DD268157A1 - DERMOPHARMZEUTIC PREPARATION - Google Patents

Abstract

The invention relates to a dermopharmaceutical preparation. The invention is everywhere applicable where strongly entzuschte, burned by a-, b- and g-radiation and damaged skin is to be cured. According to the invention, the object is achieved by adding to the preparation superoxide dismutase in pure form or with compounds such as protein, nucleic acid, hormones, vitamins and catalase. Preferably, the superoxide dismutase is derived from yeast and is added in amounts of 0.1-10%. Talc with a special grain spectrum can also be added to this preparation.

Description

Field of application of the invention

The invention is applicable everywhere where highly inflamed, burned by α, β andy radiation skin and damaged skin to be cured.

Characteristic of the known state of the art

It is known to use enzymes, the suporoxide dismutase in cosmetic preparations such as skin and hair care products.

Superoxide dismutase improves the breathing of skin cells. The skin becomes supple and elastic. In DE-PS 2545986 a variety of cosmetic preparations are described.

The superoxide dismutase is obtained from blood or marine bacteria according to DE-OS 2417508.

European Patent 0019474 describes the recovery of superoxide dismutase from yeasts.

Patients who are treated with α, β or y radiation due to their cancer may experience severe and severe skin damage in the radiation exposure area.

So far, these patients are treated with powders that consist essentially of talcum. Through the talcum it comes to clogging of the pores and there are protracted inflammatory processes.

Object of the invention

The aim of the invention is to develop a dermopharmaceutical preparation which protects the skin from α, β andy radiation or heals after damaging action.

Explanation of the essence of the invention

It is an object of the present invention to develop dermopharmaceutical preparations which cause healing and regeneration of the skin.

According to the invention the object is achieved in that the preparation is added superoxide dismutase.

It is expedient to add the superoxide dismutase in amounts of 0.1% to 10% to the preparation. Particularly suitable is the superoxide dismutase, which was obtained from yeast, as are still in digestion nor substances such as proteins, nucleic acid, vitamins, hormones and catalase, which also have a positive effect on the skin and the effect of superoxide dismutase underline.

If the preparations talcum added, it is only fully effective and not harmful if a particle size range of 20% 0-5μπι, 30% 5-10μηι, 20% 10-15Mm, 15% 15-20Mm, 20-25% and 5%> 25μπΊ is maintained. The suporoxide radicals have a central role to play. Superoxide dismutases are enzymes that disproportionate the radical superoxide ion and, as a result, intervene causally in the inflammatory process.

The enzyme, preferably yeast-derived, superoxide dismutase is used in oil / water or water / oil emulsions, gels or powders. These preparations have been specially formulated for the prevention of radiation damage caused by α, β and ^

developed and applied.

If these preparations were applied to damaged skin, the urine regenerated w ': a few days.

By the order before the irradiation damage could be effectively avoided. The i'.wX remains supple and inflammatory.

embodiment The invention will be explained below to β embodiments.

1. Design Bullet - Oil / Wafer Emulsions A 20-year-old yeast suspension is added with activators and subjected to power ultrasound flow. In this case, the yeast cells are fully disrupted and the release of the zeiiinhaltsstoffe. Uio liberated superoxide dismutase can now be processed in isolated form or in combination with the other Zeliinhaltsstoffen. Recipe for the oil / Wauser emulsion

64.0% Water 2.0% Chamomile extract 2.0% Silicone oil 2.0% Paraffin oil 8.0% Emulsifier 1.5% Wool fat 3.7% Vaseline 10.0% Talc 3.0% Propylene glycol 0.3% Preservative 3.5% Superoxide dismutase from Hetestamm Saccharomyces cerecisiae, catalase, vitamins, proteins, nucleic acids

The talc is added with the following grain spectrum:

0-5μ.- !, 5-10μηι, 10-15mm, Ι5-20μπι, 20-25μηη,> 25μσ \ 15.8% 28.2% 20.2% 15.8% 1Λ8% 7.2%

Water and fat phase are heated to 70 ± 2 ° C, brought together and emulsified, and then cooled to about 25 ° C. Thereafter, the limulsion is added to the superoxide dismutase with catalase, vitamins, proteins, nucleic acid. This preparation is particularly suitable for application before irradiation with α, β and jf radiation. Of course, the protection also occurs when exposed to ultraviolet radiation.

2. Implementation Guide

Nursing mask oil / water emulsion for the regeneration and integrity of the natural creatine structures with anti-inflammatory effect.

recipe:

3.5% Vaseline 3.0% Vaseline oil 2.5% Lanolin 1.5% Sesame oil 0.3% Preservative 5.0% Cu ₂ ZNj superoxide dismutase from the yeast strain Saccharomycis cerrevisiae 0.5% Praffin oil 2.7% Propylene glycol 7.5% Emulsifier 73. 5% water

The preparation is identical to that in embodiment 1.

3. Exemplary embodiment - Nourishing powder, also anti-inflammatory

Formulation: 75.0% talcum 2.5% magnesium stearate 20.0% yeast digestion with superoxide dismutase

The talc is used with the grain spectrum according to the embodiment 1. The powder components are homogenized in a mixer and then applied.

Fourth Exemplary Embodiment - Oil / Oil Emulilone

Formulation: 55.9% water 3.0% lanolin 3.0%. Beeswax 7.0% Paraffin oil 5.0% Emulsifier 3.5% Emulsifier 2.3% Propylene glycol 0.3% Preservative 8.0% Coconut fatty acid ester 10.0% Yeast digestion Superoxide dismutase linked to proteins, nucleic acids and catalase

The preparation is carried out according to the embodiment 1. The advantage of this preparation is the prevention of fire damage at α, β, ^ radiation. If the skin to be irradiated is given the preparation before irradiation, no burns, burns, redness or inflammation of the skin occur.

5. Exemplary example - Healing water with alcohol

Formulation: 59.5% water 20.0% ethanol 20.0% yeast extract with superoxide dismutase, proteins, nucleic acid, catalase 0.5% panthenol

For dabbing wounds, this healing water is particularly suitable.

6. Illustrative Example - Bright water without alcohol

Formulation: 82.0% water 2.0% camomile extract 1.0% avocado extract 15.0% yeast extract with superoxide dismutase proteins, nucleic acid, catalase

For particularly sensitive skin, this healing water is used without alcohol.

Claims (4)

1. Dermopharmaceutical preparation for the prevention and repair of damage by σ, β andy "radiation optionally using talc, characterized in that superoxide dismutase in pure form or with compounds such as proteins, nucleic acid, vitamins and catalase is added to this preparation. 2. Dermopharmaceutical preparation according to claim 1, dadun, h characterized in that the superoxide dismutase in amounts of 0.1 to 10% is added to the preparation. 3. Dermopharmaceutical preparation according to claim 1, characterized in that the superoxide dismutase used is derived from yeast. 4. A dermopharmaceutical preparation according to claim 1, characterized in that the talcum with a particle size range of 0-5 microns 20%, 30% 5-10pm, 20% 10-15mm, 15% 15-20mm, 20-25mm and 5%> 25mm present in the preparation.