DE102013017586A1 - TREATMENT DEVICE for Magnetic Field Assisted Irradiation Therapy - Google Patents

Abstract

A biomedical treatment device for magnetic field-assisted radiation therapies is based on a cost-effective design, easy handling and complex participation of selectable different forms of energy of the electromagnetic radiation spectrum and at least one further z. B. magnetic energy form aligned. The interpretation of the spectral characteristic is based on the nature of the damaged tissue areas and their location relative to the body surface. The difficulties of both the range control and the control of the achievable depth of penetration of the visible, such as the near and middle infrared emission, as far as they were overcome with the temperature control of the skin surface with the aid of the color changes applied cholesteric liquid crystals or with the thermogrammetry with commercially available infrared cameras, forced to one Increased monitoring of the selectivity of the emission characteristics of the emission sources used as well as the frequency response of these emission sources. The cost-effective transition from high-beam coherent lasers with extremely narrow-band emission peaks to emitters 52 with non-coherent emission and a larger half-width of the emission poses a challenge for a targeted intensity modulation, especially in the area of the upper limit frequency. The treatment of larger injured or diseased areas should also be without direct wound contact can be made possible. In particular, if a group of individual emitters 52 of desired wavelengths is used instead of a laser, the emitted power, the 3-dimensional energy density of the system and the spectral and intensity characteristics of the optoelectronic emitter 52 can be adjusted to a targeted program control of the emitter to improve the clinical effect , and the efficiency of the magnetic active elements 54 and 57 can be predetermined by the suitable arrangement of the poles 55 and 56 of the permanent magnets 54 and the cutting of the magnets.

Description

A biomedical treatment device for magnetic field-assisted radiation therapies is based on a cost-effective design, easy handling and complex participation of selectable different forms of energy of the electromagnetic radiation spectrum and at least one further z. B. magnetic energy form aligned. The interpretation of the spectral characteristic is based on the nature of the damaged tissue areas and their location relative to the body surface. The difficulties of both the range control and the control of the achievable depth of penetration of the visible, such as the near and middle infrared emission, as far as they were overcome with the temperature control of the skin surface with the aid of the color changes applied cholesteric liquid crystals or with the thermogrammetry with commercially available infrared cameras, forced to one Increased monitoring of the selectivity of the emission characteristics of the emission sources used as well as the frequency response of these emission sources. Here, the cost-effective transition from high-beam coherent lasers with extremely narrow-band emission peaks to emitters with non-coherent emission and a larger half-width of the emission poses a challenge for a targeted intensity modulation, especially in the area of the upper limit frequency. The treatment of larger injured or diseased areas should be without direct Wundkontakt be enabled. Especially when a group of individual emitters of the same wavelength is to be used instead of a laser, the emitted power, the 3-dimensional energy density of the system and the spectral and intensity fluctuations of the optoelectronic or magnetic active elements are to be compensated to improve the clinical effect.

The invention relates to a biomedical treatment device in which a first form of energy of the electromagnetic radiation spectrum with at least one further z. B. magnetic energy form can be used coupled. The device is consequently designed to safely undercut all surgical performance thresholds with cautery effect and to allow for an adapted, therapeutic treatment of diseased, damaged or abnormal cell tissues of living organisms physiotherapeutically.

In the meantime, the drug therapy had achieved not only in the field of macrocirculation but also the microcirculation desired effect such. B. in the β-receptor blocker with the active ingredient nebivolol (Nebilet ^® , Berlin-Chemie). The effectiveness of beta-blockers, their association with an acceptably favorable side-effect profile, and the wide spread of diseases using beta-blockers have helped this product to the top of the sales lists of pharmaceuticals. Such drugs inhibit the action of the "stress hormone" adrenaline and the neurotransmitter norepinephrine, and are therefore a performance-enhancing substance on the doping list in sports disciplines that require high concentration and precise movement control.

Complementary therapeutic measures such as physiotherapy by massage, sauna or Kneipp treatment are also able to effectively change the functional state of the microcirculation. Some phytopharmaceuticals such as aloe vera, ginkgo bilowa, and mistletoe (Viscum album) have an expanding effect on narrowed capillaries and can initiate an improvement in microcirculation and contribute to better health and vitality. The parallel use of phytopharmaceuticals and conventional medical therapies can lead to better and faster healing results in many diseases.

A substantial increase in the concomitantly pursued microcirculation of the blood can ultimately also take place with certain physical facilities suitable for perfusion modulation. For this purpose, both devices for generating pulsating, bio-electromagnetic stimulation signals, but also massage arrangements with massage pulses with increasing and decreasing massage pressure for transporting the lymph stream, and ultimately as a Beauflagungen with radiation pulses from different areas of the electromagnetic spectrum are suitable.

A medical treatment device with alleged accelerated healing process according to Rudolf Buschky the DE3537081A1 relies on a mechanical massage roller with mechanical projections, which can be guided horizontally above a couch horizontally, while the patient can be exposed simultaneously to a magnetic field of a horseshoe-shaped permanent magnet between the south pole and the north pole above the bed. The projections of the massage roller can be connected to a stimulation current generator so they are equipped with stimulating electrodes.

To trigger pain-relieving effects, transcutaneous electrical nerve stimulation (TENS) delivers light electrical current pulses through the skin to the nerve fibers. A Radiating device for high-frequency, electromagnetic waves exists after the EP266907A3 by Victor Marcel Fellus from an antenna mounted on a flexible or rigid base. It is supplied by a signal generator with electrical signals in the low-frequency pulse periods of 1 Hz to 10 kHz internally modulated high-frequency z. With 27 MHz. A second meander-shaped electrode (13) is guided around a first central square electrode (10) of the signal transmitter antenna (5). Both electrodes are as elements of a printed circuit on a circuit board of selectable rigid or resilient flexibility and are placed on or under the body of patients and used for transcutaneous nerve stimulation.

• [1] Richard M. Dubinsky Nützlichkeit dertranskutanern elektrischen Nervenstimulierung bei neurologisachen Schmerzerkrankungen Neurology 74 (2010) Nr. 1 pp. 104–105

In the treatment of pain in neurological disorders, according to several studies of Richard M. Dubinsky (American Academy of Neurology) z. B. in back pain only a moderate benefit or even an ineffectiveness of the treatment exposed. If a variety of peripheral nerves are affected throughout the body, such as in polyneuropathy, then after clarifying the cause about the blood sugar level, renal function, bone marrow, injury or contusion control, etc. and other accompanying measures, the TENS a therapy, which may possibly show some effectiveness.

• [1] Richard M. Dubinsky Utility of Transcutaneous Electrical Nerve Stimulation in Neurologic Pain Disorders Neurology 74 (2010) # 1 pp. 104-105

Each treatment method with electro-magnetic alternating fields from equipped with magnetic coils therapy devices has tried by a variety of design of the magnetic field coils and the influence on the temporally controlled magnetic flux density more direct influence on the body's own transport and Reg ulationsmechanismen such. B. to take the vasomotion.

