DE102007049077A1 - Device for introducing gas in liquid medium in container, has lower open pulse tube and is subjected above homogeneous gas pressure impulses - Google Patents
Device for introducing gas in liquid medium in container, has lower open pulse tube and is subjected above homogeneous gas pressure impulses Download PDFInfo
- Publication number
- DE102007049077A1 DE102007049077A1 DE102007049077A DE102007049077A DE102007049077A1 DE 102007049077 A1 DE102007049077 A1 DE 102007049077A1 DE 102007049077 A DE102007049077 A DE 102007049077A DE 102007049077 A DE102007049077 A DE 102007049077A DE 102007049077 A1 DE102007049077 A1 DE 102007049077A1
- Authority
- DE
- Germany
- Prior art keywords
- pulse tube
- gas
- container
- liquid
- pulse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000007789 gas Substances 0.000 claims description 60
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
- 239000001301 oxygen Substances 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 230000000737 periodic effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 5
- 230000010349 pulsation Effects 0.000 description 22
- 238000013461 design Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 238000003958 fumigation Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003534 oscillatory effect Effects 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- BUHVIAUBTBOHAG-FOYDDCNASA-N (2r,3r,4s,5r)-2-[6-[[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound COC1=CC(OC)=CC(C(CNC=2C=3N=CN(C=3N=CN=2)[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=2C(=CC=CC=2)C)=C1 BUHVIAUBTBOHAG-FOYDDCNASA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/232—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using flow-mixing means for introducing the gases, e.g. baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71755—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding components in a pulsating or intermittent manner
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Degasification And Air Bubble Elimination (AREA)
Abstract
Description
Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Eintragen eines Gases in ein flüssiges Medium, wie z. B. in Bioreaktoren oder in Reaktionsapparaten für chemische Reaktionen.The The invention relates to an apparatus and method for entry of a gas in a liquid medium, such. B. in bioreactors or in chemical reaction reactors.
Bekannte Verfahren und Vorrichtungen zum Begasen von Flüssigkeiten basieren auf motorischen Rührsystemen, wenden eine pneumatische Begasung an oder nutzen statische Einrichtungen zur Blasenbildung und -verteilung. Je nach Stoffsystem, Apparatetyp und Aufgabenstellung wird einer dieser Varianten oder einer Kombination der Varianten der Vorzug gegeben bzw. es werden darauf aufbauend spezielle Konstruktionen und Gestaltungsvarianten realisiert.Known Methods and apparatus for fumigating liquids based on motorized stirring systems, apply a pneumatic Fumigation or use static devices for blistering and distribution. Depending on the material system, type of device and task becomes one of these variants or a combination of variants the preference given or it will build on this special constructions and design variants realized.
Diese Begasungseinrichtungen haben jeweils spezifische Nachteile, die dazu führen, dass der Einsatz bzw. die Effizienz des Einsatzes in einer Reihe von Fällen u. U. stark begrenzt ist.These Fumigators each have specific disadvantages, the lead to the use or efficiency of the mission in a number of cases u. U. is very limited.
So sind die motorisch angetriebenen Rührsysteme oft hinsichtlich der konstruktiven Gestaltung des Rührwerkzeuges, der Wellendurchführung und des Antriebes sehr aufwendig, erzeugen z. T. hohe Scherspannungen und können bei explosionsgefährdeten Stoffsystemen Probleme bereiten. Besonders auch bei Bioreaktionen ist es wichtig, hohe Scherspannungen zu vermeiden und einen gleichmäßigen Gaseintrag zu erreichen. Ihr Einsatz ist auch bei Flüssigkeiten mit sehr feinen, sehr groben oder abriebempfindlichen Feststoffen kaum sinnvoll möglich.So the motor driven stirring systems are often in view the structural design of the stirring tool, the shaft passage and the drive very expensive, generate z. T. high shear stresses and can be used with potentially explosive substance systems To cause problems. Especially in bioreactions it is important To avoid high shear stresses and a uniform gas input to reach. Their use is also with liquids very fine, very coarse or abrasion-sensitive solids barely reasonably possible.
Pneumatische Begasungssysteme, wie z. B. in Airlift-, Schlaufen- oder Strahlreaktoren angewendet, sind an bestimmte apparative Gestaltungen gebunden, haben nur eine begrenzte Gaseintragsrate und sind bei grobdispersen Suspensionen oft nicht einsetzbar.pneumatic Fumigation systems, such. B. in airlift, loop or jet reactors applied, are bound to certain apparatus designs, have only a limited gas input rate and are coarsely disperse Suspensions often can not be used.
