DE10082749T1 - Controlled release from copolymers of acrylic or methacrylic acid / L-dopa, acrylic or methacrylic acid / L-a-methyldopa, acrylic or methacrylic acid / carbidopa and their combinations - Google Patents
Controlled release from copolymers of acrylic or methacrylic acid / L-dopa, acrylic or methacrylic acid / L-a-methyldopa, acrylic or methacrylic acid / carbidopa and their combinationsInfo
- Publication number
- DE10082749T1 DE10082749T1 DE10082749T DE10082749T DE10082749T1 DE 10082749 T1 DE10082749 T1 DE 10082749T1 DE 10082749 T DE10082749 T DE 10082749T DE 10082749 T DE10082749 T DE 10082749T DE 10082749 T1 DE10082749 T1 DE 10082749T1
- Authority
- DE
- Germany
- Prior art keywords
- acrylic
- methacrylic acid
- methyldopa
- carbidopa
- dopa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 title 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 title 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title 1
- CJCSPKMFHVPWAR-JTQLQIEISA-N alpha-methyl-L-dopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 title 1
- 229960004205 carbidopa Drugs 0.000 title 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
- 229920001577 copolymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9903382-8A BR9903382A (en) | 1999-08-04 | 1999-08-04 | Copolymers of acrylic or methacrylic acid / l-dopa, acrylic or methacrylic acid / l- <244> methyldopa or acrylic or methacrylic acid / l-carbidopa, process of obtaining it and drug compositions containing the same |
| PCT/BR2000/000086 WO2001010378A2 (en) | 1999-08-04 | 2000-08-02 | Controlled release from copolymers of acrylic or methacrylic acid/l-dopa, acrylic or methacrylic acid/l-$g(a)-methyl dopa, acrylic or methacrylic acid/carbidopa and their combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10082749T1 true DE10082749T1 (en) | 2001-11-22 |
Family
ID=4073069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10082749T Withdrawn DE10082749T1 (en) | 1999-08-04 | 2000-08-02 | Controlled release from copolymers of acrylic or methacrylic acid / L-dopa, acrylic or methacrylic acid / L-a-methyldopa, acrylic or methacrylic acid / carbidopa and their combinations |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1117370A1 (en) |
| AU (1) | AU6142600A (en) |
| BR (1) | BR9903382A (en) |
| CA (1) | CA2346291A1 (en) |
| DE (1) | DE10082749T1 (en) |
| GB (1) | GB2384426A (en) |
| WO (1) | WO2001010378A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2324810A1 (en) | 2009-11-19 | 2011-05-25 | Ivoclar Vivadent AG | Filled dental material based on polymerisable dihydroxyphenylalanine derivatives |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005056708A2 (en) * | 2003-12-09 | 2005-06-23 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| WO2006026504A2 (en) * | 2004-08-27 | 2006-03-09 | Spherics, Inc. | Mucoadhesive oral formulations of high permeability, high solubility drugs |
| JP2008516893A (en) * | 2004-08-27 | 2008-05-22 | スフェリックス，インク． | Multilayer tablets and bioadhesive dosage forms |
| US20060045865A1 (en) * | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| US8491929B2 (en) * | 2005-06-23 | 2013-07-23 | Vaunnex Inc. | Bioadhesive polymers |
| CN117919217A (en) * | 2022-10-14 | 2024-04-26 | 浙江华海药业股份有限公司 | Pharmaceutical composition for treating parkinsonism and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4908404A (en) * | 1988-08-22 | 1990-03-13 | Biopolymers, Inc. | Synthetic amino acid-and/or peptide-containing graft copolymers |
| JP3180106B2 (en) * | 1990-10-24 | 2001-06-25 | 株式会社三和化学研究所 | Method for producing organic polymer compound |
-
1999
- 1999-08-04 BR BR9903382-8A patent/BR9903382A/en unknown
-
2000
- 2000-08-02 CA CA002346291A patent/CA2346291A1/en not_active Abandoned
- 2000-08-02 AU AU61426/00A patent/AU6142600A/en not_active Abandoned
- 2000-08-02 EP EP00947704A patent/EP1117370A1/en not_active Withdrawn
- 2000-08-02 WO PCT/BR2000/000086 patent/WO2001010378A2/en not_active Application Discontinuation
- 2000-08-02 GB GB0111066A patent/GB2384426A/en not_active Withdrawn
- 2000-08-02 DE DE10082749T patent/DE10082749T1/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2324810A1 (en) | 2009-11-19 | 2011-05-25 | Ivoclar Vivadent AG | Filled dental material based on polymerisable dihydroxyphenylalanine derivatives |
| US8404760B2 (en) | 2009-11-19 | 2013-03-26 | Ivoclar Vivadent Ag | Filled dental material based on polymerizable dihydroxy-phenylalanine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1117370A1 (en) | 2001-07-25 |
| GB0111066D0 (en) | 2001-06-27 |
| AU6142600A (en) | 2001-03-05 |
| GB2384426A (en) | 2003-07-30 |
| WO2001010378A2 (en) | 2001-02-15 |
| CA2346291A1 (en) | 2001-02-15 |
| WO2001010378A3 (en) | 2001-08-30 |
| BR9903382A (en) | 2001-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8130 | Withdrawal |