DE10146330A1 - Optical stimulation method and arrangement for stimulation of the visual system with responses to visual excitation contained in the ERG, EEG and MEG detected and processed - Google Patents

Optical stimulation method and arrangement for stimulation of the visual system with responses to visual excitation contained in the ERG, EEG and MEG detected and processed

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Publication number
DE10146330A1
DE10146330A1 DE10146330A DE10146330A DE10146330A1 DE 10146330 A1 DE10146330 A1 DE 10146330A1 DE 10146330 A DE10146330 A DE 10146330A DE 10146330 A DE10146330 A DE 10146330A DE 10146330 A1 DE10146330 A1 DE 10146330A1
Authority
DE
Germany
Prior art keywords
visual
eeg
stimulation
light
optical stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10146330A
Other languages
German (de)
Inventor
Peter Husar
Guenter Henning
Andreas Goetze
Klaus Schellhorn
Falk Schlegelmilch
Sebastian Berkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenoptik AG
Original Assignee
Technische Universitaet Ilmenau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Ilmenau filed Critical Technische Universitaet Ilmenau
Priority to DE10146330A priority Critical patent/DE10146330A1/en
Priority to PCT/EP2001/013477 priority patent/WO2002041768A1/en
Priority to AU2002217045A priority patent/AU2002217045A1/en
Priority to JP2002543952A priority patent/JP2004517658A/en
Priority to US10/432,834 priority patent/US7222964B2/en
Publication of DE10146330A1 publication Critical patent/DE10146330A1/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
    • A61B3/024—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/378—Visual stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pathology (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

Method for optical stimulation of the visual system for examination of the perimeter. For optical stimulation stepped light intensities are used, temporal variation of the spatial pattern used as a light stimulus is set in response to the visual system's response to the stimuli, i.e. a feedback mechanism, and signal processing methods are used to test and analyze the response to the stimuli. An Independent claim is made for a method for automatic functional control of the visual system.

Description

Die Erfindung betrifft ein Verfahren zur optischen Stimulation des visuellen Systems mit unterschiedlichen Lichtintensitäten entsprechend den Anforderungen der statischen Perimetrie und zur objektiven Auswertung adäquater stimulusbezogener elektro- und/oder magnetophysiologischer Größen.The invention relates to a method for optical Stimulation of the visual system with different Light intensities according to the requirements of static perimetry and adequate for objective evaluation stimulus-related electro- and / or magnetophysiological Sizes.

Im Stand der Technik sind Stimulationssysteme der objektiven Perimetrie bekannt, die binär gesteuerte Lichtstimulatoren verwenden. So werden beispielsweise in der Perimetrie kurzzeitig monofokal aufleuchtende Lichtmarken definierter Intensität benutzt, um die Funktionsfähigkeit des visuellen Systems zu überprüfen.In the prior art, stimulation systems are objective Perimetry known, the binary controlled light stimulators use. For example, in perimetry briefly monofocal lighting marks defined Intensity used to ensure the functionality of the visual Check system.

In neueren Systemen werden multifokale (simultan an mehreren Orten) optische Reize eingesetzt, deren zeitlicher Ablauf in der Regel von pseudo-zufälligen binären Sequenzen - allgemein als m-Sequenzen, MLS (Maximum Length Sequence) oder PRBS (Pseudo Random Binary Sequence) bekannt - gesteuert wird.In newer systems, multifocal (simultaneously on several Places) optical stimuli used, the chronological sequence in the rule of pseudo-random binary sequences - general as m-sequences, MLS (Maximum Length Sequence) or PRBS (Pseudo Random Binary Sequence) known - is controlled.

Bei den bisherigen Verfahren ist nachteilig, dass die - ob mono- oder multifokal - generierten optischen Reize während einer Untersuchung einen konstanten Intensitätspegel aufweisen. A disadvantage of the previous methods is that the - whether mono- or multifocal - generated optical stimuli during an examination a constant intensity level exhibit.  

Mit einem solchen Stimulationsmodus sind nur absolute Skotome (örtlicher Totalausfall der visuellen Funktion) und ein geringer Anteil starker relativer Skotome (örtlicher Teilausfall der visuellen Funktion, abgesenkte Empfindlichkeit) zuverlässig diagnostizierbar.With such a stimulation mode there are only absolute scotomas (local total loss of visual function) and a low proportion of strong relative scotomas (local Partial failure of the visual function, lowered Sensitivity) can be reliably diagnosed.

Zur objektiven Beantwortung der Frage nach der Wahrnehmung eines Lichtreizes an einem bestimmten retinalen Ort wird das EEG des Untersuchten analysiert und nach objektiven Kriterien das Vorhandensein einer Reizantwort detektiert. Damit liegt ein objektives topologisches Untersuchungsergebnis zur visuellen Funktion vor - allerdings nur für einen Intensitätspegel der Lichtreize.For an objective answer to the question of perception of a light stimulus at a certain retinal location EEG of the examined analyzed and according to objective criteria the presence of a stimulus response is detected. With that lies an objective topological examination result for visual function - but only for one Intensity level of the light stimuli.

