DE10015928A1 - Carrier of a medicament or some other active substance administrable via skin comprises a protective layer which is provided with an electric conductor strip running over a separable section of the protective layer - Google Patents

Abstract

The carrier (1) of a medicament or some other active substance (3) administrable to its recipient via skin comprises a protective layer (4) which is provided with an electric conductor strip (5) running over a separable section of the protective layer.

Description

The invention relates to a carrier for a medicament with a carrier element that carries an active substance on at least one side, wherein the active substance before the application of the carrier element to the skin of a receiver is covered with a protective layer.

Such a carrier is usually referred to as a plaster. Pavement used in the medical-pharmaceutical field on the one hand to Superficially covering and protecting wounds, it is beyond that already known, drugs or active substances on such patches to apply that act on a recipient through the skin surface can what the carrier with its carrier element on the skin of the effect is to be glued to the receiver. As a rule, the substance is before the Ap application of the carrier element to the skin of the recipient with a Protective layer covered to free the substance from external, if necessary, to keep negative influences.

Medicinal or active substance substances that come into contact with the skin surface of a recipient, only act as a certain time diction on the recipient, the effect leaves after a certain Ap after plication time, so that a carrier element designed as a plaster after must be exchanged for a certain time.  

Often, drug or drug recipients can no longer sufficiently remember the time at which they are the wearer have created, there is a permanent disorder in not a few patients Knowing whether the duration of application of the active substance patch is still correct right or already exceeded.

The invention / innovation is based on the task of a carrier for Medicinal product or other active substance with the characteristics of the waiter Concept of claim 1 so that the carrier in particular with regard to its time of application with electronic additional can be queried. This task is marked by the characteristic male of claim 1 solved, advantageous developments or parallel Solutions result from the sub or subclaims.

As the essence of the invention, it is initially considered that the carrier element with to provide at least one conductor track, which has a severable Section of the protective layer runs. This means that the carrier element It can be electronically queried when the protective layer was first opened that is and whether the protective layer was intact before being applied. To the ends of the conductor track are advantageously electronic Evaluation and display circuit to connect the different Zu display statuses or save times so that the user of the Carrier is able to query when he is the drug carrier or put the patch on. It is also possible to use an alarm device to inform the user when the exposure time of the substance to the The recipient's skin has expired.  

The carrier can be inserted in a housing that the evaluation and Contains display device. When spoken of in claim 3 of housing different types of housings are included. A kind of this housing can according to claim 4 on the skin of the pharmaceutical temp are placed and fastened, the one with the evaluation and display Device provided housing can, for. B. in the manner of a watch case be trained or integrated into a watch worn on the body. The electronic device can be designed to be connected emits a signal with the carrier after the predeterminable time lapse, which The desired wearing time can be entered into the evaluation and display using input elements device can be entered.

Alternatively or additionally, it is also possible for the carrier to be cut off or individually in a row in a separate storage case is arranged that at least one conductor track or contact arrangement with Counter contacts of the housing cooperates and when removing the Trä gers out of the housing the interaction of the contacts either under broken or the conductor is cut. This storage device So the case is used to apply the carrier to the skin of the doctor before application to keep the new recipient. The evaluation unit is in this Trap not worn on the body, but remains stationary in the storage housing and reminds the user of the wearer from there that the Wearing time has expired or a new dose of medicine in patch form apply is. In addition, it is also possible to enter the expiry date in the Enter evaluation and display device. This ensures that outdated medicines are brought into contact with the skin.  

Claim 11 relates to a carrier for a medicament, with one on one Skin section of a carrier element which can be placed on a drug recipient, that carries a drug substance on at least one side. After this Characteristic is the carrier or a housing accommodating the carrier provided a plurality of sensors, the evaluation scarf via contacts tion are connected. This claim can be separate or in combination with the feature of claim 1 also solve the problem, the loading to provide users of the carrier with information about the purpose in which the carrier is and / or whether he should be replaced, if necessary zen or to be renewed.

The sensors according to claim 11 can be different sensors, which either have temperatures, moisture conditions, detect chemical states or the like or such states from the Palpate the skin of the user. The individual results from the claims 12-14.

