DE102014216898A1 - Antiperspirant cosmetic products containing specific proteins from fish or birds which do not contain halides and / or hydroxyhalides of aluminum and / or zirconium - Google Patents

Abstract

The present invention relates to an antiperspirant cosmetic agent which contains at least one specific protein from fish or birds and which is free of halides and / or hydroxides of aluminum and / or zirconium. Moreover, the present invention relates to the use of a specific protein as well as a non-therapeutic method of reducing transpiration of the body. The addition or use of this at least one specific protein ensures an effective influence on the sweat gland (s) and thus results in a significant reduction of axillary sweat, even in the absence of antiperspirant aluminum salts.

Description

The present invention relates to an antiperspirant cosmetic which contains at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, if appropriate at least one propellant and special proteins from fish or birds. The cosmetic agent according to the invention contains no antiperspirant halides and / or hydroxides of aluminum and / or zirconium. The addition of the at least one special protein results in an influence on the sweat gland (s).

Furthermore, the present invention relates to a packaging unit (kit-of-parts) containing a cosmetic agent according to the invention and a cosmetic agent with at least one antiperspirant active ingredient.

Moreover, the present invention relates to the use of specific proteins from fish or birds for at least partially influencing the sweat gland (s).

In addition, the present invention relates to the use of a combination which contains at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, if appropriate at least one propellant and special proteins from fish or birds for reducing and / or preventing perspiration, in particular axillary sweat or perspiration of other body regions. The combination according to the invention contains no antiperspirant halides and / or hydroxides of aluminum and / or zirconium.

Furthermore, the present invention relates to a non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which an inventive antiperspirant cosmetic agent or a packaging unit according to the invention is applied to the skin, in particular on the skin of the armpits, and for at least 1 Hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remains on the skin of the armpits.

Finally, the present invention relates to an antiperspirant cosmetic agent without halides and / or hydroxides of aluminum and / or zirconium, which comprises at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, optionally containing at least one propellant and at least one hydrolyzed collagen isolated from fish. The addition of such collagens results in an influence on the sweat gland (s).

Washing, cleansing and caring for one's own body is a basic human need, and modern industry is constantly trying to meet these needs of man in a variety of ways. Especially important for daily hygiene is the permanent elimination or at least reduction of body odor and underarm wetness. Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as impregnated flexible substrates (towels).

Prior art cosmetic antiperspirants contain at least one antiperspirant compound, in particular in the form of halides and / or hydroxyhalides of aluminum and / or zirconium, in addition to at least one oil or a wax and a fragrance component or perfume. These antiperspirant compounds reduce sweat secretion of the body by temporarily narrowing and / or obstructing the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60 percent. On the other hand, they have an additional deodorizing effect due to their antimicrobial effect.

Halides and / or hydroxy halides of aluminum and / or zirconium, combined with the acidic pH of these antiperspirants, can cause unpleasant skin reactions in some users. In addition, the use of the aforementioned antiperspirant compounds can lead to staining on clothing.

There is therefore a need to exchange antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium with other antiperspirant cosmetic agents. These antiperspirant active ingredients should have a good antiperspirant effect, good skin compatibility and easy formulatability. In addition, these antiperspirant active ingredients should have no negative impact on the storage stability of the antiperspirant cosmetic agents.

It is an object of the present invention to provide a perspiration-inhibiting cosmetic agent which avoids or at least mitigates the disadvantages of the prior art and which has good skin compatibility with at the same time reliable reduction of underarm wetness. In addition, the antiperspirant cosmetic agent should have a high storage stability.

It has now surprisingly been found that the use of at least one protein from fish or birds in cosmetic products results in an antiperspirant effect which is almost comparable to the antiperspirant effect of formulations with aluminum salts and / or aluminum-zirconium complexes. The at least one protein must cause a change in the light absorption of 1 to 100% with a change in the pH of at least 0.5 in a pH range of pH 4.0 to pH 8.0. The antiperspirant effect of the invention is achieved without the addition of antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und
• c) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt,

wobei das schweißhemmende kosmetische Mittel keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält. The subject of the present invention is thus an antiperspirant cosmetic containing

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and
• c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein from fish or birds is isolated and wherein the at least one protein at a pH Change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight the sample mixture used for the determination of the change of the light absorption, a change of the light absorption of 1 to 100%, causes

wherein the antiperspirant cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium.

The use of the at least one protein from fish or birds with the abovementioned special physical properties in the antiperspirant cosmetic agents according to the invention is carried out-without wishing to be limited to this theory-to selectively influence the sweat gland (s). This targeted influencing of the sweat gland (s) may, for example, consist in a gelation of the at least one protein at pH values which are present exclusively within the excretory ducts of the sweat glands. In this way, an effective blockage of the excretory ducts of the sweat glands can be ensured without the antiperspirant effect of the cosmetic product according to the invention being reduced by premature undesired gel formation due to the addition of the at least one specific protein. Furthermore, the targeted influencing the sweat gland (s) but also in a disturbance of the charge balance within the sweat gland (s) exist, which leads to an influence on the sweat production, in particular to a reduction of welding production. Thus, even in the absence of antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium, effective reduction of armpit sweat is ensured.

The term "antiperspirant" is understood according to the invention to reduce or reduce the perspiration of the sweat glands of the body.

In addition, the term "halides and / or hydroxyhalides of aluminum and / or zirconium" in the present invention, in particular chlorides, bromides and iodides of aluminum and zirconium and compounds of the formulas Al (OH) _y X and Zr (OH) _z X understood, wherein X in the above formulas is a halide ion.

Furthermore, the term "cosmetic oil" in the context of the present invention is understood to mean an oil which is suitable for cosmetic use and which is immiscible with water in all amounts. The cosmetic oil used according to the invention is neither fragrances nor essential oils.

In addition, the term "fragrances" in the context of the present invention means substances having a molecular weight of 74 to 300 g / mol, which contain at least one osmophoric group in the molecule and have an odor and / or taste, d. H. they are able to excite the receptors of the hair cells of the olfactory system. Osmophore groups are covalently bonded to the molecular skeleton groups in the form of hydroxyl groups, formyl groups, oxo groups, alkoxycarbonyl groups, nitrile groups, nitro groups, azide groups, etc. In this context, the term "fragrances" within the meaning of the present invention also at 20 ° C and 1013 hPa liquid perfume oils, perfumes, or perfume oil ingredients.

In addition, the term "waxes" in the context of the present invention means substances which are kneadable at 20 ° C or solid to brittle hard, have a coarse to finely crystalline structure and color translucent to opaque, but not glassy. Furthermore, these substances melt above 25 ° C without decomposition, are slightly above the melting point slightly liquid (less viscous), have a strong temperature-dependent consistency and solubility and are polishable under light pressure.

The term "proteins" refers according to the invention to chemical compounds which form acid amide-like linked condensation products of amino acids by means of peptide bonds. The number of amino acids in the proteins is preferably 2 to 1,000, preferably 2 to 500, in particular 2 to 60, amino acids. According to the invention, the term "proteins" also means hydrolyzates of proteins which contain protein fractions having different amino acid sequences and molecular weights. Moreover, in the context of the present invention, this term also means mixtures of proteins from fish or birds.

In addition, the term "change in the light absorption of the at least one protein" is understood to mean both the positive and negative changes in the light permeability of the sample mixture, in particular the protein solution, and the absorption of light by the at least one protein or the sample mixture.

Furthermore, the term "pH change" is understood to mean the continuous change in the pH. The continuous change in the pH can be achieved for example by titration, or uniform addition of a base or acid.

The term "sample mixture" refers according to the invention to a mixture of the at least one specific protein with a solvent, in particular water, buffer or saline aqueous solutions.

In addition, the term "fatty acids" as used in the context of the present invention means aliphatic carboxylic acids which have unbranched or branched carbon radicals having 4 to 40 carbon atoms. The fatty acids used in the present invention may be both naturally occurring and synthetically produced fatty acids. Furthermore, the fatty acids may be monounsaturated or polyunsaturated.