In order to be able to achieve a significant increase in the microcirculation of the blood as well as other features of bodily functions controllable, longer-lasting, prophylactic and therapeutically relevant improved, according to Peter Glem after EP2391420A1 the perfusion modulation by a synergistic effect of three device units, the first of the generation of a pulsating electromagnetic field, the second of the carriage of the lymph stream by massage application and the third is to lead by heating by infrared radiation. A control unit controls the activation of two selected or all three mentioned device units. The pulse sequences conducted with a time delay on therapy coils generate defined pulsed electromagnetic fields. A first pulse train gives magnetic flux densities of 35 to 100 μTesla for 100 to 200 ms and a flux density of only 2-40 μTesla for 10 to 20 ms. The pulse trains are transmitted to at least one connected coil and, with their local regulation of the microcirculation, influence autorhythmic contraction movements of the smooth vessel wall musculature - known as vasomotion. With the massage device for conveying the lymph stream, a pressure pulse train with compressive forces in the range of 2 to 65 N, which is transmitted to a leg cuff with a number of compression chambers, is generated with a flat formation of massage arrangements horizontally next to one another and vertically one above the other using a pump control device. For heating, three different subranges of the infrared radiation are optionally used: infrared A (wavelength 0.8-1.4 μm for penetration depths into the skin up to 6 mm), infrared B, (wavelength 1.40-3.0 μm for penetration depths in the skin up to 2 mm) and infrared C (wavelength 3.0-10.0 μm, penetration into the skin to 1 mm). Surprisingly, however, here are the growing penetration depths of the IR radiation with decreasing wavelength. (also in WO02010086301 S. 9 Z. 8-10) in their effect on the temperature-sensitive parameters of the microcirculation such. B the percentage current-time volume (flow of near-surface and lower microvascular networks of the skin: right middle finger, in different tissue depths 3 and 8 mm {K 155}) has not yet been revealed, as shown by the analysis of flow rates in the two mentioned tissue depths with 1400 % and 400% of the total blood flow after a sauna session is known. An undifferentiated interpretation of the thermogrammetrically recorded temperature distribution by means of cholestrinic liquid crystal mixtures on the skin surface overstrains the condition analysis in deeper tissue and vessel networks a priori.

The best way to meet tailored metabolic needs is and will be with sophisticated, costly and maintenance-intensive measurement {K 134} flow in the arterial inflow and venous outflow of capillaries, local hematocrit, blood cell flow velocity, and accumulation, adhesion, and transmigration White blood cells on and through the vessel walls in the tissue provable.

• [5] N. G. Basov, V. A. Danilychev, Y. Popov, D. D. Khodkevich Laser for vacuum region of the spectrum with excitation of liquid xenon by an electron beam Zh. Eksp. Fiz. i Tekh. Pis'ma. Red. Nr. 12, 1970, S. 473–474.
• G. Stoeppler*, M. Schellhorn, and M. Eichhorn Enhanced Beam Quality for Medical Applications at 6.45 μm by Using a RISTRA ZGP OPO1 Laser Physics, Vol. 22 (2012) No. 6, pp. 1095–1098. ISSN 1054-660X, Online 25.12.2012 Stoeppler 6,45 μ RISTRA für Med-Appl Laser Physics 22-2012-6 S. 1095–8

Devices are known for the physiotherapeutic and surgical treatment of disease herds with the help of laser radiation of certain very well-defined wavelength with the primary use of gas lasers - (far IR with CO ₂ laser, blue argon, red krypton or HeNe- Lasers, UV noble gas halide lasers from ArF, KrF, XeCl and XeF as cutting lasers), solid-state lasers made of crystalline material such as yttrium aluminum garnet with a laser active ion doping of Nd (for Nd: YAG laser for low absorption in water at 1.064 μm), Er (for strong absorption in water at 2.94 μm) or Yb (for highly doped disk laser Yb: YAG laser, at 1030 nm), of dye lasers in which the emitter dye such as e.g. B. rhodamine (types 6B, G or 123) dissolved in a solvent is excited by a pump laser, and laser diodes of binary, ternary or quaternary compound semiconductors of III. and V. group, as well as II. and VI. Group of the periodic table. These devices include several devices that have been prepared and manufactured both in Russia and in other countries.

• [5] NG Basov, VA Danilychev, Y. Popov, DD Khodkevich Laser for the vacuum region with the excitation of liquid xenon by an electron beam Zh. Eksp. Fiz. i Tekh. Pis'ma. Red. No. 12, 1970, p. 473-474.
• G. Stoeppler *, M. Schellhorn, and M. Eichhorn Enhanced Beam Quality for Medical Applications at 6.45μm by Using a RISTRA ZGP OPO1 Laser Physics, Vol. 22 (2012) no. 6, pp. 1095-1098. ISSN 1054-660X, Online 25.12.2012 Stoeppler 6.45 μ RISTRA for Med-Appl Laser Physics 22-2012-6 p. 1095-8

In the initial approach was in the use of radiotherapy z. B. after Hermann von Dechend and the AT129 515 pointed to the correspondence of the daily rhythm of the life processes of a living being with the use rhythm of radiation sources, which are considered as an available additional source for irradiation with light, heat, as well as with electric and magnetic radiation, and proposed the coupling of one or more of these rhythms. Accordingly, the irradiation devices should be equipped with rhythm takers of respiration, circulation, etc. for pulse, heartbeat, respiratory meter, electrocardiograph or the like. With the rhythm determined on the patient by the rhythm pickup, the control of the rhythm of the radiation field was controlled by diaphragms, surges, resistances and so on. Thus, the color of the light coming into effect or the type of radiation up to X-rays should be taken into account and be used rhythmically modulated at appropriate times.

(d = 2 ΜΜ ab 1985 in der SU auf dem Markt) ergänzt durch einen einzelnen Halbleiterlaser mit einer Laserbande zwischen 0,84–0,89 μm eingebaut und von einem ringförmigen Permanentmagneten umkränzt. Andererseits liefert ein im Aufsetzkopf ebenfalls installierter Photoempfänger Signale über die Größe der von der Oberfläche der Epidermis reflektierten Strahlung, die nicht in das Therapieobjekt eindringen konnte. Diese Einkopplungsverluste sind auf einer Anzeige in einem über Kabel angeschlossenen Steuerpult dargestellt und ermöglichen dem Therapeuten über eine Synchronisierschaltung auf den Stromregulierungsblock für die Steuerzweige der Leuchtdioden bzw. auf den Steuerzweig für den Impulsgenerator und den Impulsmodulator des Lasers zuzugreifen. Nachteil dieser Therapievorrichtung ist jedoch, dass außer über die Oberflächenreflexion der eingesetzten Belichtung und Bestrahlung keine weiteren Verlustprofile bei der Transmission im Therapieobjekt oder bei Veränderungen der Reichweite erfasst und berücksichtigt werden können. Größere Inhomogenitäten des Magnetfeldes als im Streufeld eines Ringmagneten treten zweifellos bei der Anwendung statischer Magnetfeldern auf, wenn nur einzelne permanent-magnetische Stabmagnete oder Säulenmagnete gemäß der RU2080136C1 (9a) eingesetzt werden.To improve and increase the accuracy of the individual dosage of absorbable radiation dose at selected radiation energy during the therapeutic treatment of internal organs as well as to properly account for the losses of laser energy and dose in / at the epidermis is according to AK Polonskij and the RU2072879C1 (9) with the aid of the functional linkage of the magneto-laser therapy on the one hand in a treatment terminal and its attachment head a group of light emitting diodes connected in parallel

(d = 2 ΜΜ from 1985 in the SU on the market) supplemented by a single semiconductor laser with a laser band built in between 0.84-0.89 microns and encircled by an annular permanent magnet. On the other hand, a photoreceiver also installed in the attachment head provides signals about the size of the radiation reflected from the surface of the epidermis which could not penetrate into the therapeutic object. These coupling losses are shown on a display in a cable connected control panel and allow the therapist via a synchronizing circuit to access the current regulating block for the control branches of the light emitting diodes or to the control branch for the pulse generator and the pulse modulator of the laser. Disadvantage of this therapy device, however, is that except on the surface reflection of the exposure and radiation used no further loss profiles in the transmission in the therapy object or changes in range can be detected and taken into account. Larger inhomogeneities of the magnetic field than in the stray field of a ring magnet undoubtedly occur in the application of static magnetic fields, if only single permanent-magnetic bar magnets or column magnets according to the RU2080136C1 (9a) are used.

