DD233941B1 - APPLICABLE FRIENDLY MICROBICIDES - Google Patents

Description

Particularly suitable as combination partners are:

1. aldehydes: formaldehyde, formaldehyde releasers e.g. N-methylolchloroacetamide, 1,3,5-hexahydrotriazine, glutaric dialdehyde, glyoxal.

2. Quaternary ammonium compounds: dimethylbenzyldodecylammonium chloride, dimethylbenzylacetamido-benzylammonium chloride.

3. Phenol derivatives: p-chloro-m-cresol, p-hydroxy-diphenyl-methane.

4. Alcohols: 1,1,1-Trichloro-4-methyl-4-penten-2-ol

i.i.i-TrichloM-methyl-S-pentene ^ ol

5. 2-ethyl-hex-2-enal

The active compound combinations according to the invention contain, in addition to 2-hydroxybutyraldehyde (1), at least 2 further active ingredients, such as, for example, aldehydes (2), quaternary ammonium compounds (3). Phenol derivatives (4) or alcohols (5) in the following proportions by weight:

1: 2; 3; 4: 5 = 1: 0-3 preferably 0.05-1: 0-5 preferably 0.01-1; 0-4 preferably 0.05-1.2: 0-8 preferably 0, 05-2 In addition to the active ingredients conventional auxiliaries such as water, emulsifiers, surfactants, perfume, solubilizers and others be added to the formulation.

The total active substance concentration of the ready-to-use solution for disinfection is 0.5-4%. Depending on the application, concentrations of 0.1-2.5% total active substance content, based on the medium to be preserved, are used for preservation.

The active compound combinations according to the invention are distinguished by improved ease of use such as reduced odor, reduced vapor pressure, reduced acute and chronic toxicity, reduced corrosiveness and a balanced spectrum of activity against bacteria, fungi and viruses.

According to the aim of the invention is by lowering the HCHO content in the use solution by at least Vi according to application examples according to 1.2. achieved with an air change of> 8h ~ ¹ in the air during the contact time of the disinfectant. After completion of the prescribed exposure time, the permissible MAK value of 0.5 ppm is guaranteed.

In the following, the invention will be explained with reference to some examples, without thereby restricting them.

Example: Bactericidal, fungicidal and virucidal action The disinfectant effect of agents according to the invention was tested in comparison to known technical solutions under comparable conditions on different test germs and the effect was compared on the basis of assessments.

1. Table of test samples

1.1. Compare products

1. 2-hydroxybutyraldehyde

2. formaldehyde

3. Glutaraldehyde

4. Dimethylalkyl (C 1 -C 4 -benzylammonium chloride (C4)

5. dimethylalkyl (Cn-cis-acetamidobenzylammonium chloride

6. p-chloro-m-cresol

7.!, I.i-Trichloro-methyl-pentene-ol (pentenol)

The comparator preparations contain, in addition to the active ingredient, corresponding auxiliaries in the form of surfactants and emulsifiers as well as solubilizers and water.

The concentration of the active ingredients was 20-40%, the emulsifiers 5-10%, solubilizers 5-20% ethylene glycol.

1.2. WirkstoHkombinationen in weight ratios

8. 2-Hydroxy-butyraldehyde: Formaldehyde: C ₄ = 1: 0.25: 0.05

9. 2-hydroxybutyraldehyde: formaldehyde: C ₄ = 1: 0.25: 0.7

10. 2-Hydroxy-butyraldehyde: formaldehyde: C _4: pentenol = 1: 0.25: 0.1: 1.0

11. 2-Hydroxy-butyraldehyde: C _4: pentenol = 1: 0.7: 1.0

12. 2-Hydroxy-butyraldehyde: C ₄ : p-chloro-m-cresol = 1: 0.7: 1.0

13. 2-Hydroxy-butyraldehyde: Glutaric dialdehyde: C ₄ = 1: 0.025: 0.05

14. 2-Rydroxy-butyraldehyde: glutaric dialdehyde: C ₄ : formaldehyde = 1: 0.025: 0.05: 0.25

2. Test methods

The basis for the bactericidal, fungicidal and vfrucidal testing are the guidelines for the disinfectant test of the German Society for Hygiene and Microbiology (DGHM - 1981) and the German Veterinary Society (DVG -1984). In addition to the qualitative suspension test, the quantitative laboratory germ carrier test with organic load (wood seed carrier and linen lobe) was used.