Finally, in the context of the present invention, the term "fatty alcohols" is to be understood as meaning aliphatic, monohydric, primary alcohols which have unbranched or branched hydrocarbon radicals having from 4 to 40 carbon atoms. The fatty alcohols used in the invention may also be monounsaturated or polyunsaturated.

The statement wt .-% relates in the present case, unless stated otherwise, to the total weight of the antiperspirant cosmetic agents according to the invention.

As a first component a), the cosmetic compositions according to the invention contain at least one substance which is selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes.

In the context of the present invention, the cosmetic oil which is liquid at 20 ° C. and 1013 hPa is selected from the group of (i) volatile cyclic silicone oils, in particular cyclic and linear ones Silicone oils; (ii) volatile non-silicone oils, especially liquid paraffin oils and isoparaffin oils; (iii) nonvolatile silicone oils; (iv) non-volatile non-silicone oils; and (v) their mixtures.

According to the invention, the term "volatile oil" denotes oils which have a vapor pressure of 2.66 Pa to 40,000 Pa (0.02 to 300 mm Hg) at 20 ° C. and an ambient pressure of 1013 hPa, preferably 10 to 12,000 Pa (0, 1 to 90 mm Hg), more preferably from 13 to 3000 Pa (0.1 to 23 mm Hg), especially 15 to 500 Pa (0.1 to 4 mm Hg).

In addition, the term "nonvolatile oils" in the context of the present invention means oils which have a vapor pressure of less than 2.66 Pa (0.02 mm Hg) at 20 ° C. and an ambient pressure of 1013 hPa.

It may be preferred according to the invention to use mixtures of volatile silicone oils and volatile non-silicone oils in the antiperspirant cosmetic agents according to the invention, since this results in a drier skin feel. Further, within the present invention, it may be preferred for the antiperspirant cosmetic agents to contain a non-volatile silicone oil and / or a non-volatile non-silicone oil to sequester insoluble ingredients such as talc or skin-dried ingredients.

Particularly preferred according to the invention is the use of mixtures of nonvolatile and volatile cosmetic oils, since in this way parameters such as skin feel, visibility of the residue and stability of the antiperspirant cosmetic agent according to the invention can be adjusted and the agent can thus be better adapted to the needs of the consumer.

The volatile and non-volatile silicone oils which can be used in the context of the present invention, as well as volatile and non-volatile non-silicone oils, are disclosed, for example, in the published patent applications DE 10 2010 063 250 A1 and DE 10 2012 222 692 A1 disclosed.

According to a preferred embodiment of the present invention, the cosmetic oil which is liquid at 20 ° C. and 1013 hPa is in a total amount of 0.02 to 98% by weight, preferably of 2 to 85% by weight, preferably of 4 to 75% by weight. -%, more preferably from 6 to 70 wt .-%, even more preferably from 8 to 60 wt .-%, in particular from 8 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent.

As component a) of the cosmetic compositions according to the invention, at least one fragrance may also be present. However, mixtures of different fragrances are preferably used, which together produce an appealing scent. Fragrances which can be used in the context of the present invention are described, for example, in the published patent application DE 10 2010 063 250 A1 disclosed.

Particularly pleasant-smelling antiperspirant cosmetic agents according to the invention are obtained if the at least one perfume in a total amount of 0.00001 to 15 wt .-%, preferably from 0.001 to 9 wt .-%, preferably from 0.01 to 8 wt .-% , more preferably from 0.1 to 7 wt .-%, even more preferably from 0.2 to 6 wt .-%, in particular from 0.2 to 2 wt .-%, based on the total weight of the antiperspirant cosmetic agent is.

Furthermore, the antiperspirant cosmetic agents according to the invention may contain as component a) a wax. Preferably, this wax is selected from the group of (i) fatty acid glycerol mono-, di- and triesters; (ii) Butyrospermum Parkii (Shea Butter); (iii) esters of saturated monohydric C _8-18 alcohols with saturated C _12-18 monocarboxylic acids; (iv) linear, primary C ₁₂ -C ₂₄ alkanols; (v) esters of a saturated monohydric C _16-60 alkanol and a saturated C ₈ -C ₃₆ monocarboxylic acid; (vi) glycerol triesters of saturated linear C _12-30 carboxylic acids, which may be hydroxylated; (vii) natural vegetable waxes; (viii) animal waxes; (ix) synthetic waxes; and (x) their mixtures. In the context of the present invention preferably usable waxes are in the published patent application DE 10 2012 222 692 A1 disclosed.

In the context of the present invention, it is preferred for the wax to be present in a total amount of from 0.01 to 50% by weight, preferably from 3 to 40% by weight, preferably from 5 to 30% by weight, in particular from 6 to 25 Wt .-%, based on the total weight of the antiperspirant cosmetic agent.

According to one embodiment of the present invention, it may be provided that the antiperspirant cosmetic agents according to the invention contain, as constituent b), a blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the antiperspirant cosmetic agent. If the cosmetic compositions of the invention contain a propellant, this is preferably in a total amount of 1 to 98 wt .-%, preferably from 20 to 90 wt .-%, preferably from 30 to 85 wt%, in particular from 40 to 75 wt. %, based on the total weight of the antiperspirant cosmetic agent. In this case, the cosmetic compositions according to the invention are formulated as propellant-driven aerosols. Preferred propellants (propellants) are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1,1-difluoroethane, tetrafluoropropenes, both individually and in their mixtures. Also hydrophilic propellants, such. As carbon dioxide, can be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (eg., Propane / butane) is present in excess. Particularly preferred are propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.

As a third component c), the antiperspirant cosmetic agent according to the invention contains at least one special protein which is isolated from fish or birds.

A particularly effective reduction of armpit sweat by the at least one specific protein is achieved in the context of the present invention, if the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-% , preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30% by weight, in particular from 2.0 to 20% by weight, based on the total weight of the antiperspirant cosmetic agent. Without wishing to be limited to this theory, the use of the abovementioned amounts of the at least one specific protein results in a significant influence on the sweat gland (s) by protein formation in the excretory ducts of the sweat glands or by influencing the charge balance within the sweat gland (s). In this way, an excellent antiperspirant effect is ensured. Furthermore, the use of the abovementioned amounts of the at least one specific protein does not lead to unstable formulations, so that the stability of the antiperspirant cosmetic agents according to the invention is ensured even over long storage periods.

Particularly good results with regard to the reduction and / or reduction of underarm wetness and skin compatibility and storage stability are obtained if the at least one protein has an average molecular weight M _{w of} from 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da. The average molecular weight M _w can be determined, for example, by gel permeation chromatography (GPC) ( Andrews P .; "Estimation of the Molecular Weights of Proteins by Sephadex Gel Filtration"; Biochem. J., 1964, 91, pages 222 to 233 ).

According to a preferred embodiment of the present invention, the at least one protein has an isoelectric point which ranges from pH 4.0 to pH 10.0, preferably from pH 4.0 to pH 9.5, in particular from pH 4.0 to pH 8.0. In particular, proteins which have an isoelectric point in the abovementioned pH range have proven to be advantageous in terms of the antiperspirant effect and the stability of the cosmetic compositions according to the invention in the context of the present invention.

A particularly high antiperspirant effect, skin compatibility and storage stability is ensured in the context of the present invention, if the at least one protein is a change in light absorption at a pH change of at least 0.5 in a pH range of pH 4.5 to pH 7 , 5, in particular from pH 5.0 to pH 7.0, at a concentration of 0.001 to 10 wt .-% protein, based on the total weight of the sample mixture used for pH measurement, and a temperature of 20 ° C causes. Without wishing to be limited to this theory, the use of the at least one specific protein, which causes a change in the light absorption in a specific pH range, results in a significantly increased influence on the sweat gland (s) by pH-selective gel formation in the excretory ducts of the sweat glands or by disturbance of the charge balance of the sweat gland (s). In this way, an excellent antiperspirant effect of the cosmetic compositions of the invention is ensured, which is comparable to the antiperspirant effect of aluminum salt-containing or aluminum zirconium salt-containing cosmetic agents of the prior art.