Statische Gasverteiler ohne mechanisch oder pneumatisch initiierte Flüssigkeitsbewegung ermöglichen nur einen relativ geringen Gaseintrag, erfordern hohe Gasdrücke und erzeugen kaum die gewünschte Mischung bzw. Umwälzung der Flüssigkeit. Ausgehend von dieser Situation wurden verschiedene Weiterentwicklungen und Erfindungen, u. a. auch zum Prinzip des Gaseintrages, getätigt.static Gas distributor without mechanically or pneumatically initiated liquid movement allow only a relatively small gas input, require high gas pressures and hardly produce the desired Mixing or circulation of the liquid. outgoing from this situation were various advancements and Inventions, u. a. also to the principle of gas entry, made.
So
beschreibt die
In
Die
Anwendung einer Vibrationskammer mit mindestens einer elastischen
hin- und herbewegbaren Wand wird in
Zur
Erzeugung einer schonenden Wirkung eines Rührens dient
ein in
In
Die
Anwendung einer Resonanzschwingung zur Verbesserung der Sauerstoffzuführung
für Zellkulturen in Bioreaktoren mit Hohlfasern wird in
Im Sinne einer Weiterentwicklung des Standes der Technik liegt der vorliegenden Erfindung die Aufgabe zugrunde, eine Begasungsart zu schaffen, die keine beweglichen mechanischen Teile im Behandlungsraum besitzt, relativ geringe Scherkräfte erzeugt und auch für Suspensionen gut geeignet ist. Daneben sollte die Vorrichtung apparativ einfach gestaltet und das Betreiben der Begasungseinrichtung bei einem vertretbaren Energieverbrauch möglich sein.in the The purpose of a further development of the prior art is the present invention, the object of a gassing to create no moving mechanical parts in the treatment room owns, produces relatively low shear forces and also for Suspensions is well suited. In addition, the device should apparatus simply designed and the operation of the gassing at a reasonable energy consumption possible.
Der Gegenstand der Erfindung ist somit eine Vorrichtung und ein Verfahren zur Begasung von Flüssigkeiten und Suspensionen in chemischen Mehrphasenreaktoren, in Bioreaktoren oder in anderen Apparaten der erläuterten Art.Of the The invention thus relates to a device and a method for fumigation of liquids and suspensions in chemical multiphase reactors, in bioreactors or in other apparatus explained Art.
Diese
Aufgabe wird dadurch gelöst, dass in den Behandlungsraum
(
Überraschenderweise
wurden in Abhängigkeit von der Art der Pulsation und von
den geometrischen Bedingungen jeweils typische Pulsationsfrequenzen
gefunden, die relativ hohe Begasungsraten und Mischeffekte bewirken.
Durch eine entsprechende Gestaltung des unteren Pulsrohrrandes (
Die
Kombination von Pulsrohr und Gasverteiler in einem Behälter
mit einem gewölbten Boden ist in
In
Ein
weiteres Gestaltungsbeispiel der erfinderischen Pulsrohrtechnik
zur Begasung zeigt
Die Anwendung der Erfindung wird nachfolgend anhand von Beispielen näher beschrieben.The Application of the invention will be described in more detail below by way of examples described.
Beispiel 1:Example 1:
In
eine Apparatur gemäß
Es wurde eine Sauerstoffeintragsrate von 0,81 gl–1h–1 gemessen.An oxygen input rate of 0.81 gl -1 h -1 was measured.
Durch
den Einsatz eines Stromstörers (
Beispiel 2:Example 2:
In
eine Apparatur gemäß
Es wurde eine Sauerstoffeintragsrate von 0,49 gl–1h–1 gemessen.An oxygen uptake rate of 0.49 gl -1 h -1 was measured.
Beispiel 3:Example 3:
In
eine Apparatur gemäß
Es wurde eine Sauerstoffeintragsrate von 0,45 gl–1h–1 gemessen.An oxygen uptake rate of 0.45 gl -1 h -1 was measured.
Beispiel 4:Example 4:
In
eine Apparatur mit vier Pulsrohren gemäß
Für diese Bedingungen betrug die Sauerstoffeintragsrate 0,41 gl–1h–1.For these conditions, the oxygen input rate was 0.41 gl -1 h -1 .
- 11
- Behältercontainer
- 22
- Behälterdeckelcontainer lid
- 33
- Pulsrohrpulse tube
- 44
- oberer Gasraum im Pulsrohrupper Gas space in the pulse tube
- 55
- DruckgaszuführungPressure gas supply
- 66
- PulsgasableitungPulse gas discharge
- 77
- PulsationssteuergerätPulsationssteuergerät
- 88th
- Druckgasbeaufschlagungcompressed gas
- 99
- Stromstörer im Pulsrohrbaffles in the pulse tube
- 1010
- Flüssigkeitsraumliquid space
- 1111
- PulsrohraustrittPulse tube outlet
- 1212
- unterer Rand des Pulsrohreslower Edge of the pulse tube
- 1313
- Boden des Behältersground of the container
- 1414
- oberer Gasraum im Behälterupper Gas room in the tank
- 1515
- Gasabführung aus dem Behältergas discharge from the container
- 1616
- zusätzliche Gaszuführungadditional gas supply
- 1717
- Begasungseinrichtung, Gasverteilergassing, gas distributor
- 1818
- Trennwand zwischen Behälter und Pulsgaskammerpartition wall between container and pulse gas chamber
- 1919
- Gasraum der Pulsgaskammerheadspace the pulse gas chamber
ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION
Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.