• – eine Lampe, die 1.) einen schmalen Lichtstrahl mit einer Halbwinkeldivergenz bis zu 10° bei einer Intensität von zumindest 20 mW/nm im Spektralbereich von 600 bis 750 nm zur photodynamischen Behandlung aufweist und die 2.) zumindest zur hyperthermischen Behandlung im Spektralbereich von 1.200 bis 1.700 nm eine Leistung von 2 mW/nm erbringt, dazu
• – einen Filterspiegel 3.), der eine harte durchgehend dielektrische Filterbeschichtung auf Glas hat und dadurch eine Lichtdurchlässigkeit von zumindest 60% im Bereich von 600 bis 750 nm und zumindest 5% im Bereich von 1.200 bis 1.700 nm besitzt, aber die Strahlung im Bereich von 750 bis 1.200 nm gut reflektiert,
• – ein Glaslinsensystem (4.) mit einer Antireflexionsbeschichtung,
• – ein dichroitisches Filter (5.), das aus einer harten durchgehend dielektrischen Beschichtung besteht, die auf Glas niedergeschlagen ist, und eine Lichtdurchlässigkeit von zu mindest 60% oberhalb von 600 nm und eine vernachlässigbare Lichtdurchlässigkeit un terhalb von 600 nm hat,
• – eine Glasfaseroptik (6.) mit einem Durchmesser im Bereich von zwischen 1 bis 12 mm, getrennt von oder als Teil eines Endoskops, und
• – ein wirksames Luftkühlsystem (7.) zum Abführen der erzeugten Wärme, um in der Vor richtung eine Innentemperatur von maximal 50°C einzuhalten. Gemäß Anspruch 6 der DE...980C2 erfolgt die Erwärmung durch einen CO2-Laser oder einen Nd:YAG-Laser:

With the DE19507980C2 (8) should be registered with ESC Medical Systems Ltd. IL z. For example, an improved device for effective treatment of certain hard skin tumors (such as skin cancer) as well as internal organs such as the colon, vagina, urinary bladder can be created after tumor-localizing photosensitization with relevant reagents. This is done with photo-sensitizers such as porphirin, aminoolevinic acid, or with phthalocyanine, chlorin o. Ä. M., The absorption spikes are in the 350-450 nm and 650-720 nm range. The device then aims on the one hand to an effective treatment with improved utilization of synergy effects and on the other hand to a gentle treatment as possible. Devices according to DE ... 980C2 for simultaneous photodynamic (PDT) and hyperthermic (HTP) treatment possess

• A lamp having 1.) a narrow light beam with a Halbwinkeldivergenz up to 10 ° at an intensity of at least 20 mW / nm in the spectral range of 600 to 750 nm for photodynamic treatment and 2.) at least for hyperthermic treatment in the spectral range of 1,200 to 1,700 nm provides a power of 2 mW / nm, in addition
• A filter mirror 3) having a hard continuous dielectric filter coating on glass and thereby having a light transmission of at least 60% in the range of 600 to 750 nm and at least 5% in the range of 1200 to 1700 nm, but the radiation in the range of 750 to 1,200 nm well reflected,
• A glass lens system (4) with an antireflection coating,
• A dichroic filter (5.) consisting of a hard continuous dielectric coating deposited on glass and having a light transmission of at least 60% above 600 nm and a negligible light transmission below 600 nm,
• A glass fiber optic (6) with a diameter in the range of between 1 to 12 mm, separated from or as part of an endoscope, and
• - An effective air cooling system (7.) for dissipating the heat generated to comply in the front direction an internal temperature of 50 ° C maximum. According to claim 6 of DE 980C2, the heating takes place by means of a CO2 laser or an Nd: YAG laser:

However, correct placement of the zones of action of these and similar therapy devices on the affected sensitized target site is quite cumbersome, especially if the zones are not on the surface but deeper in the tissue and the depth control and adjustment is difficult or impossible is.

For cost-effective adaptation to at least one of the absorption bands of the absorption spectra of the individual, known photosensitizers for photodynamic therapy are after DE60105473T2 (8a) Replace all laser diodes with non-coherent emitting LEDs and provide for simplified supply from a battery of parallel strings of series connected select LED's. If, in such a parallel series circuit, 288 LEDs supplied from a 48 V battery are supplied with 90 mA per line, then a tailored ventilation ventilation is absolutely necessary. For the wavelength range between approximately 430 to 644 nm, all types of compound semiconductors and the types of diodes constructed from these materials that can be used for the targeted wavelengths and their manufacturers are named.

If, however, in a physiotherapeutic device for light beam therapy, the treatment should be adjustable to different photosensitizers on the patient's body, then according to AE Vorona et al. and the RU2349355 C2 (8b) the device is constructed from several, preferably three independently controllable parallel-serial circuits and connected to corresponding separate power supply units. The three sub-matrices are then set up with LED's for the emission areas red, green and blue and are operated by separate microcontrollers via corresponding setting mechanisms and keyboards, display units, digital-analog converters and pulse stabilizers.

For medically influencing pain level perception and healing support for skin diseases, inflammation and seasonal affective disorders such. As the winter depression is said to Darren Starwynn and the USPS7198633 (8c) one opposite the DE19507980C2 disarmed, energetic stimulation system on the basis of the effect of a colored light emission on the human or animal body to effect. The probe system includes a light-integrating chamber in which, thanks to the reflective inner surface, the light of various wavelengths emitted by a plurality of LEDs emits color tones in RGB format and in the Y range (> 620 nm,> 525 nm, Y: 577). 597 nm) can be set constant or floating by a controller with a controlled color change program. About an imaging lens, a portion of the radiation from the chamber can also be coupled into an optical fiber and guided to a treatment point.

In pediatric oncology, in particular in the integrated treatment of infants with capillary or cavernous hemangioma, a reduced duration of treatment and an individual concept for improving the quality of life and the functional condition of the child are becoming apparent ZI Borodina, EA Shejko et al. according to the RU2464053C2 the ulcer formation was carried out by exposure to monochromatic light at 670 nm taking into account diagnostic indications. The exposure is based on infrared spectrographic thermography and is the basis for determining the radiation dose W to be used in J / cm ² . To promote the regression of the hemangioma and the formation of soft scars, the radiation dose is limited to the allowable temperature increases in increments between +0.8 to + 1.0 ° C; +0.6 to + 0.7 ° C; 0.3-0.5 ° C or 0.1-0.2 ° C with the appropriate dose between 2.25-0.25 J / cm ² . This eliminates the need for alternative cryotherapy, hormone therapy or other radiation therapy measures.

