DE102007045919A1 - Active agent combination, useful e.g. to combat animal pest and to prepare insecticidal and acaricidal agent, comprises a substituted 5H-furan-2-one compound and a compound e.g. spirotetramat, spirodiclofen and spiromesifen - Google Patents

Abstract

Active agent combination comprises at least a substituted 5H-furan-2-one compound (I), where (I) excludes 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one and 4-{[(6-chloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one; and at least a compound of spirotetramat, spirodiclofen, spiromesifen and 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-aza-spiro[4.5]dec-3-en-2-one. Active agent combination comprises at least a substituted 5H-furan-2-one compound of formula (I), where (I) excludes 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one and 4-{[(6-chloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one; and at least a compound of spirotetramat, spirodiclofen, spiromesifen and 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-aza-spiro[4.5]dec-3-en-2-one. A : 6-fluoro-pyrid-3-yl, 6-chloro-pyrid-3-yl, 6-bromo-pyrid-3-yl, 5-fluoro-6-chloro-pyrid-3-yl, 2-chloro-1,3-thiazol-5-yl or 5,6-dichloro-pyrid-3-yl; and R 1>CH 3, cyclopropyl, CH 3O, 2-fluoroethyl or 2,2-difluoro-ethyl. Independent claims are included for: (1) a procedure for combating animal pests comprising applying the active substance combination on animal pests and/or their habitat and/or seeds; (2) preparing insecticidal and acaricidal agent comprising mixing the active substance combination with stretching agent and/or surface active agents; and (3) seeds, which are treated with the active agent combination. [Image] ACTIVITY : Pesticide; Insecticide; Acaricide; Anthelmintic; Nematocide; Virucide; Avicide; Antibacterial; Fungicide; Antialgal; Animal Repellent; Antimicrobial. MECHANISM OF ACTION : None given.

Description

The The present invention relates to novel drug combinations which at least one known compound of formula (I) on the one hand and at least one known compound from the class of Tetron or Tetramic acids on the other hand contain and very good to combat of animal pests such as insects and unwanted Acarids are suitable. The invention also relates to methods for Control of animal pests on plants and seed, the use of the invention Drug combinations for the treatment of seeds, a procedure for the protection of seed and not least that with the invention Drug combinations treated seeds.

in welcher
A für Pyrid-2-yl oder Pyrid-4-yl steht oder für Pyrid-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Fluor, Chlor, Brom, Methyl, Trifluormethyl oder Trifluormethoxy oder für Pyridazin-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Chlor oder Methyl oder für Pyrazin-3-yl oder für 2-Chlor-pyrazin-5-yl oder für 1,3-Thiazol-5-yl, welches gegebenenfalls in 2-Position substituiert ist durch Chlor oder Methyl, oder
A für einen Rest Pyrimidinyl, Pyrazolyl, Thiophenyl, Oxazolyl, Isoxazolyl, 1,2,4-Oxadiazolyl, Isothiazolyl, 1,2,4-Triazolyl oder 1,2,5-Thiadiazolyl steht, welcher gegebenenfalls durch Fluor, Chlor, Brom, Cyano, Nitro, C₁-C₄-Alkyl (welches gegebenenfalls durch Fluor und/oder Chlor substituiert ist), C₁-C₃-Alkylthio (welches gegebenenfalls durch Fluor und/oder Chlor substituiert ist), oder C₁-C₃-Alkylsulfonyl (welches gegebenenfalls durch Fluor und/oder Chlor substituiert ist), substituiert ist, oder
A für einen Rest

in welchem
X für Halogen, Alkyl oder Halogenalkyl seht
Y für Halogen, Alkyl, Halogenalkyl, Halogenalkoxy, Azido oder Cyan steht und
R¹ für Alkyl, Halogenalkyl, Alkenyl, Halogenalkenyl, Alkinyl, Cycloalkyl, Cycloalkylalkyl, Halogencycloalkyl, Alkoxy, Alkoxyalkyl, oder Halogencycloalkylalkyl steht,
insektizide Wirkung aufweisen (vgl. EP 0 539 588 und die nicht vor-veröffentlichten internationalen Anmeldungen PCT/EP2007/002386 , PCT/EP2007/002385 und PCT/EP2007/002392 ).It is already known that compounds of the formula (I)

in which
A is pyrid-2-yl or pyrid-4-yl or pyrid-3-yl which is optionally substituted in the 6-position by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy or for pyridazin-3-yl, which is optionally substituted in the 6-position by chlorine or methyl or for pyrazine-3-yl or 2-chloro-pyrazine-5-yl or 1,3-thiazol-5-yl, which is optionally substituted in the 2-position by chlorine or methyl, or
A is a radical pyrimidinyl, pyrazolyl, thiophenyl, oxazolyl, isoxazolyl, 1,2,4-oxadiazolyl, isothiazolyl, 1,2,4-triazolyl or 1,2,5-thiadiazolyl, which is optionally substituted by fluorine, chlorine, bromine, Cyano, nitro, C ₁ -C ₄ -alkyl (which is optionally substituted by fluorine and / or chlorine), C ₁ -C ₃ -alkylthio (which is optionally substituted by fluorine and / or chlorine), or C ₁ -C ₃ Alkylsulfonyl (which is optionally substituted by fluorine and / or chlorine), or
A for a rest

in which
X represents halogen, alkyl or haloalkyl
Y is halogen, alkyl, haloalkyl, haloalkoxy, azido or cyano and
R ^{1 is} alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, halocycloalkyl, alkoxy, alkoxyalkyl, or halocycloalkylalkyl,
have insecticidal activity (cf. EP 0 539 588 and the unpublished international applications PCT / EP2007 / 002386 . PCT / EP2007 / 002385 and PCT / EP2007 / 002392 ).

worin entweder
R¹¹ = CH₃
R¹² = H
R¹³ = CH₃
R¹⁴ = H
R¹⁵ = COOC₂H₅
R¹⁶ = OCH₃
n = 1
M = N-H
oder
R¹¹ = Cl
R¹² = Cl
R¹³ = H
R¹⁴ = H
R¹⁵ = COC(CH₃)₂C₂H₅
R¹⁶ = H
n = 1
M = O
oder
R¹¹ = CH₃
R¹² = CH₃
R¹³ = H
R¹⁴ = CH₃
R¹⁵ = COCH₂–C(CH₃)₃
R¹⁶ = H
n = 0
M = O
oder
R¹¹ = CH₃
R¹² = H
R¹³ = CH₃
R¹⁴ = H
R¹⁵ = H
R¹⁶ = OCH₃
n = 1
M = N-H
insektizide Eigenschaften aufweisen (vgl. EP-A-528 156 und EP-915 846 ).Furthermore, it is known that compounds of the formula (Π)

in which either
R ¹¹ = CH ₃
R ¹² = H
R ¹³ = CH ₃
R ¹⁴ = H
R ¹⁵ = COOC ₂ H ₅
R ¹⁶ = OCH ₃
n = 1
M = NH
or
R ¹¹ = Cl
R ¹² = Cl
R ¹³ = H
R ¹⁴ = H
R ¹⁵ = COC (CH ₃ ) ₂ C ₂ H ₅
R ¹⁶ = H
n = 1
M = O
or
R ¹¹ = CH ₃
R ¹² = CH ₃
R ¹³ = H
R ¹⁴ = CH ₃
R ¹⁵ = COCH ₂ -C (CH ₃ ) ₃
R ¹⁶ = H
n = 0
M = O
or
R ¹¹ = CH ₃
R ¹² = H
R ¹³ = CH ₃
R ¹⁴ = H
R ¹⁵ = H
R ¹⁶ = OCH ₃
n = 1
M = NH
have insecticidal properties (cf. EP-A-528 156 and EP-915 846 ).

Formula (II) therefore includes the following compounds of formula (IIa), common name spirotetramate, (IIb), common name spirodiclofen, (IIc), common name spiromesifen, and (IId) wherein the compound of formula (IIa) in the cis configuration (cf. EP-A-01523472 ) or as a mixture of the cis and trans configuration:

These compounds have been disclosed in published patents and scientific publications. The compounds of the formula (IIa) and (IIb) are commercially available as single active agents in agents for controlling animal pests. These compounds and remedies are in compendiums like "The Pesticide Manual, 14th edition, CDS Thomlin (Ed.), British Crop Protection Council, Surrey, UK, 2006" described, which is hereby incorporated by reference.

The Effect of the insecticidal compound of the formula (I) or the active substance from the ketoenol class is generally good. Especially at low application rates and certain pests However, they do not always satisfy the needs of agricultural practice, and there is still a need at an economically efficient and ecological safe pest control.

Further include claims made of insecticidal compounds the lowering of the dosage amount; a significant broadening including the spectrum of pests to be controlled resistant pests; increased application security; a reduced toxicity to plants and thus a better plant compatibility; the fight the pests in their various stages of development; a better behavior during the production of the insecticides Compounds, for example during grinding or Mixing, during their storage or during their application; a very beneficial biocidal spectrum itself at low concentrations with concomitant good compatibility by warm-blooded animals, fish and plants; and achieving an additional effect, for example an algicidal, anthelmintic, avicides, bactericides, fungicides, molluscs, nematicides, plant-activating, rodenticidal or virucidal activity.

Further specific requirements for vegetative and generative plant propagation material used insecticidal compounds include a negligible Phytotoxicity when applied to the seed and plant propagation material, a compatibility with soil conditions (eg what the binding the connection to the soil), a systemic effect in the plant, no negative impact on germination and one Effectiveness during the life cycle of the corresponding Pest.

task The invention is the satisfaction of one or more of the above mentioned claims such. B. the lowering of Dosage amount, a broadening of the combinable spectrum on damages, including resistant pests, and in particular the specific requirements of applicability on vegetative and generative plant propagation material.

It has now been found that combinations of at least one compound of the formula (I), provided that 4 - {[(6-chloropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one are excluded, and at least one compound of the formula (II) are synergistically effective and combating animal pests. Surprisingly is the insecticidal and acaricidal activity of the invention Drug combinations significantly higher than the sum of Effects of the individual active substances. It is an unpredictable real synergistic effect before and not just an effect supplement.

The synergistic effect of the active compound combinations according to the invention a compound of formula (I) and an active compound of the class The ketoenole extends the scope of the compound of the formula (I) and the active ingredient from the class of ketoenols primary by a reduction in the dosage amount and by an extension the spectrum of combinable pests. So can be with the invention Active ingredient combination of a compound of formula (I) and an active ingredient from the class of ketoenols still a high degree of pest control achieve, even in cases where the individual connections the active compound combinations according to the invention the low applied rates no sufficient effect demonstrate.

additionally to the synergistic effect described above the active compound combinations according to the invention still show more surprising benefits, including increased application security; a diminished one Phytotoxicity and thus a better plant compatibility; the fight against pests in their various Stages of development; better behavior during the preparation of the insecticidal compounds, for example during grinding or mixing, during their storage or during their application; a very advantageous one biocidal spectrum even at low concentrations with it accompanied by good tolerance by warm-blooded animals, Fish and plants; and achieving an additional Effect, for example, an algicidal, anthelmintic, avicidal, bactericidal, fungicidal, molluscicides, nematicides, plant-activating, rodenticidal or virucidal activity.

Farther was surprisingly found that the inventive Active ingredient combinations especially for the protection of seeds and / or sprouts and leaves of a plant grown from the seeds against damage by pests. The active compound combinations according to the invention show thus a negligible phytotoxicity the application to the plant propagation material, a compatibility with soil conditions (eg what the binding of the compound to the Soil), a systemic effect in the plant, no negative impact on germination and effectiveness during the corresponding pest lifecycle.

The active compound combinations according to the invention contain at least one compound of the formula (II) in addition to at least one compound of the formula (I). The active compounds according to the invention preferably contain exactly one compound of formula (I) and exactly one compound of formula (II). Also preferred are active compound combinations which are a compound of the formula (I) and two compounds of the formula (II). Preference is furthermore given to mixtures which contain two compounds of the formula (I) and one compound of the formula (II).

The following are preferred subgroups for the compounds of the formula (I) mentioned above in the active compound combinations according to the invention with at least one of the compounds of the formula (II), with the proviso that 4 - {[(6-chloropyrid-3-yl ) methyl] (methyl) amino} furan-2 (5H) -one and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one are excluded.
A is preferably 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid-3-yl, 6-methyl-pyrid-3-yl, 6-trifluoromethyl-pyridine 3-yl, 6-trifluoromethoxypyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 6-methyl-1,4-pyridazin-3-yl, 2-chloro-1,3-thiazole 5-yl or 2-methyl-1,3-thiazol-5-yl, 2-chloro-pyrimidin-5-yl, 2-trifluoromethyl-pyrimidin-5-yl, 5,6-difluoro-pyrid-3-yl, 5-Chloro-6-fluoro-pyrid-3-yl, 5-bromo-6-fluoro-pyrid-3-yl, 5-iodo-6-fluoro-pyrid-3-yl, 5-fluoro-6-chloro pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5-bromo-6-chloro-pyrid-3-yl, 5-iodo-6-chloro-pyrid-3-yl, 5-fluoro 6-bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid-3-yl, 5-fluoro-6-iodo-pyrid-3-yl, 5-Chloro-6-iodo-pyrid-3-yl, 5-bromo-6-iodo-pyrid-3-yl, 5-methyl-6-fluoro-pyrid-3-yl, 5-methyl-6-chloro pyrid-3-yl, 5-methyl-6-bromo-pyrid-3-yl, 5-methyl-6-iodo-pyrid-3-yl, 5-difluoromethyl-6-fluoro-pyrid-3-yl, 5- Difluoromethyl-6-chloro-pyrid-3-yl, 5-difluoromethyl-6-bromo-pyrid-3-yl or 5-difluoromethyl-6-iodo-pyrid-3-yl.
R ¹ preferably represents optionally fluorine-substituted C ₁ -C ₅ -alkyl, C ₂ -C ₅ -alkenyl, C ₃ -C ₅ -cycloalkyl, C ₃ -C ₅ -cycloalkylalkyl or C ₁ -C ₅ -alkoxy.
A particularly preferably represents the radical 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromopyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 2 Chloro-1,3-thiazol-5-yl, 2-chloro-pyrimidin-5-yl, 5-fluoro-6-chloro-pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5 Bromo-6-chloro-pyrid-3-yl, 5-fluoro-6-bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid-3 -yl, 5-methyl-6-chloro-pyrid-3-yl, 5-chloro-6-iodo-pyrid-3-yl or 5-difluoromethyl-6-chloro-pyrid-3-yl.
R ¹ particularly preferably represents methyl, methoxy, ethyl, propyl, vinyl, allyl, propargyl, cyclopropyl, 2-fluoroethyl, 2,2-difluoroethyl or 2-fluorocyclopropyl.
A very particularly preferably represents the radical 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid-3-yl, 5-fluoro-6-chloropyrid-3 yl, 2-chloro-1,3-thiazol-5-yl or 5,6-dichloro-pyrid-3-yl.
R ¹ very particularly preferably represents methyl, cyclopropyl, methoxy, 2-fluoroethyl or 2,2-difluoroethyl.
A is most preferably the residue 6-chloro-pyrid-3-yl or 5-fluoro-6-chloro-pyrid-3-yl.
R ¹ is most preferably methyl, 2-fluoroethyl or 2,2-difluoro-ethyl.

