DE102004009154A1 - Novel combination of hexyl 2-(4-diethylamino-2-hydroxybenzoyl)-benzoate and triheptylin is used as a light stabilizer especially in cosmetics or dermatological compositions - Google Patents

Abstract

A light-protective combination of hexyl 2-(4-diethylamino-2-hydroxybenzoyl)-benzoate and triheptylin (glyceryl triheptanoate) is new. An independent claim is also included for the use of triheptylin as a solvent, solvent aid or solubilizer for hexyl 2-(4-diethylamino-2-hydroxybenzoyl)-benzoate, especially in light stabilizers.

Description

The The present invention relates to cosmetic and dermatological sunscreen preparations, in particular skin care cosmetic and dermatological sunscreen preparations.

The damaging Effect of the ultraviolet part of solar radiation on the skin is well known. While Beams with one wavelength, which is less than 290 nm (the so-called UVC range), from the Ozone layer in the earth's atmosphere be absorbed, causing rays in the range between 290 nm and 320 nm, the so-called UVB range, an erythema, a simple Sunburn or even more or less severe burns.

When a maximum of the erythema efficiency of sunlight becomes the tighter Range indicated around 308 nm.

To the Protection against UVB radiation, numerous compounds are known which are mostly derivatives of the 3-benzylidene camphor, 4-aminobenzoic acid, the cinnamic acid, salicylic acid, benzophenone and 2-phenylbenzimidazole.

Also for the Range between about 320 nm and about 400 nm, the so-called UVA range, it is important to have available filter substances, as well as its Rays damage can cause. It has been proven that UVA radiation to injury the elastic and collagen fibers of the connective tissue performs what the skin ages prematurely, and that she as the cause of numerous phototoxic and photoallergic reactions see is. The injurious Influence of UVB radiation can be amplified by UVA radiation.

The UV radiation can also lead to photochemical reactions, wherein then the photochemical reaction products in the skin metabolism intervention.

mainly are such photochemical reaction products to free radical compounds, e.g. Hydroxyl radicals. Also undefined radical photoproducts that are formed in the skin itself, can because of their high reactivity uncontrolled follow-up reactions to the day. But also singlet oxygen, a non-radical excited state of the oxygen molecule can occur in UV irradiation, as are short-lived epoxides and many Other. Singlet oxygen, for example, stands out over the normally present triplet oxygen (radical ground state) by increased reactivity out. However, there are also excited, reactive (radical) triplet states of the oxygen molecule.

Further counts UV radiation to ionizing radiation. So there is a risk that even ionic species at UV exposure, which in turn oxidative in to be able to intervene in the biochemical processes.

worin

• • R¹ und R² unabhängig voneinander Wasserstoff, C₁-C₂₀-Alkyl, C₃-C₁₀-Cycloalkyl oder C₃-C₁₀-Cycloalkenyl bedeuten, wobei die Substituenten R¹ und R² gemeinsam mit dem Stickstoffatom, an das sie gebunden sind, einen 5- oder 6-Ring bilden können und
• • R³ einen C₁-C₂₀-Alkyl Rest bedeutet.

Advantageous photoprotective hydroxybenzophenones are characterized by the following generic structural formula:

wherein

• • R ¹ and R ² independently of one another are hydrogen, C ₁ -C ₂₀ -alkyl, C ₃ -C ₁₀ -cycloalkyl or C ₃ -C ₁₀ -cycloalkenyl, where the substituents R ¹ and R ² together with the nitrogen atom to which they are bound to form a 5- or 6-ring and
• • R ^{3 is} a C ₁ -C ₂₀ -alkyl radical.

und unter dem Uvinul A Plus bei der Fa. BASF erhältlich ist.A particularly advantageous hydroxybenzophenone in the context of the present invention is 2- (4'-diethylamino-2'-hydroxybenzoyl) -benzoic acid hexyl ester (also: aminobenzophenone), which has the following structure:

and Uvinul A Plus is available from BASF.

Of the The main disadvantage of this UV filter is its poor solubility in lipids. Known solvents for this UVB filters can a maximum of about 15 wt .-% of this filter, corresponding to about 1-1.5 wt .-% dissolved, and thus active, UV filter substance.

aus und kann, ebenfalls bekannterweise, als Lösungsmittel für viele organische Substanzen eingesetzt werden. Triheptylin ist beispielsweise erhältlich unter der Handelsbezeichnung Dermofeel TC7 von der Dr. Straetmans GmbH.The use of triheptylin in cosmetics is known per se. It is characterized by the structural formula

from and can, also known, be used as a solvent for many organic substances. Triheptylin is available, for example, under the trade name Dermofeel TC7 from Dr. Ing. Straetmans GmbH.