In the context of the present invention, it is preferred if the pH change is achieved by addition of bicarbonates or carbonates, in particular of sodium bicarbonates.

According to a preferred embodiment of the present invention, the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.

According to the invention, the term "unmodified proteins" is to be understood as meaning proteins which have not been treated by means of chemical processes, for example hydrolysis or chemical modification, or by physical methods, such as, for example, purification, separation and irradiation.

Furthermore, the term "hydrolyzed proteins" or "protein hydrolysates" according to the invention are understood to mean proteins which are prepared by chemical, in particular alkaline or acid, hydrolysis, by enzymatic hydrolysis and / or by a combination of the two types of hydrolysis. For enzymatic degradation all hydrolytic enzymes are suitable, such as alkaline proteases. Overviews of the production of protein hydrolysates are, for example, from G. Schuster and A. Domsch in soaps oils Fette Wachse 108, (1982) 177 and Cosm.Toil. 99, (1984) 63 , from HW Steisslinger in Parf.Kosm. 72, (1991) 556 and F. Aurich et al. in Tens.Surf.Det. 29, (1992) 389 published. Mixtures of individual amino acids which are obtained merely by mixing the pure substances of the amino acids, as well as total hydrolysates which consist only of individual amino acids, do not fall within the scope of the present invention under the term "hydrolyzed proteins" or "protein hydrolysates".

In addition, the term "chemically modified proteins" in the context of the present invention are proteins which, by chemical reaction of the reactive groups of the proteins, in particular the hydroxyl, amine, imidazole, guanidino and / or thiol groups of the side chains of Amino acids of the protein, with hydrophobic and / or cationic and / or anionic compounds.

In addition, the term "physically modified proteins" in the context of the present invention are proteins which have been modified by physical action, in particular by heat and / or light and / or fractionation.

In the context of this embodiment, it is particularly preferred if the at least one protein is selected from the group of chemically modified, in particular hydrophobically modified, proteins. In this connection, the hydrophobically modified protein is one or more C _4-30 carbon chains, wherein the C _4-30 hydrocarbon chains linear, cyclic, branched, unbranched, may be saturated, unsaturated and aromatic and wherein the C _4-30 - Hydrocarbon chains are bonded via ether and / or ester and / or amine and / or amide bonds to the protein residue.

Moreover, it is preferred in the context of this embodiment if the at least one protein is selected from the group of chemically modified, in particular cationically modified, proteins. The cationically modified protein therefore preferably contains one or more radicals of the formula R ¹ -N ⁺ (CH ₃ ) ₂ -CH ₂ -CH (OH) -CH ₂ -XR, in which R ^{1 is} an alkyl group having 1 to 30 carbon atoms, an alkenyl group having 1 to 30 carbon atoms, a hydroxyalkyl group having 1 to 30 carbon atoms, in particular a methyl group, a C _10-14 alkyl or a C _10-14 alkenyl group, X is O, N or S and R is the protein residue. The cationization of the proteins with the above-described radicals can be achieved by reacting the proteins with the corresponding halides of the above formula, the radicals described above being bonded to the protein via ether and / or ester and / or amide and / or amine bonds could be. For the purposes of the present invention, the term "protein residue" is to be understood as meaning the backbone of the corresponding protein formed by the linking of amino acids, to which the cationic group is bonded via the abovementioned bonds.

Particularly good results are obtained in the context of this embodiment, when the at least one protein is selected from the group of hydrolyzed proteins.

According to a further particularly preferred embodiment of the present invention, the at least one protein effects a change in light absorption of from 1.5 to 90%, preferably from 2 to 80%, preferably from 2.5 to 70%, more preferably from 3 to 65%, in particular from 3.5 to 60%. Proteins isolated in particular from fish or birds, which bring about the aforementioned change in light absorption, lead to an excellent antiperspirant effect in the context of the present invention. The change in the light absorption can be done on a change in the light transmittance of the sample mixture, in particular by turbidity, as well as on the absorption of light by the sample mixture, in particular by the protein itself.

The changes of the light absorption underlying this invention with a pH change of at least 0.5 can be determined by measuring the light transmission of a light beam through the sample mixture. The measurements of light transmission are performed using a Methrom Optrode 6.1115.000 at a wavelength of 574 nm (green-yellow) in mV (resolution 0.1 mV) in an open sample vessel at 23 ° C and 1013 mbar. The pH change in the pH range of 4.0 to 8.0 is achieved by slowly and continuously adding a carbonate or bicarbonate solution, preferably a 1% by weight sodium bicarbonate solution, to the sample mixture to measure the pH achieved with a pH electrode and with stirring at a speed of 1000 rpm. The change in light absorption caused by the at least one protein is calculated according to the formula ΔL = [(| L _i | / | L ₀ |] · 100. In this formula, L _i stands for the light transmission before and after the change in the pH at least 0.5 in the pH range of 4.0 to 8.0, preferably of pH 4.5 and 7.5, in particular of pH 5.0 and 7.0, so for example light transmission at pH 5 , 0 minus light transmission at pH 6.0. In this formula, L ₀ stands for the difference between the light transmission at pH 4.0 and at pH 8.0, preferably at pH 4.5 and at pH 7.5, in particular at pH 5.0 and at pH 7.0, for example light transmission at pH 8.0 minus light transmission at pH 4.0 The at least one specific protein in the antiperspirant cosmetic agents according to the invention effects a change in the light absorption of 1 to 100 as determined by the above method However, the present invention is not directed to antiperspirant cosmetic compositions limited, which contain at least one special protein, which causes a determined by the above method, the change in light absorption of 1 to 100%. It also includes antiperspirant cosmetic compositions containing at least one specific protein which, by other methods, causes a change in light absorption of 1 to 100%.

For the purposes of the present invention, it is preferred if the concentration of the at least one protein in the mixture used to determine the change in light absorption is from 0.005 to 10% by weight, preferably from 0.05 to 5% by weight, preferably from 0 , 07 to 3 wt .-%, in particular from 0.09 to 2 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, is.

According to the invention, the at least one protein preferably effects a change in the light absorption with a pH change of at least 0.5 and at most 3.5, preferably at least 0.5 and at most 2.5, in particular at least 0.5 and at most 1, 5th The change in the pH can be achieved in particular by the addition of acids or bases, preferably bases in the form of carbonates or bicarbonates, in the appropriate amount.

According to another preferred embodiment of the present invention, the antiperspirant cosmetic agent has a pH of from pH 2 to pH 10. Within this range, a stable formulation of the cosmetic compositions of the invention is possible without undesirable interactions between the ingredients of the antiperspirant cosmetic agents according to the invention occur. The setting of the desired pH value can be carried out according to the invention by using acids and bases known to those skilled in the art and customary in antiperspirant cosmetic agents.

According to the invention, it is further preferred if the antiperspirant cosmetic agent additionally contains at least one preservative. Preservatives which are preferred according to the invention are formaldehyde releasers iodopropynyl butylcarbamates, parabens, phenoxyethanol, ethanol, benzoic acid and salts thereof, dibromodicyanobutane, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea, 5-chloro-2-methyl-4-isothiazoline. 3-one, 2-chloroacetamide, benzalkonium chloride, benzyl alcohol, salicylic acid and salicylates. Further preservatives which can be used in the context of the present invention are the substances listed in Annex 6 of the Cosmetics Regulation, as well as cosmetic raw materials with preservative properties or raw materials which support or enhance the preservative action of the abovementioned preservatives. The preservatives are preferably in a total amount of 0.01 to 10 wt .-%, preferably from 0.1 to 7 wt .-%, preferably from 0.2 to 5 wt .-%, in particular from 0.3 to 2.0 wt .-%, based on the total weight of the antiperspirant cosmetic agent.