In order to reduce the general losses of laser energy and radiation power in the penetration of the epidermal tissue z. B. by their heating due to the radiation absorption for the setpoint control of the laser radiation intensity usable, is after the RU2214844C1 (10) based on a temperature measurement in the epidermis now made with the help of a thermistor in equipped with laser and photodiodes irradiation terminal, a control of the target value of the current laser radiation dose. The thermistor signal is monitored for temperature changes and fed together with the reflection signal of the epidermis of the photodiode via an adder a differential amplifier and from there to a voltage-frequency converter, which converts an electrical voltage in a proportional frequency to the voltage controlled oscillator. The oscillator frequency f driving the power source of the laser emitter on the one hand, and provides on the irradiation time t (in s) by means of a setpoint assembly of the laser dose that one in the irradiated tissue area S absorbed (in cm ²⁾ dose W _n (in J / cm ²⁾ is reduced by a product of the pulse power P _{pulse of} the laser source (in watts), the pulse duration τ _0.5 between the increase of the pulse level over 50% and the drop back to 50% and below, and from a balance factor taking into account the wavelength-dependent Reflection ρ (λ) at the surface and the temperature dependence of the absorption ξ (Θ) in the tissue.
formula 1 f = W _n × S × t / P _pulse × τ _0.5 × (1 - (ρ (λ) + ξ (Θ)) (1)

In order to effectively achieve biological effects through heat treatment while still providing pain relief during therapy, even when treated with laser devices of the above construction, the EP1626778B1 (11) a control unit for the laser beam source, wherein a temperature sensor for the infrared range, the temperature of the irradiated surface more accurately detected time-resolved scanning. This happens before, during and after the laser was switched on temporarily. The instantaneous temperature of the skin surface is then compared during the therapy phase with a maximum allowable temperature threshold, which was determined in an advanced examination phase in the temperature range of 35 ° C to about 50 ° C. By a feedback control loop then the radiation dose of the laser light over a selectable pulse rate between 0.5 and 400 Hz in a selected temperature range of z. B. 35 to 45 ° C. Alternatively, the laser light via a tilting mirror but similar to the line-by-line control of screens is scanned over areas of 10-20 cm diameter.

With the monitoring only of the surface temperature of the therapy zone, however, a knowledge of the thermal state in deeper tissue zones is not to win. The organ skin as a border organ to the environment is not only a comparatively large body organ. Through a variety of differentiated cells, it is connected to the management of different functions with the main regulatory systems of the organism such as temperature regulation, circulatory regulation, immune defense and sensory functions. For the clarification of the functional morphology of the upper skin, a stratification of the stratum in four layers above the basal lamina has proven to be effective: the horny layer, the granule layer, the prickle cell layer and the matrix layer. ( Klopp district. 2008 p. 399 )

The endeavor to make the conditions for the laser light transport between the therapy source and the therapeutic object less lossy and more practical has, according to the DE69526371T2 (12) to provide a transparent coupling device as possible, which reduces the reflection losses on the plate-like layered cornea and improves the penetration and transmissibility in and through the horny layer in affected deeper layers as possible. For this purpose, a flexible, transparent hydrogel coupling layer is brought between a layered or plate-shaped light source, formed from a mat with numerous exit points for coupled laser light, and the therapeutic object, in the hydrogels have a water content of 60% and more and there is a hydrogenation of the horny layer , The photo-medicament to be used for photodynamic therapy is then chosen so that its light energy can be activated in the favorable range between 590-700 nm. Hydrogenation also increases the chemical transparency of the drug.

A similar limitation of skin damage and burns in the therapeutic or cosmetic radiation treatment should after the US8226696B1 (13) by a flash lamp therapy on the basis of a filled with xenon gas, and clocked by a special supply circuit controlled light tube allows. With the tube operated at a current density of 1.2-2.4 kA / cm ² and pulse durations of 100 ms, the absolute radiation intensity between 0.5 and 5.0 W / cm ² becomes very dependent on the wavelength and with shorter light pulse lengths emitted from 10-70 ms. The undesirably wide spectral distribution of the emission is corrected as required by two filters. A long-wave Heat-resistant passport filter blocks the spectral range from UV to 510 nm. A water filling in a reflector, consisting of a steel block trough covered with a ceramic layer, absorbs the spectral region that is otherwise absorbed by the water in the skin tissue. Simultaneously, a water circulation contributes to the cooling of the treatment device and, accordingly, of the channel water. Beyond the pass filter disc and orthogonal to the disc sets in contrast to DE69526371T2 a one-piece light guide plate according to the lamp length and transmits the light from the lamp to the remote therapy object.

Although laser radiation sources with absolutely narrowband emission do not require pass filters, they are in principle harmful to the nonlinear optical phenomena used, unless they are adjusted to the intended application by a limited pulsed operation with extremely short light pulse lengths (for example, only from 1 fs-1 ns). Cell tissue damage when transient short-term thresholds are exceeded are either due to thermomechanical damage to the cell structure or to irreversible thermal denaturation of various proteins that appear in the scheme of the amino acid and protein pool (see, for example, US Pat. R. Klinke and S. Silbernagl Textbook of Physiology Georg Thieme Verlag p. 366, 360 ), caused.

In order to avoid the risk of injury from laser therapy and even to allow self - treatment of the patient and to reduce equipment costs in the DE10120629A1 proposed exclusively laser-free irradiation of nasal, cervical and / or almond tissue. Preferably, monochromatic radiation generated by at least one light-emitting diode is supplied to the tissue to be irradiated by means of a light guide, where it is emitted, preferably diffusely distributed. An irradiation apparatus developed for the first time by the submitter of DE..0629A1 has an energy source stored in its housing, the light source designed as a light-emitting diode, a circuit connecting the light source with the energy source and a circuit for regulating the energy supply to the light source. A supporting magnetic field is based on a permanent magnet, which is arranged in the head part of the treatment device.

The advantages of the treatment device according to DE..0629A1 are lost, however, if less accessible treatment regions, whether in the deeper levels of the body or in body cavities that can no longer be reached by the patient, should be treated.

For the physiotherapeutic treatment of wounds and injuries according to the invention of VLADISLAV N. KHRISTOFOROV et al. after RU2128063C1 Emitters applied from the infrared range in combination with magnetic fields. Both pulsed lasers and continuous-wave light emitting diodes are suitable as radiation sources. The two sources of illumination or illumination are electrically connected to an individual control unit for adjusting the optical power via the supply voltage. On a Actual value display are both sources monitored. As a mechanical support for a washer for holding the power supply of the housed laser and LED elements is a static ring magnet. The LEDs are tilted relative to the central longitudinal axis of the lead wires. Lasers and LEDs also allow the transmission of the photodynamic effect into the deeper zones of organs and are associated with their sufficiently long-term stable emission and usability.

According to another embodiment of magnetic field-assisted therapeutic treatment devices is in a similar basic concept, as just described, in the RU2134601C1 the device head is equipped with a magnifying attachment, so that a maximum optical concentration of the coherent as the non-coherent emission is achieved in the space between the aperture plane and the Aufsetzfuß the Katheteraufsatzs.

For the treatment of animals after the RU2129889C1 the laser radiation emanating from the device head is set by adjusting the amplitude of the laser power supply and the laser pulse repetition frequency. The therapy device thus generates a controllable laser radiation and enables continuous LED and magnetic field operation. The arrangement of the active elements and the supply of drive signals, which cause a mixture of the radiation powers of the active elements involved with a significantly lower penetration of the radiation, increase the efficiency of the treatment.

A medical device from ALBERT YAKOVLEVICH GRABOVSCHINER after the US020090254155A1 The company MILTA PKP GIT Moscow based on the transmission of energy from multiple energy sources of one or more types of energy used according to claim 3 and 7 of the application Radiation sources from selected areas of the entire electromagnetic spectrum. In the infrared range, these include the long-wave IR of 8-15 μm, the medium-wave IR of 3-8 μm, the short-wave IR of 1.4-3 μm and the near IR of 0.75-1.4 μm. The various radiators are arranged medially in the middle third of a lamp bell, with a laser centrally and z. B. eight LEDs are placed in a circle around the center. In the visible spectral range, the wavelengths for red are 620-750 nm, for orange 590-620 nm, for yellow 570-590 nm, for green 495-570 nm, for blue 450-495 nm and for violet 380-450 nm.

