impact on the storage stability of the cosmetic agents used for sweat inhibition.

It is an object of the present invention to provide antiperspirant active ingredients whose use avoids or at least mitigates the disadvantages of the prior art and their use Use in a high skin compatibility at the same time reliable reduction of underarm wetness results.

It has now surprisingly been found that the use of cosmetic compositions containing a combination of at least one specific amino acid derivative with at least one protein from pulses of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma and which are free of aluminum-containing compounds , leads to a prevention and / or reduction of transpiration of the body, which is almost comparable to the use of known halides and / or hydroxyhalides of aluminum and / or zirconium.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels,
• c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht,
• d) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und
• e) keine aluminiumhaltigen Verbindungen,

zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen. The subject of the present invention is thus a use of a cosmetic agent containing

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic agent,
• c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation,
• d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs, and
• e) no aluminum-containing compounds,

for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions.

The use of aluminum salt-free cosmetic products which contain a combination of a specific amino acid derivative and a protein from pulses of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma, is - without wishing to be limited to this theory - a purposeful influence the sweat gland (s) on which the reduction and / or prevention of sweat is based using the aforementioned combination. This targeted influencing of the sweat gland (s) may, for example, consist in a gelation of the at least one protein at pH values which are present exclusively within the excretory ducts of the sweat glands. In this way, an effective blockage of the excretory ducts of the sweat glands can be ensured without the antiperspirant effect of the cosmetic compositions used according to the invention being reduced by premature undesired gel formation due to the addition of the at least one specific protein. Furthermore, the targeted influencing the sweat gland (s) but also in a disturbance of gland function by the specific amino acid derivative, which leads to an influence on the sweat production, in particular to a reduction of sweat production. Thus, even in the absence of antiperspirant aluminum-containing and / or aluminum-zirconium containing compounds, effective reduction of underarm perspiration is ensured.

The term "physiologically acceptable cations" is understood according to the invention to mean those cations which are non-toxic or non-toxic or harmless to the organism, in particular the human and the animal organism.

Furthermore, the term "cosmetic oil" in the context of the present invention is understood to mean an oil which is suitable for cosmetic use and which is immiscible with water in all amounts. The cosmetic oil used according to the invention are neither fragrances nor essential oils.

In addition, the term "fragrances" for the purposes of the present invention means substances having a molecular weight of 74 to 300 g / mol, which contain at least one osmophoric group in the molecule and have an odor and / or taste, d. H. they are able to excite the receptors of the hair cells of the olfactory system. Osmophore groups are covalently bonded to the molecular skeleton groups in the form of hydroxyl groups, formyl groups, oxo groups, alkoxycarbonyl groups, nitrile groups, nitro groups, azide groups, etc. In this context, the term "fragrances" within the meaning of the present invention also at 20 ° C and 1013 hPa liquid perfume oils, perfumes, or perfume oil ingredients.

In addition, the term "waxes" in the context of the present invention means substances which are kneadable at 20 ° C or solid to brittle hard, have a coarse to finely crystalline structure and color translucent to opaque, but not glassy. Furthermore, these substances melt above 25 ° C without decomposition, are slightly above the melting point slightly liquid (less viscous), have a strong temperature-dependent consistency and solubility and are polishable under light pressure.

The term "protein" refers according to the invention to chemical compounds which form acid amide-like linked condensation products of amino acids by means of peptide bonds. The number of amino acids in the proteins is preferably at least 2 and at most 1,000 amino acids. According to the invention, the term "protein" also means hydrolyzates of a protein which contain protein fractions having different amino acid sequences and molecular weights. Moreover, in the context of the present invention, this term also includes mixtures of proteins occurring in pulses of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma.

In addition, in the context of the present invention, the term "pulses" are to be understood as meaning plants which, from just one carpel, form a legume (also called legume) which bursts at the abdominal and back seams when ripe. However, according to the invention, this term also means the seeds, in particular the mature seeds, of the plants mentioned above.

In addition, the term "aluminum-containing compounds" in the context of the present invention, in particular chlorides, bromides and iodides of aluminum and / or zirconium and compounds of the formulas Al (OH) _y X and Zr (OH) _z X understood, where X in the above formulas is a halide ion.

In addition, the term "fatty acids" as used in the context of the present invention means aliphatic carboxylic acids which have unbranched or branched carbon radicals having 4 to 40 carbon atoms. The fatty acids used in the present invention may be both naturally occurring and synthetically produced fatty acids. Furthermore, the fatty acids may be monounsaturated or polyunsaturated.

Finally, in the context of the present invention, the term "fatty alcohols" is to be understood as meaning aliphatic, monohydric, primary alcohols which have unbranched or branched hydrocarbon radicals having from 4 to 40 carbon atoms. The fatty alcohols used in the invention may also be monounsaturated or polyunsaturated.

The statement wt .-% refers in the present case, unless otherwise stated, on the total weight of the invention used, blowing agent-free cosmetic products.

As a first component a), the cosmetic agents used according to the invention contain at least one substance which is selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes.

In the context of the present invention, the cosmetic oil which is liquid at 20 ° C. and 1013 hPa is selected from the group of (i) volatile cyclic silicone oils, in particular cyclic and linear silicone oils; (ii) volatile non-silicone oils, especially liquid paraffin oils and isoparaffin oils; (iii) nonvolatile silicone oils; (iv) non-volatile non-silicone oils; and (v) their mixtures.

According to the invention, the term "volatile oil" denotes oils which have a vapor pressure of 2.66 Pa to 40,000 Pa (0.02 to 300 mm Hg) at 20 ° C. and an ambient pressure of 1013 hPa, preferably 10 to 12,000 Pa (0, 1 to 90 mm Hg), more preferably from 13 to 3000 Pa (0.1 to 23 mm Hg), especially 15 to 500 Pa (0.1 to 4 mm Hg).

In addition, the term "nonvolatile oils" in the context of the present invention means oils which have a vapor pressure of less than 2.66 Pa (0.02 mm Hg) at 20 ° C. and an ambient pressure of 1013 hPa.

It may be preferred according to the invention to use mixtures of volatile silicone oils and volatile non-silicone oils in the antiperspirant cosmetic agents used according to the invention, since this results in a drier skin feel. Furthermore, in the context of the present invention, it may be preferred for the cosmetic agents used according to the invention to comprise a nonvolatile silicone oil and / or a nonvolatile non-silicone oil in order to mask insoluble constituents, such as talc or skin-dried ingredients.

Particularly preferred according to the invention is the use of mixtures of nonvolatile and volatile cosmetic oils, since in this way parameters such as skin feel, visibility of the residue and stability of the antiperspirant cosmetic agent used according to the invention can be adjusted and the agent can thus be better adapted to the needs of the consumer.

The volatile and non-volatile silicone oils which can be used in the context of the present invention, as well as volatile and non-volatile non-silicone oils, are disclosed, for example, in the published patent applications DE 10 2010 063 250 A1 and DE 10 2012 222 692 A1 disclosed.

According to a preferred embodiment of the present invention, the cosmetic oil which is liquid at 20 ° C. and 1013 hPa is in a total amount of 0.02 to 98% by weight, preferably of 2 to 85% by weight, preferably of 4 to 75% by weight. -%, more preferably from 6 to 70 wt .-%, still more preferably from 8 to 60 wt .-%, in particular from 8 to 20 wt .-%, based on the total weight of the propellant-free cosmetic composition containing.

As constituent a) of the cosmetic agents used according to the invention it is also possible for at least one perfume to be present. However, mixtures of different fragrances are preferably used, which together produce an appealing scent. Fragrances which can be used in the context of the present invention are described, for example, in the published patent application DE 10 2010 063 250 A1 disclosed.

