DE102006047157A1 - Cosmetic or dermatological composition comprises 2-isopropyl-5-methylcyclohexylcarbonyl-D-alanine methyl ester and a skin lightener - Google Patents

Abstract

Cosmetic or dermatological composition comprises 2-isopropyl-5-methylcyclohexylcarbonyl-D-alanine methyl ester (I) and a skin lightener. ACTIVITY : Dermatological. No biological data given. MECHANISM OF ACTION : None given.

Description

The The present invention relates to cosmetic cosmetic or dermatological Preparations containing 2-isopropyl-5-methylcyclohexanecarbonyl-D-alanine methyl ester and one or more skin lightening agents against unwanted pigmentation the skin, in particular postinflammatory hyperpigmentation.

For pigmentation the skin is responsible for the melanocytes, which are in the lowest Layer of the epidermis, the stratum basale, beside the basal cells as - ever Depending on skin type either isolated or more or less frequently occurring - pigment-forming Cells are found.

melanocytes contain as characteristic cell organelles melanosomes, in which the melanin is formed. Among other things when excited by UV radiation is amplified Melanin formed. This is about the living layers of the epidermis (keratinocytes) ultimately into the Horny layer (corneocytes) transported and calls one more or less pronounced brownish to brown-black skin.

melanin is formed as the final stage of an oxidative process, in which Tyrosine with the participation of enzyme tyrosinase via several intermediates to brown to brown-black eumelanins (DHICA and DHI melanin) or with the involvement of sulfur-containing compounds to the reddish Converted to phaeomelanin becomes. DHICA and DHI melanin are produced via the common intermediates Dopaquinone and dopachrome. The latter will, partly with participation other enzymes, either in indole-5,6-quinone carboxylic acid or converted into indole-5,6-quinone, from which the two mentioned eumelanins arise.

The Formation of phaeomelanin runs under over the intermediates dopaquinone and cysteinyldopa. Is controlled the expression of the melanin-synthesizing enzymes by a specific transcription factor (microphthalmia-associated transcription factor, MITF). In addition to the described enzymatic processes of Melanin synthesis are other melanogenesis proteins in melanosomes significant. An important role here seems to be the so-called p-protein, the exact function is still unclear.

In addition to the process of melanin synthesis in the melanocytes described above, in the pigmentation of the skin and the transfer of melanosomes, their retention in the epidermis and their degradation and degradation of melanin is of crucial importance. It has been shown that the transport of melanosomes from the melanocytes into the keratinocytes, the PAR-2 receptor is important ( Seiberg, M., et al., 2000, J. Cell. Sci., 113: 3093-101 ).

Further have size and shape the melanosomes influence their light-scattering properties and thus the color appearance of the skin. For example, in black Africans we find increasingly large spheroidale, individually present melanosomes, while in Caucasians rather smaller, grouped melanosomes found.

issues with hyperpigmentation of the skin have many causes or are concomitant many biological processes, e.g. UV radiation (e.g., freckles, ephelides), genetic disposition, False pigmentation of the skin during wound healing or scarring (postinflammatory hyperpigmentation) or skin aging (e.g., Lentigines seniles).

To inflammatory Reactions of the pigmentation system of the skin partially reacts opposite reactions. It can be both post-inflammatory Hyper- as well as hypopigmentations come. postinflammatory Hypomelanoses occur u. a. often associated with atopy, lupus erythematosus and psoriasis. The different reaction forms of the pigmentation system of human skin resulting from inflammatory phenomena only very incomplete Understood.

issues Postinflammatory hyperpigmentation is common darker skin types. Especially in male colored people is the problem the pseudofolliculitis barbae is known to be cosmetically undesirable Associated with or resulting in defective pigmentation. Also forms of melasma, which is especially common among women of Asian affiliation in the face and décolleté area occur, as well as various forms of irregular pigmentation of the skin become postinflammatory hyperpigmentation counted. Furthermore, dark circles under the eyes become postinflammatory as well Hyperpigmentation is considered, with the underlying inflammation mostly subclinical.