The area division is closely matched to the hue coordinates of the color chart of monochromatic colors as defined in the CIE 1931 Chart of the International Commission on Illumination (CIE) for a relation between the color perception of the human eye and the physical cause of the color stimulus. As a result, the therapist's eye can easily recognize the current emission band, but can not determine whether this radiation band is really constant over the therapy time and really is and remains perfectly adapted to the given cause of inflammation or the tumor-localizing photosensitization wavelength. In the UV range, the near UV with the long-wave UVA range of 400-320 nm, the medium-wave UVB range of 320-280 nm and the short-wave UVC range of less than 280 nm are taken into account. The distance or vacuum UV of 200-10 nm is also proposed for use.

According to claims 3 and 17 and sections 69 and 79, magnetic field generating elements are also added to the aforementioned energy sources that generate fields with magnetic flux densities below 50 mT (500 Gauss), preferably below 30 mT and are preferably administered by radiation therapy. Magnetic fields keep ionized molecules in a disassembled state and increase the energy potential at the molecular and cell levels. The magnetic field application should be suitable for establishing an energy-mediated protection of the organisms from the environmental effects of climatic factors and electromagnetic fields.

The disadvantage of these devices is that the ring magnet is directed only with the stray field of a pole on the surfaces to be treated, whereby the magnetic efficiency is limited to the tissue, and the range of action of the semiconductor radiator. In addition, the design features and the therapeutic efficacy and reproducibility of the results are in need of improvement.

OBJECT OF THE INVENTION

is to mitigate the shortcomings of the use of static magnetic and dynamic or static optoelectronic treatment devices in magnetic field assisted photoelectromagnetic physiotherapy in limiting the range of the therapeutically useful stray magnetic field and the range or access to lower or inaccessible therapeutic regions in both magnetic and magnetic fields; supported as in radiation field-based treatments. The treatment device is intended to serve a broader field of application, which is also burdened with access problems to the treatment region, and can be used in aftercare for operations, in the healing of diseases, in prophylactic healing practice, and finally in the targeted stimulation of the performance of any healthy organisms.

The therapy devices according to the invention should preferably act in the near infrared region of the radiation spectrum and can be based on commercially available semiconductor chips and components. In particular, from the wide market offer a selection of the emitters to be used for the therapy equipment by a tailored selection management before final assembly and a controlled operations management in the final product to ensure that all unwanted deviations in the opto-electronic characteristics of each radiator type and the scattering These values of the different individual radiators of this radiator type are eliminated and remain.

Now, the drive circuits for a larger number of individual emitters are to be designed so that a emitter assembly in operation as possible with modulations up to the THz range can be tested.

Finally, the radiation therapy treatment device is to be supplemented by appropriate permanent magnetic components so that the magnetic field range in the therapeutically treated body of humans or animals is not limited to the range of the selected NIR radiation, but also areas in the lower neighborhood of the absorption zone of the radiation can still stimulate with sufficient magnetic field strength.

Ultimately, weaknesses of the laser-assisted therapy, which also occur under the known problems of a water-related transmission blockage of tissue in therapeutically relevant spectral regions and come through a particularly high proportion of inelastic and elastic scattering of the laser radiation to effect and increase the thermal overload of the tissue to reduce ,

THE INVENTION SOLUTION

• – im Therapiekopf Halbleiterstrahler, Permanentmagneten und optische sowie thermische Detektoren, die über eine zugeschnittene Steuerelektronik an eine Stromversorgung aus dem Netz oder einer Batterie angeschlossen sind, so dass
• – in den effektiveren Wirkungsbereich des Streufeldbereich des gerichteten magnetischen Gleichfeldes von Permanentmagneten im Therapieobjekt auch
• – die nichtkohärenten Emissionen von Lichtquellen und/oder von thermischen Strahlungsquellen immer aus geeigneten Hableitermaterialien bevorzugt aus direkten und indirekten Halbleitern mit adaptierten Emissionsimpulsen wirksam zu- bzw. abschaltbar sind dass diese Emissionsimpulse mit Hilfe einer zugeschnittene Impulsform für den Flußstrom betrieb erzeugt werden, die aus einer Fourierreihenentwicklung hervorgegangen ist, dass über eine Ansteuerschaltung alsdann Impulsstrompegel im Grenzstrombereich von bis zu 10⁴ mA und mit steilen Anstiegsflanken bis zur Grenzfrequenz im –3dB-Bereich zu erzeugen sind und Tastverhältnisse von 400 bis 1000 mit Impulslängen in der Größenordnung von 10^–7 s gewählt sind und dass
• – durch eine Platzierungshilfe, bestehend aus Detektor- und Manipulatorelementen, einerseits das zu therapierende Objekt geortet und ein therapeutisches Behandlungssignal zu dem therapeutischen Zielpunkt manuell durch den Patienten selbst oder eine Schwenkeinrichtung der Strahlungsquellen in Koinzidenzlage gebracht werden kann.

The physiotherapy device according to the invention with an adaptable therapy head in a device housing contains

• In the therapy head semiconductor emitters, permanent magnets and optical and thermal detectors, which are connected via a tailored control electronics to a power supply from the mains or a battery, so that
• - In the more effective range of the stray field of the directed magnetic DC field of permanent magnets in the therapy object also
• - The non-coherent emissions of light sources and / or thermal radiation sources always from suitable Hableitermaterialien preferably from direct and indirect semiconductors with adapted emission pulses effectively switched on or off that these emission pulses are generated by means of a tailored pulse shape for the flow stream operation, consisting of a Fourierreihenentwicklung has emerged that via a drive circuit then impulse current levels in the limiting current range of up to 10 ⁴ mA and with steep rising edges to the limit frequency in the -3dB range are generated and duty cycles selected from 400 to 1000 with pulse lengths in the order of 10 ^-7 s are and that
• - By a placement aid, consisting of detector and manipulator elements, on the one hand, the object to be treated located and a therapeutic treatment signal to the therapeutic target point manually by the patient or a pivoting device of the radiation sources can be brought into coincidence.

The therapy head on the device housing is equipped with a plurality of permanent magnets, which are mounted as a group of individual magnets on adjacent mounting positions of a unitary mounting plate. Each magnet faces only one pole to the body part to be irradiated. In the vicinity of each magnet but at least one second magnet is arranged, whose polarity but opposite to that of the neighbor in the pair is aligned. At least the magnets of a pair have the same height and are mounted on a mounting plate of a continuous magnetic flux conductor and fixed in this position.

Depending on the field of application of the device, the magnetic flux guide is designed as a flexible, easy-to-arching foil for a conformable placement plane of the free magnetic end of each magnet in the pair or as a rigid support of a magnet pair or a pair group. For the second application of the rigid support, the use of soft iron is expedient, since here the magnetic resistance between the magnetic columns involved can be kept vanishingly small. But also stainless steel is suitable.

The second functional unit of the therapy head is formed by the illumination or the irradiation unit and provides either optical or thermal stimulation of the tissue zones to be dynamically stimulated. Preferably also those zones which have been previously activated by sensitization.

Here, the depth range associated with a selected radiation is intended to cause a local thermal stimulation according to the penetration depth of the radiation in different layers of the epidermis, dermis or subcutis by a treatment action.

Further details and advantages of the invention will become apparent from the claims and from the description of subsequent exemplary embodiments, which are explained in detail with reference to the drawings.

It shows

1 : Absorption characteristics of water and hemoglobin and the location of currently applied laser types

2 : Overall view of the physiotherapy device with an adaptable therapy head on a device housing

3 : Schematic diagram of the circuit for operating the irradiation device

4 : Cross-sectional view through the therapeutically active part with the relevant magnetic field-assisted radiation therapy active elements.