True, in DE 196 51 058 describe the use of tricaprylin to solubilize 4,4 ', 4''- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid tris (2-ethylhexyl ester). However, this document could not point the way to the present invention.

It was surprising and for the expert does not foresee that photoprotective drug combinations from 2- (4'-diethylamino-2'-hydroxybenzoyl) -benzoic acid hexyl ester and triheptylin, or the use of triheptylin as a solvent, solubilizers or solubilizer for 2- (4'-diethylamino-2'-hydroxybenzoyl) benzoate, especially for the use in light stabilizers, the disadvantages of the state the technology would remedy the situation.

It is possible according to the invention Use levels of 2- (4'-diethylamino-2'-hydroxybenzoyl) -benzoic acid hexyl ester in cosmetic or dermatological preparations against the State of the art to double.

It was surprising that the addition of triheptylin stabilized solutions of the 2- (4'-diet hylamino-2'-hydroxybenzoyl) -benzoesäurehexylester is effected, since the latter substance not only has poor solubility, but also easily recrystallized from its solution. The invention therefore also provides a process for stabilizing solutions of hexyl 2- (4'-diethylamino-2'-hydroxybenzoyl) benzoate, characterized in that an effective triheptylin content is added to such solutions.

The Total amount of 2- (4'-diethylamino-2'-hydroxybenzoyl) -benzoic acid hexyl ester in the finished cosmetic or dermatological preparations is advantageously from the range of 0.1-10.0 wt .-%, preferably 0.5-6.0 wt .-% selected based on the total weight of the preparations.

The Total amount of triheptylin in the finished cosmetic or dermatological Preparations are advantageously from the range of 0.1-25.0% by weight, preferably 0.5-15.0 % By weight selected, based on the total weight of the preparations.

It is an advantage, weight ratios of 2- (4'-diethylamino-2'-hydroxybenzoyl) -benzoic acid hexyl ester and triheptylin in the range of 1:25 to 5: 1, preferably 1: 5 to 4: 1, to choose.

Cosmetic and dermatological preparations according to the invention advantageously also contain inorganic pigments based on metal oxides and / or other sparingly soluble or insoluble metal compounds, in particular the oxides of titanium (TiO ₂ ), zinc (ZnO), iron (eg Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon (SiO ₂ ), manganese (eg MnO), aluminum (Al ₂ O ₃ ), cerium (eg Ce ₂ O ₃ ), mixed oxides of the corresponding metals and mixtures of such oxides. Particular preference is given to pigments based on TiO ₂ .

It is particularly advantageous in the context of the present invention, although not mandatory if the inorganic pigments are in hydrophobic form that is, they superficial are treated water-repellent. This surface treatment can consist of that the Pigments according to known methods with a thin hydrophobic Layer be provided.

One such method is, for example, that the hydrophobic surface layer according to a reaction according to n TiO ₂ + m (RO) ₃ Si-R '→ n TiO ₂ (surface) is produced. n and m are stoichiometric parameters to be used as desired, R and R 'are the desired organic radicals. For example, in analogy to DE-OS 33 14 742 illustrated hydrophobized pigments are advantageous.

Advantageous TiO ₂ pigments are available, for example, under the trade names MT 100 T from TAYCA, furthermore M 160 from Kemira and T 805 from Degussa.

The cosmetic according to the invention and / or dermatological sunscreen formulations may be compounded as usual and cosmetic and / or dermatological light protection, furthermore for the treatment, care and cleansing of the skin and / or hair and as a make-up product in decorative cosmetics.

to Application are the cosmetic and dermatological according to the invention Preparations in the for Cosmetics usual Applied to the skin and / or hair in sufficient quantity.

Especially preferred are those cosmetic and dermatological preparations, which are in the form of a sunscreen. Advantageous can this in addition at least one further UVA filter and / or at least one other UVB filter and / or at least one inorganic pigment, preferred an inorganic micropigment.