In many cases become such post-inflammatory Fehlpigmentierung by action Of sunlight (UV light) still reinforced, without it to one UV-induced inflammation (Sunburn) is coming.

Active ingredients and preparations are known which counteract skin pigmentation. In practical use are essentially preparations based on hydroquinone, but on the one hand only after several weeks of application show their effect, the excessively long use on the other hand is of concern for toxicological reasons. By Albert Kligman et al. a so-called triformula was developed, which represents a combination of 0.1% tretinoin, 5.0% hydroquinone, 0.1% dexamethasone ( A. Kligman, 1975, Arch. Dermatol., 111: 40-48 ). However, this formulation is also very controversial because of possible irreversible changes in the pigmentation system of the skin.

Further find skin peeling Methods (chemical and mechanical "peels") application, however, often inflammatory Reactions and postinflammatory thereafter Hyperpigmentation even to stronger instead of reduced pigmentation. All these common procedures, also for the treatment of postinflammatory hypergigments Being applied are characterized by crucial side effects out.

aim The following invention was thus, the disadvantageous state to remedy the technology.

The The present invention relates in a very particular embodiment cosmetic and dermatological preparations with reduced skin irritation.

The cooling effect of cosmetic preparations is based on two basic principles:
Use of components that volatilize after topical application gaseous and the required amount of energy, the so-called evaporation enthalpy, to a large part of the skin surface. Therefore, suitable liquid components are used in corresponding non-occlusive cosmetics. Ethanol has proved to be particularly suitable here, in addition formulations with a high water content likewise show a clear cooling effect.

commitment from so-called "cooling Agents "with the heat receptors the skin interact and thus a feeling of cold trigger, without a measurable one physical cooling to generate. Therefor menthol and various menthol derivatives (Frescolate, Physcool, Questice L, etc.). In particular, high ethanol contents menthol and its derivatives are, in addition to the irritative potential, especially because of their distinct inherent odor for numerous Uses from olfactory viewpoint not suitable. Often In addition, such substances simultaneously cause one Circulation increase, on the contrary causes a feeling of warmth.

In The literature, for example, ionic compounds, in particular Ammonium salts, as cooling Agents described. As a cooling Preparations are also widely used isopropanolic gels with camphor and menthol additive applied.

The Use of these substances, especially on irritated skin, is in any case problematic. About that In addition, many of these compounds are poorly water-soluble. Your Use is therefore limited to a few cosmetics and dermatics.

task So it was the present invention, nourishing cosmetic and to provide medical preparations that are not the disadvantages of the prior art, in particular those which, on the skin or mucous membranes applied, moisturizing and / or cooling effect.

The DE 43 12 656 describes the use of cosmetically or pharmaceutically acceptable substances with positive enthalpy of solution in cosmetic or medical topical preparations, characterized in that the substance or substances in the preparations are present in a largely anhydrous medium and / or shielded by a material barrier of an aqueous medium.

Even though this procedure basically can lead to cosmetically satisfactory preparations, however, these are Galenically extremely expensive manufacture.

It was therefore the object of the present invention, the evils of the prior art To help and provide cooling cosmetic or dermatological preparations available, which are easy to prepare, no irritant effect on skin or mucous membranes - for example, unpleasant tingling or itching - and donate pleasant cooling when used as intended.

So Especially against the background of the not completely understood Reactions of the pigmentation system of the skin completely surprisingly shown that Cosmetic or dermatological preparations containing 2-isopropyl-5-methylcyclohexanecarbonyl-D-alanine methyl ester and one or more skin lightening agents against unwanted pigmentation the skin are extremely effective and to a more even Pigmentation - and simultaneous cooling contribute to the skin.

In a particularly preferred form of use this applies to the treatment of the following hyperpigmentation conditions: postinflammatory Hyperpigmentation after inflammatory Reactions, especially those associated with shaving melasma, uneven skin tone, especially as a result of excessive sun exposure.

It showed that in a particularly preferred embodiment 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester used in combination with UV filters. In addition to prevention and Treatment of postinflammatory hyperpigmentation by the preparations according to the invention as a particularly preferred embodiment, showed a preferred embodiment of the formulations according to the invention also effective in the treatment of hypoglycemic reactions.