In the context of the present invention it is preferred if the antiperspirant cosmetic agent is present as a water-in-oil emulsion. This may in particular be a sprayable water-in-oil emulsion which can be sprayed by means of a propellant. In this context, it is preferred if the present invention in the form of a water-in-oil emulsion antiperspirant cosmetic agent containing at least one protein in a total amount of 0.1 to 70 wt .-%, preferably from 0.5 to 60 wt %, preferably from 1.0 to 50% by weight, more preferably from 1.5 to 40% by weight, even more preferably from 2.0 to 30% by weight, in particular from 2.0 to 20% by weight .-%, based on the total weight of the antiperspirant cosmetic agent contains.

However, it may equally be preferred according to the invention if the antiperspirant cosmetic agent is present as an oil-in-water emulsion. In this case, the cosmetic agent according to the invention is preferably sprayed as a propellant-free pump spray or squeeze spray or applied as a roll-on. In this context, it is preferred if the present in the form of an oil-in-water emulsion antiperspirant cosmetic agent containing at least one protein in a total amount of 0.1 to 70 wt .-%, preferably from 0.5 to 60 wt. -%, preferably from 1.0 to 50 wt .-%, more preferably from 1.5 to 40 wt%, even more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt. %, based on the total weight of the antiperspirant cosmetic agent.

According to a further preferred embodiment of the present invention, the cosmetic compositions according to the invention may contain only a low content of free water or no free water. For the purposes of the present invention, free water is understood to mean water which is different from water of crystallization, water of hydration or similar molecularly bound water of the constituents used. The antiperspirant cosmetic agent preferably contains free water in a total amount of less than 10% by weight, preferably less than 8% by weight, preferably less than 5% by weight, more preferably less than 3% by weight. even more preferably less than 1% by weight, in particular 0% by weight, based on the total weight of the antiperspirant cosmetic agent.

Within the scope of a further embodiment, however, it is likewise preferred according to the invention if the antiperspirant cosmetic agent is present as an aqueous, aqueous-alcoholic or aqueous-glycolic solution. Since the cosmetic compositions according to the invention contain no antiperspirant halides and / or hydroxyhalides of aluminum and / or zirconium which have a reduced antiperspirant effect by the addition of protic solvents, protic solvents, such as aqueous solutions, can be used according to the invention for formulating the antiperspirant cosmetic agents according to the invention without a significant reduction in the antiperspirant effect. Therefore, the addition of the at least one specific protein, even with the use of protic solvents, ensures an effective influence on the sweat gland (s) and thus an excellent antiperspirant effect.

In connection with this embodiment of the present invention, it has surprisingly been found that the influence on the sweat gland (s) by the at least one specific protein can be significantly increased if the antiperspirant cosmetic agents according to the invention comprise free water in an amount of 5 to 99% by weight. based on the total weight of the antiperspirant cosmetic agent. In a particularly preferred embodiment of the present invention, the antiperspirant cosmetic agent therefore contains free water in a total amount of 5 to 96 wt .-%, preferably from 15 to 80 wt .-%, preferably from 30 to 70 wt .-%, in particular of 40 to 60 wt .-%, based on the total weight of the antiperspirant cosmetic agent.

Furthermore, it is preferred in connection with this embodiment if the antiperspirant cosmetic agent ethanol in a total amount of 1 to 99 wt .-%, preferably from 5 to 70 wt .-%, preferably from 7 to 50 wt .-%, in particular of 10 to 30 wt .-%, based on the total weight of the antiperspirant cosmetic agent contains. As stated above, even high levels of protic solvents, such as ethanol, can be used by the use of the at least one specific protein without adversely affecting the antiperspirant effect of the antiperspirant cosmetic agent of the present invention.

The application of the antiperspirant cosmetic agent according to the invention can be carried out by means of various methods. According to a preferred embodiment, the antiperspirant is cosmetic preparations formulated as a spray application. The spray application is carried out with a spray device which contains a filling of the liquid, viscous-flowable, suspension-shaped or powdered antiperspirant cosmetic agent according to the invention in a container. The filling may be under the pressure of a propellant (compressed gas cans, compressed gas packages, aerosol dispensers), or it may be a mechanically operated pump sprayer without propellant (pump sprays / squeeze bottle). The atomization of the antiperspirant cosmetic agent may be effected physically, mechanically or electromechanically, for example by piezoelectric effects or electrical pumps. In the context of this embodiment, usable containers and removal devices are, for example, in the published patent application DE 10 2012 222 692 A1 described.

The antiperspirant cosmetic may further preferably be formulated as a stick, soft solid, cream, gel, roll-on, loose or compact powder. The formulation of the antiperspirant cosmetic agents according to the invention in a particular dosage form, such as, for example, an antiperspirant roll-on, an antiperspirant stick or an antiperspirant gel, preferably conforms to the requirements of the intended use. Depending on the intended use, the antiperspirant cosmetic agents according to the invention can therefore be present in solid, semisolid, liquid, disperse, emulsified, suspended, gelatinous, multiphase or powdery form. For the purposes of the present invention, the term liquid also includes any types of solid dispersions in liquids. In the context of the present invention, multiphase antiperspirant cosmetic agents according to the invention are also understood to mean agents which have at least two different phases with a phase separation and in which the phases can be arranged horizontally, ie one above the other, or vertically, ie side by side. The application can be done for example with a roller ball applicator or by means of a fixed pin.

It may also be preferred within the scope of the present invention if the antiperspirant cosmetic agent is contained on and / or in a disposable substrate selected from the group of wipes, pads and bulbs. Especially preferred are wet wipes, i. prefabricated for the user, preferably individually packaged, wet wipes, such as. B. from the field of glass cleaning or from the field of wet toilet paper are well known. Such wet wipes, which can advantageously also contain preservatives, are impregnated or applied with an antiperspirant cosmetic agent according to the invention and preferably individually packaged. Preferred substrate materials are selected from porous sheet-like cloths. These wipes include wipes of woven and nonwoven synthetic and natural fibers, felt, paper or foam, such as hydrophilic polyurethane foam. Deodorizing or antiperspirant substrates which are preferred according to the invention can be obtained by impregnation or impregnation or else by melting a perspiration-inhibiting cosmetic agent according to the invention onto a substrate.

According to the invention, the antiperspirant cosmetic agent preferably contains at least one broad adjuvant selected from the group of (i) emulsifiers and / or surfactants; (ii) thickeners; (iii) chelating agents; (iv) deodorant agents; (v) monohydric and / or polyhydric alcohols and / or polyethylene glycols; (vi) skin-cooling agents; (vii) pH adjusters; (viii) skin care ingredients, such as moisturizers, skin soothing substances, skin lightening substances, skin smoothing substances; and (ix) their mixtures.

Emulsifiers and surfactants which are preferably suitable according to the invention are selected from anionic, cationic, nonionic, amphoteric, in particular ampholytic and zwitterionic emulsifiers and surfactants. Surfactants are amphiphilic (bifunctional) compounds which consist of at least one hydrophobic and at least one hydrophilic moiety. The hydrophobic moiety is preferably a hydrocarbon chain of 8 to 28 carbon atoms, which may be saturated or unsaturated, linear or branched. Particularly preferably, this C ₈ -C ₂₈ -alkyl chain is linear. Emulsifiers and surfactants which can preferably be used in the context of the present invention are described, for example, in the published patent applications DE 10 2012 222 692 A1 . DE 10 2010 063 250 A1 such as DE 10 2010 055 816 A1 disclosed.

Substances which are selected from cellulose ethers, xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, pectins, agar, carrageenan, tragacanth, gum arabic, karaya gum, tara gum, gellan, gelatin are preferably used to thicken the antiperspirant cosmetic agents according to the invention , Propylene glycol alginate, alginic acids and their salts, polyvinylpyrrolidones, polyvinyl alcohols, polyacrylamides, physically (eg by pre-gelatinization) and / or chemically modified starches, acrylic acid-acrylate copolymers, acrylic acid-acrylamide copolymers, acrylic acid-vinylpyrrolidone copolymers, acrylic acid Vinylformamide copolymers and polyacrylates. Particularly preferred thickeners are furthermore selected from carbomers. Carbomers are thickening crosslinked polymers of acrylic acid, methacrylic acid and their salts. The crosslinking can be effected by means of polyfunctional compounds such as polyalkylene ethers of polysaccharides or polyalcohols, for example sucrose allyl ether, pentaerythritol allyl ether, propylene allyl ether. Preferred in the context of the present invention are homopolymers of acrylic acid or salts thereof which are crosslinked with a pentaerythritol allyl ether, a sucroseallyl ether or a propylene allyl ether. A thickening agent which can be used in the context of the present invention is a copolymer of C _10-30 -alkyl acrylate, acrylic acid, methacrylic acid and esters thereof, which is crosslinked with a sucrose allyl ether or a pentaerythritol allyl ether. Thickener based on carbomers are products sold under the trade name Carbopol ^® (BF Goodrich, Ohio, USA) available such as Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001, Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20, or Carbopol ultrez 21.