In a highlighted group of compounds of formula (I), A is 6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (I), A is 6-bromopyrid-3-yl

In a further highlighted group of compounds of the formula (I) A is 6-chloro-1,4-pyridazin-3-yl

In einer weiteren hervorgehobenen Gruppe von Verbindungen der Formel (I) steht A für 5-Fluor-6-chlor-pyrid-3-yl,In a further highlighted group of compounds of the formula (I) A is 2-chloro-1,3-thiazol-5-yl

In a further highlighted group of compounds of the formula (I) A is 5-fluoro-6-chloropyrid-3-yl,

In a further highlighted group of compounds of the formula (I) A is 5-fluoro-6-bromo-pyrid-3-yl,

In a further highlighted group of compounds of the formula (I) A is 5,6-dichloropyrid-3-yl,

In another highlighted group of compounds of formula (I), R ^{1 is} methyl.

In another highlighted group of compounds of formula (I), R ^{1 is} ethyl.

In another highlighted group of compounds of formula (I), R ^{1 is} cyclopropyl.

In another highlighted group of compounds of formula (I), R ^{1 is} 2-fluoroethyl.

In another highlighted group of compounds of formula (I), R ^{1 is} 2,2-difluoroethyl.

The listed above in general or in preferred ranges Remaining definitions or explanations can be used with each other, So also between the respective preferential ranges; can be combined arbitrarily.

According to the invention preferred are compounds of the formula (I) in which a combination the meaning given above is preferred.

Particularly according to the invention Preference is given to compounds of the formula (I) in which a combination the meanings listed above as being particularly preferred is present.

Completely according to the invention Particular preference is given to compounds of the formula (I) in which a combination of those listed above as very particularly preferred Meanings exist.

in welcher
B für Pyrid-2-yl oder Pyrid-4-yl steht oder für Pyrid-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Fluor, Chlor, Brom, Methyl, Trifluormethyl oder Trifluormethoxy oder für Pyridazin-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Chlor oder Methyl oder für Pyrazin-3-yl oder für 2-Chlor-pyrazin-5-yl oder für 1,3-Thiazol-5-yl, welches gegebenenfalls in 2-Position substituiert ist durch Chlor oder Methyl,
R² für Halogenalkyl, Halogenalkenyl, Halogencycloalkyl oder Halogencycloalkylalkyl steht, A preferred subgroup of the compounds of the formula (I) are those of the formula (Ia)

in which
B is pyrid-2-yl or pyrid-4-yl or pyrid-3-yl, which is optionally substituted in the 6-position by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy or pyridazin-3-yl, which is optionally substituted in the 6-position by chlorine or methyl or for pyrazine-3-yl or 2-chloro-pyrazin-5-yl or for 1,3-thiazol-5-yl, which is optionally substituted in the 2-position by chlorine or methyl,
R ^{2 is} haloalkyl, haloalkenyl, halocycloalkyl or halocycloalkylalkyl,

Preferred substituents or ranges of the radicals listed in formula (Ia) mentioned above and below are explained below.
B is preferably 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid-3-yl, 6-methyl-pyrid-3-yl, 6-trifluoromethyl-pyridine 3-yl, 6-trifluoromethoxypyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 6-methyl-1,4-pyridazin-3-yl, 2-chloro-1,3-thiazole 5-yl or 2-methyl-1,3-thiazol-5-yl.
R ² preferably represents fluoro-substituted C ₁ -C ₅ -alkyl, C ₂ -C ₅ -alkenyl, C ₃ -C ₅ -cycloalkyl or C ₃ -C ₅ -cycloalkylalkyl.
B particularly preferably represents the radical 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromopyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 2 chloro-1,3-thiazol-5-yl.
R ² particularly preferably represents 2-fluoroethyl, 2,2-difluoro-ethyl, 2-fluoro-cyclopropyl.
B is very particularly preferably the radical 6-chloropyrid-3-yl.
R ² very particularly preferably represents 2-fluoroethyl or 2,2-difluoroethyl.

In a highlighted group of compounds of formula (Ia) B is 6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ia) B is 6-bromopyrid-3-yl

In a further highlighted group of compounds of the formula (Ia) B is 6-chloro-1,4-pyridazin-3-yl

In another highlighted group of compounds of formula (Ia), R ^{2 is} 2-fluoroethyl.

In another highlighted group of compounds of formula (Ia), R ^{2 is} 2,2-difluoroethyl.

in welcher
D für einen Rest

steht in welchem
X und Y die oben angegebenen Bedeutungen haben,
R³ für Wasserstoff, Alkyl, Alkenyl, Alkinyl, Cycloalkyl oder Alkoxy steht,Another preferred subgroup of the compounds of the formula (I) are those of the formula (Ib)

in which
D for a rest

is in which
X and Y have the meanings given above,
R ^{3 is} hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or alkoxy,

Preferred substituents or ranges of the radicals listed in the formula (Ib) mentioned above and below are explained below.
D is preferably one of the radicals 5,6-difluoropyrid-3-yl, 5-chloro-6-fluoropyrid-3-yl, 5-bromo-6-fluoropyrid-3-yl, 5-iodo 6-fluoropyrid-3-yl, 5-fluoro-6-chloro-pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5-bromo-6-chloro-pyrid-3-yl , 5-iodo-6-chloro-pyrid-3-yl, 5-fluoro-6-bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid 3-yl, 5-fluoro-6-iodo-pyrid-3-yl, 5-chloro-6-iodo-pyrid-3-yl, 5-bromo-6-iodo-pyrid-3-yl, 5-methyl 6-fluoro-pyrid-3-yl, 5-methyl-6-chloro-pyrid-3-yl, 5-methyl-6-bromo-pyrid-3-yl, 5-methyl-6-iodo-pyrid-3 -yl, 5-difluoromethyl-6-fluoropyrid-3-yl, 5-difluoromethyl-6-chloro-pyrid-3-yl, 5-difluoromethyl-6-bromo-pyrid-3-yl, 5-difluoromethyl-6 iodo-pyrid-3-yl.
R ³ is preferably C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl, C ₂ -C ₄ -alkynyl or C ₃ -C ₄ -cycloalkyl.
D is more preferably 5-fluoro-6-chloro-pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5-bromo-6-chloro-pyrid-3-yl, 5-fluoro-6 bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid-3-yl, 5-methyl-6-chloro-pyrid-3-yl, 5 Chloro-6-iodo-pyrid-3-yl or 5-difluoromethyl-6-chloro-pyrid-3-yl.
R ³ particularly preferably represents C ₁ -C ₄ -alkyl.
D is most preferably 5-fluoro-6-chloro-pyrid-3-yl or 5-fluoro-6-bromo-pyrid-3-yl.
R ³ very particularly preferably represents methyl, ethyl, propyl, vinyl, allyl, propargyl or cyclopropyl.
D is most preferably 5-fluoro-6-chloro-pyrid-3-yl. R ³ most preferably represents methyl or cyclopropyl.

In another highlighted group of compounds of formula (Ib) D is 5-fluoro-6-chloro-pyrid-3-yl,

In another highlighted group of compounds of formula (Ib), D is 5,6-dichloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ib), D is 5-bromo-6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ib) D is 5-methyl-6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ib), D is 5-fluoro-6-bromo-pyrid-3-yl

In another highlighted group of compounds of formula (Ib), D is 5-chloro-6-bromo-pyrid-3-yl

In another highlighted group of compounds of formula (Ib), D is 5-chloro-6-iodo-pyrid-3-yl

In another highlighted group of compounds of formula (Ib), R ^{3 is} methyl.

In another highlighted group of compounds of formula (Ib), R ^{3 is} ethyl.

In another highlighted group of compounds of formula (Ib), R ^{3 is} cyclopropyl.

in welcher
E für einen Rest

steht in welchem
X und Y die oben angegebenen Bedeutungen haben und
R⁴ für Halogenalkyl, Halogenalkenyl, Halogencycloalkyl oder Halogencycloalkylalkyl steht.Another preferred subgroup of the compounds of the formula (I) are those of the formula (Ic)

in which
E for a rest

is in which
X and Y have the meanings given above, and
R ^{4 is} haloalkyl, haloalkenyl, halocycloalkyl or halocycloalkylalkyl.

Preferred substituents or ranges of the radicals listed in the formula (Ic) mentioned above and below are explained below.
E is preferably one of the radicals 5,6-difluoropyrid-3-yl, 5-chloro-6-fluoropyrid-3-yl, 5-bromo-6-fluoropyrid-3-yl, 5-iodo 6-fluoropyrid-3-yl, 5-fluoro-6-chloro-pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5-bromo-6-chloro-pyrid-3-yl , 5-iodo-6-chloro-pyrid-3-yl, 5-fluoro-6-bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid 3-yl, 5-fluoro-6-iodo-pyrid-3-yl, 5-chloro-6-iodo-pyrid-3-yl, 5-bromo-6-iodo-pyrid-3-yl, 5-methyl 6-fluoro-pyrid-3-yl, 5-methyl-6-chloro-pyrid-3-yl, 5-methyl-6-bromo-pyrid-3-yl, 5-methyl-6-iodo-pyrid-3 -yl, 5-difluoromethyl-6-fluoropyrid-3-yl, 5-difluoromethyl-6-chloro-pyrid-3-yl, 5-difluoromethyl-6-bromo-pyrid-3-yl, 5-difluoromethyl-6 iodo-pyrid-3-yl.
R ⁴ preferably represents fluoro-substituted C ₁ -C ₅ -alkyl, C ₂ -C ₅ -alkenyl, C ₃ -C ₅ -cycloalkyl or C ₃ -C ₅ -cycloalkylalkyl.
E is more preferably 2-chloro-pyrimidin-5-yl, 5-fluoro-6-chloro-pyrid-3-yl, 5,6-dichloro-pyrid-3-yl, 5-bromo-6-chloro-pyrid 3-yl, 5-fluoro-6-bromo-pyrid-3-yl, 5-chloro-6-bromo-pyrid-3-yl, 5,6-dibromo-pyrid-3-yl, 5-methyl-6 -chloro-pyrid-3-yl, 5-chloro-6-iodo-pyrid-3-yl or 5-difluoromethyl-6-chloro-pyrid-3-yl.
R ⁴ particularly preferably represents 2-fluoroethyl, 2,2-difluoroethyl, 2-fluoro-cyclopropyl.
E is most preferably 5-fluoro-6-chloro-pyrid-3-yl.
R ⁴ is very particularly preferably 2-fluoroethyl or 2,2-difluoroethyl.

In a further highlighted group of compounds of the formula (Ic) E is 5-fluoro-6-chloropyrid-3-yl,

In another highlighted group of compounds of formula (Ic) E is 5,6-dichloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ic) E is 5-bromo-6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ic) E is 5-methyl-6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Ic), E is 5-fluoro-6-bromo-pyrid-3-yl

In another highlighted group of compounds of formula (Ic) E is 5-chloro-6-bromo-pyrid-3-yl

In another highlighted group of compounds of formula (Ic) E is 5-chloro-6-iodo-pyrid-3-yl

In another highlighted group of compounds of formula (Ic), R ^{4 is} 2-fluoroethyl.

In another highlighted group of compounds of formula (Ic), R ^{4 is} 2,2-difluoroethyl.

in welcher
G für Pyrid-2-yl oder Pyrid-4-yl steht oder für Pyrid-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Fluor, Chlor, Brom, Methyl, Trifluormethyl oder Trifluormethoxy oder für Pyridazin-3-yl, welches gegebenenfalls in 6-Position substituiert ist durch Chlor oder Methyl oder für Pyrazin-3-yl oder für 2-Chlor-pyrazin-5-yl oder für 1,3- Thiazol-5-yl, welches gegebenenfalls in 2-Position substituiert ist durch Chlor oder Methyl, und
R⁵ für C₁-C₄-Alkyl, C₂-C₄-Alkenyl, C₂-C₄-Alkinyl, C₃-C₄-Cycloalkyl oder C₁-C₄-Alkoxy steht, mit der Maßgabe, dass 4-{[(6-Chlorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on und 4-{[(6-Chlorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on ausgeschlossen sind.A preferred subgroup of the compounds of the formula (I) are those of the formula (Id)

in which
G is pyrid-2-yl or pyrid-4-yl or pyrid-3-yl which is optionally substituted in the 6-position by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy or for pyridazin-3-yl, which is optionally substituted in the 6-position by chlorine or methyl or for pyrazine-3-yl or 2-chloro-pyrazine-5-yl or 1,3-thiazol-5-yl, which is optionally substituted in the 2-position by chlorine or methyl, and
R ^{5 is} C ₁ -C ₄ alkyl, C ₂ -C ₄ alkenyl, C ₂ -C ₄ alkynyl, C ₃ -C ₄ cycloalkyl or C ₁ -C ₄ alkoxy, with the proviso that 4 - {[(6-chloropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl) amino} furan 2 (5H) -one are excluded.

Preferred substituents or ranges of the radicals listed in the formula (Id) mentioned above and below are explained below.
G preferably represents 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid-3-yl, 6-methyl-pyrid-3-yl, 6-trifluoromethyl-pyridine 3-yl, 6-trifluoromethoxypyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 6-methyl-1,4-pyridazin-3-yl, 2-chloro-1,3-thiazole 5-yl or 2-methyl-1,3-thiazol-5-yl.
R ⁵ is preferably C ₁ -C ₄ -alkyl, C ₁ -alkoxy, C ₂ -C ₄ -alkenyl, C ₂ -C ₄ -alkynyl or C ₃ -C ₄ -cycloalkyl.
G particularly preferably represents the radical 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromopyrid-3-yl, 6-chloro-1,4-pyridazin-3-yl, 2 chloro-1,3-thiazol-5-yl,
R ⁵ particularly preferably represents methyl, methoxy, ethyl, propyl, vinyl, allyl, propargyl or cyclopropyl.
G is very particularly preferably the radical 6-chloropyrid-3-yl.
R ⁵ very particularly preferably represents methyl or cyclopropyl.

In a highlighted group of compounds of formula (Id) G is 6-chloro-pyrid-3-yl

In another highlighted group of compounds of formula (Id) G is 6-bromo-pyrid-3-yl

In a further highlighted group of compounds of the formula (Id) G is 6-chloro-1,4-pyridazin-3-yl

In a further highlighted group of compounds of the formula (Id) G is 2-chloro-1,3-thiazol-5-yl

In another highlighted group of compounds of formula (Id), G is 6-fluoro-pyrid-3-yl

In a further highlighted group of compounds of the formula (Id) G for 6-trifluoromethylpyrid-3-yl

In another highlighted group of compounds of formula (Id), G is 6-fluoro-pyrid-3-yl

In another highlighted group of compounds of formula (Id), R ^{5 is} methyl.