Particularly appealing cosmetic agents used according to the invention are obtained when the at least one perfume in a total amount of 0.00001 to 15 wt .-%, preferably from 0.001 to 9 wt .-%, preferably from 0.01 to 8 wt .-% , more preferably from 0.1 to 7 wt .-%, even more preferably from 0.2 to 6 wt .-%, in particular from 0.2 to 2 wt .-%, based on the total weight of the blowing agent-free cosmetic agent containing is.

Furthermore, the cosmetic agents used according to the invention may contain as component a) a wax. Preferably, this wax is selected from the group of (i) fatty acid glycerol mono-, di- and triesters; (ii) Butyrospermum Parkii (Shea Butter); (iii) esters of saturated monohydric C _8-18 alcohols with saturated C _12-18 monocarboxylic acids; (iv) linear C ₁₂ -C 24 primary alkanols; (v) esters of a saturated monohydric _C16-60 alkanol and a saturated C8 _-C36 monocarboxylic acid; (vi) glycerol triesters of saturated linear C _12-30 carboxylic acids, which may be hydroxylated; (vii) natural vegetable waxes; (viii) animal waxes; (ix) synthetic waxes; and (x) their mixtures. In the context of the present invention preferably usable waxes are in the published patent application DE 10 2012 222 692 A1 disclosed.

In the context of the present invention, it is preferred for the wax to be present in a total amount of from 0.01 to 50% by weight, preferably from 3 to 40% by weight, preferably from 5 to 30% by weight, in particular from 6 to 25 Wt .-%, based on the total weight of the blowing agent-free cosmetic agent is included.

According to one embodiment of the present invention, it may be provided that the cosmetic agents used according to the invention contain as component b) a blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the blowing agent-free cosmetic agent. If the cosmetic agents used according to the invention contain a propellant, this is preferably in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight, based on the total weight of the cosmetic composition. In this case, the cosmetic agents used according to the invention are formulated as propellant-driven aerosols. Preferred propellants (propellants) are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1,1-difluoroethane, tetrafluoropropenes, both individually and in their mixtures. Also hydrophilic propellants, such. As carbon dioxide, can be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (eg., Propane / butane) is present in excess. Particularly preferred are propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.

As a third component c), the cosmetic agent used according to the invention contains at least one specific amino acid derivative of the formula (I).

Preferably, amino acid derivatives are used which have no alkyl groups on the nitrogen atom. In the formula (I), therefore, R ¹ and R ² each independently represent a hydrogen atom.

Furthermore, in the context of the present invention it is preferred if in the formula (I) n represents integers from 2 to 9, preferably from 2 to 7, preferably from 2 to 6, in particular 2 or 3. Particularly good results in the context of the present invention are obtained when n in the formula (I) is the integer 3. The use of cosmetic agents containing such amino acid derivatives leads to a particularly high reduction or reduction of sweat.

According to the invention, it may further be preferred if in the formula (I) X ^{+ is} a hydrogen atom.

In a particularly preferred embodiment of the present invention, gamma-aminobutyric acid is used as the compound of the formula (I) in the cosmetic compositions used according to the invention. Gamma-aminobutyric acid differs from the proteinogenic, ie occurring in proteins, alpha-amino acids by the position of the amino group relative to the carboxyl group. While the amino group in the proteinogenic amino acids is at the carbon atom adjacent to the carboxyl group, gamma-aminobutyric acid has the amino group on the third carbon atom after the carboxyl group. The use of gamma-aminobutyric acid in combination with the at least one specific protein results in a particularly effective reduction or reduction of perspiration and does not lead to skin intolerances during use. In addition, when using the gamma-aminobutyric acid no incompatibilities with the other ingredients of the cosmetic compositions used in the invention, so that a high storage stability of these agents is guaranteed.

The at least one compound of the formula (I) is preferably used in a total amount of from 0.0002 to 20% by weight, preferably from 0.005 to 20% by weight, preferably from 0.001 to 20% by weight, more preferably from 0.01 to 20 wt .-%, in particular from 0.1 to 20 wt .-%, based on the total weight of the blowing agent-free cosmetic agent used. The use of the aforementioned amounts ensures effective reduction or reduction of sweat and does not lead to negative interactions with the other ingredients of the cosmetic compositions used in the invention.

As a fourth component d), the cosmetic agent used according to the invention contains at least one special protein from legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma. The genus with the Latin name Pisum refers to legumes in the form of peas and includes, for example, the Schalerbse (also called Pahl-, Pal- or Kneifelerbse), the pea, the sugar pea (also called Kaiserschote, Kiefelerbse, Kefe or Zuckerschote) and the Riesenerbse. Under the Latin name Phaseolus fall legumes in the form of beans, such as the lima bean, the tepary bean, the bean of fire, the make-up bean and the kidney bean (also called bush bean or barley bean). Pulses with the Latin name Vigna, such as the bean mat, the Adzukibohne, the common bean, the mung bean, the Bambara peanut and the rice bean, and the legumes with the Latin name Macrotyloma, such as the bean or horse bean, are also in shape of beans in front.

Particularly good results with regard to the reduction and / or reduction of underarm wetness and skin compatibility and storage stability are obtained when the at least one protein has an average molecular weight Mw of from 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da. The average molecular weight Mw can be determined, for example, by gel permeation chromatography (GPC) ( Andrews P .; "Estimation of the Molecular Weights of Proteins by Sephadex Gel Filtration"; Biochem. J., 1964, 91, pages 222 to 233 ).

According to a preferred embodiment of the present invention, the at least one protein has an isoelectric point which ranges from pH 3.0 to pH 10.0, preferably from pH 4.0 to pH 9.5, in particular from pH 4.0 to pH 8.0. In particular, proteins which have an isoelectric point in the abovementioned pH range have proven to be advantageous in terms of the antiperspirant effect and the stability of the cosmetic agents used according to the invention in the context of the present invention.

According to a preferred embodiment of the present invention, the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.

According to the invention, the term "unmodified proteins" is to be understood as meaning proteins which have not been treated by means of chemical processes, for example hydrolysis or chemical modification, or by physical methods, such as, for example, purification, separation and irradiation.

Furthermore, the term "hydrolyzed proteins" or "protein hydrolysates" according to the invention are to be understood as meaning proteins which are prepared by chemical, in particular alkaline or acid hydrolysis, by enzymatic hydrolysis and / or by a combination of both types of hydrolysis. For enzymatic degradation all hydrolytic enzymes are suitable, such as alkaline proteases. Overviews of the production of protein hydrolysates are, for example, from G. Schuster and A. Domsch in soaps oils Fette Wachse 108, (1982) 177 and Cosm.Toil. 99, (1984) 63 , from HW Steisslinger in Parf.Kosm. 72, (1991) 556 and F. Aurich et al. in Tens.Surf.Det. 29, (1992) 389 published. Mixtures of individual amino acids which are obtained merely by mixing the pure substances of the amino acids, as well as total hydrolysates which consist only of individual amino acids, do not fall within the scope of the present invention under the term "hydrolyzed proteins" or "protein hydrolysates".

In addition, the term "chemically modified proteins" in the context of the present invention are proteins which, by chemical reaction of the reactive groups of the proteins, in particular the hydroxyl, amine, imidazole, guanidino and / or thiol groups of the side chains of Amino acids of the protein, with hydrophobic and / or cationic and / or anionic compounds.

In addition, the term "physically modified proteins" in the context of the present invention are proteins which have been modified by physical action, in particular by heat and / or light and / or fractionation.