Furthermore, lipophilic thickening agents can be used to thicken the antiperspirant cosmetic agents according to the invention. Lipophilic thickeners which are preferred according to the invention are selected from hydrophobized clay minerals, bentonites, pyrogenic silicas and derivatives thereof.

In order to further support the influence of the sweat gland (s) by the at least one specific protein, it may be advantageous for the antiperspirant cosmetic agents according to the invention to comprise at least one chelating agent, in a total amount of from 0.01 to 3.0% by weight, preferably from 0.02 to 1.0% by weight, in particular from 0.05 to 0.1% by weight, based on the total weight of the antiperspirant agent according to the invention. In the context of the present invention, preferred chelating agents are selected from the group of β-alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, calcium disodium, ammonium and triethanolamine salts of ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid (HEDTA) and their sodium salts. sodium salts of nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid, phytic acid, hydroxypropyl cyclodextrin, methylcyclodextrin, Aminotrimethylenphosphonat pentasodium, ethylenediamine pentasodium, diethylenetriamine pentaacetate pentasodium, pentasodium triphosphate, potassium EDTMP, sodium EDTMP, Natriumdihydroxyethylglycinat, sodium phytate, Natriumpolydimethylglycinophenolsulfonat, tetrahydroxyethylethylenediamine, tetrahydroxypropylethylenediamine, Tetrakaliumetidronat , Tetrasodium tetidronate, tetrasodiumiminodisuccinate, trisodium ethylenediamine disuccinate, tetrasodium N, N-bis ( Carboxymethyl) glutamate, tetrasodium DL-alanine-N, N-diacetate and desferrioxamine.

The deodorizing effect of the antiperspirant cosmetic agents according to the invention can be further increased if at least one deodorant active ingredient having antibacterial and / or bacteriostatic and / or enzyme-inhibiting and / or odor-neutralizing and / or odor-absorbing action in a total amount of 0.0001 to 40% by weight. %, preferably from 0.2 to 20 wt .-%, preferably from 1 to 15 wt .-%, in particular from 1.5 to 5 wt .-%, based on the total weight of the antiperspirant cosmetic agent according to the invention, is contained. If ethanol is used in the compositions according to the invention, this does not apply in the context of the present invention as a deodorant active ingredient, but as a constituent of the carrier. According to the invention preferred deodorant agents are, for example, in the published patent application DE 10 2010 063 250 A1 disclosed.

Preferred antiperspirant cosmetic agents according to the invention also contain at least one water-soluble polyhydric C _2-9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 50 ethylene oxide units and mixtures thereof. This does not include the abovementioned deodorant active ingredients in the form of 1,2-alkanediols. Preferred alkanols and water-soluble polyethylene glycols are, for example, in the published patent application DE 10 2010 063 250 A1 described.

According to another embodiment of the present invention, the antiperspirant cosmetic agents further contain at least one skin-cooling agent. Skin-cooling active ingredients suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, eg. Menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxypropanediol, menthone glycerol acetal (9-methyl-6- (1-methylethyl) -1,4-dioxaspiro (4.5) decane-2-methanol), monomethyl succinate, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate. Preferred skin-cooling active ingredients are menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidonecarboxylic acid and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate, as well as mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol.

According to the invention, the pH adjusting agents used are preferably acids and / or alkalizing agents and / or buffers. As acids according to the invention preferably inorganic acids (such as hydrochloric acid, sulfuric acid or phosphoric acid) or organic acids (such as citric acid, tartaric acid or malic acid) are used. The alkalizing agents which can be used according to the invention are preferably selected from the group which is formed from ammonia, basic amino acids, alkali metal hydroxides, carbonates and bicarbonates, alkanolamines, for example amino-2-methyl-1-propanol, monoethanolamine, triethanolamine, diethanolamine and triisopropanolamine, alkali metal metasilicates, Urea, morpholine, N-methylglucamine, imidazole, alkali phosphates and alkali hydrogen phosphates. The alkali metal ions used are preferably lithium, sodium, potassium, in particular sodium or potassium. Suitable buffer systems in the context of the present invention are in particular carbonic acid-bicarbonate buffer, carbonic acid-silicate buffer, acetic acid-acetate buffer, phosphate buffer, ammonia buffer, citric acid or citrate buffer, buffer based on tris (hydroxymethyl) -aminomethane, buffer Base of 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid, buffer based on 4- (2-hydroxyethyl) piperazine-1-propanesulfonic acid, buffer based on 2- (N-morpholino) ethanesulfonic acid and barbital acetate buffer , The choice of the corresponding buffer system depends on the desired pH of the antiperspirant cosmetic agents according to the invention.

The preferred embodiments described below contain no antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium:

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen

enthalten, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt. In a preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative and
• At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes

wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based to the total weight of the sample mixture used for the determination of the change of the light absorption, a change of the light absorption of 1 to 100%.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel,
• – 0,01 bis 2 Gew.-%, vorzugsweise 0,1 bis 1 Gew.-%, bevorzugt 0,2 bis 0,7 Gew.-%, insbesondere 0,3 bis 0,5 Gew.-% eines Verdickungsmittels, und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen

enthalten, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt. In a further preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative,
• From 0.01 to 2% by weight, preferably from 0.1 to 1% by weight, preferably from 0.2 to 0.7% by weight, in particular from 0.3 to 0.5% by weight, of a thickener, and
• At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes

wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, a change in the light absorption of 1 to 100% causes.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens ein Treibmittel in einer Gesamtmenge von 1 bis 98 Gew.-%, vorzugsweise von 20 bis 90 Gew.-%, bevorzugt von 30 bis 85 Gew-%, insbesondere von 40 bis 75 Gew.-%,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen

enthalten, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt. In a preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one blowing agent in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative and
• At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes

wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, a change in the light absorption of 1 to 100% causes.

• – mindestens ein Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,0 bis 50 Gew.-%, bevorzugt von 1,5 bis 40 Gew-%, weiter bevorzugt von 2,0 bis 30 Gew.-%, insbesondere von 2,0 bis 20 Gew.-%,
• – 12 bis 98 Gew.-%, vorzugsweise 25 bis 55 Gew.-%, bevorzugt 30 bis 50 Gew.-%, insbesondere 35 bis 45 Gew.-% Wasser,
• – mindestens ein Treibmittel in einer Gesamtmenge von 1 bis 98 Gew.-%, vorzugsweise von 20 bis 90 Gew.-%, bevorzugt von 30 bis 85 Gew-%, insbesondere von 40 bis 75 Gew.-%,
• – mindestens einen Emulgator und/oder ein Tensid,
• – mindestens ein pH-Stellmittel,
• – mindestens ein Konservierungsmittel,
• – 0,01 bis 2 Gew.-%, vorzugsweise 0,1 bis 1 Gew.-%, bevorzugt 0,2 bis 0,7 Gew.-%, insbesondere 0,3 bis 0,5 Gew.-% eines Verdickungsmittels, und
• – mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen

enthalten, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt. In a further preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

• - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.0 to 50 wt .-%, preferably from 1.5 to 40% by weight, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,
• From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,
• At least one blowing agent in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight,
• At least one emulsifier and / or a surfactant,
• At least one pH adjusting agent,
• - at least one preservative,
• From 0.01 to 2% by weight, preferably from 0.1 to 1% by weight, preferably from 0.2 to 0.7% by weight, in particular from 0.3 to 0.5% by weight, of a thickener, and
• At least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1013 hPa, fragrances and waxes

wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, a change in the light absorption of 1 to 100% causes.