In another highlighted group of compounds of formula (Id), R ^{5 is} cyclopropyl.

• • Verbindung (I-1), 4-{[(6-Brompyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002386 .
• • Verbindung (I-2), 4-{[(6-Fluorpyrid-3-yl)methyl](2,2-difluorethyl)amino} furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002386 .
• • Verbindung (I-3), 4-{[(2-Chlor-1,3-thiazol-5-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002386 .
• • Verbindung (I-4), 4-{[(6-Chlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002386 .
• • Verbindung (I-5), 4-{[(6-Chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino} furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002386 .
• • Verbindung (I-6), 4-{[(6-Chlor-5-fluorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002385
• • Verbindung (I-7), 4-{[(5,6-Dichlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002392 .
• • Verbindung (I-8), 4-{[(6-Chlor-5-fluorpyrid-3-yl)methyl](cyclopropyl)amino} furan-2(5H)-on, besitzt die Formel
  
  und ist bekannt aus der nicht vor-veröffentlichten internationalen Patentanmeldung PCT/EP2007/002385 .

Specifically, the following compounds of the general formula (I) may be mentioned:

• Compound (I-1), 4 - {[(6-Bromopyrid-3-yl) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002386 ,
• Compound (I-2), 4 - {[(6-fluoropyrid-3-yl) methyl] (2,2-difluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002386 ,
• Compound (I-3), 4 - {[(2-chloro-1,3-thiazol-5-yl) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002386 ,
• Compound (I-4), 4 - {[(6-chloropyrid-3-yl) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002386 ,
• Compound (I-5), 4 - {[(6-chloropyrid-3-yl) methyl] (2,2-difluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002386 ,
• Compound (I-6), 4 - {[(6-chloro-5-fluoropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002385
• Compound (I-7), 4 - {[(5,6-dichloropyrid-3-yl) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002392 ,
• Compound (I-8), 4 - {[(6-chloro-5-fluoropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one, has the formula
  
  and is known from the unpublished international patent application PCT / EP2007 / 002385 ,

Prefers contain the active compound combinations according to the invention at least one of the compounds of formula (I) selected is selected from the group consisting of the compounds of the above-mentioned formulas (I-a), (I-b), (I-c) or (I-d), with the proviso that 4 - {[(6-chloropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one are excluded, and a compound of formula (II).

The contain active compound combinations according to the invention furthermore preferably at least one of the compounds of the formula (I), which is selected from the group consisting of the Compounds of the above-mentioned formulas (I-a), (I-b) or (I-c) and a compound of formula (II).

The active compound combinations according to the invention particularly preferably contain at least one of the compounds of the formula (I) in which A is selected from the radicals 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid 3-yl, 5-fluoro-6-chloro-pyrid-3-yl, 2-chloro-1,3-thiazol-5-yl and 5,6-dichloro-pyrid-3-yl and R ^{1 is} selected from the Radicals methyl, cyclopropyl, methoxy, 2-fluoroethyl or 2,2-difluoro-ethyl, with the proviso that 4 - {[(6-chloropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -on and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl) amino) furan-2 (5H) -one are excluded, and and a compound of formula (II).

Most preferably, the active compound combinations according to the invention contain at least a compound of the formula (I) which is selected from the group consisting of the compounds of the formulas (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7) and (I-8), and and a compound of the formula (II).

This gives the combinations listed in Table 1, each combination represents a very particularly preferred embodiment of the invention per se. Table 1 Containing active ingredient combination No combination of active ingredients Compound of the formula (I) Compound of the formula (II) 1-1 I-1 and IIa 1-2 I-1 and cis-IIa 1-3 I-1 and IIb 1-4 I-1 and IIc 1-5 I-1 and IId 2-1 I-2 and IIa 2-2 I-2 and cis-IIa 2-3 I-2 and IIb 2-4 I-2 and IIc 2-5 I-2 and IId 3-1 I-3 and IIa 3-2 I-3 and cis-IIa 3-3 I-3 and IIb 3-4 I-3 and IIc 3-5 I-3 and IId 4-1 I-4 and IIa 4-2 I-4 and cis-IIa 4-3 I-4 and IIb 4-4 I-4 and IIc 4-5 I-4 and IId 5-1 I-5 and IIa 5-2 I-5 and cis-IIa 5-3 I-5 and IIb 5-4 I-5 and IIc 5-5 I-5 and IId 6-1 I-6 and IIa 6-2 I-6 and cis-IIa 6-3 I-6 and IIb 6-4 I-6 and IIc 6-5 I-6 and IId 7-1 I-7 and IIa 7-2 I-7 and cis-IIa 7-3 I-7 and IIb 7-4 I-7 and IIc 7-5 I-7 and IId 8-1 8 I- and IIa 8-2 8 I- and cis-IIa 8-3 8 I- and IIb 8-4 8 I- and IIc 8-5 8 I- and IId

If the active ingredients in the active compound combinations according to the invention are present in certain weight ratios, the synergistic effect is particularly pronounced. However, the weight ratios of the active ingredients in the drug combinations can be varied within a relatively wide range. In general, the combinations according to the invention comprise an active compound of the formula (I) and a compound of the formula (II) in the following preferred and particularly preferred mixing ratios:
Preferred mixing ratio: 125: 1 to 1: 125
Particularly preferred mixing ratio: 25: 1 to 1:25

The mixing ratios are based on weight ratios. The ratio is to be understood as compound of the formula (I): compound of the formula (I). Further mixing ratios of the compound of the formula (I) to give a compound of the formula (II) are listed below and sorted according to increasing preference of the mixing ratios: 95: 1 to 1:95, 95: 1 to 1:90, 95: 1 to 1 : 85, 95: 1 to 1:80, 95: 1 to 1:75, 95: 1 to 1:70, 95: 1 to 1:65, 95: 1 to 1:60, 95: 1 to 1:55 , 95: 1 to 1:50, 95: 1 to 1:45, 95: 1 to 1:40, 95: 1 to 1:35, 95: 1 to 1:30, 95: 1 to 1:25, 95 : 1 to 1:20, 95: 1 to 1:15, 95: 1 to 1:10, 95: 1 to 1: 5, 95: 1 to 1: 4, 95: 1 to 1: 3, 95: 1 to 1: 2, 90: 1 to 1:90, 90: 1 to 1:95, 90: 1 to 1:85, 90: 1 to 1:80, 90: 1 to 1:75, 90: 1 to 1 : 70, 90: 1 to 1:65, 90: 1 to 1:60, 90: 1 to 1:55, 90: 1 to 1:50, 90: 1 to 1:45, 90: 1 to 1:40 , 90: 1 to 1:35, 90: 1 to 1:30, 90: 1 to 1:25, 90: 1 to 1:20, 90: 1 to 1:15, 90: 1 to 1:10, 90 : 1 to 1: 5, 90: 1 to 1: 4, 90: 1 to 1: 3, 90: 1 to 1: 2, 85: 1 to 1:85, 85: 1 to 1:95, 85: 1 to 1:90, 85: 1 to 1:80, 85: 1 to 1:75, 85: 1 to 1:70, 85: 1 to 1:65, 85: 1 to 1:60, 85: 1 to 1 : 55, 85: 1 to 1:50, 85: 1 to 1:45, 85: 1 to 1:40, 85: 1 to 1:35, 85: 1 to 1:30, 85: 1 to 1:25, 85: 1 to 1:20, 85: 1 to 1 : 15, 85: 1 to 1:10, 85: 1 to 1: 5, 85: 1 to 1: 4, 85: 1 to 1: 3, 85: 1 to 1: 2, 80: 1 to 1:80 , 80: 1 to 1:95, 80: 1 to 1:90, 80: 1 to 1:85, 80: 1 to 175, 80: 1 to 1:70, 80: 1 to 1:65, 80: 1 to 1:60, 80: 1 to 1:55, 80: 1 to 1:50, 80: 1 to 1:45, 80: 1 to 1:40, 80: 1 to 1:35, 80: 1 to 1 : 30, 80: 1 to 1:25, 80: 1 to 1:20, 80: 1 to 1:15, 80: 1 to 1:10, 80: 1 to 1: 5, 80: 1 to 1: 4 , 80: 1 to 1: 3, 80: 1 to 1: 2, 75: 1 to 1:75, 75: 1 to 1:95, 75: 1 to 1:90, 75: 1 to 1:85, 75 : 1 to 1:80, 75: 1 to 1:70, 75: 1 to 1:65, 75: 1 to 1:60, 75: 1 to 1:55, 75: 1 to 1:50, 75: 1 to 1:45, 75: 1 to 1:40, 75: 1 to 1:35, 75: 1 to 1:30, 75: 1 to 1:25, 75: 1 to 1:20, 75: 1 to 1 : 15, 75: 1 to 1:10, 75: 1 to 1: 5, 75: 1 to 1: 4, 75: 1 to 1: 3, 75: 1 to 1: 2, 70: 1 to 1:70 , 70: 1 to 1:95, 70: 1 to 1:90, 70: 1 to 1:85, 70: 1 to 1:80, 70: 1 to 1:75, 70: 1 to 1:65, 70 : 1 to 1:60, 70: 1 to 1:55, 70: 1 to 1:50, 70: 1 to 1:45, 70: 1 to 1:40 , 70: 1 to 1:35, 70: 1 to 1:30, 70: 1 to 1:25, 70: 1 to 1:20, 70: 1 to 1:15, 70: 1 to 1:10, 70 : 1 to 1: 5, 70: 1 to 1: 4, 70: 1 to 1: 3, 70: 1 to 1: 2, 65: 1 to 1:65, 65: 1 to 1:95, 65: 1 to 1:90, 65: 1 to 1:85, 65: 1 to 1:80, 65: 1 to 1:75, 65: 1 to 1:70, 65: 1 to 1:60, 65: 1 to 1 : 55, 65: 1 to 1:50, 65: 1 to 1:45, 65: 1 to 1:40, 65: 1 to 1:35, 65: 1 to 1:30, 65: 1 to 1:25 , 65: 1 to 1:20, 65: 1 to 1:15, 65: 1 to 1:10, 65: 1 to 1: 5, 65: 1 to 1: 4, 65: 1 to 1: 3, 65 : 1 to 1: 2, 60: 1 to 1:60, 60: 1 to 1:95, 60: 1 to 1:90, 60: 1 to 1:85, 60: 1 to 1:80, 60: 1 to 1:75, 60: 1 to 1:70, 60: 1 to 1:65, 60: 1 to 1:55, 60: 1 to 1:50, 60: 1 to 1:45, 60: 1 to 1 : 40, 60: 1 to 1:35, 60: 1 to 1:30, 60: 1 to 1:25, 60: 1 to 1:20, 60: 1 to 1:15, 60: 1 to 1:10 , 60: 1 to 1: 5, 60: 1 to 1: 4, 60: 1 to 1: 3, 60: 1 to 1: 2, 55: 1 to 1:55, 55: 1 to 1:95, 55 : 1 to 1:90, 55: 1 to 1:85, 55: 1 to 1:80, 55: 1 to 1:75, 55: 1 to 1:70, 55: 1 to 1:65, 55: 1 to 1:60, 55: 1 to 1:50, 55: 1 to 1:45, 55: 1 to 1:40, 55: 1 to 1:35, 55: 1 to 1:30, 55: 1 to 1:25, 55: 1 to 1:20, 55: 1 to 1:15, 55: 1 to 1:10, 55: 1 to 1: 5, 55: 1 to 1 : 4, 55: 1 to 1: 3, 55: 1 to 1: 2, 50: 1 to 1:95, 50: 1 to 1:90, 50: 1 to 1:85, 50: 1 to 1:80 , 50: 1 to 1:75, 50: 1 to 1:70, 50: 1 to 1:65, 50: 1 to 1:60, 50: 1 to 1:55, 50: 1 to 1:45, 50 : 1 to 1:40, 50: 1 to 1:35, 50: 1 to 1:30, 50: 1 to 1:25, 50: 1 to 1:20, 50: 1 to 1:15, 50: 1 to 1:10, 50: 1 to 1: 5, 50: 1 to 1: 4, 50: 1 to 1: 3, 50: 1 to 1: 2, 45: 1 to 1:45, 45: 1 to 1 : 95, 45: 1 to 1:90, 45: 1 to 1:85, 45: 1 to 1:80, 45: 1 to 1:75, 45: 1 to 1:70, 45: 1 to 1:65 , 45: 1 to 1:60, 45: 1 to 1:55, 45: 1 to 1:50, 45: 1 to 1:40, 45: 1 to 1:35, 45: 1 to 1:30, 45 : 1 to 1:25, 45: 1 to 1:20, 45: 1 to 1:15, 45: 1 to 1:10, 45: 1 to 1: 5, 45: 1 to 1: 4, 45: 1 to 1: 3, 45: 1 to 1: 2, 40: 1 to 1:40, 40: 1 to 1:95, 40: 1 to 1:90, 40: 1 to 1:85, 40: 1 to 1 : 80, 40: 1 to 1:75, 40: 1 to 1:70, 40: 1 to 1:65, 40: 1 to 1:60, 40: 1 to 1:55, 40: 1 to 1:50 , 40: 1 to 1:45, 40: 1 to 1:35, 40: 1 to 1:30, 40: 1 to 1:25, 40: 1 to 1: 2 0, 40: 1 to 1:15, 40: 1 to 1:10, 40: 1 to 1: 5, 40: 1 to 1: 4, 40: 1 to 1: 3, 40: 1 to 1: 2, 35: 1 to 1:35, 35: 1 to 1:95, 35: 1 to 1:90, 35: 1 to 1:85, 35: 1 to 1:80, 35: 1 to 1:75, 35: 1 to 1:70, 35: 1 to 1:65, 35: 1 to 1:60, 35: 1 to 1:55, 35: 1 to 1:50, 35: 1 to 1:45, 35: 1 to 1:40, 35: 1 to 1:30, 35: 1 to 1:25, 35: 1 to 1:20, 35: 1 to 1:15, 35: 1 to 1:10, 35: 1 to 1: 5, 35: 1 to 1: 4, 35: 1 to 1: 3, 35: 1 to 1: 2, 30: 1 to 1:30, 30: 1 to 1:95, 30: 1 to 1:90, 30: 1 to 1:85, 30: 1 to 1:80, 30: 1 to 1:75, 30: 1 to 1:70, 30: 1 to 1:65, 30: 1 to 1:60, 30: 1 to 1:55, 30: 1 to 1:50, 30: 1 to 1:45, 30: 1 to 1:40, 30: 1 to 1:35, 30: 1 to 1:25, 30: 1 to 1:20, 30: 1 to 1:15, 30: 1 to 1:10, 30: 1 to 1: 5, 30: 1 to 1: 4, 30: 1 to 1: 3, 30: 1 to 1: 2, 25: 1 to 1:25, 25: 1 to 1:95, 25: 1 to 1:90, 25: 1 to 1:85, 25: 1 to 1:80, 25: 1 to 1:75, 25: 1 to 1:70, 25: 1 to 1:65, 25: 1 to 1:60, 25: 1 to 1:55, 25: 1 to 1:50, 25: 1 to 1:45, 25: 1 to 1:40, 25: 1 to 1:35, 25: 1 to 1:30, 25: 1 to 1:20, 25: 1 to 1:15, 25: 1 to 1:10, 25: 1 to 1: 5, 25: 1 to 1: 4, 25: 1 to 1: 3, 25: 1 to 1: 2, 20: 1 to 1:95, 20: 1 to 1 : 90, 20: 1 to 1:85, 20: 1 to 1:80, 20: 1 to 1:75, 20: 1 to 1:70, 20: 1 to 1:65, 20: 1 to 1:60 , 20: 1 to 1:55, 20: 1 to 1:50, 20: 1 to 1:45, 20: 1 to 1:40, 20: 1 to 1:35, 20: 1 to 1:30, 20 : 1 to 1:25, 20: 1 to 1:15, 20: 1 to 1:10, 20: 1 to 1: 5, 20: 1 to 1: 4, 20: 1 to 1: 3, 20: 1 to 1: 2, 15: 1 to 1:15, 15: 1 to 1:95, 15: 1 to 1:90, 15: 1 to 1:85, 15: 1 to 1:80, 15: 1 to 1 : 75, 15: 1 to 1:70, 15: 1 to 1:65, 15: 1 to 1:60, 15: 1 to 1:55, 15: 1 to 1:50, 15: 1 to 1:45 , 15: 1 to 1:40, 15: 1 to 1:35, 15: 1 to 1:30, 15: 1 to 1:25, 15: 1 to 1:20, 15: 1 to 1:10, 15 : 1 to 1: 5, 15: 1 to 1: 4, 15: 1 to 1: 3, 15: 1 to 1: 2, 10: 1 to 1:10, 10: 1 to 1:95, 10: 1 to 1:90, 10: 1 to 1:85, 10: 1 to 1:80, 10: 1 to 1:75, 10: 1 to 1: 70, 10: 1 to 1:65, 10: 1 to 1:60, 10: 1 to 1:55, 10: 1 to 1:50, 10: 1 to 1:45, 10: 1 to 1:40, 10: 1 to 1:35, 10: 1 to 1:30, 10: 1 to 1:25, 10: 1 to 1:20, 10: 1 to 1:15, 10: 1 to 1: 5, 10: 1 to 1: 4, 10: 1 to 1: 3, 10: 1 to 1: 2, 5: 1 to 1: 5, 5: 1 to 1:95, 5: 1 to 1:90, 5: 1 to 1:85, 5: 1 to 1:80, 5: 1 to 1:75, 5: 1 to 1:70, 5: 1 to 1:65, 5: 1 to 1:60, 5: 1 to 1: 55, 5: 1 to 1:50, 5: 1 to 1:45, 5: 1 to 1:40, 5: 1 to 1:35, 5: 1 to 1:30, 5: 1 to 1:25, 5: 1 to 1:20, 5: 1 to 1:15, 5: 1 to 1:10, 5: 1 to 1: 4, 5: 1 to 1: 3, 5: 1 to 1: 2, 4: 1 to 1: 4, 4: 1 to 1:95, 4: 1 to 1:90, 4: 1 to 1:85, 4: 1 to 1:80, 4: 1 to 1:75, 4: 1 to 1:70, 4: 1 to 1:65, 4: 1 to 1:60, 4: 1 to 1:55, 4: 1 to 1:50, 4: 1 to 1:45, 4: 1 to 1: 40, 4: 1 to 1:35, 4: 1 to 1:30, 4: 1 to 1:25, 4: 1 to 1:20, 4: 1 to 1:15, 4: 1 to 1:10, 4: 1 to 1: 5, 4: 1 to 1: 3, 4: 1 to 1: 2, 3: 1 to 1: 3, 3: 1 to 1:95, 3: 1 to 1:90, 3: 1 to 1:85, 3: 1 to 1:80, 3: 1 b is 1:75, 3: 1 to 1:70, 3: 1 to 1:65, 3: 1 to 1:60, 3: 1 to 1:55, 3: 1 to 1:50, 3: 1 to 1 : 45, 3: 1 to 1:40, 3: 1 to 1:35, 3: 1 to 1:30, 3: 1 to 1:25, 3: 1 to 1:20, 3: 1 to 1:15 , 3: 1 to 1:10, 3: 1 to 1: 5, 3: 1 to 1: 4, 3: 1 to 1: 2, 2: 1 to 1: 2, 2: 1 to 1:95, 2 : 1 to 1:90, 2: 1 to 1:85, 2: 1 to 1:80, 2: 1 to 1:75, 2: 1 to 1:70, 2: 1 to 1:65, 2: 1 to 1:60, 2: 1 to 1:55, 2: 1 to 1:50, 2: 1 to 1:45, 2: 1 to 1:40, 2: 1 to 1:35, 2: 1 to 1 : 30, 2: 1 to 1:25, 2: 1 to 1:20, 2: 1 to 1:15, 2: 1 to 1:10, 2: 1 to 1: 5, 2: 1 to 1: 4 , 2: 1 to 1: 3.