Bei den viel häufigeren relativen Skotomen ist es notwendig, mehrere logarithmisch abgestufte Lichtpegel zu verwenden, um lokal auftretende Empfindlichkeitsverluste topographisch zu erfassen, wie dies in der statischen Perimetrie üblich ist.With the much more common relative scotomas it is necessary to use multiple logarithmically graded light levels locally occurring sensitivity losses topographically capture, as is common in static perimetry.

Unter Verwendung der bisherigen Stimulationsmethoden würde die Objektivierung der statischen Perimetrie eine inakzeptable Verlängerung der Untersuchungszeit zur Folge haben.Using the previous stimulation methods the objectification of static perimetry unacceptable extension of the examination time to have.

Aufgabe der Erfindung ist es deshalb, ein Verfahren anzugeben, mit dem es möglich ist, in sinnesphysiologisch adäquater Weise einen bezüglich des Zeitverlaufs und der verwendeten Intensitätspegel im Sinne der Signaltheorie optimierten optischen Reiz zu generieren und anhand einer oder mehrerer elektro- und/oder magnetophysiologischer Größen die Wahrnehmungsfunktion bezüglich der Empfindlichkeit topographisch zu überprüfen. The object of the invention is therefore a method specify with which it is possible in sensory physiological adequately one with respect to the passage of time and the used intensity level in the sense of signal theory to generate an optimized optical stimulus and based on a or several electro- and / or magnetophysiological variables the perceptual function regarding sensitivity to check topographically.  

Erfindungsgemäß gelingt die Lösung dieser Aufgabe mit den kennzeichnenden Merkmalen des Patentanspruches 1.According to the invention this problem is solved with the characterizing features of claim 1.

Vorteilhafte Ausgestaltungen des erfindungsgemäßen Verfahrens sind in den Unteransprüchen angegeben.Advantageous embodiments of the method according to the invention are specified in the subclaims.

Bei dem erfindungsgemäßen Verfahren ist von Vorteil, dass mit ihm das Empfindlichkeitsprofil des Gesichtsfeldes - wie in der statischen Perimetrie üblich - erstellt werden kann. Dies war bei den bisherigen Methoden nicht der Fall. Damit wird erstmals ein direkter Vergleich von subjektiven und objektiven perimetrischen Untersuchungsergebnissen möglich. Da das neue Verfahren völlig automatisch abläuft, ist die Patientenbelastung besonders niedrig. Ein wesentliches Merkmal ist weiterhin eine deutlich höhere funktionsdiagnostische Zuverlässigkeit, die sich aus der Eliminierung von Fehlern des Patienten sowie des untersuchenden Arztes ergibt.It is advantageous in the method according to the invention that with him the sensitivity profile of the visual field - as in static perimetry - can be created. This was not the case with the previous methods. So that will for the first time a direct comparison of subjective and objective perimetric test results possible. Since the new procedure runs completely automatically, the Patient burden particularly low. An essential one Characteristic is still a significantly higher one functional diagnostic reliability resulting from the Elimination of patient and patient errors examining doctor results.

Die Erfindung wird im Folgenden mit Hilfe einer Zeichnung näher erläutert. Die dazugehörige Zeichnung zeigt:The invention is described below with the aid of a drawing explained in more detail. The accompanying drawing shows:

Fig. 1 ein Blockschaltbild des Messplatzes zur Ermittlung des Empfindlichkeitsprofils des visuellen Systems Fig. 1 is a block diagram of the measuring station for determining the sensitivity profile of the visual system

Der Patient sitzt vor einer kugelförmigen Projektionsfläche - dem Perimeter 1 - in der an definierten Stellen Lichtreize adäquater Intensität entweder mittels aktiver Lichtquellen (LED - lichtemittierende Dioden) oder mit einem Projektionssystem mit einer kalibrierten Lichtquelle erzeugt werden. Diese Lichtreize werden von einem Steuerrechner 2 derart gesteuert, dass der zeitliche Intensitätsverlauf des abgestrahlten Lichtes entsprechend den Forderungen der Signaltheorie in seinen statistischen Momenten der vorgegebenen Korrelationsfunktion entspricht. Die Lichtintensität sowie der zeitliche Verlauf des von den Lichtquellen produzierten Lichtreizes sind in ausreichender Breite über den physiologisch interessierenden Bereich einstellbar.The patient sits in front of a spherical projection surface - the perimeter 1 - in which light stimuli of adequate intensity are generated at defined points either by means of active light sources (LED - light-emitting diodes) or with a projection system with a calibrated light source. These light stimuli are controlled by a control computer 2 in such a way that the temporal intensity profile of the emitted light corresponds in its statistical moments to the predefined correlation function in accordance with the requirements of signal theory. The light intensity and the temporal course of the light stimuli produced by the light sources can be set to a sufficient width over the physiologically interesting range.

