DD275697A1 - METHOD OF VULCANIZING TUBE SEEDS FROM HIGHLY MOLECULAR, BIOLOGICALLY ACTIVE POLYMERIC MATERIALS - Google Patents

Abstract

The invention relates to a process for the vulcanization of tubes made of high molecular weight, biologically effective polymer materials with electron beams to the content. The admixing of a molecular sieve loaded with biologically active substances and the use of a metal mandrel in radiation crosslinking achieve a uniform state of crosslinking without impairing the biological activity of the active substance. With the method according to the invention, there is the possibility of continuous production of the hoses. The vulcanization process is used in the plastics and rubber processing industry.

Description

Field of application of the invention The invention relates to a process for the vulcanization of high molecular weight materials, which are suitable for hoses with specific Properties, in particular with biological effectiveness, are used. The invention is used in the plastics and rubber processing industry. Characteristic of the known state of the art The production of high-molecular-weight, biologically-active materials using classical thermal techniques Vulcanization is known (DD-PS 252381, DD-PS 252382, DD-PS 252838). Since the biologically active Substances are thermally unstable, the vulcanization can be done only with a maximum of 60 ° C and not in the otherwise usual Temperature range of thermal vulcanization. This requires a long vulcanization time of 80 to 100h, giving a

rational production process prevented.

An additional disadvantage is that the use of Vulkanisationsbuschleunigern a toxic effect of Products can be produced. Another vulcanization process for the crosslinking of rubber is the radiation vulcanization, which is also extensive in the Specialized patent literature has been and will be treated. Jedccii according to experts of experts will be the radiation vulcanization

in the rubber industry can not enforce because there are many limitations and difficulties in the application, such as. B.

the high cost, associated with high costs and property deterioration of the rubber products occurs, as in

Rubber, rubber and plastics from 1976, p. 532 is described. The application of the electron beam crosslinking is in the literature especially for tires made of different types of rubber,

electrical insulation, electrical conductors and the like examined (rubber, rubber and plastics 1984 S.864ff.).

From DE-OS 3603738 it is known to crosslink natural rubber latex with the aid of ionizing radiation by radiation chemistry. To

an absorbed dose is used which leads to heating of the material.

Under the current conditions of the radiation vulcanization, which are known from the prior art, it is not possible Produce hoses made of high molecular weight biologically active polymer materials in this way, as by

high-energy radiation, the effectiveness of the biological substance is degraded. So conditions must be found that still preserve the effectiveness of the biological substance.

Target animal invention

The aim of the invention is to develop a process for the vulcanization of hoses made of high molecular weight, biologically active polymer materials, which improves the quality of the tubes and rationally designed by considerable time savings vulcanization.

Presentation of the veson of the invention The object of the invention is a vulcanization process for hoses made of high molecular weight, biologically active To develop polymer materials in which neither thermal nor by radiation-chemical influences on the Hoses the effectiveness of the biologically active substance is degraded and a permanent storage of biological

active substance is achieved.

According to the invention, this object is achieved by the biologically active substance before admixture to Hose material is bonded to a molecular sieve and the entire mixture then onto a full metal mandrel

is extruded.

Surprising catfish led these technological steps to a negligible small degradation of the effectiveness of the

biologically active substance.

The radiation vulcanization is carried out with the usual methods for high polymer materials and energy doses, the Full metal mandrel remains in the hose. In addition, a technological step in the manufacture of a tube with biologically active substance by eliminating

By the radiation crosslinking at the same time the sterilization of the hoses takes place.

Another advantage of this method is that the compatibility of the tubes has been improved, since no Vulkanisationsmittel are erforderorlish that by their use in the classical vulcanization toxic properties

cause the tubing. The optionally used activators boi the radiation vulcanization to further

Lowering the temperature does not cause any toxic properties of the vulcanizate. By using a molecular sieve and a metal full dome, a uniform state of crosslinking of the high

polymeric, biologically effective tubing guarantees the entire length without compromising biological effectiveness.

Durcli the inventive method, the possibility is created, the hoses with biologically active substances also

to be vulcanized in a continuous procedure.

The vulcanization process according to the invention is explained in more detail in one embodiment.

exemplary Pale crepe 63.37 mass shares in% electron beam material Molekularsieb' adduct 2.64 mass shares in% 10OkGy chalk 17.85 mass shares in% 20 s stearic acid 1.37 parts by weight in% 06mm SpezialparaffinRB 1.26 mass shares in% Antioxidant 4 1.37 Massages in% zinc oxide 3.48 mass shares in% Titanium dioxide 1.80 Massages in % Facts R17 6.76 mass shares in% 100.00 mass shares in% * as support material (Or high molecular weight, biologically active subotaroars Technological parameters: of radiation: Radiation dose: Irradiation time: Metal mandrel (solid material):

Prüfergebnisstt: Biological activity after incubation on rubber material in human pulp piasma.

incubation period It's on <%) Thrombfnzelt • - Strahlungsver (%) Injoktions- 100 conventional wetting M 5 / 185 method 100 vulcanization (%) polyanionic 213 heparin 100 M 5 / polyanion 121 Connection- 233 100 nischeVerbindg. 133 adduct 246 (S) 100 adduct 140 (S) 260 (Min) 14 100 (S) 160 26 280 0 15 100 17 180 32 313 30 15 20 193 35 6Q 15 21 207 37 120 15 24 39 180 15 27 42 240 15 29 47 300 31

The detection of biological activity after incubation of Kautschr.kmaterial in Humanzitratpiasma is performed as follows: Defined rubber discs (100mm 0; 250mg) are incubated at 37 ⁰ C in 4ml Humanzitratpiasma and depending on

the incubation period determines the extent of thrombosis.

For this purpose, 2 ml of plasma with 0.2 ml Tris buffer (0.15 mol / l) and 0.1 ml thrombin (SNJH-E / ml) are taken from the complete batch.

and measured the time to recovery (instrument KZM-W .Schwelle 30 ").

As a result of the test, it was found that the radiation-crosslinked rubber material over the conventional

vulcanized material in the plasma causes a substantial extension of the thrombin time. Another advantage of the radiation-crosslinked biomaterial is that the necessary radiation sterilization of the hoses is eliminated after the conventional vulcanization process.

Claims (3)

1. A process for the vulcanization of hoses made of high molecular weight, biologically active polymer materials, prepared by conventional mixing method, characterized in that the mixture is added before the radiation vulcanization loaded with a biologically active substance molecular sieve or sheet silicate and then the high molecular weight material extruded onto a solid mandrel made of metal and is radiation crosslinked. 2. The method according to claim 1, characterized in that the Strahlenvulkanisationsdosis 40 to 12OkGy, preferably 10OkGy, in multi-sided irradiation. 3. The method according to claim 1 and 2, characterized in that for radiation crosslinking activators, such as triallyl, trimethylpropane trimethacrylate, wherein the proportion of 0.5 to 20 parts by mass in%, based on the total mixture, is added to the high molecular weight mixture.