Zitierte PatentliteraturCited patent literature
- - DE 10050030 [0007] - DE 10050030 [0007]
- - DE 2514197 [0008] - DE 2514197 [0008]
- - DE 3543022 [0009] - DE 3543022 [0009]
- - DE 3923928 [0010] - DE 3923928 [0010]
- - DE 3739650 [0011] - DE 3739650 [0011]
- - DE 10211106 [0012] - DE 10211106 [0012]
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007049077A DE102007049077A1 (en) | 2007-10-12 | 2007-10-12 | Device for introducing gas in liquid medium in container, has lower open pulse tube and is subjected above homogeneous gas pressure impulses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007049077A DE102007049077A1 (en) | 2007-10-12 | 2007-10-12 | Device for introducing gas in liquid medium in container, has lower open pulse tube and is subjected above homogeneous gas pressure impulses |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102007049077A1 true DE102007049077A1 (en) | 2009-04-16 |
Family
ID=40435451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102007049077A Withdrawn DE102007049077A1 (en) | 2007-10-12 | 2007-10-12 | Device for introducing gas in liquid medium in container, has lower open pulse tube and is subjected above homogeneous gas pressure impulses |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE102007049077A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009031104B3 (en) * | 2009-06-29 | 2010-12-16 | Khs Gmbh | Method and device for enriching and in particular saturating a liquid with a gas and filling device |
JP2017023996A (en) * | 2015-07-15 | 2017-02-02 | 国立大学法人 鹿児島大学 | Bubble generating device and bubble generating method |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2514197A1 (en) | 1975-04-01 | 1976-10-14 | Linde Ag | Bubbling of gases into liquids - in large quantities with minimal energy consumption |
DE3543022C1 (en) | 1985-12-05 | 1987-08-13 | Bruno Gruber | Appliance for mixing gas into a liquid |
DE3739650C1 (en) | 1987-11-23 | 1989-05-24 | Immuno Ag | Fermenter for growing cell cultures |
DE3923928A1 (en) | 1989-07-19 | 1991-01-24 | Werner Prof Dr Ing Stahl | BIOREACTOR |
DE10050030A1 (en) | 2000-10-06 | 2002-05-02 | Schulz Verfahrenstechnik Gmbh | Process for introducing gases into liquid media e.g. in the microbial degradation of pollutants in effluent comprises using a rotor surrounding a concentric rotating traveller |
DE10211106A1 (en) | 2002-03-12 | 2003-10-02 | Bio En Consult Innovations Und | Plant cell cultivation reactor receives pulsed supply of oxygen from liquid/gas bioreactor linked to a liquid/sold bioreactor |
-
2007
- 2007-10-12 DE DE102007049077A patent/DE102007049077A1/en not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2514197A1 (en) | 1975-04-01 | 1976-10-14 | Linde Ag | Bubbling of gases into liquids - in large quantities with minimal energy consumption |
DE3543022C1 (en) | 1985-12-05 | 1987-08-13 | Bruno Gruber | Appliance for mixing gas into a liquid |
DE3739650C1 (en) | 1987-11-23 | 1989-05-24 | Immuno Ag | Fermenter for growing cell cultures |
DE3923928A1 (en) | 1989-07-19 | 1991-01-24 | Werner Prof Dr Ing Stahl | BIOREACTOR |
DE10050030A1 (en) | 2000-10-06 | 2002-05-02 | Schulz Verfahrenstechnik Gmbh | Process for introducing gases into liquid media e.g. in the microbial degradation of pollutants in effluent comprises using a rotor surrounding a concentric rotating traveller |
DE10211106A1 (en) | 2002-03-12 | 2003-10-02 | Bio En Consult Innovations Und | Plant cell cultivation reactor receives pulsed supply of oxygen from liquid/gas bioreactor linked to a liquid/sold bioreactor |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009031104B3 (en) * | 2009-06-29 | 2010-12-16 | Khs Gmbh | Method and device for enriching and in particular saturating a liquid with a gas and filling device |
JP2017023996A (en) * | 2015-07-15 | 2017-02-02 | 国立大学法人 鹿児島大学 | Bubble generating device and bubble generating method |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8122 | Nonbinding interest in granting licences declared | ||
R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Effective date: 20110502 |