In the context of this embodiment, it is particularly preferred if the at least one protein is selected from the group of chemically modified, in particular hydrophobically modified, proteins. In this context, the hydrophobically modified protein has one or more C _4-30 carbon groups, wherein the C _4-30 hydrocarbon groups may be linear, cyclic, branched, unbranched, saturated, unsaturated and aromatic and wherein the C _{4-30 hydrocarbon groups} Hydrocarbon groups are bonded via ether and / or ester and / or amine and / or amide bonds to the protein residue.

Moreover, it is preferred in the context of this embodiment if the at least one protein is selected from the group of chemically modified, in particular cationically modified, proteins. The cationically modified protein preferably contains one or more radicals of the formula R ³ -N ⁺ (CH ₃ ) ₂ -CH ₂ -CH (OH) -CH ₂ -AR, in which R ^{3 is} an alkyl group having 1 to 30 Carbon atoms, an alkenyl group having 1 to 30 carbon atoms, a hydroxyalkyl group having 1 to 30 carbon atoms, in particular a methyl group, a C _10-18 alkyl or a C _10-18 alkenyl group, A is O, N or S and R is the Protein residue stand. The cationization of the proteins with the above-described radicals can be achieved by reacting the proteins, in particular the reactive groups of the amino acids of the proteins, with the corresponding halides of the above formula, wherein the radicals described above via ether and / or ester and / or Amide and / or amine bonds may be bound to the protein. For the purposes of the present invention, the term "protein residue" is to be understood as meaning the backbone of the corresponding protein formed by the linking of amino acids, to which the cationic group is bonded via the abovementioned bonds.

With regard to the antiperspirant effect, the skin compatibility and the storage stability of the cosmetic compositions used according to the invention, it is particularly preferred if the at least one protein is a protein isolated from pulses of the genus Pisum, wherein the protein is hydrolyzed and optionally cationically modified. Without wishing to be limited to this theory, the use of these special proteins in combination with the specific amino acid derivative, in particular gamma-aminobutyric acid, results in a significantly increased influence of the sweat gland (s) by pH-selective gel formation and / or disturbance of glandular function. In this way, an excellent antiperspirant effect of the cosmetic compositions used in the invention is ensured, which is comparable to the use of aluminum salt-containing or aluminum zirconium salt-containing cosmetic agents of the prior art.

According to another particularly preferred embodiment of the present invention, the at least one protein effects at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for determining the change in light absorption, a change in the light absorption of 1 to 100%, preferably from 1.5 to 90%, preferably from 2 to 80%, more preferably from 2.5 to 70%, even more preferably from 3 to 65%, especially from 3.5 to 60%. According to the invention, the term "change in the light absorption of the at least one protein" means both the positive and negative changes in the light transmission of the sample mixture, in particular the protein solution, and the absorption of light by the at least one protein or the sample mixture. Furthermore, the term "pH change" is understood to mean the continuous change in the pH. The continuous change in the pH can be achieved for example by titration, or uniform addition of a base or acid. The term "sample mixture" refers according to the invention to a mixture of the at least one specific protein with a solvent, in particular water, buffer or saline aqueous solutions.

The changes in light absorption with a pH change of at least 0.5 can be determined by measuring the light transmission of a light beam through the sample mixture. The measurements of light transmission are performed using a Methrom Optrode 6.1115.000 at a wavelength of 574 nm (green-yellow) in mV (resolution 0.1 mV) in an open sample vessel at 23 ° C and 1013 mbar. The pH change in the pH range of 4.0 to 8.0 is achieved by slowly and continuously adding a carbonate or bicarbonate solution, preferably a 1% by weight sodium bicarbonate solution, to the sample mixture to measure the pH achieved with a pH electrode and with stirring at a speed of 750 to 850 rpm. The change in light absorption caused by the at least one protein is calculated according to the formula ΔL = [(| L _i | / | L ₀ |] · 100. In this formula, Li represents the difference in light transmission before and after change of the pH by at least 0.5 in the pH range of 4.0 to 8.0, preferably of pH 4.5 and 7.5, in particular of pH 5.0 and 7.0. L ₀ is in this Formula for the difference from the light transmission at pH 4.0 and at pH 8.0, preferably at pH 4.5 and at pH 7.5, especially at pH 5.0 and at pH 7.0, so for example light transmission at pH 8.0 minus light transmission at pH 4.0 The at least one specific protein in the antiperspirant cosmetic agents used according to the invention effects a change in light absorption of 1 to 100% as determined by the above method, but the present invention is not based on the use of antiperspirant cosmetic Limited agents that contain at least one special protein contain, which causes a change of the light absorption of 1 to 100% determined by the above method. It also encompasses the use of antiperspirant cosmetic agents which contain at least one specific protein which, by other methods, effects a change in light absorption of 1 to 100%.

In the context of the present invention, it is preferred if the concentration of the at least one protein in the sample mixture used to determine the change in the light absorption of 0.005 to 10 wt .-%, preferably from 0.05 to 5 wt .-%, preferably from 0 , 07 to 3 wt .-%, in particular of 0.09 to 2 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, is.

According to the invention, the at least one protein preferably effects a change in the light absorption with a pH change of at least 0.5 and at most 3.5, preferably at least 0.5 and at most 2.5, in particular at least 0.5 and at most 1, 5th The change in the pH can be achieved in particular by the addition of acids or bases, preferably bases in the form of carbonates or bicarbonates, in the appropriate amount.

A particularly effective reduction of armpit sweat is achieved in the context of the present invention, if the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30% by weight, in particular from 2.0 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent. The use of the abovementioned amounts of the at least one specific protein in combination with the specific amino acid derivative results in a significant influence on the sweat gland (s). In this way, an excellent antiperspirant effect is ensured. Furthermore, the use of the abovementioned amounts of the at least one specific protein does not lead to negative interactions with the other ingredients of the cosmetic agents used according to the invention, so that a high storage stability is ensured.

According to a further preferred embodiment of the present invention, the cosmetic agent has a pH of from pH 2 to pH 10. Within this range, a stable formulation of the cosmetic compositions used in the invention is possible without undesirable interactions between the ingredients occur. The adjustment of the desired pH value can be carried out according to the invention by using acids and bases which are known to the person skilled in the art and are customary in cosmetic agents.

According to the invention it is further preferred if the cosmetic agent additionally contains at least one preservative. Preservatives which are preferred according to the invention are formaldehyde releasers iodopropynyl butylcarbamates, parabens, phenoxyethanol, ethanol, benzoic acid and salts thereof, dibromodicyanobutane, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea, 5-chloro-2-methyl-4-isothiazoline. 3-one, 2-chloroacetamide, benzalkonium chloride, benzyl alcohol, salicylic acid and salicylates. Further preservatives which can be used in the context of the present invention are the substances listed in Annex 6 of the Cosmetics Regulation, as well as cosmetic raw materials with preservative properties or raw materials which support or enhance the preservative action of the abovementioned preservatives. The preservatives are preferably in a total amount of 0.01 to 10 wt .-%, preferably from 0.1 to 7 wt .-%, preferably from 0.2 to 5 wt .-%, in particular from 0.3 to 2, 0 wt .-%, based on the total weight of the blowing agent-free cosmetic agent.

In the context of the present invention it is preferred if the antiperspirant cosmetic agent is present as a water-in-oil emulsion. This may in particular be a sprayable water-in-oil emulsion which can be sprayed by means of a propellant, or a gelatinous water-in-oil emulsion which is applied by means of a dispenser. In this context, it is preferred if the cosmetic agent used in the form of a water-in-oil emulsion - in each case based on the total weight of the propellant-free cosmetic agent - the at least one compound of formula (I) in a total amount of 0.0002 to 20% by weight, preferably from 0.005 to 20% by weight, preferably from 0.001 to 20% by weight, more preferably from 0.01 to 20% by weight, in particular from 0.1 to 20% by weight, and the at least one protein in a total amount of from 0.1 to 70% by weight, preferably from 0.5 to 60% by weight, preferably from 1.0 to 50% by weight preferably from 1.5 to 40% by weight, even more preferably from 2.0 to 30% by weight, in particular from 2.0 to 20% by weight.