The compounds of formula (I) or the active compounds of the class of tetronic or tetramic acids having at least one basic center are capable of forming, for example, acid addition salts, e.g. B. with strong inorganic acids such as mineral acids, eg. As perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphoric acid or a hydrohalic acid, with strong organic carboxylic acids such as unsubstituted or substituted, z. B. halogen-substituted, C ₁ -C ₄ alkanecarboxylic acids, eg. As acetic acid, saturated or unsaturated dicarboxylic acids, eg. As oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and phthalic acid, hydroxycarboxylic acids, eg. As ascorbic acid, lactic acid, malic acid, tartaric acid and citric acid, or benzoic acid, or with organic sulfonic acids such as unsubstituted or substituted, z. B. halogen-substituted, C ₁ -C ₄ alkane or arylsulfonic, z. For example, methane or p-toluenesulfonic acid. The compounds of formula (I) or the class of ketoenols having at least one acidic group are capable of forming, for example, salts with bases, e.g. As metal salts such as alkali or alkaline earth salts, z. For example, sodium, potassium or magnesium salts, or salts with ammonia or an organic amine such as morpholine, piperidine, pyrrolidine, a lower mono-, di- or trialkyl, z. For example, ethyl, diethyl, triethyl or dimethylpropylamine, or a lower mono-, di- or Trihydroxyalkylamin, z. As mono-, di- or triethanolamine. In addition, if appropriate, corresponding internal salts can be formed. Agrochemically advantageous salts are preferred in the context of the invention. In view of the close relationship between the compounds of formula (I) or the active substances of the class of ketoenols in free form and in the form of their salts, reference should be made above and below to the free compounds of formula (I) or free compounds of the class the ketoenols or their salts are understood to include the corresponding salts or the free compounds of the formula (I) or the free active substances from the class of ketoenols, if appropriate and appropriate. This also applies correspondingly to tautomers of the compounds of the formula (I) or of the active compounds from the class of ketoenols and to their salts.

in the For the purposes of the present invention, the term "active ingredient combination" for different combinations of compounds of the formula (I) and active ingredients from the class of tetronic or tetramic acids, z. B. in the form of a single ready mix ("ready-mix"), in a combined spray mix composed of separate formulations of the individual active ingredients, eg. B. one Tank mix ("tank mix") or in a combined use the individual active substances, if they are applied sequentially, z. Successively within a reasonably short period of time, z. For example, a few hours or days. According to one preferred embodiment is the order of application the compounds of the formula (I) and the active compounds from the class Tetronic or tetramic acids for the execution not critical to the present invention.

At the Use of the active compound combinations according to the invention As insecticides and acaricides, the application rates depending on the type of application within a larger one Range can be varied. The application rate of the invention Combination of active ingredients is in the treatment of parts of plants, z. B. leaves from 0.1 to 10,000 g / ha, preferably from 10 up to 1,000 g / ha, more preferably from 50 to 300 g / ha (when used By pouring or dropping the application rate can even be reduced especially when inert substrates such as rockwool or perlite be used); in the seed treatment from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of seed, especially preferably from 2.5 to 25 g per 100 kg of seed, most preferably from 2.5 to 12.5 g per 100 kg of seed; at the soil treatment of 0.1 to 10,000 g / ha, preferably from 1 to 5,000 g / ha.

These Application rates are only an example: and not limiting in the sense called the invention.

The Active compound combinations according to the invention can Be used to plants within a period of time after the treatment against the infestation by the mentioned animal Protect pests. The period, within its protection generally extends to 1 to 28 days, preferably to 1 to 14 days, more preferably for 1 to 10 days, most preferably for 1 to 7 days after the treatment of the plants with the active ingredients or up to 200 days after a seed treatment.

The active compound combinations according to the invention are suitable for good plant tolerance, favorable toxicity to warm-blooded animals and good environmental compatibility for the protection of plants and plant organs, for increasing crop yields, improving the quality of the crop and for controlling animal pests, in particular insects, arachnids, helminths, nematodes and mollusks in agriculture, horticulture, livestock, forests, gardens and recreational facilities, in the protection of materials and materials and in the hygiene sector. They can preferably be used as crop protection agents. They are effective against normally sensitive and resistant species as well as against all or individual stages of development. The above mentioned pests include:
From the order of the Anoplura (Phthiraptera) z. Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.
From the class of Arachnida z. Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus Spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Oligonychus spp., Omithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp , Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici.
From the class of Bivalva z. B. Dreissena spp. From the order of Chilopoda z. Geophilus spp., Scutigera spp.
From the order of Coleoptera z. Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus Spp., Ceuthorhynchus spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Curculio spp., Cryptorhynchus lapathi, Dermestes spp., Diabrotica spp., Epilachna spp., Faustinus cubae, Gibbium psylloides, Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha, Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Popillia japonica, Premnotrypes spp., Psylliodes chrysocephala, Ptinus spp. , Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Starchus spp., Symphyletes spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.
From the order of Collembola z. B. Onychiurus armatus.
From the order of Dermaptera z. B. Forficula auricularia.
From the order of Diplopoda z. B. Blaniulus guttulatus.
From the order of Diptera z. B. Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chrysomyia spp., Cochliomyia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dermatobia hominis, Drosophila spp., Fannia spp , Gastrophilus spp., Hylemyia spp, Hyppobosca spp., Hypoderma spp., Liriomyza spp. Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Stomoxys spp. , Tabanus spp., Tannia spp., Tipula paludosa, Wohlfahrtia spp.
From the class of Gastropoda z. B. Arion spp., Biomphalaria spp., Bulinus spp .; Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Succinea spp.
From the class of helminths z. Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori; Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp, Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosome spp, Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti.

Furthermore, protozoa, such as Eimeria, can be combated.
From the order of Heteroptera z. B. Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp , Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodnius spp , Sahlbergella singularis, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.
From the order of Homoptera z. Acyrthosipon spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp. Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Doralis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp. Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Geococcus coffeae, Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaph it spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga , Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp. Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp. , Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vi tifolii.
From the order of Hymenoptera z. B. Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.
From the order of Isopoda z. Armadillidium vulgare, Oniscus asellus, Porcellio scaber.
From the order of Isoptera z. Reticulitermes spp., Odontotermes spp.
From the order of Lepidoptera z. B. Acronicta major, Aedia leucomelas, Agrotis spp., Alabama argillacea, Anticarsia spp., Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Cheimatobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp., Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa spp., Feltia spp., Galleria mellonella, Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma spp., Lithocolletis blancardella, Lithophane antennata , Loxagrotis albicosta, Lymantria spp., Malacosoma neustria, Mamestra brassicae, Mocis repanda, Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, Pectinophora gossypiella, Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Pseudaletia spp. , Pseudoplusia includens, Pyrausta nubilalis, Spodoptera spp., Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana, Trichoplusia spp.
From the order of Orthoptera z. Acheta domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerca gregaria.
From the order of Siphonaptera z. Ceratophyllus spp., Xenopsylla cheopis.
From the order of Symphyla z. B. Scutigerella immaculata.
From the order of Thysanoptera z. B. Biodiotis spips, Heliothrips spp., Hercinothrips femoralis, Kakothrips spp., Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.
From the order of Thysanura z. B. Lepisma saccharina.

To the plant parasitic nematodes include z. B. Anguina spp., Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp., Heliocotylenchus spp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp., Tylenchorhynchus spp., Tylenchulus spp., Tylenchulus semipenetrans, Xiphinema spp.

The Active compound combinations according to the invention can optionally in certain concentrations or application rates also as herbicides, safeners, growth regulators or agents for Improvement of plant properties, or as microbicides, for example as fungicides, antimycotics, bactericides, viricides (including Anti-viral agents) or as anti-MLO agents (Mycoplasma-like-organism) and RLO (Rickettsia-like-organism).

The active compounds can be converted into the customary formulations, such as solutions, emulsions, Injection powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granulated granules, suspension-emulsion concentrates, active substance-impregnated natural substances, active substance-impregnated synthetic substances, fertilizers and microencapsules in polymeric substances.

These Formulations are prepared in a known manner, for. B. by Mixing the active ingredients with extenders, ie liquid Solvents and / or solid carriers, optionally using surface-active Agents, ie emulsifiers and / or dispersants and / or foaming agents. The preparation of the formulations takes place either in suitable facilities or even before or during the application.

When Excipients may find use in such substances are suitable, the agent itself or and / or derived therefrom Preparations (eg spray mixtures, seed dressing) special To give properties, such as certain technical properties and / or special biological properties. As typical Auxiliaries are suitable: extenders, solvents and Carriers.

When Extenders are suitable for. As water, polar and nonpolar organic chemical liquids z. B. from the classes of aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, Alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which may be also substituted, etherified and / or esterified), ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly) ethers, the simple and substituted amines, amides, Lactams (such as N-alkylpyrrolidones) and lactones, the sulfones and sulfoxides (such as dimethyl sulfoxide).

in the Case of using water as an extender can z. As well as organic solvents as auxiliary solvent be used. Come as liquid solvents essentially in question: aromatics, such as xylene, toluene, or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic Hydrocarbons, such as cyclohexane or paraffins, for. B. petroleum fractions, mineral and vegetable oils, alcohols, such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, Methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylsulfoxide, as well as water.

According to the invention Carrier a natural or synthetic, organic or inorganic substance, which solid or liquid may be, with which the active ingredients for better usability, in particular for application to plants or parts of plants or seeds, mixed or are connected. The solid or liquid carrier is generally inert and should be used in agriculture be.