When Particularly preferred indications would be postinflammatory hyperpigmentation due to the pseudofollicularis barbae as well as melasma.

2-Isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester is characterized by the following structure:

Synthesis of 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester [syn: (R) -2 - [((1R, 2S, 5R) -2-isopropyl-5-methyl-cyclohexanecarbonyl) -amino] -propionic acid methyl ester may be made in accordance with the following rule:
1.0 g of D-alanine methyl ester hydrochloride (obtained from Aldrich Chemical Co.) was dissolved in 28 ml of diethyl ether and 1 ml of double-distilled water and cooled to 0 ° C. A spatula tip of the catalyst diaminopyrimidine was added. 1.62 ml of p-menthyl chloride was added dropwise, followed by 2 ml of triethylamine. Flakes of a no-mist precipitate formed in the mixture, which was stirred overnight at room temperature. The precipitate was dissolved in ethyl acetate, washed with double-distilled water and dried over sodium sulfate. The organic phase was evaporated under reduced pressure to give 2 g of the final product, which crystallized at room temperature. The expected molecular mass and structure were confirmed by mass spectrometer or NMR spectrum.

Advantageous is in particular a use according to the invention, characterized that the preparations 0.0001 to 5 wt .-%, in particular 0.001 to 1 wt .-%, more preferably 0.005 to 0.15 wt .-% of 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester contained, based on the total weight of the preparation.

Advantageous Furthermore, in particular a use according to the invention, characterized in that the preparations 0.001 to 10 wt .-%, in particular 0.05 to 5 wt .-%, especially 0.01 to 2% by weight of one or more of the skin containing lightening agents, based on the total weight the preparation.

Of the skin lightening agents used in the invention, can be selected advantageously:
8-hexadecene-1,16-dicarboxylic acid, ursolic acid, agouti peptides, liquorice root extract, hydroquinone, green tea extract, arbutin, biotin, mulberry extract (Uvae ursii), glycyrrhizin, placental extract, ascorbyl glucosides, endothelin antagonists from chamomile extract.

Cosmetic and dermatological preparations according to the invention can be present in various forms. For example, they may contain a solution, an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) type or of the oil-in-water (O / W) type, a multiple emulsion, for example water-type. in oil-in-water (W / O / W), a gel, a solid stick, an ointment or even an aerosol. It is also advantageous in accordance with the invention to present folic acid and / or derivatives thereof in encapsulated form, for example in collagen matrices and other customary encapsulating materials, for example as cellulose encapsulates, in gelatin, wax matrices or liposomally encapsulated. In particular wax matrices like those in the DE-OS 43 08 282 have been described, have turned out to be favorable.

It is possible, too and advantageous for the purposes of the present invention, folic acid and / or their derivatives in aqueous systems or to add surfactant preparations for cleansing the skin and hair.

The cosmetic according to the invention and dermatological preparations may be cosmetic adjuncts contain as they usually do used in such preparations, e.g. Preservatives, Bactericides, perfumes, Substances for preventing foaming, dyes, pigments, the one coloring Have thickening agents, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other usual ones Components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

• – Mineralöle, Mineralwachse
• – Öle, wie Triglyceride der Caprin- oder der Caprylsäure, ferner natürliche Öle wie z.B. Rizinusöl;
• – Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z.B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;
• – Alkylbenzoate;
• – Siliconöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils such as triglycerides of capric or caprylic acid, further natural oils such as castor oil;
• Fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with lower C-number alcohols, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with lower C-number alkanoic acids or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of Emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected the group of esters from saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then chosen advantageous are from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, Isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. Jojoba oil.

The aqueous phase the preparations according to the invention contains optionally advantageous alcohols, diols or polyols lower C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, Ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore lower alcohols C number, e.g. Ethanol, isopropanol, 1,2-propanediol, glycerin as well in particular one or more thickening agents, which or which chosen favorably can be from the group silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g. Hyaluronic acid, xanthan gum, hydroxypropyl methylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.