However, it may equally be preferred according to the invention if the antiperspirant cosmetic agent is present as an oil-in-water emulsion. In this case, the cosmetic agent according to the invention is preferably sprayed as a propellant-containing aerosol, propellant-free pump spray or squish spray or applied as a roll-on. In this context, it is preferred if the cosmetic agent used in the form of an oil-in-water emulsion - in each case based on the total weight of the propellant-free cosmetic agent - the at least one compound of formula (I) in a total amount of 0.0002 to 20% by weight, preferably from 0.005 to 20% by weight, preferably from 0.001 to 20% by weight, more preferably from 0.01 to 20% by weight, in particular from 0.1 to 20% by weight, and the at least one protein in a total amount of from 0.1 to 70% by weight, preferably from 0.5 to 60% by weight, preferably from 1.0 to 50% by weight, more preferably from 1.5 to 40% by weight, still more preferably from 2.0 to 30% by weight, especially from 2.0 to 20% by weight.

According to a further preferred embodiment of the present invention, the cosmetic agents used according to the invention may contain only a low content of free water or no free water. For the purposes of the present invention, free water is understood to mean water which is different from water of crystallization, water of hydration or similar molecularly bound water of the constituents used. The cosmetic agent used according to the invention preferably contains free water in a total amount of less than 10% by weight, preferably less than 8% by weight, preferably less than 5% by weight, more preferably less than 3% by weight. %, even more preferably less than 1 wt .-%, in particular of 0 wt .-%, based on the total weight of the blowing agent-free cosmetic agent.

Within the scope of a further embodiment, however, it is likewise preferred according to the invention if the cosmetic agent is present as an aqueous, aqueous-alcoholic or aqueous-glycolic solution. Since the cosmetic compositions used according to the invention do not contain antiperspirant halides and / or hydroxyhalides of aluminum and / or zirconium, which have a reduced antiperspirant effect by the addition of protic solvents, protic solvents, such as aqueous solutions, can be used according to the invention for formulating the cosmetic compositions. without a significant reduction in the antiperspirant effect. Therefore, the addition of the at least one specific protein in combination with a specific amino acid derivative, even with the use of protic solvents, ensures an effective influence on the sweat gland (s) and thus an excellent antiperspirant effect.

In connection with this embodiment of the present invention, it has surprisingly been found that the influence of the sweat gland (s) can be significantly increased by the combination of at least one specific amino acid derivative and at least one specific protein when the cosmetic agent used according to the invention contains free water in an amount of 5 to 99 wt .-%, based on the total weight of the blowing agent-free cosmetic agent. In a particularly preferred embodiment of the present invention, the cosmetic product therefore contains free water in a total amount of 5 to 96 wt.%, Preferably 15 to 80 wt.%, Preferably 30 to 70 wt.%, In particular 40 to 60 wt .-%, based on the total weight of the blowing agent-free cosmetic agent.

Furthermore, in connection with this embodiment, it is preferred if the cosmetic agent contains ethanol in a total amount of 1 to 99% by weight, preferably from 5 to 70% by weight, preferably from 7 to 50% by weight, in particular from 10 to 30 wt .-%, based on the total weight of the blowing agent-free cosmetic composition contains. As stated above, by using the combination of at least one specific amino acid derivative and at least one specific protein, even high levels of protic solvents, such as ethanol, can be used without adversely affecting the antiperspirant effect of the cosmetic agents used in the present invention.

The application of the cosmetic agent used according to the invention can be carried out by means of various methods. According to a preferred embodiment, the cosmetic agent is formulated as a spray application. The spray application is carried out with a spraying device which contains in a container a filling of the liquid, viscous-flowable, suspension-shaped or pulverulent cosmetic agent used according to the invention. The filling may be under the pressure of a propellant (compressed gas cans, compressed gas packages, aerosol dispensers), or it may be a mechanically operated pump sprayer without propellant (pump sprays / squeeze bottle). The atomization of the cosmetic agent may be effected physically, mechanically or electromechanically, for example by piezoelectric effects or electrical pumps. In the context of this embodiment, usable containers and removal devices are, for example, in the published patent application DE 10 2012 222 692 A1 described.

The cosmetic agent may further preferably be formulated as a stick, soft solid, cream, gel, roll-on, loose or compact powder. The formulation of the cosmetic agents used according to the invention in a specific dosage form, such as, for example, an antiperspirant roll-on, an antiperspirant stick or an antiperspirant gel, is preferably based on the requirements of the intended use. Depending on the intended use, the antiperspirant cosmetic agents used according to the invention can therefore be present in solid, semisolid, liquid, disperse, emulsified, suspended, gelatinous, multiphase or powdery form. Under the concept of the liquid fall within the meaning of the present Invention also any types of solid dispersions in liquids. Furthermore, in the context of the present invention, multiphase cosmetic agents used according to the invention are understood to mean agents which have at least 2 different phases with a phase separation and in which the phases can be arranged horizontally, ie one above the other, or vertically, ie side by side. The application can be done for example with a roller ball applicator or by means of a fixed pin.

It may also be preferred within the scope of the present invention if the cosmetic agent is contained on and / or in a disposable substrate selected from the group of wipes, pads and bulbs. Especially preferred are wet wipes, i. prefabricated for the user, preferably individually packaged, wet wipes, such as. B. from the field of glass cleaning or from the field of wet toilet paper are well known. Such wet wipes, which can advantageously also contain preservatives, are impregnated or applied with a cosmetic agent used according to the invention and preferably individually packaged. Preferred substrate materials are selected from porous sheet-like cloths. These wipes include wipes of woven and nonwoven synthetic and natural fibers, felt, paper or foam, such as hydrophilic polyurethane foam. Deodorizing or antiperspirant substrates which are preferred according to the invention can be obtained by impregnation or impregnation or else by melting a cosmetic agent used according to the invention onto a substrate.

In the context of the present invention, it can furthermore be provided that the cosmetic agents used according to the invention contain further active ingredients and ingredients.

Uses preferred according to the invention are therefore characterized in that the cosmetic agent comprises at least one wide auxiliary selected from the group of (i) emulsifiers and / or surfactants; (ii) thickeners; (iii) chelating agents; (iv) deodorant agents; (v) monohydric and / or polyhydric alcohols and / or polyethylene glycols; (vi) skin-cooling agents; (vii) pH adjusters; (viii) skin care ingredients, such as moisturizers, skin soothing substances, skin lightening substances, skin smoothing substances; and (ix) mixtures thereof.

Emulsifiers and surfactants which are preferably suitable according to the invention are selected from anionic, cationic, nonionic, amphoteric, in particular ampholytic and zwitterionic emulsifiers and surfactants. Surfactants are amphiphilic (bifunctional) compounds which consist of at least one hydrophobic and at least one hydrophilic moiety. The hydrophobic moiety is preferably a hydrocarbon chain of 8 to 28 carbon atoms, which may be saturated or unsaturated, linear or branched. Particularly preferably, this C ₈ -C ₂₈ -alkyl chain is linear. Emulsifiers and surfactants which can preferably be used in the context of the present invention are described, for example, in the published patent applications DE 10 2012 222 692 A1 . DE 10 2010 063 250 A1 such as DE 10 2010 055 816 A1 disclosed.