3. Test organisms

bacteria

1. Escherichia coli

2. Pseudomonas aeruginosa

3. Staphylococcus aureus

4. Streptococcus faecalis fungi

1. Candida albicans

2. Trichophyton mentagrophytes

3. Penicillium spec.

4. Aspergillus niger

1. ECBO virus

2. Aujeszky's virus

4. Assessment of the microbicidal effect

The following ratings were used:

1 no effect

2 low effect (killing after at least 240 min)

3 medium effect (killing after at least 120min)

4 good effects (killing after at least 60min)

5 very good effect (kill after at least 30min)

5. Results of the test 5.1. Bactericidal effect

Suspension test at 0.1% total active substance concentration

Test pattern Effect on test organisms

No. 1 2 J

1 2 2 2 1 2 3 4 3 2 3 5 5 Oil 5 4 4 3 Oil 5 5 4 3 e 5 6 4 4 5 4 7 5 5 Oil 5 8th 5 5 cn 4 9 5 5 cn 5 10 5 Oil 5 Oil 11 4 4 4 4 12 4 4 4 4 13 5 5 4 4 14 5 5 5 5

Combination 8-14 without 2-hydroxybutyraldehyde

Test pattern Effect on test organisms

No. 1 2

8 3 3 3 2

9 3 3 3 3

10 3 3 3 3

11 2 2 2 2

12 2 2 2 2

13 3 3 2 2

14 3 3 3 3

Germ carrier test at 0.5% drug concentration

Test samples Test organisms

No. 12 3 4

2 2 1 1 3 4 2 2 5 5 4 3 2 2 2 2 2 2 2 2 2 2 2 2 4 4 3 3 5 4 3 3 Oil 4 4 3 5 5 4 4 4 4 4 4 4 4 4 4 5 5 5 4 5 5 5 5

-4- 233 Combination 8-14 without 2-hydroxybutyraldehyde

samples Effect on test organisms 2 3 4 No. 1 2 1 1 8th 3 2 2 1 9 3 3 2 2 10 3 2 2 2 11 2 2 2 2 12 2 3 3 2 13 3 3 3 3 14 3

5.2.Fungicidal action

Suspension test at 0.1% total active substance concentration

samples test organisms 2 test organisms 2 3 4 No. 1 2 1 2 2 2 1 2 2 2 3 3 2 2 3 3 4 4 4 3 3 5 3 5 3 4 3 4 5 3 4 3 4 3 5 5 4 4 3 3 3 6 4 3 3 3 2 2 7 5 4 4 4 3 3 8th 5 4 5 4 4 3 9 5 5 5 5 4 4 10 5 4 5 4 4 3 11 4 .4 4 4 4 3 12 4 5 4 5 5 4 13 5 5 5 5 5 5 14 5 Germ carrier test at 0.5% total active substance concentration 5 samples No. 3 4 1 2 2 2 3 2 3 4 4 4 3 3 5 3 3 6 3 2 7 3 3 8th 3 3 9 4 3 10 4 4 11 3 2 12 3 2 13 5 4 14 5 5

5.3. Virucidal action at 0.5% total drug concentration

Test sample no.

test organisms

1 1 2 2 4 4 3 4 5 4 1 5 5 1 5 6 1 2 7 2 3 8th 4 5 9 4 5 10 4 5 13 5 5 14 5 5

Example: ease of use

The assessment of the ease of use was based on the evaluation of practical application studies, animal experiments and corrosion studies. The funds are assessed in the respective application concentration required.

Bon'rtur:

odor toxicity skin damage allergy corrosion 1 penetrating highly toxic severely damaging to the skin strong allergy strongly corrosive 2 strong mediocre toxic mediocre moderate allergy moderately corrosive skin-damaging 3 moderately weakly toxic slightly damaging to the skin weak allergy slightly corrosive 4 little or non-toxic little or not not allergenic little or not skin-damaging corrosive medium Odor toxicity skin damage Allergy corrosion 2 1 2 1 1 2 8th 3 3 3 2 3 9 3 3 3 2 3 10 3 3 3 3 3 11 2 3 3 4 3 12 2 3 3 4 3 13 3 3 3 4 3 14 3 3 3 3 3

According to the aim of the invention is by lowering the HCHO content in the use solution by at least ² h according to application examples according to 1.2. when air changes> 8h ^-1 in rooms, a decisive decrease in the concentration of formaldehyde in the air is achieved during the exposure time of the disinfectant. After completion of the prescribed exposure time, the permissible MAK value of 0.5 ppm is guaranteed.