The active substance according to claim 14 can either be a separate active substance be, which is only additionally placed on the carrier to a detectable Bring about reaction, but it is also possible that the active ingredient Medicinal product itself or an active ingredient contained in the medicinal substance is fabric. Non-medical active ingredients are also addressed, e.g. B. che mix or cosmetic active ingredients.

To the associated for the evaluation and display device It is useful to protect processors from the voltage sources required Lich, via the sensors or cutting the conductor tracks value and display device, d. H. the processor activity for the first time to ak activate.  

In a further development of the invention, it is also possible to add more to the carrier Integrate sensors that, for example, pulse rate, heart rhythm, Scan blood sugar, blood pressure and the like and either display or transmitted to a separate evaluation circuit by radio. So that exists the possibility of a recipient wearing the patch according to the invention, to monitor for his physical reaction and in the case of To give intolerances to the active substance warning signals for example in that the plaster should be removed immediately.

According to claim 23, activation elements are in the area of the substance available, through which the release of substances to the skin accelerates or ver can be hesitated. The possible activation elements are examples se heating elements, capacitive elements, chemical activators, moisture dispensing elements and the like. The control of the tax amount speed of the substance can be controlled from the outside, for example see a doctor who has the option of verifying with the carrier tied receiver device to access by radio.

A transmission device can also be arranged in the housing with which information stored in the evaluation circuit a separate evaluation computer can be transferred. This will it is possible that the physical reactions to a substance immediately recorded who that can.  

According to claim 27, the carrier with other identical or similar Carriers can be arranged in a common receiving box, with each When a carrier is removed, an electronic start pulse is generated in the recording generated device relating to a temporal reminder function triggers the maximum wearing time. This electronic start impulse can triggered by different sensors, for example by egg ne light barrier or the like.

If the evaluation and advertising is integrated in the carrier, it can be made of flexible film material. The carrier element can have a dome-like shape, it is possible on which the Arrange a solar cell facing away from the skin to a Support or form a voltage supply unit. It is also possible Lich to train the carrier from soft, pillow-like material, whereby increased comfort is achieved. In the same sense, it is possible also form the housing like a pillow, in which the carrier to inte is freeze.

According to claim 32, the carrier should be trained in the manner of a module carrier det and be in prescribed subjects medicinal products of different kinds or Number can be introduced. There are also different Senso ren provided, if necessary with electronic evaluation and Display circuits can be connected.

In a development of the invention, it is also possible to protect the protective film Patch between a battery contact and a contact of the evaluation  and display circuit so that when removing the Protective film of the battery contact contacts the mating contact and thus the Device is turned on.

The invention is based on exemplary embodiments in the drawings guren explained in more detail. These show:

Fig. 1 is a schematic sectional view through a plaster-like carrier with a substance that is covered by a protective layer over which a conductor runs;

Fig. 2 is a plan view of the carrier of FIG. 1:

Fig. 3 is a support which is inserted into a storage case with an electronic evaluating and display circuit;

Fig. 4 is a schematic sectional view of a carrier inserted into a housing before being placed on the skin surface;

Fig. 5 is a schematic representation of a housing in which a carrier is inserted;

Fig. 6 is a schematic sectional view through a housing with an inserted carrier;

Fig. 7 is a schematic representation of a carrier with inter grated evaluation and display circuit;

Fig. 8 is a schematic representation of a storage housing with several inserted carriers;

Fig. 9 shows a carrier with different active ingredients, sensors, evaluation elements and transmitting / receiving devices in a schematic representation.

The carrier 1 is intended to receive a medicament or another active substance that acts over the skin of a recipient. The carrier 1 has a carrier element 2 which carries on at least one side a medicament or active substance, which is referred to below as substance 3 . The substance 3 is covered with a protective layer 4 before the application of the Trägerelemen tes 2 on the skin of the drug recipient. The carrier element 2 is provided with a conductor track 5 which extends over a section 6 of the protective layer 4 which can be cut or opened.

The ends 7 of the conductor track 5 are connected to an electronic evaluation and display circuit 8 , via which the integrity of the protective layer 4 can be displayed on the one hand or in which a removal time of the carrier element 2 from a storage unit 9 can be saved.