Substances which are selected from cellulose ethers, xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, pectins, agar, carrageenan (carrageenan), tragacanth, gum arabic, karaya gum, tara gum, gellan, gelatin are preferably used to thicken the cosmetic agents used according to the invention , Propylene glycol alginate, alginic acids and their salts, polyvinylpyrrolidones, polyvinyl alcohols, polyacrylamides, physically (eg by pre-gelatinization) and / or chemically modified starches, acrylic acid-acrylate copolymers, acrylic acid-acrylamide copolymers, acrylic acid-vinylpyrrolidone copolymers, acrylic acid Vinylformamide copolymers and polyacrylates. Particularly preferred thickeners are furthermore selected from carbomers. Carbomers are thickening crosslinked polymers of acrylic acid, methacrylic acid and their salts. The crosslinking can be effected by means of polyfunctional compounds such as polyalkylene ethers of polysaccharides or polyalcohols, for example sucrose allyl ether, pentaerythritol allyl ether, propylene allyl ether. Preferred in the context of the present invention are homopolymers of acrylic acid or salts thereof which are crosslinked with a pentaerythritol allyl ether, a sucroseallyl ether or a propylene allyl ether. A thickening agent which can be used in the context of the present invention is a copolymer of C _10-30 -alkyl acrylate, acrylic acid, methacrylic acid and esters thereof, which is crosslinked with a sucrose allyl ether or a pentaerythritol allyl ether. Thickener based on carbomers are products sold under the trade name Carbopol ^® (BF Goodrich, Ohio, USA) available such as Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001, Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20, or Carbopol ultrez 21.

Furthermore, lipophilic thickening agents can be used to thicken the cosmetic compositions used according to the invention. Lipophilic thickeners which are preferred according to the invention are selected from hydrophobized clay minerals, bentonites, pyrogenic silicas and derivatives thereof.

In order to further support the influence of the sweat gland (s) by the combination of at least one specific amino acid derivative and at least one specific protein, it may be advantageous to use at least one chelating agent, in a total amount of from 0.01 to 3, of the cosmetic agents used in accordance with the invention. 0 wt .-%, preferably from 0.02 to 1.0 wt .-%, in particular from 0.05 to 0.1 wt .-%, based on the total weight of the blowing agent-free cosmetic composition, to add. In the context of the present invention, preferred chelating agents are selected from the group of β-alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, calcium disodium, ammonium and triethanolamine salts of ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid (HEDTA) and their sodium salts. sodium salts of nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid, phytic acid, hydroxypropyl cyclodextrin, methylcyclodextrin, Aminotrimethylenphosphonat pentasodium, ethylenediamine pentasodium, diethylenetriamine pentaacetate pentasodium, pentasodium triphosphate, potassium EDTMP, sodium EDTMP, Natriumdihydroxyethylglycinat, sodium phytate, Natriumpolydimethylglycinophenolsulfonat, tetrahydroxyethylethylenediamine, tetrahydroxypropylethylenediamine, Tetrakaliumetidronat , Tetrasodium tetidronate, tetrasodiumiminodisuccinate, trisodium ethylenediamine disuccinate, tetrasodium N, N-bis ( Carboxymethyl) glutamate, tetrasodium DL-alanine-N, N-diacetate and desferrioxamine.

The deodorizing effect of the cosmetic agents used according to the invention can be further increased if at least one deodorant active ingredient having antibacterial and / or bacteriostatic and / or enzyme inhibiting and / or odor-neutralizing and / or odor-absorbing action in a total amount of 0.0001 to 40% by weight. %, preferably from 0.2 to 20 wt .-%, preferably from 1 to 15 wt .-%, in particular from 1.5 to 5 wt .-%, based on the total weight of the blowing agent-free cosmetic agent is included. If ethanol is used in the cosmetic agents used according to the invention, this does not apply in the context of the present invention as a deodorant active ingredient, but as a constituent of the carrier. According to the invention preferred deodorant agents are, for example, in the published patent application DE 10 2010 063 250 A1 disclosed.

Preferred cosmetic agents used according to the invention furthermore contain at least one water-soluble polyhydric C _2-9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 50 ethylene oxide units and mixtures thereof. This does not include the abovementioned deodorant active ingredients in the form of 1,2-alkanediols. Preferred alkanols and water-soluble polyethylene glycols are, for example, in the published patent application DE 10 2010 063 250 A1 described.

According to a further embodiment of the present invention, the cosmetic agents used according to the invention furthermore contain at least one skin-cooling active substance. Skin-cooling active ingredients suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, eg. Menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxypropanediol, menthone glycerol acetal (9-methyl-6- (1-methylethyl) -1,4-dioxaspiro (4.5) decane-2-methanol), monomethyl succinate, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate. Preferred skin-cooling active ingredients are menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidonecarboxylic acid and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate, as well as mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol.

According to the invention, the pH adjusting agents used are preferably acids and / or alkalizing agents and / or buffers. As acids according to the invention preferably inorganic acids (such as hydrochloric acid, sulfuric acid or phosphoric acid) or organic acids (such as citric acid, gluconic acid, tartaric acid or malic acid) are used. The alkalizing agents which can be used according to the invention are preferably selected from the group which is formed from ammonia, basic amino acids, alkali metal hydroxides, carbonates and bicarbonates, alkanolamines, for example amino-2-methyl-1-propanol, monoethanolamine, triethanolamine, diethanolamine and triisopropanolamine, alkali metal metasilicates, Urea, morpholine, N-methylglucamine, imidazole, alkali phosphates and alkali hydrogen phosphates. The alkali metal ions used are preferably lithium, sodium, potassium, in particular sodium or potassium. Suitable buffer systems in the context of the present invention are in particular carbonic acid-bicarbonate buffer, carbonic acid-silicate buffer, acetic acid-acetate buffer, phosphate buffer, ammonia buffer, citric acid or citrate buffer, buffer based on tris (hydroxymethyl) -aminomethane, buffer Base of 4- (2-hydroxyethyl) - 1-piperazinethanesulfonic acid, buffer based on 4- (2-hydroxyethyl) -piperazine-1-propanesulfonic acid, buffer based on 2- (N-morpholino) ethanesulfonic acid and barbital acetate buffer. The choice of the corresponding buffer system depends on the desired pH of the cosmetic agents used according to the invention.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt,
• – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0002 bis 20 Gew.-%, vorzugsweise von 0,005 bis 20 Gew.-%, bevorzugt von 0,001 bis 20 Gew-%, weiter bevorzugt von 0,01 bis 20 Gew.-%, insbesondere von 0,1 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und
• 1.013 hPa flüssig sind, Riechstoffen und Wachsen enthalten.

In a preferred embodiment, the cosmetic agents used according to the invention are characterized in that they contain, based on the total weight of the blowing agent-free cosmetic agent,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs,
• - At least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20 wt%, more preferably from 0.01 to 20 Wt .-%, in particular from 0.1 to 20 wt .-%,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative and
• At least one substance selected from the group of cosmetic oils, which is at 20 ° C and
• 1,013 hPa are liquid, fragrances and waxes included.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt,
• – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0002 bis 20 Gew.-%, vorzugsweise von 0,005 bis 20 Gew.-%, bevorzugt von 0,001 bis 20 Gew-%, weiter bevorzugt von 0,01 bis 20 Gew.-%, insbesondere von 0,1 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel,
• – 0,01 bis 5 Gew.-%, vorzugsweise 0,1 bis 2 Gew.-%, bevorzugt 0,2 bis 0,7 Gew.-%, insbesondere 0,3 bis 0,5 Gew.-% eines Verdickungsmittels, und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen enthalten.