In particular, mixtures of the abovementioned solvents are used. For alcoholic Solvents can be another component of water.

Inventive emulsions are advantageous and contain e.g. the said fats, waxes and other fat bodies, as well as water and an emulsifier, as usually for one such type of formulation is used.

gels according to the invention usually contain Low C-number alcohols, e.g. Ethanol, isopropanol, 1,2-propanediol, Glycerol and water or an above-mentioned oil in the presence a thickening agent, preferably in oily-alcoholic gels Silica or an aluminum silicate, in aqueous-alcoholic or alcoholic Gels is preferably a polyacrylate.

When Propellant for according to the invention aerosol containers sprayable Preparations are the usual known volatile, liquefied Propellants, for example hydrocarbons (propane, butane, isobutane) suitable, which are used alone or in mixture with each other can. Also, compressed air is advantageous to use.

Advantageous can preparations according to the invention Furthermore Contain substances that absorb UV radiation in the UVB range, the total amount of filter substances being e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1.0 to 6.0% by weight is, based on the total weight of the preparations to cosmetic Preparations available to put the hair or the skin in front of the entire area protect the ultraviolet radiation. You can also as a sunscreen for Hair or the skin serve.

The following examples are intended to illustrate the present invention without limiting it. All amounts, proportions and percentages are, unless otherwise stated, percentages by weight, based on the weight and the total amount or on the total weight of the preparations. Example 1: W / O cream Polyglyceryl-3 diisostearate 5.0 Polyglyceryl-2 dipolyhydroxystearate 2.5 cetearyl 2 cetyl alcohol 2 C12-15 alkyl benzoate 8th Caprylic acid / capric acid triglyceride 6 octyldodecanol 5 Octamethyltetrasiloxane (cyclomethicone) 2 Süßholzuextrakt 5 Citric acid, sodium salt 0.5 butylmethoxydibenzoylmethane 0.5 ethylhexyl triazone 1 ethylhexylmethoxycinnamate 5 Mulberry extract (Uvae ursi) 0.1 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester 0.5 retinyl palmitate 0.05 phenoxyethanol 0.1 p-Hydroxybenzoic acid alkyls (paraben) 0.1 glycerin 7.5 Fillers (distarch phosphate, SiO ₂ , talc, aluminum stearate, BHT) 0.2 Perfume qs water Ad 100 Example 2: Hydrodispersion / gel cream cetyl alcohol 2 shea butter 1 Caprylic acid / capric acid triglyceride 2 octyldodecanol 1 Octamethyltetrasiloxane (cyclomethicone) 5 Dimethylpolysiloxane (dimethicone) 1 polydecene 2 ethylhexylmethoxycinnamate 3 Until Ethylhexyloxyphenol-methoxyphenyltriazin 0.5 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester 0.5 Octadecenedioic acid 0.5 sodium ascorbyl 0.05 Ubiquinol 0.2 phenoxyethanol 0.3 p-Hydroxybenzoic acid alkyls (paraben) 0.4 Crosslinked alkyl acrylate (alkyl acrylate cospolymer) 0.2 glycerin 5 Perfume qs water Ad 100

Claims (4)

Cosmetic or dermatological preparations containing 2-isopropyl-5-methylcyclohexanecarbonyl-D-alanine methyl ester and one or more skin lightening agents. Preparations according to Claim 1, characterized that the skin lightening agent (s) is chosen or are selected from the group octadecenedioic acid, 8-hexadecene-1,16-dicarboxylic acid, ursolic acid, agouti peptides, Licorice root extract, Hydroquinone, green tea extract, Arbutin, biotin, mulberry extract (Uvae ursii), glycyrrhizin, placental extract, Ascorbyl glucosides, endothelin antagonists from chamomile extract. Preparations according to one of the preceding claims, characterized in that it is 0.001% by weight to 10% by weight, preferably 0.01 Wt .-% to 1.0 wt .-%, in particular 0.05-0.5 wt .-%, based on the Total weight of preparations containing 2-isopropyl-5-methyl-cyclohexanecarbonyl-D-alanine methyl ester. Use of preparations according to one of the preceding claims to lighten the skin.