The carrier 1 can be inserted into a housing 10 which contains the evaluation and display device 8 . It can be the housing 10 of the storage unit 9 . However, it is also conceivable to provide a housing 11 which can be placed on the skin 16 of the drug recipient and fastened there. The housing 11 provided with the evaluation and display device 8 can be designed in the manner of a watch case or can be integrated in a watch that can be worn on the body, for example a wristwatch.

An electronic start pulse can be generated by the conductor track 5 , which is processed by the evaluation and display device 8 and emits a warning signal after a predeterminable time period after the start pulse. For this purpose, the desired wearing time of the carrier 1 can be entered into the evaluation and display device 8 , for which purpose input elements 12 in the form of buttons, adjustment crowns and the like are provided.

In FIGS. 3 and 8 it can be seen how the carrier 1 in the form of individual applications such in the housing 10 of the storage unit 9 is disposed, said at least one conductor track 5 for a removal of the support or the support application from the housing 10 the conductor track is cut or the contacts 13 are interrupted.

Fig. 7 shows an integrated form of the carrier 1 , in which the carrier 1 itself is connected to the evaluation and display device 8 or comprises it inseparably. The evaluation and display unit 8 is connected to the carrier element 2 via a holding layer 14 . On the upper side 15 , the layer 14 is transparent or translucent, so that an optical display can shine through the layer 14 .

9 is referred to below . There, a carrier is shown with a carrier element 2 on which a plurality of sensors 20 , 21 are connected , which are connected via contacts 22 to an evaluation circuit 23 . The sensors 20 , 21 can be temperature or humidity sensors. The sensors 20 , 21 can, however, also be reactive to an active substance 24 , which is degraded on the skin of the drug recipient as the wearer 1 wears down. The active substance 24 can either be the medicament or an active substance contained in the medicinal substance. However, it is also possible to see a separate active ingredient which is attached separately to the substance 3 of the drug on the carrier element 2 and has no other medical effects on the recipient, but only has the task of reacting with appropriate sensors.

It is provided that the evaluation and display device 8 and / or the evaluation circuit 23 is activated for the first time via the sensors 20 , 21 and / or the cutting of the conductor track 5 .

Via the sensors 20 , 21 and the evaluation circuit 23 , a signal can be generated if a predetermined wearing or exposure time is sufficient, if the medicinal substance or the active substance has been consumed without a medicinal effect and / or an intolerance of the medicinal product or of Carrier element is registered on the skin portion of the wearer.

The sensors 20 , 21 can also be used to measure the pulse rate, heart rhythm, blood pressure and blood sugar and the like. In principle, all types of sensors that can be applied to a plaster are conceivable, which can interact in some way with the patient, his skin or the active substance.

The outputs of the sensors can be transmitted to the separate evaluation circuit 23 via separate data transfer contacts and via a transmission device 25 .

From Fig. 9 it can still be seen that in the area of the drug substance 3 or in the area of the separate active substance 24 activation elements 30 in the form of heating elements, capacitive elements, chemical actuators and the like are arranged, which via the evaluation circuit 23 for acceleration or deceleration the drug substance delivery to the skin 16 are controllable. The activation elements 30 are controlled via signals which can be controlled via a transmitting and receiving device 25 connected to the carrier 1 .

Information stored in the evaluation circuit 23 can be transmitted via the transceiver 25 to a separate evaluation computer 40 which is located, for example, at a doctor or at a research facility which carries out "clinical research".

The carrier can have a dome-like shape and be formed like a pillow. A battery can be supported via a solar cell 50 , which is indicated in FIG. 9.

The carrier can be modular and have compartments that in the as carrier elements with drugs of different types or numbers can be introduced. Also the introduction of different Senso Ren in the manner of module inserts is conceivable.

Regarding the housings that can be placed on the skin Different housing shapes conceivable, the wristwatches or go out pillow-like housing. For example, the Trä with a chest band on the chest of the recipient or the Integrate carrier into a stocking-like element so that the drug or a substance on the ankle or calf area of the Acts on the recipient.  