In the context of the present invention, it can also be provided to use the cosmetic agent according to the invention as part of a two-component agent. For this purpose, the individual components are preferably stored in separate containers and applied in succession or simultaneously to the skin in any order.

• a) mindestens einen ersten Container (C1), enthaltend ein kosmetisches Mittel (M1) umfassend mindestens einen schweißhemmenden Wirkstoff, und
• b) mindestens einen zweiten Container (C2), enthaltend ein kosmetisches Mittel (M2) umfassend mindestens ein Protein, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist, wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt und wobei das kosmetische Mittel keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält.

A further subject of the present invention is therefore a packaging unit (kit-of-parts), comprising - made up separately -

• a) at least one first container (C1) containing a cosmetic agent (M1) comprising at least one antiperspirant active substance, and
• b) at least one second container (C2) containing a cosmetic agent (M2) comprising at least one protein, wherein the at least one protein is isolated from fish or birds, wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt %, based on the total weight of the sample mixture used to determine the change in light absorption, causes a change in light absorption of 1 to 100% and wherein the cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium.

The term "antiperspirant active ingredient" is understood according to the invention as meaning active ingredients which reduce or reduce the perspiration of the sweat glands of the body. However, this does not include the fish or bird proteins contained in the cosmetic agent (M2), which cause a change in light absorption under the conditions described above.

With respect to the cosmetic agent (M2) in the container (C2) mutatis mutandis applies to the cosmetic compositions of the invention.

Another object of the present invention is the use of a protein for at least partially influencing the sweat gland (s), wherein the at least one protein from fish or birds is isolated and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight for determining the change of Light absorption used sample mixture, a change in light absorption of 1 to 100%, causes.

By influencing the sweat gland (s), the influencing of the sweat gland (s) according to the invention is to be understood as meaning that the secretion of sweat from the excretory duct is avoided or reduced. Without wishing to be limited to one theory, this can be done, for example, by forming a gel and / or precipitation of the at least one specific protein in the excretory duct of the sweat gland or the excretory ducts of the sweat glands. However, the use of the at least one specific protein can also lead to a disturbance of the charge balance within the excretory ducts of the sweat glands. Regarding the use according to the invention mutatis mutandis applies to the cosmetic antiperspirant agents of the invention.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und
• c) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist, wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt und

wobei die Kombination keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält,
zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen. In addition, another object of the present invention is the use of a combination containing

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and
• c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein from fish or birds is isolated, wherein the at least one protein at a pH Change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight the sample mixture used for the determination of the change of the light absorption, causes a change of the light absorption of 1 to 100%, and

wherein the combination does not contain halides and / or hydroxy halides of aluminum and / or zirconium,
for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions.

The term "combination" in the sense of the present invention comprises a mixture of the above-indicated ingredients a), b) and c). Regarding the use of the above-mentioned combination, mutatis mutandis the statements made on the antiperspirant cosmetic agents according to the invention and on the use according to the invention apply.

• a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen,
• b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und
• c) mindestens ein aus Fischen isoliertes Collagen in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das Collagen hydrolysiert ist,

wobei das schweißhemmende kosmetische Mittel keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält. In addition, another object of the present invention is a antiperspirant cosmetic containing

• a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,
• b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and
• c) at least one collagen isolated from fish in a total amount of from 0.1 to 70% by weight, based on the total weight of the antiperspirant cosmetic, wherein the collagen is hydrolyzed,

wherein the antiperspirant cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium.

With regard to further preferred embodiments of this article, mutatis mutandis, the statements made regarding the antiperspirant cosmetic agents according to the invention and the use according to the invention apply.

Finally, another object of the present invention is a non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which an inventive antiperspirant cosmetic agent or a packaging unit according to the invention is applied to the skin, in particular on the skin of the armpits, and for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remains on the skin of the armpits.

If the packaging unit according to the invention is used in the context of the method according to the invention, it may be provided that first the cosmetic agent (M1) is applied in the container (C1) and then the cosmetic agent (M2) is applied in the container (C2). However, it is also possible that initially the cosmetic agent (M2) in the container (C2) and then the cosmetic agent (M1) in the container (C1) is applied. In addition, the cosmetic agent (M1) in the container (C1) and the cosmetic agent (M2) in the container (C2) can also be applied simultaneously. The time span between the application of the two means (M1) and (M2) is from 0 seconds to 24 hours.

Regarding the method according to the invention mutatis mutandis applies to the antiperspirant cosmetic agents according to the invention as well as to the use according to the invention.

• 1. Schweißhemmendes kosmetisches Mittel, enthaltend a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und c) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt, wobei das schweißhemmende kosmetische Mittel keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält.
• 2. Schweißhemmendes kosmetisches Mittel nach Punkt 1, dadurch gekennzeichnet, dass das mindestens eine Protein in einer Gesamtmenge von 0,5 bis 60 Gew.-%, vorzugsweise von 1,5 bis 50 Gew.-%, bevorzugt von 2 bis 40 Gew-%, weiter bevorzugt von 2,5 bis 30 Gew.-%, insbesondere von 3 bis 20 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, enthalten ist.
• 3. Schweißhemmendes kosmetisches Mittel nach einem der Punkte 1 oder 2, dadurch gekennzeichnet, dass das mindestens eine Protein ein mittleres Molekulargewicht M_w von 150 bis 100.000 Da, vorzugsweise von 180 bis 50.000 Da, bevorzugt von 200 bis 10.000 Da, weiter bevorzugt von 250 bis 8.000 Da, insbesondere von 300 bis 5.000 Da, aufweist.
• 4. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein eine Veränderung der Lichtabsorption bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,5 bis pH 7,5, insbesondere von pH 5,0 bis pH 7,0, bei einer Konzentration von 0,001 bis 10 Gew.-% Protein, bezogen auf das Gesamtgewicht der zur pH-Messung verwendeten Probenmischung, und einer Temperatur von 20 °C bewirkt.
• 5. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass die pH-Wert Änderung durch Zugabe von Hydrogencarbonaten oder Carbonaten, insbesondere von Natriumhydrogencarbonaten, erfolgt.
• 6. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein ausgewählt ist aus der Gruppe von (i) nicht modifizierten Proteinen; (ii) hydrolysierten Proteinen; (iii) chemisch modifizierten Proteinen, insbesondere hydrophob und/oder kationisch und/oder anionisch modifizierten Proteinen; (iv) physikalisch modifizierten Proteinen, insbesondere fraktionierten und/oder gereinigten und/oder bestrahlten Proteinen; (v) hydrolysierten nicht modifizierten Proteinen; (vi) hydrolysierten und chemisch modifizierten Proteinen, insbesondere hydrolysierten und hydrophob und/oder kationisch und/oder anionisch modifizierten Proteinen; (vii) hydrolysierten und physikalisch modifizierten Proteinen, insbesondere fraktionierten und/oder gereinigten und/oder bestrahlten Proteinen; sowie (viii) deren Mischungen.
• 7. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein eine Veränderung der Lichtabsorption von 1,5 bis 90 %, vorzugsweise von 2 bis 80 %, bevorzugt von 2,5 bis 70 %, weiter bevorzugt von 3 bis 65 %, insbesondere von 3,5 bis 60 %, bewirkt.
• 8. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass die Konzentration des Proteins in der zur Bestimmung der Veränderung der Lichtabsorption verwendeten Mischung von 0,005 bis 10 Gew.-%, vorzugsweise von 0,05 bis 5 Gew.-%, bevorzugt von 0,07 bis 3 Gew.-%, insbesondere von 0,09 bis 2 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Mischung, beträgt.
• 9. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das mindestens eine Protein eine Veränderung der Lichtabsorption bei einer pH-Wert Änderung von mindestens 0,5 und höchstens 3,5, vorzugsweise von mindestens 0,5 und höchstens 2,5, insbesondere von mindestens 0,5 und höchstens 1,5, bewirkt.
• 10. Schweißhemmendes kosmetisches Mittel nach einem der vorangehenden Punkte, dadurch gekennzeichnet, dass das schweißhemmende kosmetische Mittel einen pH-Wert von pH 2 bis pH 10 aufweist.
• 11. Verpackungseinheit (Kit-of-Parts), umfassend – getrennt voneinander konfektioniert – a) mindestens einen ersten Container (C1), enthaltend ein kosmetisches Mittel (M1) umfassend mindestens einen schweißhemmenden Wirkstoff, und b) mindestens einen zweiten Container (C2), enthaltend ein kosmetisches Mittel (M2) umfassend mindestens ein Protein, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist, wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt und wobei das kosmetische Mittel (M2) keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält.
• 12. Verwendung mindestens eines Proteins zur zumindest teilweisen Beeinflussung der Schweißdrüse(n), wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist und wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt.
• 13. Verwendung einer Kombination, enthaltend a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und c) mindestens ein Protein in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das mindestens eine Protein aus Fischen oder Vögeln isoliert ist, wobei das mindestens eine Protein bei einer pH-Wert Änderung von mindestens 0,5 in einem pH-Bereich von pH 4,0 bis pH 8,0, einer Temperatur von 20 °C bis 40 °C und einer Konzentration des Proteins von 0,001 bis 10 Gew.-%, bezogen auf das Gesamtgewicht der für die Bestimmung der Veränderung der Lichtabsorption verwendeten Probenmischung, eine Veränderung der Lichtabsorption von 1 bis 100 %, bewirkt und wobei die Kombination keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält, zur Reduzierung und/oder Verhinderung von Schweiß, insbesondere Achselschweiß oder Schweiß anderer Körperregionen.
• 14. Schweißhemmendes kosmetisches Mittel, enthaltend a) mindestens einen Stoff, ausgewählt aus der Gruppe von kosmetischen Ölen, welche bei 20 °C und 1.013 hPa flüssig sind, Riechstoffen und Wachsen, b) Treibmittel in einer Gesamtmenge von 0 bis 99 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, und c) mindestens ein aus Fischen isoliertes Collagen in einer Gesamtmenge von 0,1 bis 70 Gew.-%, bezogen auf das Gesamtgewicht des schweißhemmenden kosmetischen Mittels, wobei das Collagen hydrolysiert ist, wobei das schweißhemmende kosmetische Mittel keine Halogenide und/oder Hydroxyhalogenide von Aluminium und/oder Zirconium enthält
• 15. Nicht-therapeutisches kosmetisches Verfahren zur Verhinderung und/oder Reduzierung der Transpiration des Körpers, bei welchem ein schweißhemmendes kosmetisches Mittel nach einem der Punkte 1 bis 10 oder 14 oder eine Verpackungseinheit nach Punkt 11 auf die Haut, insbesondere auf die Haut der Achselhöhlen, aufgetragen wird und für mindestens 1 Stunde, vorzugsweise für mindestens 2 Stunden, bevorzugt für mindestens 4 Stunden, insbesondere für mindestens 6 Stunden, auf der Haut der Achselhöhlen verbleibt.