In a further preferred embodiment, the cosmetic agents used according to the invention are characterized in that they contain, based on the total weight of the blowing agent-free cosmetic agent,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs,
• - At least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20 wt%, more preferably from 0.01 to 20 Wt .-%, in particular from 0.1 to 20 wt .-%,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative,
• From 0.01 to 5% by weight, preferably from 0.1 to 2% by weight, preferably from 0.2 to 0.7% by weight, in particular from 0.3 to 0.5% by weight, of a thickener, and
• - At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%, .-%, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt,
• – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0002 bis 20 Gew.-%, vorzugsweise von 0,005 bis 20 Gew.-%, bevorzugt von 0,001 bis 20 Gew-%, weiter bevorzugt von 0,01 bis 20 Gew.-%, insbesondere von 0,1 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens ein Treibmittel in einer Gesamtmenge von 1 bis 98 Gew.-%, vorzugsweise von 20 bis 90 Gew.-%, bevorzugt von 30 bis 85 Gew-%, insbesondere von 40 bis 75 Gew.-%,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen enthalten.

In a preferred embodiment, the cosmetic agents used according to the invention are characterized in that they contain, based on the total weight of the blowing agent-free cosmetic agent,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, .-%, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs,
• - At least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20 wt%, more preferably from 0.01 to 20 Wt .-%, in particular from 0.1 to 20 wt .-%,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one blowing agent in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative and
• - At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%, .-%, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt,
• – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0002 bis 20 Gew.-%, vorzugsweise von 0,005 bis 20 Gew.-%, bevorzugt von 0,001 bis 20 Gew-%, weiter bevorzugt von 0,01 bis 20 Gew.-%, insbesondere von 0,1 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens ein Treibmittel in einer Gesamtmenge von 1 bis 98 Gew.-%, vorzugsweise von 20 bis 90 Gew.-%, bevorzugt von 30 bis 85 Gew-%, insbesondere von 40 bis 75 Gew.-%,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel,
• – 0,01 bis 5 Gew.-%, vorzugsweise 0,1 bis 2 Gew.-%, bevorzugt 0,2 bis 0,7 Gew.-%, insbesondere 0,3 bis 0,5 Gew.-% eines Verdickungsmittels, und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen enthalten.

In a further preferred embodiment, the cosmetic agents used according to the invention are characterized in that they contain, based on the total weight, blowing agent-free of the cosmetic agent,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, .-%, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs,
• - At least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20 wt%, more preferably from 0.01 to 20 Wt .-%, in particular from 0.1 to 20 wt .-%,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one blowing agent in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative,
• From 0.01 to 5% by weight, preferably from 0.1 to 2% by weight, preferably from 0.2 to 0.7% by weight, in particular from 0.3 to 0.5% by weight, of a thickener, and
• - At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels,
• c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom stehen, n für ganze Zahlen von 2 oder 3 steht, und X⁺ für Wasserstoff steht,
• d) mindestens ein aus Hülsenfrüchten der Gattung Pisum isoliertes Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das Protein hydrolysiert ist und gegebenenfalls kationisch modifiziert ist, und
• e) keine aluminiumhaltigen Verbindungen,

zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen. Another object of the present invention is the use of an antiperspirant cosmetic agent containing

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic agent,
• c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,
  
  wherein R ₁ and R ₂ , each independently of one another, represent a hydrogen atom, n represents integers of 2 or 3, and X ^{+ represents} hydrogen,
• d) at least one protein isolated from legumes of the genus Pisum in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the protein is hydrolyzed and optionally cationically modified, and
• e) no aluminum-containing compounds,

for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions.

With regard to further preferred embodiments of this article mutatis mutandis applies to the cosmetic agents used in the invention.

In the context of the present invention, it may also be envisaged to prepare the cosmetic agent used according to the invention as a two-component agent. The individual components For this purpose, they are preferably stored in separate containers and applied in succession or simultaneously to the skin in any order. Separation into multicomponent systems is particularly preferred where incompatibilities of the ingredients are to be expected or feared.

• a) mindestens einen ersten Container (C1), umfassend ein kosmetisches Mittel (M1) enthaltend mindestens einen schweißhemmenden Wirkstoff, und
• b) mindestens einen zweiten Container (C2), umfassend ein kosmetisches Mittel (M2), enthaltend – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, – Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels, – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht, – mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und – keine aluminiumhaltigen Verbindungen.

A further subject of the present invention is therefore a packaging unit (kit-of-parts), comprising - made up separately -

• a) at least one first container (C1), comprising a cosmetic agent (M1) containing at least one antiperspirant active substance, and
• b) at least one second container (C2) comprising a cosmetic agent (M2) containing - at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes, - propellant in a total amount of from 0 to 99% by weight, based on the total weight of the cosmetic composition, of at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic composition .
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, - At least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs , and - no aluminum-containing compounds.

The term "antiperspirant active ingredient" is understood according to the invention as meaning active ingredients which reduce or reduce the perspiration of the sweat glands of the body. However, this does not include the compounds of the formula (I) present in the cosmetic product (M2) and the proteins from legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma.

According to a preferred embodiment of this subject of the invention, gamma-aminobutyric acid is used as compound of the formula (I) in the cosmetic product (M2).

Furthermore, in the context of this embodiment it is preferred if the at least one protein in the cosmetic agent (M2) is a protein isolated from legumes of the genus Pisum (peas), the protein being hydrolyzed and optionally cationically modified.

With regard to further ingredients of the cosmetic compositions (M1) and (M2) as well as the further embodiments of this subject matter of the invention, mutatis mutandis the statements made regarding the cosmetic agents used according to the invention apply.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels,
• c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht,
• d) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und
• e) keine aluminiumhaltigen Verbindungen enthält.

Finally, another object of the present invention is a non-therapeutic cosmetic method for preventing and / or reducing perspiration of the body, in which an antiperspirant cosmetic agent or the cosmetic agents (M1) and (M2) of the packaging unit according to the invention to the skin, in particular on the skin of the underarms, is / remain for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remain on the skin of the armpits, wherein the antiperspirant cosmetic agent

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic agent,
• c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation,
• d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs, and
• e) contains no aluminum-containing compounds.

In the case of the packaging unit according to the invention, it may be provided that first the cosmetic agent (M1) with the antiperspirant active ingredient and then the cosmetic agent (M2), containing a combination of at least one specific amino acid derivative and at least one specific protein, is applied. However, it is also possible first to apply the cosmetic product (M2) and then to use a cosmetic product (M1). In addition, the cosmetic agent (M2) and the cosmetic agent (M1) can also be applied simultaneously to the skin. The time between application of these two remedies is from 0 seconds to 24 hours.

Furthermore, within the scope of this subject matter of the invention it is preferred if the cosmetic agent (s) remains on the skin of the armpits after application for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours ,

Particularly good results are obtained in the context of this subject of the invention, when gamma-aminobutyric acid is used as the compound of formula (I).

According to a further preferred embodiment of this subject of the invention, the at least one protein comprises a protein isolated from pulses of the genus Pisum (peas), wherein the protein is hydrolyzed and optionally cationically modified.

With regard to further embodiments of the method according to the invention, mutatis mutandis applies to the cosmetic agents used according to the invention and to the packaging unit according to the invention.