5 : Superposition of several frequencies according to a Fourierreihenentwicklung for the generation of an LED drive signal to achieve short high current pulses. By subsequently clipping the negative signals, the required flux direction pulses are available.

6 : Necessary frequency response of the radiation emitters for the therapeutic treatment device

7 : Adaptation of the radiation lobe of the LED to the format of the therapy object by changing the dome height of the activated LED

8th Extension of the scanning window of the emitter (s) by means of variable pivoting of the main emission axis of the individual emitters with the aid of a cycloid and a toothed rack.

The peculiarity of the radiation therapy according to the invention consists in the fact that according to the findings on the high absorption of radiation to the OH groups of the water in the tissue on the reduced range of all in the 1 Named solid state laser and the CO2 gas laser and the above-mentioned disadvantages of these coherent radiation sources is taken into account. Therefore, emitters of radiation with non-coherent emission and a significantly lower absorption in areas where the absorption of water and hemoglobin is comparable, come to the fore. However, this selection orientation is by no means subordinated to the visual color perception of the retina of the eye in RGB format and the Y-range or the range of color coordinates of the monochromatic color chart according to CIE1931 of the International Lighting Commission. Most favorable from the point of view of a possible weak absorption at the OH groups of water or hemaglobin is a wavelength range between 640 and 1080 nm absorption. However, the phenomenon of massively increased scattering in the biological tissue now clings to this radiation area.

• [06] Jürgen Hirsch: Streuung des Lichtes [Ed.] M. v. Ardenne, G. Musiol, S. Reball: Effekte der Physik und ihre Anwendungen S. 600–603 Deutscher Verlag der Wissenschaften, VEB ISBN 3-326-00035-9

Instead of an ordinary straight-line transmission, either elastically named, isotropic scattering of the scattered secondary waves occurs in the tissue in all directions while maintaining frequency and phase (see Tyndall effect). Or in the case of an inelastically-named scattering with increased backward and forward scattering, part of the photons of the incoming radiation transmit energy to the excited tissue, with the frequency of the scattered radiation decreasing.

• [06] Jürgen Hirsch: Scattering of the Light [Ed.] M. v. Ardenne, G. Musiol, S. Reball: Effects of Physics and Their Applications pp. 600-603 Deutscher Verlag der Wissenschaften, VEB ISBN 3-326-00035-9

Both modes of interaction, however, have a significantly higher thermal load on the tissue when scattering laser radiation than during treatment with emitters with non-coherent emission.

The constructive design of the physiotherapy device according to the invention differs from the conventional flashlight principle and relies on a modification of a housing shape, already in a figure of our Russian applications RU2134601 C1 was proposed. Now the therapy device 1 according to 2 with a redesigned therapy head 2 equipped in a grip-friendly handling shaft 3 passes. At the front of the therapy head 2 are the therapeutic agents and control tools 4 such as light emitters, radiation sources and permanent magnets as well as radiation detectors and camera sensors housed. The back of the therapy head contains an input keyboard 5 for program selection and a display unit 6 for the reproduction of data of the program sequence. For this purpose, an LCD display is used, which visually displays the different operating parameters of the electromagnetic emitters and the influencing factors used in the working head of the device, as well as the data of the healing programs and the individual patient data.

Inside the therapy head 2 The circuits for controlling the radiation sources, detectors and sensors of the front panel and the input keyboard are located 5 and the display unit 6 , in the grip-friendly handling shaft 3 are rechargeable, modern Li-batteries arranged to secure an island operation of the device.

To achieve the required operating voltage several cells are connected in series. To secure required high pulse current peaks, a parallel connection of several branches of such series circuits is required. The winding technology of the voltage-storing foils to round cells in the Li batteries accommodates the shaft geometry. For use conditions of the therapy devices in network operation, the dimensioning of the handling shaft makes no difficulties.

1st embodiment

The circuitry details of a therapeutic irradiation device are based on a schematic diagram of the circuit for operating the therapy-active assemblies in 3 played. The power supply 31 and the charging circuit 32 loaded before the operational use of the therapy device in island operation, the Li-polymer cell batteries 33 and then allow a temporary off-grid operation. During mains operation, the battery voltage can be kept at the required voltage level, even if the power consumption is high. For island operation the display informs 6 about the still usable therapy time. Immediately stand over the control block 34 the operating voltages for program control 35 , for the microcontroller 36 , the ad 37 the current therapy situation as well as the sensor technology 38 as well as for a pulse amplifier 39 and a voltage converter 40 , the current one for a pulsed operation switched infrared diodes 41 provides required electrical power. Further groups of emitter diodes for different spectral ranges as for a second infrared range 42 or for specific areas in the visible spectrum such. B. with red LEDs 43 , blue LEDs 44 or UV LEDs 45 be directly through the microcontroller 36 connected through. The same applies to the activation of the trigger of an electrical or mechanical stimulation of special assemblies 46 , For the control of the surface temperature of the therapeutically treated tissue zone are infrared light sensors 47 Similar to the thermal imaging cameras used. Another assembly in sensor technology is with spatially resolved photodetectors 48 such as B. a CCD assembly equipped, and allows a scanning monitoring of the treatment surface in terms of the achievement of the therapy destinations and provides scanning signals to the display unit 6 , The support of the therapy process by a group of bar magnets is made by the use of permanent magnets without control over the components of the control block 34 ,

In the sectional drawing through the therapeutically active part of the therapy device with the relevant magnetic and radiation therapeutic active elements according to 4 the two main components are given in their spatial arrangement.

The first module consists of a printed circuit board 50 with a 25-60 μm copper cladding 51 , Optionally, the interconnects with vias and vias for the contact pins of the electrodes of the housing 52 provided the emitter diodes. The capping of the emitter diode chips consists of transparent plastic with a lens head diameter of 5 mm. In the cases 52 on the circuit board 50 can optionally always chips with the same emission z. B. for a first or second infrared range 41 . 42 or for the red, blue or ultraviolet spectral range 43 . 44 or 45 be included. However, it seems to be very useful to use two types of chip, preferably from the point of view of the range of the emission into the depth of the tissue and the addressing and accessibility of preplaced photosensitizers at the appropriate depth. Accordingly, in this first embodiment, emitter chips for NIR radiators 41 with an emission band between 800 and 900 nm and red LED chips with an emission band between 640-680 nm for LEDs 43 selected.

The circuit board 50 has a first type of perforations 53 , the space for the attachment of permanent magnets 54 in the form of cylindrical columns. In the direction of the surface to be irradiated of the body to be treated, each bar magnet column is aligned with only one pole. However, the adjacent bars have in the direction of the therapeutic object, a mutual orientation of the North Pole 55 and the South Pole 56 on their faces. The restriction of the ratio of the end face size of the magnets to the column height is maintained in sets. In order to increase the stray field size, alloys with high (B × H) _max energy products, high remanence (up to 1.4 T) and high coercive force jHc (> 1000 kA / m) can be selected from the range of permanent magnetic materials. For z. B. hard magnetic materials in the composition of Nd2Fe14B suitable.

A cost effective solution to increase the stray field size of the magnets 54 is it all on a coherent mounting plate 57 from a magnetic flux conductor, for example made of stainless steel, permanently and without displacement. This also blocks the action of the static fields of the bar magnets in the interior of the therapy headspace. In addition to the variant of in 4 shown insertion of the cylindrical magnetic columns 54 in the central part of the front surface of the therapy head 2 Furthermore, there is the possibility of the magnetic columns exclusively on the outer edge of a magnetic flux guide to form a ring around the field of the emitter diodes around. The combination of both variants of the arrangement of the magnetic columns may be appropriate.