The cosmetic according to the invention and dermatological preparations may be cosmetic adjuncts contain as they usually do used in such preparations, e.g. Preservatives, Bactericides, perfumes, Substances for preventing foaming, dyes, pigments, the one coloring Have effect, thickener, moisturizing and / or moisturizing Substances, fats, oils, waxes or other usual ones Components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

One additional Content of antioxidants is generally preferred. According to the invention may as cheap antioxidants all for cosmetic and / or dermatological applications suitable or common Antioxidants are used.

Advantageously, the antioxidants are selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, Glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters ) as well as their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg buthionine sulfoximines, homocysteinesulfoximine, buthionine sulfones, penta, hexa, H eptathioninsulfoximin) in very low tolerated dosages (eg pmol to μmol / kg), furthermore (metal) chelators (eg α-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (eg citric acid, lactic acid, malic acid), humic acid, bile acid , Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, furfurylidene sorbitol and its derivatives, ubiquinone and ubiquinol and derivatives thereof, vitamin C and Derivatives (eg, ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg, vitamin E acetate), vitamin A and derivatives (vitamin A palmitate), and benzylic resin coniferyl benzoate, rutinic acid and derivatives thereof, α-glycosyl rutin, ferulic acid , Furfurylidenglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and their derivatives, mannose and derivatives thereof, zinc and its derivatives (eg ZnO, ZnSO ₄ ) selenium and its derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters , Ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these drugs.

The Amount of the aforementioned antioxidants (one or more compounds) in the preparations preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 0.1 to 5% by weight, based on the total weight of the preparation.

Provided Vitamin E and / or derivatives thereof are the antioxidant (s), is advantageous, their respective concentrations from the field from 0.001-10 Wt .-%, based on the total weight of the formulation to choose.

Provided Vitamin A, or vitamin A derivatives, or carotenes or their derivatives the one or more antioxidants are advantageous, their respective Concentrations in the range of 0.001-10 wt .-%, based on the Total weight of the formulation to choose.

• – Mineralöle, Mineralwachse
• – Öle, wie Triglyceride der Caprin- oder der Caprylsäure, vorzugsweise aber Rizinusöl;
• – Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z.B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;
• – Alkylbenzoate;
• – Silikonöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils, such as triglycerides of capric or caprylic, but preferably castor oil;
• Fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with lower C-number alcohols, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with lower C-number alkanoic acids or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of Emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected the group of esters from saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain catches of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then chosen advantageous are from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, Isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. Jojoba oil.

Further can the oil phase chosen favorably are from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ether, the group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, especially 12-18 C-atoms. The fatty acid triglycerides can for example, advantageously chosen are from the group of synthetic, semisynthetic and natural (Oils, e.g. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like more.

Also any mixtures of such oil and wax components are advantageous in the sense of the present Use invention. It may also be advantageous if Waxes, for example cetyl palmitate, as the sole lipid component the oil phase use.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, butylene glycol dicaprylate / dicaprate, dicaprylyl carbonate, C ₁₂ -C ₁₃ alkyl tartrate, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

From The hydrocarbons are paraffin oil, squalane and squalene advantageous to be used in the sense of the present invention.

Advantageous can the oil phase also have a content of cyclic or linear silicone oils or Completely from such oils although it is preferred, except the silicone oil or silicone oils additional Content of other oil phase components to use.

Advantageous Cyclomethicone (Octamethylcyclotetrasiloxan) is used as a silicone oil to be used according to the invention. But also other silicone oils are advantageous for the purposes of the present invention to use for example, hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

• – Alkohole, Diole oder Polyole niedriger C-Zahl, sowie deren Ether, vorzugsweise Ethanol, Isopropanol, Propylenglykol, Glycerin, Ethylenglykol, Ethylenglykolmonoethyl- oder -monobutylether, Propylenglykolmonomethyl, -monoethyl- oder -monobutylether, Diethylenglykolmonomethyl- oder -monoethylether und analoge Produkte, ferner Alkohole niedriger C-Zahl, z.B. Ethanol, Isopropanol, 1,2-Propandiol, Glycerin sowie insbesondere ein oder mehrere Verdickungsmittel, welches oder welche vorteilhaft gewählt werden können aus der Gruppe Siliciumdioxid, Aluminiumsilikate, Polysaccharide bzw. deren Derivate, z.B. Hyaluronsäure, Xanthangummi, Hydroxypropylmethylcellulose, besonders vorteilhaft aus der Gruppe der Polyacrylate, bevorzugt ein Polyacrylat aus der Gruppe der sogenannten Carbopole, beispielsweise Carbopole der Typen 980, 981, 1382, 2984, 5984, jeweils einzeln oder in Kombination.