• 1. Verwendung eines kosmetischen Mittels, enthaltend a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels, c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht, d) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und e) keine aluminiumhaltigen Verbindungen, zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen.
• 2. Verwendung nach Punkt 1, dadurch gekennzeichnet, dass in der Formel (I) R¹ und R², jeweils unabhängig voneinander, für ein Wasserstoffatom stehen.
• 3. Verwendung nach einem der Punkte 1 oder 2, dadurch gekennzeichnet, dass in der Formel (I) n für ganze Zahlen von 2 bis 9, vorzugsweise von 2 bis 7, bevorzugt von 2 bis 6, insbesondere für 2 oder 3, steht.
• 4. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass als Verbindung der Formel (I) gamma-Aminobuttersäure eingesetzt wird.
• 5. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass die mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0002 bis 20 Gew.-%, vorzugsweise von 0,005 bis 20 Gew.-%, bevorzugt von 0,001 bis 20 Gew-%, weiter bevorzugt von 0,01 bis 20 Gew.-%, insbesondere von 0,1 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, eingesetzt wird.
• 6. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein ein mittleres Molekulargewicht Mw von 150 bis 100.000 Da, vorzugsweise von 180 bis 50.000 Da, bevorzugt von 200 bis 10.000 Da, weiter bevorzugt von 250 bis 8.000 Da, insbesondere von 300 bis 5.000 Da, aufweist.
• 7. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein einen isoelektrischen Punkt aufweist, welcher im Bereich von pH 3,0 bis pH 10,0, vorzugsweise von pH 4,0 bis pH 9,5, insbesondere von pH 4,0 bis pH 8,0, liegt.
• 8. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein ausgewählt aus der Gruppe von (i) nicht modifizierten Proteinen; (ii) hydrolysierten Proteinen; (iii) chemisch modifizierten Proteinen, insbesondere hydrophob und/oder kationisch und/oder anionisch modifizierten Proteinen; (iv) physikalisch modifizierten Proteinen, insbesondere fraktionierten und/oder gereinigten und/oder bestrahlten Proteinen; (v) hydrolysierten nicht modifizierten Proteinen; (vi) hydrolysierten und chemisch modifizierten Proteinen, insbesondere hydrolysierten und hydrophob und/oder kationisch und/oder anionisch modifizierten Proteinen; (vii) hydrolysierten und physikalisch modifizierten Proteinen, insbesondere fraktionierten und/oder gereinigten und/oder bestrahlten Proteinen; sowie (viii) deren Mischungen.
• 9. Verwendung nach Punkt 9, dadurch gekennzeichnet, dass das kationisch modifizierte Protein einen oder mehrere Rest(e) der Formel R³-N⁺(CH₃)₂-CH₂-CH(OH)-CH₂-A-R, in welcher R³ für eine Alkylgruppe mit 1 bis 30 Kohlenstoffatomen, eine Alkenylgruppe mit 1 bis 30 Kohlenstoffatomen, eine Hydroxyalkylgruppe mit 1 bis 30 Kohlenstoffatomen, insbesondere für eine Methylgruppe, eine C_10-18-Alkyl oder eine C_10-18-Alkenylgruppe, A für O, N oder S und R für den Proteinrest stehen, enthält.
• 10. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein ein aus Hülsenfrüchten der Gattung Pisum (Erbsen) isoliertes Protein ist, wobei das Protein hydrolysiert ist und gegebenenfalls kationisch modifiziert ist.
• 11. Verwendung nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, eingesetzt wird.
• 12. Verwendung eines schweißhemmenden kosmetischen Mittels, enthaltend a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels, c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom stehen, n für ganze Zahlen von 2 oder 3 steht, und X⁺ für Wasserstoff steht, d) mindestens ein aus Hülsenfrüchten der Gattung Pisum isoliertes Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das Protein hydrolysiert ist und gegebenenfalls kationisch modifiziert ist, und e) keine aluminiumhaltigen Verbindungen, zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen.
• 13. Verpackungseinheit (Kit-of-Parts), umfassend – getrennt voneinander konfektioniert – a) mindestens einen ersten Container (C1), umfassend ein kosmetisches Mittel (M1) enthaltend mindestens einen schweißhemmenden Wirkstoff, und b) mindestens einen zweiten Container (C2), umfassend ein kosmetisches Mittel (M2), enthaltend – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, – Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels, – mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht, – mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und – keine aluminiumhaltigen Verbindungen.
• 14. Nicht-therapeutisches kosmetisches Verfahren zur Verhinderung und/oder Reduzierung der Transpiration des Körpers, bei welchem ein schweißhemmendes kosmetisches Mittel oder die kosmetischen Mittel (M1) und (M2) Verpackungseinheit nach Punkt 14 auf die Haut, insbesondere auf die Haut der Achselhöhlen, aufgetragen wird/werden und für mindestens 1 Stunde, vorzugsweise für mindestens 2 Stunden, bevorzugt für mindestens 4 Stunden, insbesondere für mindestens 6 Stunden, auf der Haut der Achselhöhlen verbleibt/verbleiben, wobei das schweißhemmende kosmetische Mittel a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des kosmetischen Mittels, c) mindestens eine Verbindung der Formel (I) in einer Gesamtmenge von 0,0001 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels,
  
  worin R₁ und R₂, jeweils unabhängig voneinander, für ein Wasserstoffatom oder eine verzweigte oder unverzweigte C₁-C₂₀-Alkylgruppe stehen, n für ganze Zahlen von 2 bis 10 steht, und X⁺ für Wasserstoff oder ein physiologisch verträgliches Kation steht, d) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des treibmittelfreien kosmetischen Mittels, wobei das mindestens eine Protein in Hülsenfrüchten der Gattung Pisum und/oder Phaseolus und/oder Vigna und/oder Macrotyloma vorkommt, und e) keine aluminiumhaltigen Verbindungen enthält.

The present invention is outlined in particular by the following points:

• 1. Use of a cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight. %, based on the total weight of the cosmetic agent, c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the propellant-free cosmetic product,
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma and e) no aluminum-containing compounds to reduce and / or prevent perspiration, in particular axillary sweat or perspiration of other body regions.
• 2. Use according to item 1, characterized in that in the formula (I) R ¹ and R ² , in each case independently of one another, represent a hydrogen atom.
• 3. Use according to one of the items 1 or 2, characterized in that in the formula (I) n represents integers from 2 to 9, preferably from 2 to 7, preferably from 2 to 6, in particular 2 or 3.
• 4. Use according to one of the preceding points, characterized in that gamma-aminobutyric acid is used as the compound of formula (I).
• 5. Use according to one of the preceding points, characterized in that the at least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20% by weight, more preferably from 0.01 to 20% by weight, in particular from 0.1 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent.
• 6. Use according to one of the preceding points, characterized in that the at least one protein has an average molecular weight Mw of 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da.
• 7. Use according to one of the preceding points, characterized in that the at least one protein has an isoelectric point which ranges from pH 3.0 to pH 10.0, preferably from pH 4.0 to pH 9.5, in particular from pH 4.0 to pH 8.0.
• 8. Use according to one of the preceding points, characterized in that the at least one protein selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.
• 9. Use according to item 9, characterized in that the cationically modified protein one or more radical (s) of the formula R ³ -N ⁺ (CH ₃ ) ₂ -CH ₂ -CH (OH) -CH ₂ -AR, in which R ^{3 is} an alkyl group having from 1 to 30 carbon atoms, an alkenyl group having from 1 to 30 carbon atoms, a hydroxyalkyl group having from 1 to 30 carbon atoms, especially a methyl group, a C _10-18 alkyl or a C _10-18 alkenyl group, A for O, N or S and R are the protein residue contains.
• 10. Use according to one of the preceding points, characterized in that the at least one protein is a protein isolated from legumes of the genus Pisum (peas), wherein the protein is hydrolyzed and optionally cationically modified.
• 11. Use according to one of the preceding points, characterized in that the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40 % By weight, more preferably from 2.0 to 30% by weight, in particular from 2.0 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent.
• 12. Use of an antiperspirant cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight. %, based on the total weight of the cosmetic agent, c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,
  
  wherein R ₁ and R _{2 are} each independently hydrogen, n is an integer of 2 or 3, and X ^{+ is} hydrogen, d) at least one protein isolated from Pisum legume in a total amount of 0, From 1 to 70% by weight, based on the total weight of the antiperspirant cosmetic agent, wherein the protein is hydrolysed and optionally cationically modified, and e) no aluminum-containing compounds for reducing and / or preventing perspiration, in particular armpit sweat or perspiration of other body regions ,
• 13. Packing unit (kit-of-parts), comprising - made up separately from one another - a) at least one first container (C1) comprising a cosmetic agent (M1) containing at least one antiperspirant active substance, and b) at least one second container (C2) composition comprising a cosmetic agent (M2) containing - at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes, - propellant in a total amount of 0 to 99% by weight. %, based on the total weight of the cosmetic agent, of at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the propellant-free cosmetic product,
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, - At least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs , and - no aluminum-containing compounds.
• 14. A non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which an antiperspirant cosmetic agent or the cosmetic agents (M1) and (M2) the packaging unit according to item 14 is applied to the skin, in particular to the skin of the armpits, and / or for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, especially for at least 6 hours, remain on the skin of the armpits, wherein the antiperspirant cosmetic agent a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes, b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the cosmetic composition, c) at least one compound of Formula (I) in a total amount of 0.0001 to 20 wt .-%, based on the total weight of the blowing agent-free cosmetic M eans,
  
  wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs, and e) contains no aluminum-containing compounds.