REFERENCES

1

carrier

2

Carrier element

3rd

substance

4

Protective layer

5

Conductor track

6

section

7

end up

8th

Evaluation and display device

9

Storage unit

10th

casing

11

casing

12th

Input elements

13

contacts

14

layer

15

Top

16

Skin of the patient

20th

sensor

21

sensor

22

contacts

23

Evaluation circuit

24th

Active ingredient

25th

Transmitter-receiver

30th

Activation element

31

Receiving device

40

Evaluation computer

50

Solar cell

Claims (35)

1. Carrier ( 1 ) for a drug acting on the skin of a recipient or another active ingredient, with a carrier element carrying a drug or active ingredient ( 3 ) on at least one side, the substance ( 3 ) is covered with a protective layer ( 4 ) prior to the application of the carrier element ( 2 ) to the skin of a medication recipient, characterized in that the carrier element ( 2 ) is provided with at least one conductor track ( 5 ) which has a severable section ( 6 ) the protective layer ( 4 ) runs. 2. Carrier according to claim 1, characterized in that the ends ( 7 ) of the conductor track ( 5 ) are connected to an electronic evaluation and display circuit ( 8 ), on the one hand the integrity of the protective layer ( 4 ) can be displayed and / or in which a removal time of the carrier element ( 2 ) from a storage unit ( 9 ) can be stored. 3. Carrier according to claim 1 or 2, characterized in that the carrier ( 1 ) in a housing ( 10 , 11 ) can be inserted, which contains the evaluation and display device ( 8 ). 4. Carrier according to one of the preceding claims, characterized in that the housing ( 11 ) on the skin ( 16 ) of the medicament recipient can be placed and fastened there. 5. Carrier according to one of the preceding claims, characterized in that the housing ( 11 ) overlaps the carrier ( 1 ) only partially. 6. Carrier according to one of the preceding claims, characterized in that the housing ( 11 ) provided with the evaluation and display device ( 8 ) is designed in the manner of a watch case or is integrated in a watch which can be worn on the body. 7. Carrier according to one of the preceding claims, characterized in that an electronic start pulse can be generated by the conductor track ( 5 ), which can be processed by the evaluation and display device ( 8 ) and a warning signal can be generated after a predetermined time after the start pulse. 8. Carrier according to one of the preceding claims, characterized in that the desired wearing time of the carrier ( 1 ) in the evaluation and display device ( 8 ) can be entered. 9. Carrier according to one of the preceding claims, characterized in that
the carrier ( 1 ) is arranged in the form of individual applications in the special housing ( 10 ) of the storage unit ( 9 ),
that at least one conductor track ( 5 ) or a contact arrangement cooperates with counter-contacts of the housing ( 10 ) and when the carrier ( 1 ) is removed from the housing ( 10 ) either the interaction of the contacts is interrupted and / or the conductor track ( 5 ) is severed. 10. Carrier according to one of the preceding claims, characterized in that the carrier ( 1 ) itself is connected to or comprises the evaluation and display device ( 8 ). 11. Carrier according to one of the preceding claims, characterized in that the expiry date assigned to it can be entered in the evaluation and display device ( 8 ). 12. carrier ( 1 ) for a medicament, having a carrier element ( 2 ) which can be placed on a skin section of a medicament receiver and which has an active substance substance acting on the skin on at least one side ( 3 ), characterized in that the carrier ( 1 ) and / or a housing ( 11 ) accommodating the carrier has a plurality of sensors ( 20 , 21 ) which are connected to an evaluation circuit ( 8 ) via contacts ( 22 ). 13. A carrier according to claim 12, characterized in that the sensors ( 20 , 21 ) are or comprise temperature sensors. 14. Carrier according to one of the preceding claims 12 or 13, characterized in that the sensors ( 20 , 21 ) are designed as moisture sensors or include such. 15. Carrier according to one of the preceding claims, characterized in that the sensors ( 20 , 21 ) as a with the wearing time of the carrier ( 1 ) degradable active ingredient ( 24 ) are responsive. 16. A carrier according to any one of the preceding claims, characterized in that the active ingredient ( 24 ) is a medicament, an active substance contained in the medicinal substance or a separate z. B. is chemical or cosmetic active ingredient. 17. Carrier according to one of the preceding claims, characterized in that the active ingredient ( 24 ) is a separate, in addition to the drug on the carrier element ( 2 ) provided active ingredient, which has no medical effect on the recipient. 18. Carrier according to one of the preceding claims, characterized in that the sensors ( 20 , 21 ) skin contact sensors or pressure sensors to grasp. 