Ein solcher optischer Reiz ruft Veränderungen - auch Reizantworten genannt - im EEG/MEG hervor. Diese Antworten werden mit geeigneter Technik 3, einem ERG/EEG-Meßsystem und einem AD-Wandler, erfasst, verstärkt und digitalisiert. Die digitalisierten Reizantworten werden im Steuerrechner 2 verarbeitet und ausgewertet. Such an optical stimulus causes changes - also called stimulus responses - in the EEG / MEG. These answers are recorded, amplified and digitized using suitable technology 3 , an ERG / EEG measurement system and an AD converter. The digitized stimulus responses are processed and evaluated in the control computer 2 .

BezugszeichenlisteLIST OF REFERENCE NUMBERS

11

Perimeterkugel mit Lichtquellen
Perimeter ball with light sources

22

Steuerrechner
tax calculator

33

ERG/EEG-Meßsystem, AD-Wandler
EEG Elektroenzephalogramm
MEG Magnetoenzephalogramm
ERG Elektroretinogramm
ERG / EEG measuring system, AD converter
EEG electroencephalogram
MEG magnetoencephalogram
ERG electroretinogram

Claims (4)

1. Verfahren für die objektive statische Perimetrie, dadurch gekennzeichnet, dass in einer perimetrischen Untersuchung zur optischen Stimulation des visuellen Systems abgestufte Lichtintensitäten verwendet werden, der zeitliche Verlauf und das räumliche Muster der Lichtreize hinsichtlich eines objektiven Nachweises von Reizantworten im EEG bestimmt und mit Methoden der Signalverarbeitung analysiert und mit einem Detektionstest auf Vorhandensein objektiv geprüft werden.1. A method for objective static perimetry, characterized in that graded light intensities are used in a perimetric examination for optical stimulation of the visual system, the temporal course and the spatial pattern of the light stimuli are determined with regard to an objective detection of stimulus responses in the EEG and with methods of Signal processing can be analyzed and objectively checked with a detection test. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, dass zur optischen Stimulation in der perimetrischen Einrichtung die Lichtquelle oder die Lichtquellen so gesteuert werden, dass sinnesphysiologisch unterscheidbare abgestufte Lichtintensitäten wahrnehmbar sind.2. The method according to claim 1, characterized in that that for optical stimulation in the perimetric Setup the light source or light sources like this be controlled that sensory physiologically distinguishable graded light intensities are noticeable. 3. Verfahren nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass das verstärkte EEG digitalisiert und einem Auswertsystem zugeführt wird.3. The method according to any one of claims 1 or 2, characterized characterized that the reinforced EEG digitized and is fed to an evaluation system. 4. Verfahren nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass nach Verwendung geeigneter Auswertalgorithmen das objektive Empfindlichkeitsprofil des Gesichtsfeldes erstellt werden kann.4. The method according to any one of claims 1 to 3, characterized characterized that after using appropriate Evaluation algorithms the objective Sensitivity profile of the visual field created can be.
DE10146330A 2000-11-22 2001-09-20 Optical stimulation method and arrangement for stimulation of the visual system with responses to visual excitation contained in the ERG, EEG and MEG detected and processed Withdrawn DE10146330A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE10146330A DE10146330A1 (en) 2000-11-22 2001-09-20 Optical stimulation method and arrangement for stimulation of the visual system with responses to visual excitation contained in the ERG, EEG and MEG detected and processed
PCT/EP2001/013477 WO2002041768A1 (en) 2000-11-22 2001-11-21 Method and arrangement for optically stimulating the visual system
AU2002217045A AU2002217045A1 (en) 2000-11-22 2001-11-21 Method and arrangement for optically stimulating the visual system
JP2002543952A JP2004517658A (en) 2000-11-22 2001-11-21 Method and apparatus for optically stimulating the visual system
US10/432,834 US7222964B2 (en) 2000-11-22 2001-11-21 Method and arrangement for optically stimulating the visual system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10058127 2000-11-22
DE10146330A DE10146330A1 (en) 2000-11-22 2001-09-20 Optical stimulation method and arrangement for stimulation of the visual system with responses to visual excitation contained in the ERG, EEG and MEG detected and processed

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DE10146330A1 true DE10146330A1 (en) 2002-06-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009010628A1 (en) * 2009-02-20 2010-08-26 Technische Universität Ilmenau Patient's visual system i.e. eye, stimulation method, involves detecting, compensating and considering geometrical and spectral false stimulation, fundus information and motion artifacts using correction parameters in iterative process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009010628A1 (en) * 2009-02-20 2010-08-26 Technische Universität Ilmenau Patient's visual system i.e. eye, stimulation method, involves detecting, compensating and considering geometrical and spectral false stimulation, fundus information and motion artifacts using correction parameters in iterative process
DE102009010628B4 (en) * 2009-02-20 2010-10-14 Technische Universität Ilmenau Method and device for color channel-selective, fundus-controlled stimulation of the visual system

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Owner name: HUSAR, PETER, DR.-ING. HABIL., 98693 ILMENAU, DE H

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Effective date: 20120403