The following examples illustrate the present invention without, however, limiting it to:

Examples:

The protein used in the following examples is preferably a hydrolyzed legume protein of the genus Pisum, which has an average molecular weight Mw of about 500 Da. As the compound of the formula (I), gamma-aminobutyric acid is preferably used.

Cosmetic agents used according to the invention having a pH of 2.5 to 10.0 (amounts in% by weight) 1 2 3 4 5 6 7 isopropyl 0.50 0.10 0.50 1.0 2.0 3.0 5.0 Compound of the formula (I) 20 10 5.0 3.0 2.0 0.5 0.01 protein 0.50 2.0 3.0 5.0 7.0 10 20 Eumulgin B3 ^a) 3.0 3.0 3.0 4.0 4.0 4.0 5.0 Perfume 0.10 0.20 0.30 0.30 0.50 0.8 1.0 preservative 0.50 0.50 0.50 0.80 0.80 1.5 2.0 pH adjusters ad pH ad pH ad pH ad pH ad pH ad pH ad pH water ad 100 ad 100 ad 100 ad 100 ad 100 ad 100 ad 100 ^a) Eumulgin B3 (INCI: Ceteareth-30, BASF)

Cosmetic agents used according to the invention with a pH of 2.5 to 10.0 in the form of spray emulsions (amounts in% by weight) 1 2 3 4 cyclopentasiloxane 11 11 13 15 isopropyl 5.0 5.0 5.0 5.0 Dow Corning ES-5227 DM ^b) 6.0 6.0 7.0 7.0 Perfume 4.0 4.0 5.0 4.0 propylene glycol 20 20.5 18 15 phenoxyethanol 0.5 0.5 0.5 0.5 sodium benzoate 0.4 0.4 0.4 0.4 Compound of the formula (I) 1.0 0.5 2.0 0.5 protein 5.0 3.5 5.0 3.5 Hydrochloric acid, 20% ad pH ad pH ad pH ad pH water ad 100 ad 100 ad 100 ad 100 ^b) Dow Corning ES-5227 DM (INCI: dimethicone, PEG / PPG-18/18 dimethicone, Dow Corning)

Cosmetic agents used according to the invention with a pH of 2.5 to 10.0 in the form of roll-on emulsions (amounts in% by weight) 1 2 3 4 Steareth-21 1.5 1.5 2.0 2.0 Steareth-2 2.5 2.5 3.0 2.0 PPG-15 stearyl ether 0.5 0.5 1.0 0.5 Perfume 1.0 1.0 1.5 1.0 Tetrasodium EDTA 0.1 0.1 0.1 0.1 Compound of the formula (I) 1.0 0.5 2.0 0.5 protein 5.0 3.5 5.0 3.5 Hydrochloric acid, 20% ad pH ad pH ad pH ad pH water ad 100 ad 100 ad 100 ad 100

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 102010063250 A1 [0029, 0031, 0071, 0075, 0076]
• DE 102012222692 A1 [0029, 0033, 0066, 0071]
• DE 102010055816 A1 [0071]

Cited non-patent literature

• Andrews P .; "Estimation of the Molecular Weights of Proteins by Sephadex Gel Filtration"; Biochem. J., 1964, 91, pages 222 to 233 [0043]
• G. Schuster and A. Domsch in soaps oils Fette Wachse 108, (1982) 177 and Cosm.Toil. 99, (1984) 63 [0047]
• HW Steisslinger in Parf.Kosm. 72, (1991) 556 [0047]
• F. Aurich et al. in Tens.Surf.Det. 29, (1992) 389 [0047]

Claims (10)

Use of a cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic agent, c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the propellant-free cosmetic product,

wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma and e) no aluminum-containing compounds to reduce and / or prevent perspiration, in particular axillary sweat or perspiration of other body regions. Use according to claim 1, characterized in that in the formula (I) R ¹ and R ² , each independently of one another, represent a hydrogen atom. Use according to one of claims 1 or 2, characterized in that in the formula (I) n represents integers from 2 to 9, preferably from 2 to 7, preferably from 2 to 6, in particular 2 or 3. Use according to one of the preceding claims, characterized in that gamma-aminobutyric acid is used as compound of the formula (I). Use according to one of the preceding claims, characterized in that the at least one compound of formula (I) in a total amount of 0.0002 to 20 wt .-%, preferably from 0.005 to 20 wt .-%, preferably from 0.001 to 20 wt -%, more preferably from 0.01 to 20 wt .-%, in particular from 0.1 to 20 wt .-%, based on the total weight of the blowing agent-free cosmetic agent is used. Use according to any one of the preceding claims, characterized in that the at least one protein is a keratin isolated from sheep's wool or goat's wool, wherein the at least one protein is a protein isolated from legumes of the genus Pisum (peas), the protein being hydrolyzed and optionally cationic is modified. Use according to one of the preceding claims, characterized in that the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40 Gew. %, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, based on the total weight of the blowing agent-free cosmetic agent is used. Use of an antiperspirant cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight based on the total weight of the cosmetic product, c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,

wherein R ₁ and R _{2 are} each independently hydrogen, n is an integer of 2 or 3, and X ^{+ is} hydrogen, d) at least one protein isolated from Pisum legume in a total amount of 0, From 1 to 70% by weight, based on the total weight of the antiperspirant cosmetic agent, wherein the protein is hydrolysed and optionally cationically modified, and e) no aluminum-containing compounds for reducing and / or preventing perspiration, in particular armpit sweat or perspiration of other body regions , Packing unit (kit-of-parts), comprising - made up separately - a) at least one first container (C1), comprising a cosmetic agent (M1) containing at least one antiperspirant active substance, and b) at least one second container (C2) a cosmetic agent (M2) containing - at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, - blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic agent, - at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic product,

wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, - At least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs , and - no aluminum-containing compounds. A non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which an antiperspirant cosmetic agent or the cosmetic agents (M1) and (M2) packaging unit according to claim 9 is applied to the skin, in particular to the skin of the armpits and remain on the skin of the armpits for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, the antiperspirant cosmetic agent a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight, based on the total weight of the cosmetic product, c) at least one compound of the formula (I) in a total amount of from 0.0001 to 20% by weight, based on the total weight of the blowing agent-free cosmetic agent,

wherein R ₁ and R ₂ , each independently of one another, stand for a hydrogen atom or a branched or unbranched C ₁ -C ₂₀ -alkyl group, n stands for integers from 2 to 10, and X ^{+ stands} for hydrogen or a physiologically compatible cation, d) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the blowing agent-free cosmetic agent, wherein the at least one protein in legumes of the genus Pisum and / or Phaseolus and / or Vigna and / or Macrotyloma occurs, and e) contains no aluminum-containing compounds.