Suitable solid or liquid carriers are:
z. As ammonium salts and ground natural minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic minerals such as finely divided silica, alumina and silicates, as solid carriers for granules are: z. Crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite, dolomite and synthetic granules of inorganic and organic flours and granules of organic material such as paper, sawdust, coconut shells, corn cobs and tobacco stems; as emulsifying and / or foam-producing agents are in question: z. Nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, e.g. B. alkylaryl polyglycol ether, alkyl sulfonates, alkyl sulfates, aryl sulfonates and protein hydrolysates; suitable dispersants are nonionic and / or ionic substances, eg. From the classes of alcohol POE and / or POP ethers, acid and / or POP-POE esters, alkyl-aryl and / or POP-POE ethers, fatty and / or POP-POE Adducts, POE and / or POP polyol derivatives, POE and / or POP sorbitol or sugar adducts, alkyl or aryl sulfates, sulfonates and phosphates or the corresponding PO ether adducts. Further suitable oligo- or polymers, for. B. starting from vinylic monomers, from acrylic acid, from EO and / or PO alone or in combination with z. As (poly) alcohols or (poly) amines. Furthermore, find use lignin and its sulfonic acid derivatives, simple and modified celluloses, aromatic and / or aliphatic sulfonic acids and their adducts with formaldehyde.

It In the formulations, adhesives such as carboxymethylcellulose, natural and synthetic powdery, grainy or latex-shaped polymers, such as gum arabic, Polyvinyl alcohol, polyvinyl acetate, as well as natural phospholipids, such as cephalins and lecithins and synthetic phospholipids.

It For example, dyes such as inorganic pigments, e.g. Iron oxide, Titanium oxide, ferrocyan blue and organic dyes such as alizarin, Azo and metal phthalocyanine dyes and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc are used.

Further Additives can be fragrances, mineral or vegetable optionally modified oils, waxes and nutrients (also trace nutrients), such as salts of iron, manganese, boron, Copper, cobalt, molybdenum and zinc.

Farther may contain stabilizers such as cold stabilizers, Preservatives, antioxidants, light stabilizers or others the chemical and / or physical stability improving agents.

Of the Active substance content of the commercial formulations prepared application forms can vary widely. The active ingredient concentration of the use forms is in the range from 0.00000001 to 97% by weight of active ingredient in the range of 0.0000001 to 97 wt .-%, particularly preferably in the range of 0.000001 to 83 Wt .-% or 0.000001 to 5 wt .-% and most preferably in Range from 0.0001 to 1% by weight.

Of the Active compound combinations according to the invention can in their commercial formulations as well as in the These formulations were mixed with use forms other active substances such as insecticides, attractants, sterilants, Bactericides, acaricides, nematicides, fungicides, growth regulators Substances, herbicides, safeners, fertilizers or semiochemicals available.

Also a mixture with other known active substances, such as herbicides, Fertilizers, growth regulators, safeners, semiochemicals, or with agents for improving plant properties possible.

The Active compound combinations according to the invention can also when used as insecticides in their commercial Formulations and in those prepared from these formulations Application forms in mixture with synergists are present. synergists are compounds that increase the effect of the active ingredients without the added synergist itself being active got to.

The Active compound combinations according to the invention can also when used as insecticides in their commercial Formulations and in those prepared from these formulations Application forms in mixtures with inhibitors are present, the one Degradation of the active substance after application in the environment of the plant, on the surface of plant parts or in plant Reduce tissue.

The Application is done in a custom forms adapted to the applications Wise.

According to the invention all plants and parts of plants are treated. Under plants all plants and plant populations are understood here, as desired and undesirable wild plants or Crops (including naturally occurring Crop plants). Crop plants can be plants that through conventional breeding and optimization methods or by biotechnological and genetic engineering methods or Combinations of these methods can be obtained, including of the transgenic plants and including by plant variety rights estimable or unappreciable plant varieties. Under plant parts are all above ground and underground Parts and organs of plants, such as shoot, leaf, flower and roots are understood, with examples of leaves, Needles, stems, stems, flowers, fruiting bodies, Fruits and seeds as well as roots, tubers and rhizomes be listed. Part of the plant parts also harvested material as well as vegetative and generative propagation material, For example, fruits, seeds, cuttings, tubers, rhizomes, Offshoots, seeds, bulbs, sinkers and foothills.

The Treatment according to the invention of the plants and plant parts with the drug combinations takes place directly or by action on their environment, habitat or storage space according to the usual Treatment methods, eg. B. by dipping, spraying, evaporation, Nebulizing, spreading, spreading, injecting and propagating material, in particular in the case of seeds, further by single or multi-layered Envelop.

As plants which can be treated according to the invention, mention may be made of the following: cotton, flax, grapevine, fruits, vegetables, such as Rosaceae sp. (for example, pome fruits such as apple and pear, but also drupes such as apricots, cherries, almonds and peaches and soft fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example, banana trees and plantations), Rubiaceae sp. (for example, coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example, lemons, organs and grapefruit); Solanaceae sp. (for example tomatoes), Liliaceae sp., Asteraceae sp. (eg Sa lat), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumber), Alliaceae sp. leek, onion), Papilionaceae sp. (for example, peas); Main crops, such as Gramineae sp. (for example corn, turf, cereals such as wheat, rye, rice, barley, oats, millet and triticale), Asteraceae sp. (for example sunflower), Brassicaceae sp. (for example, white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, kohlrabi, radishes and rapeseed, mustard, horseradish and cress), Fabacae sp. (for example, bean, peanuts), Papilionaceae sp. (for example, soybean), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. (for example, sugar beet, fodder beet, Swiss chard, beet); Useful plants and ornamental plants in the garden and forest; and each genetically modified species of these plants.

Especially the active ingredient combinations according to the invention are suitable for the treatment of seeds. Preferred are the above as preferred or particularly preferred inventive To call combinations. This is how much of the caused by pests damage to crops already by the infestation of the seed during storage and after placing the seed in the soil as well as during and immediately after the germination of the plants. This phase is special critical, as the roots and shoots of the growing plant are particularly are sensitive and already a small damage to death can lead to the whole plant. There is therefore a particular great interest in the seed and the germinating plant to protect by the use of suitable means.

The Control of pests by the treatment The seed of plants has long been known and is the subject constant improvements. Nevertheless arise in the Treating seed a number of problems that are not always can be satisfactorily resolved. So is it desirable, methods of protection of seed and germinating To develop a plant, which is the additional spreading of Pesticides after sowing or after emergence Make plants redundant. It is still desirable, the amount of the active ingredient used in this regard to optimize that the seed and the germinating plant before the Protected as best as possible by pests without, however, the plant itself by the active ingredient used to harm. In particular, procedures should be for treatment from seed also the intrinsic insecticidal properties transgenic Include plants for optimum protection of the seed and also the germinating plant with a minimum of pesticides to reach.

The The present invention therefore more particularly relates to Method for protecting seed and germinating plants from the Infestation of pests by the seed with a Drug combination is treated. The invention Method for protecting seed and germinating plants from the Infestation of pests involves a process in which the Seed at the same time with an active substance of the formula (I) and a compound of formula (Π) is treated. It includes also a procedure in which the seed at different times with an active ingredient of formula (I) and a compound of formula (II). The invention also relates to the Use of the active compound combinations according to the invention for the treatment of seed for the protection of the seed and the resulting developing plant from pests. Further relates The invention relates to seed, which protects against pests with a combination of active substances according to the invention was treated. The invention also relates to seed, which at the same time with an active ingredient of the formula (I) and a compound of formula (II). The invention further relates on seed, which at different times with an active ingredient of the formula (I) and a compound of the formula (II). at Seed, which at different times with an active ingredient of the formula (I) and a compound of the formula (II), can the individual active ingredients of the invention By means of containing in different layers on the seed be. In this case, the layers containing an active substance of the Formula (I) and a compound of formula (II), optionally be separated by an intermediate layer. The invention relates Seeds in which an active substance of the formula (I) and a compound of formula (II) as part of a coating or in addition as a further layer or further layers are applied to a sheath.

one the advantages of the present invention is that due to the particular systemic properties of the invention Drug combinations treatment of the seed with these drug combinations not only the seed itself, but also the resulting Protects plants after emergence from pests. In this way, the immediate treatment of the culture for Time of sowing or shortly thereafter omitted.

Another advantage consists in the synergistic increase of the insecticidal activity of the active compound combinations according to the invention over the individual insecticidal active ingredient which is to be expected over the the effectiveness of the two individually applied active substances goes beyond. Also advantageous is the synergistic increase in the fungicidal activity of the active compound combinations according to the invention compared with the fungicidal single active substance, which goes beyond the expected effectiveness of the individually applied active ingredient. This allows optimization of the amount of active ingredients used.

As well it is to be regarded as advantageous that the inventive Active substance combinations, especially in transgenic seeds can be used, taking from this seed resulting plants for expression of one against pests directed protein. By the treatment such seeds with the active compound combinations according to the invention Certain pests may already be affected by the Expression of z. Insecticidal protein, and additionally by the invention Active ingredient combinations are protected from damage.

The Compounds of the invention are suitable to protect seed of any plant variety as already referred to above, in agriculture, in the greenhouse, used in forestry or horticulture. In particular, acts seeds of maize, peanut, canola, rape, poppy, Soya, cotton, turnip (eg sugar beet and fodder turnip), Rice, millet, wheat, barley, oats, rye, sunflower, tobacco, Potatoes or vegetables (eg tomatoes, cabbages). The active compound combinations according to the invention are suitable also for the treatment of seed of fruit plants and Vegetables as already mentioned above. Special meaning comes from the treatment of seeds of corn, soybeans, cotton, wheat and canola or rapeseed too.

As already mentioned above, also comes from the treatment of transgenic seed with an inventive Active ingredient combination of particular importance. It acts It is the seed of plants that usually at least a heterologous gene containing the expression of a polypeptide with especially insecticidal properties. The heterologous Genes in transgenic seeds can be made from microorganisms such as Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium originate. The present invention is suitable especially for the treatment of transgenic seeds, containing at least one heterologous gene derived from Bacillus sp. and its gene product activity against European corn borer and / or corn rootworm. It is particularly preferred this is a heterologous gene derived from Bacillus thuringiensis comes.

in the Within the scope of the present invention, the inventive Active ingredient combination alone or in a suitable formulation applied to the seed. Preferably, the seed is in a Condition treated in which is so stable that no damage occur during treatment. In general, the treatment can of the seed at any time between harvesting and sowing respectively. Usually, seed is used that of separated from the plant and from flasks, shells, stalks, Shell, wool or pulp was freed.

in the In general, care must be taken when treating the seed be that the amount of the invention applied to the seed Active ingredient combination and / or other additives chosen so will not affect the germination of the seed or the resulting plant is not damaged becomes. This is especially important in the case of active ingredients, which are certain Application rates can show phytotoxic effects.

The agents according to the invention can be applied directly, ie without containing further components and without being diluted. In general, it is preferable to apply the agents to the seed in the form of a suitable formulation. Suitable formulations and methods for seed treatment are known in the art and z. As described in the following documents: US 4,272,417 A . US 4,245,432 A . US 4,808,430 A . US 5,876,739 A . US 2003/0176428 A1 . WO 2002/080675 A1 . WO 2002/028186 A2 ,

The According to the invention can be used active ingredients converted into the usual seed dressing formulations such as solutions, emulsions, suspensions, powders, Foams, slurries or other enveloping compounds for Seeds, as well as ULV formulations.

These Formulations are prepared in a known manner by the active ingredients mixed with conventional additives, such as For example, conventional extenders and solution or diluents, dyes, wetting agents, dispersants, Emulsifiers, defoamers, preservatives, secondary Thickener, glue, gibberelline and also water.

When Dyes which can be used in the invention Pickling formulations may be included all common for such purposes dyes into consideration. Both are sparingly soluble in water Pigments as well as water-soluble dyes. Examples include the names rhodamine B, C.I. Pigment Red 112 and C.I. Solvent Red 1 dyes.

When Wetting agents which can be used in the invention Pickling formulations may be included all customary for the formulation of agrochemical active substances, the wetting-promoting substances in question. Preferably usable are alkylnaphthalene sulfonates such as diisopropyl or Diisobutylnaphthalenesulphonates.

When Dispersants and / or emulsifiers which can be used in the invention Pickling formulations may be included all conventional non-ionic for the formulation of agrochemicals, anionic and cationic dispersants into consideration. Preferably usable are nonionic or anionic dispersants or Mixtures of nonionic or anionic dispersants. Particularly suitable nonionic dispersants are ethylene oxide-propylene oxide Block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers and their phosphated or sulfated derivatives. suitable anionic dispersants are in particular lignosulfonates, polyacrylic acid salts and arylsulfonate-formaldehyde condensates.

When Defoamers can be used in the invention Mordant formulations all for the formulation of agrochemical Active ingredients usual foam-inhibiting substances to be contained. Preferably usable are silicone defoamers and magnesium stearate.

When Preservatives can be used in the invention Mordant formulations all for such purposes in be present in agrochemical means usable substances. exemplary Dichlorophene and Benzylalkoholhemiformal are mentioned.

When secondary thickening agents that can be used in the invention Pickling formulations may be included all usable for such purposes in agrochemical means Substances in question. Preference is given to cellulose derivatives, Acrylic acid derivatives, xanthan, modified clays and highly dispersed Silica.

When Glue which can be used in the invention Pickling formulations may be included all customary in pickling binders in Question. Preferably mentioned are polyvinylpyrrolidone, polyvinyl acetate, Polyvinyl alcohol and Tylose.

Gibberellins which may be present in the seed dressing formulations which can be used according to the invention are preferably the gibberellins A1, A3 (= gibberellic acid), A4 and A7, with particular preference gibberellic acid. The gibberellins are known ( see. R. Wegler "Chemie der Pflanzenschutz- und Schädlingsbekungsmittel", Vol. 2, Springer Verlag, 1970, p. 401-412 ).

The Seizing agent formulations which can be used according to the invention can either directly or after previous dilution with water for the treatment of seed of various kinds, too of seed of transgenic plants. It can in interaction with the substances formed by expression Also, additional synergistic effects occur.

to Treatment of seed with the present invention Mordant formulations or by the addition of water Preparations are all usually for the irritation usable Mishgeräte into consideration. In detail one proceeds with the irritation in such a way that one puts the seed into a mixer gives, each desired amount of seed dressing formulations either as such or after prior dilution with Add water and until even Distribution of the formulation on the seed mixes. Possibly is followed by a drying process.

The treatment method of the invention may be used for the treatment of genetically modified organisms (GMOs), e.g. As plants or seeds are used. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated into the genome. The term "heterologous gene" essentially refers to a gene which is provided or assembled outside the plant and which, when introduced into the nuclear genome, chloroplast genome or hypochondriacal genome, imparts new or improved agronomic or other properties to the transformed plant Expressed protein or polypeptide or that it is another gene, which is present in the plant or down-regulates or shuts down other genes present in the plant (for example by means of antisense technology, cosuppression technology or RNAi technology [RNA Interference]). A heterologous gene present in the genome is also referred to as a transgene. A transgene defined by its specific presence in the plant genome is referred to as a transformation or transgenic event.