With this construction, the size and uniformity of the magnetic stray field in the direction of the therapeutic object is increased and reaches a much greater depth range of the magnetic stimulation, as with the radiation sources.

2nd embodiment

In this second embodiment, the focus is less on the activation of pre-placed photosensitizers with a magnetic field-based radiation therapy, but only the unsensitized radiation therapy. In the treatment device provided for this purpose, the therapy head is equipped with a plurality of non-coherent semiconductor radiators but preferably a same spectral emission band. For this purpose, with the use of the therapy device to ensure a minimum range and a transmissible radiation dose in a tissue to be treated and to ensure that enters the setting of an adapted wavelength and the achievement of the intended biological effect. Consequently, at least one accompanying thermogrammatic monitoring of the surface of the therapeutic object is to be ensured.

A very important feature of the solution according to the invention is finally the use of a AG Dmitriev and BV Tsare nkov in the journal Physics and Technics of Semiconductors Vol. 5 (1971) No. 8 p. 1494-1502 described special high current kinetics of the emission from light or radiation emitters. While only the space charge distribution at the pn junction and a resulting first capacitance CR act at the beginning of a flux directional polarization with small currents IF <1 A / cm ^2, the emission intensity increase period is from 10% to 90% of the associated end value of the emission intensity quite a long time. However, if the flux current is increased many times over, the charge carrier diffusion in the flow direction causes an increased injection into the space of the former barrier layer and a rapid charging of a capacitance C _Diff , which in the equivalent circuit of the emitter diode additionally adds as a parallel connection to the CR capacitance. Now, however, the diffusion capacity C _diff becomes dominant with respect to the original space charge capacity CR. The effective advantage lies in the strong shortening of the charging time of the C _Diff capacitance due to the shortened diffusion paths of the charge carriers involved.

The suitable structure and operating process of the emitter is now, instead of edge emitters, which are very common in lasers, to equip certain non-coherent surface radiators already with such geometries, dopants and contact structures, the designs allow a sophisticated pulse current operation.

The superposition of Fourier series of several deterministic given periodic signals is the starting point of the pulse shape management. Fourier series whose partial sums are trigonometric sums have the general form

Die Funktion f(t) ist dann ungerade und läßt sich auf die Berücksichtigung der b_n-Glieder reduzieren.

Die Rechteckschwingung hat somit als Fourierreihe dann die endgültige Form

und kann bedarfsweise nach n-Werten zwischen 5 und 25 abgebrochen werden. 5 zeigt die erzielbare Impulsform für zwei n-Werte von 5 und 20.It is now desirable to form the function f (t) by means of Fourier series to a square wave. For this, the functions must always be periodically applied with 2π.

The function f (t) is then odd and can be reduced to the consideration of the b _n -components.

The square wave has thus as Fourierreihe then the final form

and can be canceled as needed after n-values between 5 and 25. 5 shows the achievable pulse shape for two n values of 5 and 20.

For a predeterminable value n, the resulting Fourier series development is now subjected to a clipping of the negative signals, so that only the positive pulses of the square wave have to be made the basis of the program control of a microcontroller with the connected pulse amplifier.

As an emitter structure of the appropriate chip and reduced pn junction area format, as defined above, based on a geometrical boundary of the pn junction surface and an extremely narrow high-impedance base zone near the pn junction of the radiation emitter, an AlGaAs structure has formed proven with the according to the 6 a cutoff frequency of at least 9 MHz is achievable even without additional incorporation of metal dopants for lowering the minority carrier lifetime of the nonradiative transitions, as in Si switching diodes.

The transmission characteristic of each tested radiator diode of the group, which is approved for installation in the device, can be extended in impulse mode up to / slightly above the upper frequency limit. Such IR pulse diodes can then be exploited under the condition of periodically impressed flux current pulses of 200 ns width and current peaks of 500 mA-2000 mA for the electrical activation of rapidly resonating IR radiation pulses. The flux current pulses required for this purpose are determined by the Fourier series superimposition of a plurality of deterministically predetermined periodic signals as described above 5 via the program control of the microcontroller and the connected pulse amplifier according to 3 provided. The rise and decay times of the response and turn-off behavior of the emitted radiation pulses are defactively reduced under these operating conditions so that the appropriate radiation emitters are used to form a radiation emission in the form of spike pulses and / or pulses with modulation components of THz radiation emission ,

A boundary condition for a good thermal transition from the pn junction in the semiconductor body of the radiation emitter to the external connection contacts is that the thermal resistance is by no means greater than 110 ° C / W.

3rd embodiment

This exemplary embodiment attempts to influence the angular distribution of the emission lobes of the emitter diodes of the same dominant wavelength, although all the emitters themselves are located at a fixed distance from the therapy object. Favorable conditions are to be created in order to move from a local dot matrix grid to a areally illuminated area of reduced intensity fluctuation on the illuminated or irradiated therapy zone.

In the 7 is the change in the illumination parameters of the therapy zone through the use of three emitter scales 71 . 72 and 73 reproduced with different housing shapes. The housings initially all have the same lens diameter and dome radius and are also with the same semiconductor chips 70 stocked. They differ only in the dome height, ie the distance between the Abstrahlfäche on the upper chip level and the zenith of the dome-shaped curvature of the transparent plastic body. All diodes of a relay are connected via a common supply connection and can therefore be activated at the same time. The emitter squadron 73 with the largest dome height creates the most uneven treatment grid. In contrast, the Emitterstaffel delivers 71 with the lowest dome height a significantly better balanced irradiation pattern.

An additional step towards the alignment of the illumination of the target object is possible by filling the transparent housing body with light-scattering fillers.

4th embodiment

The therapeutic body surfaces are not always flat and smooth. However, in order to be able to treat also curved surfaces in and on walls of the different body cavities, a rigid exposure or irradiation head is not sufficient, because a pivoting of the device fails due to a lack of freedom of movement. A way out in this situation provides a manipulation aid in the front of the therapy head according to 8th ,

Here is a season of identical spotlights 73 with a flexible bracket on a small rack 74 attached with the help of a cycloid 75 can be moved. Become more squadrons with different dome heights, as with the cases 71 and 72 needed, these are also flexible to attach to additional racks. If, in the area of interest of the user, it is also relay squadrons that differ in the spectral position of the emission bands instead of squadrons with different dome heights, then the controlled panning of these squadrons can be accomplished in the same way. The remaining basic equipment according to the invention of the aforementioned therapy devices remains intact in the last two embodiments to the extent that the manipulation possibilities allow.