Claims (4)

1. Application-friendly microbicidal agent, characterized in that it contains 2-hydroxybutyraldehyde (1) and at least two per se known microbicidal agents such as aldehydes or Formaldehydabspalter (2), quaternary ammonium compounds (3), phenol derivatives (4 ) or alcohols (5). 2. Composition according to claim 1, characterized in that they are known per se as microbicidal agents aldehydes or Formaldehyde releasers (2) such as glutaric dialdehyde, succinic dialdehyde, glyoxal, formaldehyde, 2-ethylhexen-2-al, hexen-2-al, N-methylolchloroacetamide and hexahydrotriazine, quaternary ammonium compounds (3) such as dimethyl (Ci ₁ -C ₁₃ ) benzylammonium chloride, dimethyl (C ₁₁ -C ₃₎ acetamidobenzylammoniumchlorid, Dimethyldodecylaminocarbomethyl-benzyl ammonium chloride, dimethyl didecyl ammonium chloride (C ₁₆₎ pyridinium chloride, phenol derivatives (4) such as p-chloro-m-cresol, p-hydroxy-diphenylmethane and alcohols (5) such as 1,1,1-trichloro-4-methyl-4-penten-2-ol, 1,1,1-trichloro-4-methyl-3-penten-2-ol. 4. Composition according to claim 1 and 2, characterized in that they 2-hydroxybutyraldehyde (1), dimethylalkyl (C ₁₁ -C ₁₃ ) acetamidobenzylammoniumchlorid or dimethylalkyl (C ₁₁ -C ₁₃ ) benzylammonium chloride (2) and formaldehyde (3) in weight ratios from (1) :( 2) :( 3) such as (1) :( 0.01-0.1) :( 0.05-0.5). Field of application of the invention The invention relates to aldehyde-based microbicidal agents and their use against undesirable and damaging microorganisms, in particular against bacteria, fungi and viruses in health care, in animal hygiene and in industry, and for the preservation of biologically vulnerable materials. Characteristic of the known technical solutions Aldehydes are of great importance both for disinfection purposes and for the preservation of technical products. The common aldehydes such as formaldehyde, glyoxal, glutaric dialdehyde, succinic dialdehyde and the a, ^ -unsaturated aldehydes (hexene-2-al-1,2-ethylhexan-2-al-1) described in the literature as effective have a broad spectrum of activity against viruses , Bacteria and fungi (DE PS 2516922, DO-PS 143023). However, due to its strong sensitizing, toxic and potentially mutagenic properties with simultaneously high volatility and its slow onset of activity, the readily available and economically effective formaldehyde has come under severe criticism. In some cases, it may no longer be used for disinfection purposes in human medicine. The same applies in certain points to glyoxal. While succinic and glutaric dialdehydes are technically difficult to obtain, a, ^ -unsaturated aldehydes have disadvantages in the form of intrusive odors, slight oxidative degradation, and low potency (see EGGENSPERGER, H .: Health Care and Disinfection 68 [1976]). , 39-55, ibid 69 [1977], 79-85, HORN, H., PRIVORA, M. and W. WEUFFEN: Handbook of Disinfection and Sterilization, Volume I and Volume II, DO PS 130907). Object of the invention The aim of the invention was the development of formaldehyde-reduced microbicidal agents with improved ease of use and easy accessibility of the active ingredients. Object of the invention The object of the invention was to develop application-friendly microbicidal agents using a special aldehyde. Explanation of the essence of the invention It has been found that 2-hydroxy-butyraldehyde in combination with two or more microbicidal active ingredients has a good microbicidal activity, although it has only an insufficient effect as the sole active agent even in higher concentrations. Combinations of 2-hydroxybutyraldehyde with one or more aldehydes and one or more quaternary ammonium compounds and / or phenol derivatives and / or specific alcohols have proved to be particularly effective.