In Dependence on plant species or plant varieties, their location and their growing conditions (soils, climate, Growing season, diet), the inventive Treatment also to over-additive ("synergistic") effects to lead. For example, the following effects are possible which go beyond the expected effects: reduced application rates and / or extended spectrum of action and / or increased efficacy of the active ingredients and compositions, which can be used according to the invention, better plant growth, increased tolerance high or low temperatures, increased tolerance Dryness or water or soil salt content, increased Flowering power, crop relief, maturing acceleration, higher yields, bigger fruits, greater plant height, intense green Color of the leaf, earlier flowering, higher Quality and / or higher nutritional value of the Harvested products, higher sugar concentration in the fruits, better shelf life and / or processability of the harvested products.

In certain application rates, the inventive Drug combinations also have a tonic effect Exercise plants. They are therefore suitable for the Mobilization of the plant defense system against attack by undesirable phytopathogenic fungi and / or microorganisms and / or viruses. This may be one of the reasons for the increased effectiveness of the invention Combinations, for example against fungi. Plant-strengthening (Resistance-inducing) substances should in the present context also mean substances or substance combinations that are able to stimulate the plant defense system so that the treated plants, if they subsequently with undesirable phytopathogenic fungi and / or microorganisms and / or viruses are inoculated, a considerable amount Resistance to these unwanted phytopathogenic Fungi and / or microorganisms and / or viruses. In the present Case is understood as undesirable phytopathogenic fungi and / or Microorganisms and / or viruses phytopathogenic fungi, bacteria and Viruses. Leave the substances according to the invention Therefore, to protect plants against attack by the mentioned Pathogens within a period of time after treatment deploy. The period over which a protective effect is achieved is generally from 1 to 10 days, preferably 1 to 7 days after treatment of the plants with the active ingredients.

To Plants and plant varieties, preferably treated according to the invention Be, count all plants that have genetic material which is particularly advantageous, useful to these plants Characteristics (whether by breeding and / or Biotechnology was achieved).

plants and plant varieties, which are also preferably treated according to the invention are against one or more biotic stress factors resistant, d. H. These plants have an improved defense against animal and microbial pests such as nematodes, insects, Mites, phytopathogenic fungi, bacteria, viruses and / or viroids on.

plants and plant varieties which are also treated according to the invention are those plants that are against one or more several abiotic stress factors are resistant. To the Abiotic stress conditions can be, for example Drought, cold and heat conditions, osmotic Stress, waterlogging, increased soil salt content, increased exposure to minerals, ozone conditions, High light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients or avoiding shadows.

Plants and plant varieties which can also be treated according to the invention are those plants which are characterized by increased yield properties. An increased yield can in these plants z. B. based on improved plant physiology, improved plant growth and improved plant development, such as water efficiency, water retention efficiency, improved nitrogen utilization, increased carbon assimilation, improved photosynthesis, increased germination and accelerated Abreife. The yield may be further influenced by improved plant architecture (under stress and non-stress conditions), including early flowering, control of flowering for hybrid seed production, seedling vigor, plant size, internode count and spacing, root growth, seed size, fruit size, Pod size, pod or ear number, number of seeds per pod or ear, seed mass, increased seed filling, reduced seed drop, reduced pod popping as well Stability. Other yield-related traits include seed composition such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction of nontoxic compounds, improved processability, and improved shelf life.

Plants which can be treated according to the invention are hybrid plants which already express the properties of heterosis or hybrid effect, which generally leads to higher yield, higher vigor, better health and better resistance to biotic and abiotic stress factors. Such plants are typically produced by crossing an inbred male sterile parental line (the female crossover partner) with another inbred male fertile parent line (the male crossbred partner). The hybrid seed is typically harvested from the male sterile plants and sold to propagators. Pollen sterile plants can sometimes be produced (eg in maize) by delaving (ie mechanical removal of the male reproductive organs or the male flowers); however, it is more common for male sterility to be due to genetic determinants in the plant genome. In this case, especially if it is. For the desired product, as one wants to harvest from the hybrid plants, the seeds, it is usually convenient to ensure that the pollen fertility in hybrid plants containing the genetic determinants responsible for male sterility, is completely restored. This can be accomplished by ensuring that the male crossing partners possess appropriate fertility restorer genes capable of restoring pollen fertility in hybrid plants containing the genetic determinants responsible for male sterility. Genetic determinants of pollen sterility may be localized in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have been described, for example, for Brassica species ( WO 1992/005251 . WO 1995/009910 . WO 1998/27806 . WO 2005/002324 . WO 2006/021972 and US 6,229,072 ). However, genetic determinants of pollen sterility may also be localized in the nuclear genome. Pollen sterile plants can also be obtained using plant biotechnology methods such as genetic engineering. A particularly favorable means for the production of male sterile plants is in WO 89/10396 For example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. The fertility can then be restorated by expression of a ribonuclease inhibitor such as barstar in the tapetum cells (eg. WO 1991/002069 ).

plants or plant varieties (using plant biotechnology methods, as the genetic engineering obtained), which treated according to the invention are herbicide-tolerant plants, d. H. Plants, against one or more given herbicides have been made tolerant. Such plants can either by genetic transformation or by selection of plants, containing a mutation conferring such herbicide tolerance, to be obtained.

Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, ie plants that have been tolerated to the herbicide glyphosate or its salts. Thus, for example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium ( Comai et al., Science (1983), 221, 370-371 ), the CP4 gene of the bacterium Agrobacterium sp. ( Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145 ), the genes responsible for an EPSPS from the petunia ( Shah et al., Science (1986), 233, 478-481 ), for an EPSPS from the tomato ( Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289 ) or for an EPSPS from Eleusine ( WO 2001/66704 ). It can also be a mutated EPSPS, such as those in EP-A 0837944 . WO 2000/066746 . WO 2000/066747 or WO 2002/026995 is described. Glyphosate-tolerant plants can also be obtained by expressing a gene encoding a glyphosate oxidoreductase enzyme as described in U.S. Pat US 5,776,760 and US 5,463,175 is encoded. Glyphosate-tolerant plants can also be obtained by expressing a gene encoding a glyphosate acetyltransferase enzyme as described in, e.g. B. WO 2002/036782 . WO 2003/092360 . WO 2005/012515 and WO 2007/024782 is encoded. Glyphosate-tolerant plants can also be obtained by culturing plants naturally occurring mutations of the genes mentioned above, as described, for example, in US Pat WO 2001/024615 or WO 2003/013226 are described, contain, selected.

Other herbicide-resistant plants are, for example, plants which have been tolerated to herbicides which inhibit the enzyme glutamine synthase, such as bialaphos, phosphinotricin or glufosinate. Such plants can be obtained by expressing an enzyme which detoxifies the herbicide or a mutant of the enzyme glutamine synthase, which is resistant to inhibition. Such an effective detoxifying enzyme is, for example, an enzyme encoding a phosphinotricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinotricin acetyltransferase are, for example, in US 5,561,236 ; US 5,648,477 ; US 5,646,024 ; US 5,273,894 ; US 5,637,489 ; US 5,276,268 ; US 5,739,082 ; US 5,908,810 and US 7,112,665 described.

Further herbicide-tolerant plants are also plants tolerant to the herbicides which inhibit the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). The hydroxyphenylpyruvate dioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is converted to homogentisate. Plants tolerant to HPPD inhibitors may be treated with a gene encoding a naturally occurring resistant HPPD enzyme or a gene encoding a mutant HPPD enzyme as described in U.S. Pat WO 1996/038567 . WO 1999/024585 and WO 1999/024586 encoded, transformed. Tolerance to HPPD inhibitors can also be achieved by transforming plants with genes encoding certain enzymes that allow the formation of homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are in WO 1999/034008 and WO 2002/36787 described. The tolerance of plants to HPPD inhibitors can also be improved by transforming plants, in addition to a gene coding for an HPPD-tolerant enzyme, with a gene coding for a prephenate dehydrogenase enzyme, as described in US Pat WO 2004/024928 is described.

Other herbicide-resistant plants are plants that have been tolerated to acetolactate synthase (ALS) inhibitors. Examples of known ALS inhibitors include sulfonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy (thio) benzoates and / or sulfonylaminocarbonyltriazolinone herbicides. It is known that various mutations in the enzyme ALS (also known as acetohydroxy acid synthase, ALIAS) confer tolerance to different herbicides or groups of herbicides, as for example in US Pat Tranel and Wright, Weed Science (2002), 50, 700-712 , but also in US 5,605,011 . US 5,378,824 . US 5,141,870 and US 5,013,659 , is described. The preparation of sulfonylurea tolerant plants and imidazolinone tolerant plants is known in US 5,605,011 ; US 5,013,659 ; US 5,141,870 ; US 5,767,361 ; US 5,731,180 ; US 5,304,732 ; US 4,761,373 ; US 5,331,107 ; US 5,928,937 ; and 5,378,824 ; as well as in the international publication WO 1996/033270 described. Other imidazolinontolerante plants are also in z. B. WO 2004/040012 . WO 2004/106529 . WO 2005/020673 . WO 2005/093093 . WO 2006/007373 . WO 2006/015376 . WO 2006/024351 and WO 2006/060634 described. Other sulfonylureas and imidazolinontolerante plants are also in z. B. WO 2007/024782 described.

Other plants which are tolerant to imidazolinone and / or sulfonylurea may be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or by mutation breeding, as for example for the soybean in US 5,084,082 , for rice in WO 1997/41218 , for the sugar beet in US 5,773,702 and WO 1999/057965 , for salad in US 5,198,599 or for the sunflower in WO 2001/065922 is described.

plants or plant varieties (which are produced by the methods of plant biotechnology, as obtained by genetic engineering), which are also treated according to the invention are insect-resistant transgenic plants, d. H. Plants that are resistant to attack by certain target insects were made. Such plants can be caused by genetic Transformation or by selection of plants that have a mutation containing such an insect resistance can be obtained.

• 1) ein insektizides Kristallprotein aus Bacillus thuringiensis oder einen insektiziden Teil davon, wie die insektiziden Kristallproteine, die von Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807–813 , von Crickmore et al. (2005) in der Bacillus thuringiensis -Toxinnomenklatur aktualisiert, online bei: http://www.lifesci.sussex.ac.uk/Home/Neil_CrickmoreSt/ ), zusammengestellt wurden, oder insektizide Teile davon, z. B. Proteine der Cry-Proteinklassen Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae oder Cry3Bb oder insektizide Teile davon; oder
• 2) ein Kristallprotein aus Bacillus thuringiensis oder einen Teil davon, der in Gegenwart eines zweiten, anderen Kristallproteins als Bacillus thuringiensis oder eines Teils davon insektizid wirkt, wie das binäre Toxin, das aus den Kristallproteinen Cy34 und Cy35 besteht ( Moellenbeck et al., Nat. Bioteclmol. (2001), 19, 668–72 ; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765–1774 ); oder
• 3) ein insektizides Hybridprotein, das Teile von zwei unterschiedlichen insektiziden Kristallproteinen aus Bacillus thuringiensis umfaßt, wie zum Beispiel ein Hybrid aus den Proteinen von 1) oben oder ein Hybrid aus den Proteinen von 2) oben, z. B. das Protein Cry1A.105, das von dem Mais-Event MON98034 produziert wird ( WO 2007/027777 ); oder
• 4) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Amindsäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier-DNA während der Klonierung oder Transformation induziert wurden, wie das Protein Cry3Bb1 in Mais-Events MON863 oder MON88017 oder das Protein Cry3A im Mais-Event MIR 604; oder
• 5) ein insektizides sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus oder einen insektiziden Teil davon, wie die vegetativ wirkenden insektentoxischen Proteine (vegetative insekticidal Proteins, VIP), die unter http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html angeführt sind, z. B. Proteine der Proteinklasse VIP3Aa; oder
• 6) ein sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus, das in Gegenwart eines zweiten sezernierten Proteins aus Bacillus thuringiensis oder B. cereus insektizid wirkt, wie das binäre Toxin, das aus den Proteinen VIP1A und VIP2A besteht ( WO 1994/21795 ); oder
• 7) ein insektizides Hybridprotein, das Teile von verschiedenen sezernierten Proteinen von Bacillus thuringiensis oder Bacillus cereus umfaßt, wie ein Hybrid der Proteine von 1) oder ein Hybrid der Proteine von 2) oben; oder
• 8) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier-DNA während der Klonierung oder Transformation induziert wurden (wobei die Kodierung für ein insektizides Protein erhalten bleibt), wie das Protein VIP3Aa im Baumwoll-Event COT 102.

The term "insect-resistant transgenic plant" as used herein includes any plant containing at least one transgene comprising a coding sequence encoding:

• 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal part thereof, such as the insecticidal crystal proteins derived from Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813 , from Crickmore et al. (2005) updated in the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_CrickmoreSt/ ), or insecticidal parts thereof, e.g. Proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb or insecticidal portions thereof; or
• 2) a Bacillus thuringiensis crystal protein or a part thereof which is insecticidal in the presence of a second crystal protein other than Bacillus thuringiensis or a part thereof, such as the binary toxin consisting of the crystal proteins Cy34 and Cy35 ( Moellenbeck et al., Nat. Bioteclmol. (2001), 19, 668-72 ; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765-1774 ); or
• 3) an insecticidal hybrid protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g. For example, the protein Cry1A.105 produced by the corn event MON98034 ( WO 2007/027777 ); or
• 4) a protein according to any of items 1) to 3) above, in which some, in particular 1 to 10, amine acids have been replaced with another amino acid to achieve a higher insecticidal activity against a target insect species and / or to broaden the spectrum of the corresponding target insect species and / or due to changes induced in the encoded DNA during cloning or transformation such as Protein Cry3Bb1 in corn events MON863 or MON88017 or the protein Cry3A in corn event MIR 604; or
• 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus or an insecticidal part thereof, such as the vegetative insecticidal protein (VIP) mentioned in U.S. Pat http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html are cited, for. B. Proteins of protein class VIP3Aa; or
• 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus, which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin consisting of the proteins VIP1A and VIP2A ( WO 1994/21795 ); or
• 7) a hybrid insecticidal protein comprising parts of various secreted proteins of Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins of 1) or a hybrid of the proteins of 2) above; or
• 8) a protein according to any one of items 1) to 3) above, in which some, in particular 1 to 10, amino acids have been replaced by another amino acid in order to achieve a higher insecticidal activity against a target insect species and / or the spectrum of the corresponding To expand target insect species and / or due to changes induced in the coding DNA during cloning or transformation (preserving the coding for an insecticidal protein), such as the protein VIP3Aa in cotton event COT 102.

Naturally is one of the insect resistant transgenic plants in the present connection also any plant that has a combination of genes coding for the proteins of a of the above classes 1 to 8. In one embodiment contains an insect-resistant plant more than a transgene, that for a protein according to one of the above 1 to 8 encodes the spectrum of the corresponding target insect species to expand or to develop a resistance of insects to delay the plants by doing so uses different proteins that target the same species of target insects are insecticidal, but a different mode of action, such as Binding to different receptor binding sites in the insect, have.