19. A carrier according to claim 18, characterized in that the evaluation and display device ( 8 ) and / or the evaluation circuit ( 23 ) can be activated for the first time via the sensors ( 20 , 21 ) and / or cutting the conductor track ( 5 ). 20. A carrier according to any one of the preceding claims, characterized in that a signal can be generated via the sensors ( 20 , 21 ) and the evaluation circuit ( 23 ) when a predetermined wearing or exposure time has been reached and / or the drug substance / active ingredient with or is consumed without medical effects and / or an incompatibility of the drug or the carrier element on the skin ( 16 ) is registered. 21. Carrier according to one of the preceding claims, characterized in that manually operable input elements ( 12 ) are arranged on the top of the housing ( 11 ). 22. Carrier according to one of the preceding claims, characterized in that in it further sensors ( 20 , 21 ) (pulse rate, heart rhythm, steto scope, blood pressure, blood sugar and the like.) Are integrated, either via data transfer contacts (interface) to the evaluation circuit ( 8 ) can be transmitted or can be transmitted to a separate evaluation computer ( 40 ) via a transmission device ( 25 ) integrated in the carrier ( 1 ) or the housing ( 10 , 11 ). 23. Carrier according to one of the preceding claims, characterized in that in the area of the pharmaceutical substance ( 3 ) and / or the active substance ( 24 ) activation elements ( 30 ) (heating elements, capacitive elements, chemical activators) are arranged, the circuit via the evaluation ( 23 ) can be controlled to accelerate or delay the delivery of substance to the skin ( 16 ). 24. Carrier according to one of the preceding claims, characterized in that the activation elements ( 30 ) are controlled via signals which can be controlled by third parties via a receiving device ( 31 ) connected to the carrier ( 1 ). 25. Carrier according to one of the preceding claims, characterized in that a combined transmitting / receiving device ( 25 ) is arranged in the housing. 26. Carrier according to one of the preceding claims, characterized in that information stored in the evaluation circuit ( 23 ) can be transmitted to a separate evaluation computer ( 40 ). 27. Carrier according to one of the preceding claims, characterized in that it is arranged with further carriers ( 1 ) in a common storage unit ( 9 ) and each time a carrier element ( 2 ) is removed, an electronic start pulse can be generated, which concerns a temporal memory function triggers the maximum wearing time of the wearer ( 1 ). 28. Carrier according to one of the preceding claims, characterized in that the carrier ( 1 ) comprising the evaluation and display circuit ( 8 ) is formed from a flexible film material. 29. Carrier according to one of the preceding claims, characterized in that the carrier element ( 2 ) has a dome-like shape. 30. Carrier according to one of the preceding claims, characterized in that the carrier and / or the housing is designed like a pillow.   31. Carrier according to one of the preceding claims, characterized in that the carrier ( 1 ) on its side facing away from the skin ( 16 ) is connected to or contains a solar cell ( 50 ). 32. Carrier according to one of the preceding claims, characterized in that the carrier ( 1 ) is designed in the manner of a module carrier and pharmaceuticals of different types or numbers and / or different sensors ( 20 , 21 ) can be introduced into the provided compartments and, if necessary, with the electronic Evaluation and display circuit ( 8 ) can be connected. 33. Carrier according to one of the preceding claims, characterized in that the protective film ( 4 ) runs between a battery contact and a contact of the evaluation and display circuit ( 8 ) and when the protective film ( 4 ) is removed, the battery contact contacts the countercontact. 34. A method for checking the integrity / originality of a drug carrier provided with an active ingredient, in particular a medicated plaster, with the following procedural steps:

• - Providing at least one protective layer on the plaster, which closes the active substance arrangement on the plaster / carrier;
• - Providing an electrical contact arrangement on the plaster, which is bridged when the protective layer is intact;
• - Providing an electronic evaluation arrangement which can be electrically connected to the contact arrangement;
• - Carrying out an electrical continuity test through the contact arrangement;
• - Removing or opening the protective layer, thereby interrupting the electrical conductor path between the contacts.

35. The method according to claim 34, characterized in that a start in the interruption of electrical continuity pulse is generated by an evaluation and display device is evaluable.