LIST OF REFERENCE NUMBERS

1

therapy device

2

therapy head

3

Handle shaft

4

therapeutic agents and control instruments

5

Input keyboard for program selection

6

display unit

31

power adapter

32

charging circuit

33

Li-Polymer cell batteries

34

control block

35

program control

36

Microcontroller that

37

Display of the current therapy situation

38

sensors

39

Boosters

40

DC converter

41

Infrared diodes, operated by pulse

42

Infrared diodes, for second infrared range

43

red LEDs

44

blue LEDs

45

UV LEDs

46

Assemblies for electrical or mechanical stimulation

47

Infrared light sensors

48

Spatial photodetectors

50

circuit board

51

copper cladding

52

Housing of the emitter diodes

53

first kind of perforations

54

permanent magnets

55

North pole of a permanent magnet

56

South pole of a permanent magnet

57

Mounting plate made of a magnetic flux conductor

70

Semiconductor chips

71

Emitter relay with 1. Housing form

72

Emitter relay with 2nd housing

73

Emitter relay with 3rd housing

74

flexible bracket on rack

75

Cycloids for moving the rack

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 3537081 A1 [0006]
• EP 266907 [0007]
• EP 2391420 A1 [0010]
• WO 02010086301 [0010]
• AT 129515 [0013]
• RU 2072879 C1 [0014]
• RU 2080136 C1 [0014]
• DE 19507980 C2 [0015, 0019]
• DE 60105473 T2 [0017]
• RU 2349355 C2 [0018]
• US 7198633 [0019]
• RU 2464053 C2 [0020]
• RU 2214844 C1 [0021]
• EP 1626778 B1 [0022]
• DE 69526371 T2 [0024, 0025]
• US 8226696 B1 [0025]
• DE 10120629 A1 [0027]
• RU 2128063 C1 [0029]
• RU 2134601 C1 [0030, 0059]
• RU 2129889 C1 [0031]
• US 020090254155 A1 [0032]

Cited non-patent literature

• Richard M. Dubinsky (American Academy of Neurology) [0008]
• Richard M. Dubinsky Utility of Transcutaneous Electrical Nerve Stimulation in Neurologic Pain Disorders Neurology 74 (2010) # 1 pp. 104-105 [0008]
• NG Basov, VA Danilychev, Y. Popov, DD Khodkevich Laser for the vacuum region with the excitation of liquid xenon by an electron beam Zh. Eksp. Fiz. i Tekh. Pis'ma. Red. No. 12, 1970, p. 473-474. [0012]
• G. Stoeppler *, M. Schellhorn, and M. Eichhorn Enhanced Beam Quality for Medical Applications at 6.45μm by Using a RISTRA ZGP OPO1 Laser Physics, Vol. 22 (2012) no. 6, pp. 1095-1098. ISSN 1054-660X, Online 25.12.2012 Stoeppler 6.45 μ RISTRA for Med-Appl Laser Physics 22-2012-6 p. 1095-8 [0012]
• AE Vorona et al. [0018]
• ZI Borodina, EA Shejko et al. [0020]
• Klopp district. 2008 p. 399 [0023]
• R. Klinke and S. Silbernagl Textbook of Physiology Georg Thieme Verlag p. 366, 360 [0026]
• Actual value display is [0029]
• [06] Jürgen Hirsch: Scattering of the Light [Ed.] M. v. Ardenne, G. Musiol, S. Reball: Effects of Physics and Their Applications pp. 600-603 Deutscher Verlag der Wissenschaften, VEB ISBN 3-326-00035-9 [0057]
• AG Dmitriev and BV Tsare [0069]

Claims (7)

MAGNETIC FIELD SUPPORTED IRRADIATOR FOR PHYSIOTHERAPY, consisting of a housing containing a therapy head 2 in a handle-like handling shaft 3 goes for a simple mechanical pivoting for a sufficient electrical energy supply of the device in isolated operation, for a program connection and intensity control of therapeutic radiation sources, for simultaneous presence of a time constant magnetic field and for a thermogrammatic control of the therapeutic effects on the therapy object and for an acoustic or . Optical information display for program execution is characterized in that - its therapy head 2 with several such, non-coherent semiconductor emitters of at least one same spectral emission band selected from the emitter types 41 - 45 - their use ensures a minimum range and radiation dose into a tissue to be treated thereby, and that for the adjustment of an adapted wavelength and the achievement of the intended biological effect - a spotlight construction 71 . 72 , or 73 and her chip format 70 based exclusively on a geometric limitation of the emission surface of the pn junction and an extremely narrow high-impedance base zone of each emitter of a kind 41 - 45 is selected and thereby a cutoff frequency of at least 9 MHz without an additional installation of metal dopants for the reduction of life for nonradiative transitions is achievable, - the transmission characteristic of each radiator of the group of the group in impulse mode to / slightly above the upper frequency limit is extendable, the impulse form to be imparted for the electrical activation of the emitters from a Fourierreihenüberlagerung several deterministic predetermined periodic signals via the program control 35 a microcontroller 36 and connected pulse amplifiers 39 with an amperage of up to 10 ⁴ mA, - while the rise and decay times of the response and Abschaltverhaltens of the emitted radiation pulses are greatly reduced, - for which by superimposing and beating the above-mentioned vibrations of selected frequency and phase angle, the appropriate, similar, are given non-coherent radiation emitter and are used for shaping a radiation emission in the form of needle pulses and / or pulses with modulation components of the radiation emission in the THz range and that the semiconductor bodies of the radiation emitter have a thermal resistance at the transition from the pn junction to the outer terminal contacts, which is preferably kept no greater than 110 ° C / W. Therapy head of the treatment device according to claim 1, characterized in that the non-coherent semiconductor emitters of the same kind spectral emission band 41 . 42 . 43 . 44 or 45 preferably individually, optionally controlled as a series connection of a small number of individual emitters. Therapy head of the treatment device according to claim 1 and 2, characterized in that in the therapy head 2 the treatment device non-coherent semiconductor emitters of the same spectral emission band are arranged, - at least two scales of the housing forms 71 . 72 or 73 exist with a different angular distribution of the emission lobe, - each scale is selectively activated and - due to a deviation of the dome height of the lens dome over the light exit surface of the chips 70 optionally led to an insufficient up to a multiple overlap of Abstrahlkegel on the therapy zone, - whereby unwanted fluctuations in the homogeneity of the illumination of the therapy field are mitigated by light-scattering additives in the plastic housing. Therapy head of the treatment device according to claim 1 to 3, characterized in that in the therapy head non-coherent semiconductor emitters of the same spectral emission band are arranged - to extend the surface of the therapy zone or - the illumination of therapy zones in body cavities by variable pivoting of the main emission axes of the emitter by means of a cycloid 75 and a bracket on a rack 74 are movable. Therapy head of the treatment device according to claim 1 to 4, characterized in that the dominant wavelength of the emission of a kind of non-coherent radiator, for example, at 875 nm. Therapy head of the treatment device according to claim 1, characterized in that the therapy device 1 for the functional completion of radiation therapy and to overcome the weaknesses of a limited penetration depth of the emission into the tissue to be treated additionally has a magnetic field supplementation such that - by an antisymmetric arrangement of the North Pole 55 and the South Pole 56 on the tissue-facing end faces of adjacent permanent magnets 54 from permanent magnetic materials, the generated magnetic stray fields, the tissue regions below the tissue modified by absorbed and / or scattered radiation are also in a, but only magnetically stimulated state displaceable, - that to increase the stray field size as a material of permanent magnets, the hard magnetic properties of neodymium iron -Bor alloys in the composition Nd2Fe14B with high energy products (B × H) max, high remanence (up to 1.4 T), high coercivities jHc (> 1000 kA / m) and high cyrie temperature in the form of disk cylinders, cylindrical rods or cuboids are used, - that they suitably magnets back on the peripheral edge and / or on the inner surface of a contiguous mounting plate of a magnetic flux conductor 57 in the forehead area of the therapy head 2 are distributed, - wherein the magnetic flux conductive mounting plate with perforations 53 are provided for the passage of radiation cones of the emitter or each housing body of the emitter as well as for the thermogrammetric control of the tissue surface with thermal image sensors 47 , Magnetic field-assisted treatment device according to claim 1, characterized in that one, for the physiotherapy programs proper connection and intensity control of the therapeutic radiation sources such that - a aufzuprägende pulse shape for the electrical activation of the emitters from a Fourierreihenüberlagerung several deterministic predetermined periodic signals via the program control 35 a microcontroller 36 and a connected pulse amplifier 39 is provided.

Images