• a. Pflanzen, die ein Transgen enthalten, das die Expression und/oder Aktivität des Gens für die Poly(ADP-ribose)polymerase (PARP) in den Pflanzenzellen oder Pflanzen zu reduzieren vermag, wie dies in WO 2000/004173 oder EP 04077984.5 oder EP 06009836.5 beschrieben ist.
• b. Pflanzen, die ein streßtoleranzförderndes Transgen enthalten, das die Expression und/oder Aktivität der für PARG kodierenden Gene der Pflanzen oder Pflanzenzellen zu reduzieren vermag, wie dies z. B. in WO 2004/090140 beschrieben ist;
• c. Pflanzen, die ein streßtoleranzförderndes Transgen enthalten, das für ein in Pflanzen funktionelles Enzym des Nicotinamidadenindinukleotid-Salvage-Biosynthesewegs kodiert, darunter Nicotinamidase, Nicotinatphosphoribosyltransferase, Nicotinsäuremononukleotidadenyltransferase, Nicotinamidadenindinukleotidsynthetase oder Nicotinamidphosphoribosyltransferase, wie dies z. B. in EP 04077624.7 oder WO 2006/133827 oder PCT/EP07/002433 beschrieben ist.

Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering), which can also be treated according to the invention, are tolerant of abiotic stressors. Such plants can be obtained by genetic transformation or by selection of plants containing a mutation conferring such stress resistance. Particularly useful plants with stress tolerance include the following:

• a. Plants which contain a transgene capable of reducing the expression and / or activity of the poly (ADP-ribose) polymerase (PARP) gene in the plant cells or plants, as described in U.S. Pat WO 2000/004173 or EP 04077984.5 or EP 06009836.5 is described.
• b. Plants containing a stress tolerance-enhancing transgene capable of reducing the expression and / or activity of the PARG-encoding genes of the plants or plant cells, as described e.g. In WO 2004/090140 is described;
• c. Plants which contain a stress tolerance-enhancing transgene encoding a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthetic pathway, including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyltransferase as described e.g. In EP 04077624.7 or WO 2006/133827 or PCT / EP07 / 002433 is described.

• 1) Transgene Pflanzen, die eine modifizierte Stärke synthetisieren, die bezüglich ihrer chemisch-physikalischen Eigenschaften, insbesondere des Amylosegehalts oder des Amylose/Amylopektin-Verhältnisses, des Verzweigungsgrads, der durchschnittlichen Kettenlänge, der Verteilung der Seitenketten, des Viskositätsverhaltens, der Gelfestigkeit, der Stärkekorngröße und/oder Stärkekornmorphologie im Vergleich mit der synthetisierten Stärke in Wildtyppflanzenzellen oder -pflanzen verändert ist, so daß sich diese modifizierte Stärke besser für bestimmte Anwendungen eignet. Diese transgenen Pflanzen, die eine modifizierte Stärke synthetisieren, sind zum Beispiel in EP 0571427 , WO 1995/004826 , EP 0719338 , WO 1996/15248 , WO 1996/19581 , WO 1996/27674 , WO 1997/11188 , WO 1997/26362 , WO 1997/32985, WO 1997/42328 , WO 1997/44472 , WO 1997/45545 , WO 1998/27212 , WO 1998/40503 , WO 99/58688 , WO 1999/58690 , WO 1999/58654 , WO 2000/008184 , WO 2000/008185 , WO 2000/28052 , WO 2000/77229 , WO 2001/12782 , WO 2001/12826 , WO 2002/101059 , WO 2003/071860 , WO 2004/056999 , WO 2005/030942 , WO 2005/030941 , WO 2005/095632 , WO 2005/095617 , WO 2005/095619 , WO 2005/095618 , WO 2005/123927 , WO 2006/018319 , WO 2006/103107 , WO 2006/108702 , WO 2007/009823 , WO 2000/22140 , WO 2006/063862 , WO 2006/072603 , WO 2002/034923 , EP 06090134.5 , EP 06090228.5 , EP 06090227.7 , EP 07090007.1 , EP 07090009.7 , WO 2001/14569 , WO 2002/79410 , WO 2003/33540 , WO 2004/078983 , WO 2001/19975 , WO 1995/26407 , WO 1996/34968 , WO 1998/20145 , WO 1999/12950 , WO 1999/66050 , WO 1999/53072 , US 6,734,341 , WO 2000/11192 , WO 1998/22604 , WO 1998/32326 , WO 2001/98509 , WO 2001/98509 , WO 2005/002359 , US 5,824,790 , US 6,013,861 , WO 1994/004693 , WO 1994/009144 , WO 1994/11520 , WO 1995/35026 bzw. WO 1997/20936 beschrieben.
• 2) Transgene Pflanzen, die Nichtstärkekohlenhydratpolymere synthetisieren, oder Nichtstärkekohlenhydratpolymere, deren Eigenschaften im Vergleich zu Wildtyppflanzen ohne genetische Modifikation verändert sind. Beispiele sind Pflanzen, die Polyfructose, insbesondere des Inulin- und Levantyps, produzieren, wie dies in EP 0663956 , WO 1996/001904 , Wo 1996/021023 , WO 1998/039460 und WO 1999/024593 beschrieben ist, Pflanzen, die alpha-1,4-Glucane produzieren, wie dies in WO 1995/031553 , US 2002/031826 , US 6,284,479 , US 5,712,107 , WO 1997/047806 , WO 1997/047807 , WO 1997/047808 und WO 2000/14249 beschrieben ist, Pflanzen, die alpha-1,6-verzweigte alpha-1,4-Glucane produzieren, wie dies in WO 2000/73422 beschrieben ist, und Pflanzen, die Alternan produzieren, wie dies in WO 2000/047727 , EP 06077301.7 , US 5,908,975 und EP 0728213 beschrieben ist.
• 3) Transgene Pflanzen, die Hyaluronan produzieren, wie dies zum Beispiel in WO 2006/032538 , WO 2007/039314 , WO 2007/039315 , WO 2007/039316 , JP 2006/304779 und WO 2005/012529 beschrieben ist.

Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention have a changed amount, quality and / or storability of the harvested product and / or altered characteristics of certain components of the harvested product, such as:

• 1) Transgenic plants that synthesize a modified starch, with regard to their physicochemical properties, in particular the amylose content or the amylose / amylopectin ratio, the degree of branching, the average chain length, the distribution of side chains, the viscosity behavior, the gel strength, the starch grain size and / or starch grain morphology is altered in comparison to the synthesized starch in wild-type plant cells or plants, so that this modified starch is better suited for certain applications. These transgenic plants that synthesize a modified starch are, for example, in EP 0571427 . WO 1995/004826 . EP 0719338 . WO 1996/15248 . WO 1996/19581 . WO 1996/27674 . WO 1997/11188 . WO 1997/26362 , WO 1997/32985, WO 1997/42328 . WO 1997/44472 . WO 1997/45545 . WO 1998/27212 . WO 1998/40503 . WO 99/58688 . WO 1999/58690 . WO 1999/58654 . WO 2000/008184 . WO 2000/008185 . WO 2000/28052 . WO 2000/77229 . WO 2001/12782 . WO 2001/12826 . WO 2002/101059 . WO 2003/071860 . WO 2004/056999 . WO 2005/030942 . WO 2005/030941 . WO 2005/095632 . WO 2005/095617 . WO 2005/095619 . WO 2005/095618 . WO 2005/123927 . WO 2006/018319 . WO 2006/103107 . WO 2006/108702 . WO 2007/009823 . WO 2000/22140 . WO 2006/063862 . WO 2006/072603 . WO 2002/034923 . EP 06090134.5 . EP 06090228.5 . EP 06090227.7 . EP 07090007.1 . EP 07090009.7 . WO 2001/14569 . WO 2002/79410 . WO 2003/33540 . WO 2004/078983 . WO 2001/19975 . WO 1995/26407 . WO 1996/34968 . WO 1998/20145 . WO 1999/12950 . WO 1999/66050 . WO 1999/53072 . US 6,734,341 . WO 2000/11192 . WO 1998/22604 . WO 1998/32326 . WO 2001/98509 . WO 2001/98509 . WO 2005/002359 . US 5,824,790 . US 6,013,861 . WO 1994/004693 . WO 1994/009144 . WO 1994/11520 . WO 1995/35026 respectively. WO 1997/20936 described.
• 2) Transgenic plants that synthesize non-starch carbohydrate polymers or non-starch carbohydrate polymers whose properties are altered compared to wild-type plants without genetic modification. Examples are plants which produce polyfructose, in particular of the inulin and levan type, as described in US Pat EP 0663956 . WO 1996/001904 , Where 1996/021023 . WO 1998/039460 and WO 1999/024593 described plants that produce alpha-1,4-glucans, as described in WO 1995/031553 . US 2002/031826 . US 6,284,479 . US 5,712,107 . WO 1997/047806 . WO 1997/047807 . WO 1997/047808 and WO 2000/14249 described plants that produce alpha-1,6-branched alpha-1,4-glucans, as shown in WO 2000/73422 and plants that produce alternan, as described in US Pat WO 2000/047727 . EP 06077301.7 . US 5,908,975 and EP 0728213 is described.
• 3) Transgenic plants that produce hyaluronan, such as in WO 2006/032538 . WO 2007/039314 . WO 2007/039315 . WO 2007/039316 . JP 2006/304779 and WO 2005/012529 is described.

plants or plant varieties (which are produced by the methods of plant biotechnology, as obtained by genetic engineering), which are also treated according to the invention plants are like cotton plants with altered Fiber properties. Such plants can be caused by genetic Transformation or by selection of plants that have a mutation containing such altered fiber properties obtained become; these include:

• a) plants, such as cotton plants, containing an altered form of cellulose synthase genes, as shown in WO 1998/000549 is described
• b) plants, such as cotton plants, which contain an altered form of rsw2 or rsw3 homologous nucleic acids, as described in US Pat WO 2004/053219 is described;
• c) plants such as cotton plants with increased expression of sucrose phosphate synthase, as described in US Pat WO 2001/017333 is described;
• d) plants such as cotton plants with an increased expression of sucrose synthase, as described in WO 02/45485 is described;
• e) plants such as cotton plants in which the timing of the passage control of the Plasmodesmen is changed at the base of the fiber cell, z. By down-regulating the fiber-selective β-1,3-glucanase, as described in U.S. Pat WO 2005/017157 is described;
• f) plants such as cotton plants with modified reactivity fibers, e.g. By expression of the N-acetylglucosamine transferase gene, including nodC, and chitin synthase genes, as described in U.S. Pat WO 2006/136351 is described.

• a) Pflanzen wie Rapspflanzen, die Öl mit einem hohen Ölsäuregehalt produzieren, wie dies zum Beispiel in US 5,969,169 , US 5,840,946 oder US 6,323,392 oder US 6,063,947 beschrieben ist;
• b) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen Linolensäuregehalt produzieren, wie dies in US 6,270828 , US 6,169,190 oder US 5,965,755 beschrieben ist.
• c) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen gesättigten Fettsäuregehalt produzieren, wie dies z. B. in US 5,434,283 beschrieben ist.

Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are plants such as oilseed rape or related Brassica plants with altered oil composition properties. Such plants can be obtained by genetic transformation or by selection of plants containing a mutation conferring such altered oil properties; these include:

• a) plants such as oilseed rape plants producing oil of high oleic acid content, such as in US 5,969,169 . US 5,840,946 or US 6,323,392 or US 6,063,947 is described;
• (b) plants such as oilseed rape plants producing low linolenic acid oil, as in US 6,270,828 . US 6,169,190 or US 5,965,755 is described.
• c) plants such as oilseed rape plants which produce oil with a low saturated fatty acid content, such as e.g. In US 5,434,283 is described.

YIELD GARD ^® (for example maize, tree: Particularly useful transgenic plants which may be treated according to the invention are plants which comprise one or more genes that encode one or more toxins are the transgenic plants which are sold under the following trade names wool, soybeans), Knockout ^® (for example maize), Bite-Gard ^® (for example maize), BT-Xtra ^® (for example maize), StarLink ^® (for example maize), Bollgard ^® (cotton), NuCOTN ^® ( cotton), NuCOTN 33B ^® (cotton), NatureGard® ^® (for example maize), Protecta ^® and NewLeaf ^® (potato). Herbicide-tolerant crops to be mentioned are, for example, corn varieties, cottons and soybean varieties sold under the following tradenames: Roundup ^Ready® (glyphosate tolerance, for example corn, cotton, soybean), Liberty ^Link® (phosphinotricin tolerance, for example rapeseed) , IMI ^® (imidazolinone) and SCS ^® (Sylfonylharnstofftoleranz), for example, maize. Herbicide-resistant plants (traditionally bred for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield ^® (for example maize).

Particularly useful transgenic plants that can be treated according to the invention are plants that contain transformation events, or a combination of transformation events, and that are listed, for example, in the files of various national or regional authorities (see, for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php ).

The listed plants can be particularly advantageous with the active compound combinations according to the invention be treated. The specified in the drug combinations above Preferential ranges also apply to the treatment of these plants. Particularly emphasized is the plant treatment with those in the present Text specifically listed drug combinations.

The active compound combinations according to the invention not only act against plant, hygiene and storage pests, but also in the veterinary sector against animal parasites (ecto- and endoparasites) such as ticks, leather ticks, mange mites, running mites, flies (stinging and licking), parasitic fly larvae, lice , Hair pieces, featherlings and fleas. These parasites include:
From the order of Anoplurida z. Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp.
From the order of Mallophagida and suborders Amblycerina and Ischnocerina z. Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.
From the order Diptera and the suborders Nematocerina and Brachycerina z. Eg Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp. Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp , Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp.
From the order of Siphonapterida z. B. Pulex spp., Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp.
From the order of Heteropterida z. Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.
From the order of Blattarida z. Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp.
From the subclass of Acari (Acarina) and the orders of Meta and Mesostigmata z. B. Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp. Pneumonyssus spp., Sternostoma spp., Varroa spp.
From the order of Actinedida (Prostigmata) and Acaridida (Astigmata) z. Eg Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp. Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., Laminosioptes spp.

The Compounds of the invention are suitable also to combat arthropods, the agricultural Livestock, such. Cattle, sheep, goats, horses, pigs, donkeys, Camels, buffaloes, rabbits, chickens, turkeys, ducks, Geese, bees, other pets such. Dogs, cats, Birds of prey, aquarium fish and so-called experimental animals, such as Hamsters, guinea pigs, rats and mice. By fighting these arthropods deaths are said and reductions in performance (in the case of meat, milk, wool, skins, Eggs, honey, etc.) are reduced, so that by the Use of the active compound combinations according to the invention a more economical and easier animal husbandry possible is.

The application of the active compound combinations according to the invention takes place in the veterinary sector and animal husbandry in a known manner by enteral administration in the form of, for example, tablets, capsules, infusions, drenches, granules, pastes, boluses, the feed-through process, suppositories, by paren oral administration, for example by injections (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.), implants, by nasal application, by dermal application in the form of, for example, dipping or bathing (dipping), spraying, pouring (pour-on and Spot-on), washing, powdering and with the aid of active substance-containing moldings, such as collars, ear tags, tail marks, limb bands, holsters, marking devices, etc.

at the application for livestock, poultry, pets etc. can be the drug combinations as formulations (for example Powders, emulsions, flowables) containing the Active ingredients in an amount of 1 to 80 wt .-%, directly or after 100 to 10,000 times dilution or use them as a chemical bath.