The present invention is outlined in particular by the following points:

• An antiperspirant cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) propellants in a total amount of 0 to 99% by weight , based on the total weight of the antiperspirant cosmetic agent, and c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein from fish or birds is isolated and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10% by weight, based on the total weight of the sample mixture used for the determination of the change in the light absorption, a change in the light absorption of 1 to 100%, wherein the antiperspirant cosmetic contains no halides and / or hydroxy halides of aluminum and / or zirconium.
• 2. antiperspirant cosmetic agent according to item 1, characterized in that the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.5 to 50 wt .-%, preferably from 2 to 40 Gew. %, more preferably from 2.5 to 30 wt .-%, in particular from 3 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
• 3. Antiperspirant cosmetic agent according to one of the items 1 or 2, characterized in that the at least one protein has an average molecular weight M _w of 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da.
• An antiperspirant cosmetic composition according to any one of the preceding points, characterized in that said at least one protein exhibits a change in light absorption at a pH change of at least 0.5 in a pH range of pH 4.5 to pH 7.5, in particular from pH 5.0 to pH 7.0 a concentration of 0.001 to 10 wt .-% protein, based on the total weight of the sample mixture used for pH measurement, and a temperature of 20 ° C causes.
• 5. antiperspirant cosmetic agent according to one of the preceding points, characterized in that the pH change by addition of bicarbonates or carbonates, in particular of sodium bicarbonates occurs.
• 6. An antiperspirant cosmetic agent according to any one of the preceding points, characterized in that the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.
• An antiperspirant cosmetic composition according to any one of the preceding points, characterized in that said at least one protein exhibits a change in light absorption of from 1.5 to 90%, preferably from 2 to 80%, preferably from 2.5 to 70%, more preferably from 3 to 65%, in particular from 3.5 to 60% causes.
• An antiperspirant cosmetic composition according to any one of the preceding points, characterized in that the concentration of the protein in the mixture used to determine the change in light absorption is from 0.005 to 10% by weight, preferably from 0.05 to 5% by weight. preferably from 0.07 to 3 wt .-%, in particular from 0.09 to 2 wt .-%, based on the total weight of the mixture used for the determination of the change in light absorption, is.
• 9. antiperspirant cosmetic agent according to one of the preceding points, characterized in that the at least one protein a change in light absorption at a pH change of at least 0.5 and at most 3.5, preferably at least 0.5 and at most 2, 5, in particular of at least 0.5 and at most 1.5 causes.
• 10. antiperspirant cosmetic agent according to one of the preceding points, characterized in that the antiperspirant cosmetic agent has a pH of pH 2 to pH 10.
• 11. Packing unit (kit-of-parts), comprising - made up separately from one another - a) at least one first container (C1) containing a cosmetic agent (M1) comprising at least one antiperspirant active substance, and b) at least one second container (C2) containing a cosmetic agent (M2) comprising at least one protein, wherein the at least one protein is isolated from fish or birds, wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4, 0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for determining the change in light absorption, a change in the light absorption from 1 to 100%, and wherein the cosmetic agent (M2) contains no halides and / or hydroxy halides of aluminum and / or zirconium.
• 12. Use of at least one protein for at least partially influencing the sweat gland (s), wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for the determination of the change in light absorption, a Change in light absorption from 1 to 100%, causes.
• 13. Use of a combination comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight , based on the total weight of the antiperspirant cosmetic agent, and c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein from fish or birds is isolated wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10% by weight, based on the total weight of the sample mixture used for the determination of the change in light absorption, a change in the light absorption of 1 to 100%, and wherein the combination no halides un Contains d / or hydroxy halides of aluminum and / or zirconium, for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions.
• 14. An antiperspirant cosmetic composition comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight based on the total weight of the antiperspirant cosmetic, and c) at least one collagen isolated from fish in a total amount of from 0.1 to 70% by weight, based on the total weight of the antiperspirant cosmetic, wherein the collagen is hydrolyzed; antiperspirant cosmetic agents does not contain halides and / or hydroxyhalides of aluminum and / or zirconium
• A non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which an antiperspirant cosmetic product according to any one of items 1 to 10 or 14 or a packaging unit according to item 11 on the skin, in particular on the skin of the armpits, is applied and remains on the skin of the armpits for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours.

The following examples illustrate the present invention without, however, limiting it to:

Examples:

1. Change in light absorption

• 1) Hydrolysiertes Collagenprotein,
• 2) Hydrolysiertes Collagenprotein mit einem mittleren Molekulargewicht M_w von etwa 1.000 Da, und
• 3) Hydrolysiertes Collagenprotein mit einem mittleren Molekulargewicht M_w von etwa 2.000 Da.

The following fish-isolated proteins were used:

• 1) hydrolyzed collagen protein,
• 2) Hydrolyzed collagen protein having an average molecular weight M _w of about 1,000 Da, and
• 3) Hydrolyzed collagen protein with an average molecular weight M _w of about 2,000 Da.