The aqueous phase of the preparations according to the invention optionally contains advantageous

• Alcohols, diols or polyols of low C number, and also their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore low C-number alcohols, for example ethanol, isopropanol, 1,2-propanediol, glycerol and in particular one or more thickening agents, which can be advantageously selected from the group of silicon dioxide, aluminum silicates, polysaccharides or their derivatives, for example hyaluronic acid, xanthan gum , Hydroxypropylmethylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of so-called Carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.

The cosmetic or dermatological sunscreen preparations advantageously inorganic pigments, in particular micropigments, e.g. in amounts of 0.1 wt .-% to 30 wt .-%, preferably in amounts of 0.5% by weight to 10% by weight, but in particular 1% by weight to 6% by weight, based on the total weight of the preparations.

It is advantageous according to the invention except the combinations according to the invention oil-soluble UVA filters and / or UVB filters in the lipid phase and / or water-soluble UVA filters and / or UVB filters in the aqueous phase use.

Advantageous can the sunscreen formulations according to the invention contain other substances that absorb UV radiation in the UVB range, the total amount of filter substances being e.g. 0.1% by weight to 30 Wt .-%, preferably 0.5 to 20 wt .-%, in particular 1 to 15 wt .-% is, based on the total weight of the preparations to cosmetic Preparations available to put the skin in front of the entire area of the ultraviolet Protect radiation. You can also serve as a sunscreen.

• – 3-Benzylidencampher-Derivate, vorzugsweise 3-(4-Methylbenzyliden)campher, 3-Benzylidencampher;
• – 4-Aminobenzoesäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoesäure(2-ethylhexyl)ester, 4-(Dimethylamino)benzoesäureamylester;
• – Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• – Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2-Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon;
• – Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)ester;

Vorteilhafte wasserlösliche UVB-Filtersubstanzen sind z.B.:

• – Salze der 2-Phenylbenzimidazol-5-sulfonsäure wie ihr Natrium-, Kalium- oder ihr Triethanolammonium-Salz, sowie die Sulfonsäure selbst;
• – Sulfonsäure-Derivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzophenon-5-sulfonsäure und deren Salze;
• – Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z.B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure,2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und deren Salze.

The other UVB filters may be oil-soluble or water-soluble. Advantageous oil-soluble UVB filter substances are, for example:

• 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
• 4-aminobenzoic acid derivatives, preferably 2-ethylhexyl 4- (dimethylamino) benzoate, 4- (dimethylamino) benzoic acid amyl ester;
• Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
• Esters of benzalmalonic acid, preferably di-2-ethylhexyl 4-methoxybenzalmalonate;

Advantageous water-soluble UVB filter substances are, for example:

• Salts of 2-phenylbenzimidazole-5-sulphonic acid, such as its sodium, potassium or triethanolammonium salt, and the sulphonic acid itself;
• Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-Benzylidencamphers, such as 4- (2-oxo-3-bomylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfonic acid and salts thereof.

The List of other UVB filters mentioned in combination with the active compound combinations according to the invention can be used should of course not limiting.

It may also be advantageous, the combinations of the invention with others To combine UVA filters that were previously commonly used in cosmetic Preparations are included. These substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. These combinations or preparations containing these combinations contain, are the subject of the invention. It can be used for the UVB combination Quantities are used.

Also advantageous according to the invention is 2,4-bis [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) -imino] -6- (2-ethylhexyl) -imino-1,3,5-triazine having the CAS no. 288254-16-0, which is available from 3V Sigma under the trade name Uvasorb K2A ^®.

Advantageous broadband filters or UV-B filter substances are, for example, triazine derivatives, such as. B. dioctylbutylamidotriazone (INCI: diethylhexyl butamido triazone), which is available under the trade designation UVASORB HEB from Sigma 3V; and 4,4 ', 4''- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2-ethylhexyl ester), also: 2,4,6-tris [ anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: octyl Triazone), which is sold by BASF Aktiengesellschaft under the trade name Uvinul ^® T 150th

Favorable Broadband filter according to the present invention is also the 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.