Furthermore has been found that the inventive Drug combinations a high insecticidal activity against insects show that destroy technical materials.

By way of example and preferably without limiting however, the following insects are mentioned:
Beetles such as Hylotrupes bajulus, Chlorophorus pilosis, Anobium punctatum, Xestobium rufovillosum, Ptilinus pecticornis, Dendrobium pertinex, Ernobius mollis, Priobium carpini, Lyctus brunneus, Lyctus africanus, Lyctus planicollis, Lyctus linearis, Lyctus pubescens, Trogoxylon aequale, Minthes rugicollis, Xyleborus spec. Tryptodendron spec. Apate monachus, Bostrychus capucins, Heterobostrychus brunneus, Sinoxylon spec. Dinoderus minutus;
Hymenoptera such as Sirex juvencus, Urocerus gigas, Urocerus gigas taignus, Urocerus augur;
Termites such as Kalotermes flavicollis, Cryptotermes brevis, Heterotermes indicola, Reticulitermes flavipes, Reticulitermes santonensis, Reticulitermes lucifugus, Mastotermes darwiniensis, Zootermopsis nevadensis, Coptotermes formosanus;
Bristle tails like Lepisma saccharina.

Under technical materials are non-living in the present context Materials, such as preferably plastics, adhesives, Glues, papers and cartons, leather, wood, woodworking products and paints.

The ready-to-use agents may, if appropriate, further Insecticides and optionally one or more fungicides included.

Regarding possible additional Zumischpartner be on referenced the above insecticides and fungicides.

at the same time can the drug combinations of the invention for protection against the growth of objects, in particular of Hulls, sieves, nets, structures, quays and Signaling equipment associated with seawater or brackish water, be used.

Further can the drug combinations of the invention alone or in combination with other active ingredients as antifouling agent be used.

The active ingredient combinations are also suitable for controlling animal pests in the. Household, hygiene and storage protection, in particular of insects, arachnids and mites, in closed rooms, such as apartments, factory buildings, offices, vehicle cabins u. Ä. occur. They can be used to control these pests, alone or in combination with other active ingredients and adjuvants in household insecticide products. They are effective against sensitive and resistant species and against all stages of development. These pests include:
From the order of Scorpionidea z. B. Buthus occitanus.
From the order of Acarina z. B. Argas persicus, Argas reflexus, Bryobia ssp., Dermanyssus gallinae, Glyciphagus domesticus, Ornithodorus moubat, Rhipicephalus sanguineus, Trombicula alfreddugesi, Neutrombicula autumnalis, Dermatophagoides pteronissimus, Dermatophagoides forinae.
From the order of Araneae z. B. Aviculariidae, Araneidae.
From the order of Opiliones z. Pseudoscorpiones chelifer, Pseudoscorpiones cheiridium, Opiliones phalangium.
From the order of Isopoda z. B. Oniscus asellus, Porcellio scaber.
From the order of Diplopoda z. B. Blaniulus guttulatus, Polydesmus spp.
From the order of Chilopoda z. B. Geophilus spp ..
From the order of Zygentoma z. Ctenolepisma spp., Lepisma saccharina, Lepismodes inquilinus.
From the order of Blattaria z. Blatta orientalies, Blattella germanica, Blattella asahinai, Leucophaea maderae, Panchlora spp., Parcoblatta spp., Periplaneta australasiae, Periplaneta americana, Periplaneta brunnea, Periplaneta fuliginosa, Supella longipalpa.
From the order of Saltatoria z. B. Acheta domesticus.
From the order of Dermaptera z. B. Forficula auricularia.
From the order of Isoptera z. Kalotermes spp., Reticulitermes spp. From the order of Psocoptera z. Lepinatus spp., Liposcelis spp.
From the order of Coleoptera z. Anthrenus spp., Attagenus spp., Dermestes spp., Latheticus oryzae, Necrobia spp., Ptinus spp., Rhizopertha dominica, Sitophilus granarius, Sitophilus oryzae, Sitophilus zeamais, Stegobium paniceum.
From the order of Diptera z. Aedes aegypti, Aedes albopictus, Aedes taeniorhynchus, Anopheles spp., Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Drosophila spp., Fannia canicularis, Musca domestica, Phlebotomus spp., Sarcophaga carnaria, Simulium spp. , Stomoxys calcitrans, Tipula paludosa.
From the order of Lepidoptera z. Achroia grisella, Galleria mellonella, Plodia interpunctella, Tinea cloacella, Tinea pellionella, Tineola bisselliella.
From the order of Siphonaptera z. Ctenocephalides canis, Ctenocephalides felis, Pulex irritants, Tunga penetrans, Xenopsylla cheopis.
From the order of Hymenoptera z. B. Camponotus herculeanus, Lasius fuliginosus, Lasius niger, Lasius umbratus, Monomorium pharaonis, Paravespula spp., Tetramorium caespitum.
From the order of Anoplura z. Pediculus humanus capitis, Pediculus humanus corporis, Pemphigus spp., Phylloera vastatrix, Phthirus pubis.
From the order of Heteroptera z. Cimex hemipterus, Cimex lectularius, Rhodinus prolixus, Triatoma infestans.

The Application in the field of household insecticides takes place alone or in combination with other suitable active substances, such as phosphoric acid esters, Carbamates, pyrethroids, neonicotinoids, growth regulators or agents from other known classes of insecticides.

The Application is in aerosols, non-pressurized sprays, z. Pump and atomizer sprays, fog machines, foggers, Foams, gels, evaporator products with evaporator plates made of cellulose or plastic, liquid evaporators, gel and membrane evaporators, propeller driven evaporators, energyless or passive evaporation systems, moth papers, moth bags and moth gels, as granules or dusts, in straw baits or bait stations.

The good insecticidal and acaricidal activity of the invention Drug combinations can be seen in the following examples. While the individual active ingredients in the action weaknesses show the combinations have an effect over a simple sum of effects goes beyond.

One synergistic effect is always with insecticides and acaricides then before, if the effect of the drug combinations greater is the sum of the effects of the individually applied drugs.

The expected effect for a given combination of two drugs can. to SR Colby, Weeds 15 (1967), 20-22 calculated as follows:

X

den Abtötungsgrad, ausgedrückt in % der unbehandelten Kontrolle, beim Einsatz des Wirkstoffes A in einer Aufwandmenge von m g/ha oder in einer Konzentration von m ppm bedeutet,

Y

den Abtötungsgrad, ausgedrückt in % der unbehandelten Kontrolle, beim Einsatz des Wirkstoffes B in einer Aufwandmenge von n g/ha oder in einer Konzentration von n ppm bedeutet und

E

den Abtötungsgrad, ausgedrückt in % der unbehandelten Kontrolle, beim Einsatz der Wirkstoffe A und B in Aufwandmengen von m und n g/ha oder in einer Konzentration von m und n ppm bedeutet,

dann istIf

X

the degree of killing, expressed in% of the untreated control, when using the active substance A at a rate of mg / ha or in a concentration of m ppm,

Y

the degree of killing, expressed in% of the untreated control, when using the active ingredient B in an application rate of ng / ha or in a concentration of n ppm means and

e

the degree of killing, expressed as% of the untreated control, when using the active compounds A and B at application rates of m and ng / ha or in a concentration of m and n ppm,

then

If the actual insecticidal or acaricidal degree of killing is greater than calculated, the combination is over-additive in its killing, ie there is a synergistic effect. In this case, he has to do that The rate of kill observed to be greater than the value for the expected kill rate (E) calculated from the above formula is greater. Example A Myzus persicae test Solvent: 78 parts by weight of acetone 1.5 parts by weight of dimethylformamide emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

to Preparation of a suitable preparation of active ingredient 1 part by weight of active compound is mixed with the stated amounts Solvent and emulsifier and dilute the concentrate with emulsifier-containing water to the desired concentration.

cabbage leaves (Brassica oleracea), which is strongly affected by the green peach aphid (Myzus persicae) are infected by dipping in the preparation of active compound treated the desired concentration.

To the desired time, the kill is determined in%. 100% means that all aphids are killed were; 0% means that no aphids killed were. The determined kill values are calculated by the Colby formula (see above).

• * gef. = gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

Tabelle A, Seite 2 Pflanzenschädigende Insekten Myzus persicae – Test

• * gef. = gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

Beispiel B Phaedon cochleariae – Larven-Test Lösungsmittel: 78 Gewichtsteile Aceton 1,5 Gewichtsteile Dimethylformamid Emulgator: 0,5 Gewichtsteile Alkylarylpolyglykolether In this test, z. For example, the following active ingredient combinations according to the present application have a synergistically enhanced activity in comparison with the individually applied active ingredients: TABLE A, Page 1 Plant damaging insects Myzus persicae test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

Table A, page 2 Plant Harmful Insects Myzus persicae - Test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

Example B Phaedon cochleariae larval test Solvent: 78 parts by weight of acetone 1.5 parts by weight of dimethylformamide emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

to Preparation of a suitable preparation of active ingredient 1 part by weight of active compound is mixed with the stated amounts Solvent and emulsifier and dilute the concentrate with emulsifier-containing water to the desired concentration.

cabbage leaves (Brassica oleracea) by dipping in the preparation of active compound the desired concentration and treated with larvae of the horseradish leaf beetle (Phaedon cochleariae), while the leaves are still wet.

To the desired time, the kill is determined in%. 100% means that all beetle larvae are killed were; 0% means that no beetle larvae are killed were. The determined kill values are calculated by the Colby formula (see above).

• * gef. = gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

Tabelle B, Seite 2 Pflanzenschädigende Insekten Phaedon cochleariae Larven – Test

• * gef. = gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

Beispiel C Spodoptera frugiperda – Larven-Test Lösungsmittel: 78 Gewichtsteile Aceton 1,5 Gewichtsteile Dimethylformamid Emulgator: 0,5 Gewichtsteile Alkylarylpolyglykolether In this test, the following active ingredient combination according to the present application showed a synergistically enhanced effectiveness in comparison to the individually applied active ingredients: Table B, page 1 Plant Harmful Insects Phaedon cochleariae larval test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

Table B, page 2 Plant Harmful Insects Phaedon cochleariae larval test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

Example C Spodoptera frugiperda larval test Solvent: 78 parts by weight of acetone 1.5 parts by weight of dimethylformamide emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

to Preparation of a suitable preparation of active ingredient 1 part by weight of active compound is mixed with the stated amounts Solvent and emulsifier and dilute the concentrate with emulsifier-containing water to the desired concentration.

cabbage leaves (Brassica oleracea) by spraying with the drug preparation treated in the desired concentration and with larvae of the army worm (Spodoptera frugiperda) occupies as long as the leaves are still wet.

To the desired time, the kill is determined in%. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed. The determined Killing values are calculated according to the Colby formula (see above).

• * gef.= gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

Beispiel D Tetranychus urticae – Test (OP-resistent/Spritzbehandlung) Lösungsmittel: 78 Gewichtsteile Aceton 1,5 Gewichtsteile Dimethylformamid Emulgator: 0,5 Gewichtsteile Alkylarylpolyglykolether In this test, the following active ingredient combinations according to the present application show a synergistically enhanced effectiveness in comparison to the individually applied active ingredients: Table 1, p. 1 Plant-damaging insects Spodoptera frugiperda larvae test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

Example D Tetranychus urticae test (OP resistant / spray treatment) Solvent: 78 Parts by weight acetone 1.5 Parts by weight of dimethylformamide emulsifier: 0.5 Parts by weight of alkylaryl polyglycol ether

to Preparation of a suitable preparation of active ingredient 1 part by weight of active compound is mixed with the stated amounts Solvent and emulsifier and dilute the concentrate with emulsifier-containing water to the desired concentration.

Discs of bean leaves (Phaseolus vulgaris) from all stages of the common spider mite (Tetranychus urticae) are treated with an active ingredient preparation sprayed the desired concentration.

To the desired time, the effect is determined in%. there means 100% that all spider mites have been killed; 0% means that no spider mites have been killed.

• * gef. = gefundene Wirkung
• ** ber. = nach der Colby-Formel berechnete Wirkung

In this test, the following active ingredient combination according to the present application showed a synergistically enhanced effectiveness in comparison to the individually applied active ingredients: Table D, page 1 Plant-damaging mites Tetranychus urticae - test

• * gef. = found effect
• ** calc. = calculated according to the Colby formula

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

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Claims (13)

Active substance combinations containing at least one compound of the formula (I)

in which A is the radical 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromo-pyrid-3-yl, 5-fluoro-6-chloro-pyrid-3-yl, Is 2-chloro-1,3-thiazol-5-yl or 5,6-dichloro-pyrid-3-yl and R ^{1 is} methyl, cyclopropyl, methoxy, 2-fluoroethyl or 2,2-difluoro-ethyl, with with the proviso that 4 - {[(6-chloropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one and 4 - {[(6-chloropyrid-3-yl) methyl] (cyclopropyl ) amino} furan-2 (5}) -one are excluded, and at least one compound from the group spirotetramat (IIa), spirodiclofen (IIb), spiromesifen (IIc) and the compound of formula (IId):

Active substance combinations according to claim 1, characterized in that the compound of formula (I) is selected is selected from the group consisting of the compounds of the formulas (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7) and (I-8). Use of active compound combinations as in claim 1 or 2 for controlling animal pests. Method for controlling animal pests, characterized in that one drug combinations, as in Claim 1 or 2 defines animal pests and / or whose habitat and / or seed is allowed to act. Method according to claim 4, characterized in that that is an active ingredient of the formula (I) and one of the active ingredients of the formula (IIa), cis- (IIa), (IIb), (IIc) and (IId) to the same Time on seed. Method according to claim 4, characterized in that that is an active ingredient of the formula (I) and one of the active ingredients of the formula (IIa), cis- (IIa), (IIb), (Ic) and (IId) to different Times on seed. Process for the preparation of insecticidal and acaricidal Agent, characterized in that one comprises active ingredient combinations, as defined in claim 1 or 2, with extenders and / or surface-active Mixed substances. Use of an active ingredient combination according to claim 1 or 2 for the treatment of seeds. Use of active compound combinations according to claim 1 or 2 for the treatment of transgenic plants. Use of active compound combinations according to claim 1 or 2 for the treatment of seeds of transgenic plants. Seed, which with a combination of active ingredients was treated according to claim 1 or 2. Seed according to claim 11, which at the same time with an active ingredient of the formula (I) and one of the active ingredients of Formula (IIa), cis- (IIa), (IIb), (IIc) and (IId) was treated. Seed according to claim 11, which is different Times with an active ingredient of the formula (I) and one of the active ingredients of formula (IIa), cis- (IIa), (IIb), (IIc) and (IId).