The determination of the change in light absorption caused by the aforementioned proteins in a pH range of 4.0 to 8.0 with a pH change of at least 0.5 is carried out as follows: TABLE 1 Sample Solution (Data in% by weight) EGG* E-II * E-III * Hydrolyzed collagen protein ^a) 17 - - Hydrolyzed collagen protein ^b) - 5.0 - Hydrolyzed collagen protein ^c) - - 5.0 HCl Add pH Add pH Add pH water Add 100 Add 100 Add 100 * according to the invention
^a) Marine Hydrolyzed Collagen; (INCI: Hydrolyzed collagen; 6% by weight solution in water; ISP Ashland)
^b) Promois W-42U; (INCI: Hydrolyzed Collagen; 20 wt .-% solution in water, _Mw about 1,000 Da; Seiwa Kasei Co. Ltd.)
^c) Promois W-52U; (INCI: Hydrolyzed collagen, 20% by weight solution in water, M _w about 2,000 Da, Seiwa Kasai Co. Ltd.)

To determine the change in light absorption, a Methrom Titrando 905 from Methrom (USA) was used, which is equipped with a Methrom Optrode 6.1115.000 and a pH electrode from Methrom. The Methrom Titrando 905 is controlled via the Tiamo software from Methrom. First, 30 ml of a sample solution according to Table 1, which had a pH of 3.0, were placed in the open sample vessel of the Methrom Titrando 905. Subsequently, at 23 ° C. and 1013 mbar with stirring (stirring speed 8 of the Titrando 905, corresponding to about 1000 rpm), a 1% strength by weight sodium bicarbonate solution was continuously added until a pH of 7.5 was reached. During the addition of the 1% strength by weight sodium bicarbonate solution, the light transmission of a light beam through this sample solution with a Methrom Optrode 6,1115,000 at a wavelength of 574 nm (green-yellow) in mV (resolution 0.1 mV). Each measurement is carried out twice and from this the mean value is formed.

The change in light absorption caused by the above-mentioned peptides was determined according to the formula ΔL = [(| L _i | / | L ₀ |] · 100. In this formula, L _{i represents} the difference in light transmittance and after changing the pH by at least 0.5 in the pH range of 4.0 to 8.0, preferably of pH 4.5 and 7.5, in particular of pH 5.0 and 7.0 L ₀ in this formula for the difference from the light transmission at pH 4.0 and at pH 8.0, preferably at pH 4.5 and at pH 7.5, in particular at pH 5.0 and at pH 7.0.

At a pH change of 1.0 between pH 5.0 and pH 6.0 (difference in light absorption at pH 5.0 minus pH 6.0, value Li) is in a pH range of 4.5 to 7.5 (Difference in light absorption at pH 7.5 minus pH 4.5 forms value L ₀ ) caused these proteins the change in the light absorption ΔL given in Table 2. Table 2: Change in light absorption ΔL sample solution ΔL [%] EGG 13 E-II 51 E-III 4

2. Formulations

• 1) Hydrolysiertes Collagenprotein,
• 2) Hydrolysiertes Collagenprotein mit einem mittleren Molekulargewicht M_w von etwa 1.000 Da, und
• 3) Hydrolysiertes Collagenprotein mit einem mittleren Molekulargewicht M_w von etwa 2.000 Da.

The fish-isolated protein used in the following examples is preferably selected from the following proteins:

• 1) hydrolyzed collagen protein,
• 2) Hydrolyzed collagen protein having an average molecular weight M _w of about 1,000 Da, and
• 3) Hydrolyzed collagen protein with an average molecular weight M _w of about 2,000 Da.

Antiperspirant cosmetic agents according to the invention with a pH of 2.5 to 10.0 (amounts in% by weight) 1 2 3 4 5 6 7 isopropyl 0.50 0.10 0.50 1.0 2.0 3.0 5.0 protein 0.50 2.0 3.0 5.0 7.0 10 20 Eumulgin B3 ^d) 3.0 3.0 3.0 4.0 4.0 4.0 5.0 Perfume 0.10 0.20 0.30 0.30 0.50 0.8 1.0 preservative 0.50 0.50 0.50 0.80 0.80 1.5 2.0 pH adjusters ad pH ad pH ad pH ad pH ad pH ad pH ad pH water ad 100 ad 100 ad 100 ad 100 ad 100 ad 100 ad 100 ^d) Eumulgin B3 (INCI: Ceteareth-30, BASF)

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 102010063250 A1 [0033, 0035, 0070, 0074, 0075]
• DE 102012222692 A1 [0033, 0037, 0066, 0070]
• DE 102010055816 A1 [0070]

Cited non-patent literature

• Andrews P .; "Estimation of the Molecular Weights of Proteins by Sephadex Gel Filtration"; Biochem. J., 1964, 91, pages 222 to 233 [0042]
• G. Schuster and A. Domsch in soaps oils Fette Wachse 108, (1982) 177 and Cosm.Toil. 99, (1984) 63 [0048]
• HW Steisslinger in Parf.Kosm. 72, (1991) 556 [0048]
• F. Aurich et al. in Tens.Surf.Det. 29, (1992) 389 [0048]

Claims (10)

 Antiperspirant cosmetic containing a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein from fish or birds is isolated and wherein the at least one protein at a pH Change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight the sample mixture used for the determination of the change of the light absorption, a change of the light absorption of 1 to 100%, causes wherein the antiperspirant cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium. Antiperspirant cosmetic agent according to claim 1, characterized in that the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1.5 to 50 wt .-%, preferably from 2 to 40 wt%, more preferably from 2.5 to 30 wt .-%, in particular from 3 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included. Antiperspirant cosmetic agent according to one of claims 1 or 2, characterized in that the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures. Antiperspirant cosmetic agent according to one of the preceding claims, characterized in that the at least one protein a change in the light absorption of 1.5 to 90%, preferably from 2 to 80%, preferably from 2.5 to 70%, more preferably from 3 to 65%, in particular from 3.5 to 60% causes. Antiperspirant cosmetic agent according to one of the preceding claims, characterized in that the concentration of the protein in the mixture used to determine the change in light absorption of 0.005 to 10 wt .-%, preferably from 0.05 to 5 wt .-%, preferably from 0.07 to 3 wt .-%, in particular from 0.09 to 2 wt .-%, based on the total weight of the mixture used for the determination of the change in the light absorption, is. Packing unit (kit-of-parts), comprising - made up separately - a) at least one first container (C1) containing a cosmetic agent (M1) comprising at least one antiperspirant active substance, and b) at least one second container (C2) containing a cosmetic agent (M2) comprising at least one protein, wherein the at least one protein is isolated from fish or birds, wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the determination of the change and the cosmetic agent (M2) does not contain halides and / or hydroxy halides of aluminum and / or zirconium.  Use of at least one protein for at least partially influencing the sweat gland (s), wherein the at least one protein is isolated from fish or birds and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4 , 0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for determining the change in the light absorption, a change of Light absorption of 1 to 100%, is effected. Use of a combination comprising a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, b) blowing agents in a total amount of 0 to 99% by weight to the total weight of the antiperspirant cosmetic agent, and c) at least one protein in a total amount of from 0.1 to 70% by weight, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein is isolated from fish or birds, wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 Wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, a change in the light absorption of 1 to 100%, causes and wherein the combination no halides and / or it contains hydroxyhalides of aluminum and / or zirconium, for the reduction and / or prevention of perspiration, in particular axillary sweat or perspiration of other body regions.  Antiperspirant cosmetic containing d) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, e) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and f) at least one collagen isolated from fish in a total amount of from 0.1 to 70% by weight, based on the total weight of the antiperspirant cosmetic, wherein the collagen is hydrolyzed, wherein the antiperspirant cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium  A non-therapeutic cosmetic method of preventing and / or reducing transpiration of the body comprising applying an antiperspirant cosmetic according to any one of claims 1 to 5 or 9 or a packaging unit according to claim 6 to the skin, in particular to the skin of the armpits and for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remains on the skin of the armpits.