Bis-resorcinyl triazine derivatives are also advantageous UV filter substances for the purposes of the present invention. Particularly advantageous according to the invention is 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Bis , which is available under the trade name Tinosorb ^® S from CIBA-Chemikalien GmbH -Ethylhexyloxylphenol methoxyphenyl triazine). Another advantageous bis-resorcinyl triazine derivative is 2- [4,6-bis (2,4-dimethylphenyl) -1,3,5-triazin-2-yl] -5- (octyloxy) phenol (CAS No .: 2725- 22-6).

An advantageous broadband filter for the purposes of the present invention is also the 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which is available under the trade name Tinosorb ^® M from CIBA-Chemikalien GmbH.

Favorable Broadband filter according to the present invention is also the 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.

Especially Advantageous UV filter substances are also phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt (INCI: bisimidazylate, trade name: Neoheliopan AP), and 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI: Octocrylene, trade name: Uvinul N-539),

Further is advantageous, the active compound combinations according to the invention with other UVA and / or UVB filters to combine.

It is also particularly advantageous to use the active compound combinations according to the invention with salicylic acid derivatives, some of which are known, which can also absorb UV radiation. To common UV filters belong

object The invention also provides a method for producing the cosmetic according to the invention and / or dermatological sunscreen preparations obtained therefrom characterized in that one in a conventional manner, the - (4'-diethylamino-2'-hydroxybenzoyl) -benzoesäurehexylester in triheptyl or an oil phase containing triheptylin with uniform stirring and optionally below Heating suspended and if desired homogenized, optionally with other lipid components and optionally combined with one or more emulsifiers, hereinafter the oil phase with the aqueous phase, in which optionally a thickener has been incorporated is, and which preferably has about the same temperature like the oil phase, if desired, mixed homogenized and allowed to cool to room temperature. After cooling to Room temperature can, especially if still volatile components incorporated are to be repeated homogenization done.

The The following examples are intended to illustrate the present invention, without restricting it. All Quantities, percentages and percentages are, unless otherwise stated indicated on the weight and the total amount or on the total weight the preparations.

I. O / W sunscreen emulsions

II. Foamed O / W Emulsions:

Union the at 78 ° C heated fat / sunscreen filter phase with the heated to 75 ° C water / sunscreen filter phase. Homogenization by means of a sprocket dispersing machine (rotor-stator principle) at 65 ° C. Stirring for 45 min in Becomix with gassing with nitrogen at 1 bar with cooling 30 ° C. encore the additive at 30 ° C (Perfume). Homogenization by means of a sprocket dispersing machine (rotor-stator principle) at 23 ° C.

Union the at 78 ° C heated fat / sunscreen filter phase with the heated to 75 ° C water / sunscreen filter phase. Homogenization by means of a sprocket dispersing machine (rotor-stator principle) at 65 ° C. Stirring for 45 min in Becomix with fumigation with helium at 1 bar with cooling on 30 ° C. encore the additive at 30 ° C (Perfume). Homogenization by means of a sprocket dispersing machine (rotor-stator principle) at 23 ° C.

III. PIT emulsions (for use as a soaking solution, spray or aerosol)

IV. Thin-liquid to sprayable W / O emulsions (for use as impregnation solution, spray or aerosol)

V. W / O Sunscreen Emulsions (Creams & Lotions)

VI. Hydrodispersions (for use as lotion, impregnation solution or spray)

VII. Solid-State Emulsions ("Pickering Emulsions")

VIII. Oils and oil gels

IX. concentrates

Claims (4)

Sunscreen effective drug combinations 2- (4'-diethylamino-2'-hydroxybenzoyl) benzoate and triheptylin. Use of triheptylin as solvent, solubilizer or solubilizer for 2- (4'-diethylamino-2'-hydroxybenzoyl) benzoate, especially for the use in sunscreens. Combinations according to claim 1 or use according to Claim 2, characterized in that the total amount of hexyl 2- (4'-diethylamino-2'-hydroxybenzoyl) benzoate in the finished cosmetic or dermatological preparations from the range of 0.1-10.0 Wt .-%, preferably 0.5-6.0 % By weight selected is, in each case based on the total weight of the preparations. Combinations according to claim 1 or use according to Claim 2, characterized in that the total amount of triheptylin in the finished cosmetic or dermatological preparations from the range of 0.1-25.0 Wt .-%, preferably 0.5-15.0 % By weight selected is, in each case based on the total weight of the preparations.