DD217988A1 - SELF-TIMELY PROSTHESIS CLEANING AGENT - Google Patents

Abstract

The invention relates to a self-dentifrice cleaning agent in tablet, powder or granular form with tartar-emitting properties, which also has an improved stability with respect to the active oxygen content. Such a cleaning agent is obtained by adding an N-disubstituted 1-aminoalkane-1,1-diphosphonic acid, in particular dimethylamino-methane-diphosphonic acid, to the largely conventional carbon dioxide-releasing detergent compositions.

Description

Cleaning products for dentures

Field of application of the invention

The invention relates to an automatic denture cleaning agent in tablet, powder or granular form.

Characteristic: the known technical solutions

There are already numerous compositions for denture cleanser known: Among them, the cleaner with effervescent effect of increased importance, since the onset of dissolution in water bubbling allows a relatively rapid distribution of the active ingredients. The effervescent effect is usually achieved by the release of oxygen or carbon dioxide. For the purpose of cleaning the dentures of adhering food residues and other impurities, the known denture cleanser compositions contain in the majority of suitable oxidizing agents or, much less frequently, enzymes such as amylases, dextranases, tryptases and / or lipases. For the oxidative degradation of impurities are many times. Oxydationmittel used, which simultaneously trigger the desired effervescent effect. These are usually peroxo compounds such as alkali metal perborates, alkali metal peroxophosphates, alkali monoprene sulfates, alkali metal percarbonates, peroxosulfates and urea / hydrogen peroxide adducts which release active oxygen. The peroxo compounds ^: are used individually or in a mixture, mixtures often have an increased oxidizing power. Due to the liberation of the oxygen, however, the oxidation and cleaning action of the solutions rapidly decreases.

for a sufficient consignment thus a relatively high content of active oxygen carriers is required.

The decrease in the oxidation and cleaning effect can also be counteracted so that compositions. are chosen, which release carbon dioxide when dissolved in water instead of oxygen. The resulting solutions must be acidic, neutral or at most slightly alkaline. The carbon dioxide is thereby produced by reaction of a suitable combination of one or more solid, inorganic or organic acids or acid salts and suitable carbon dioxide carriers, frequently using as acids amidosulfonic acids, tartaric acid, citric acid, adipic acid, fumaric and maleic acid, as acidic salts, e.g. Hydrogen sulfates or acidic phosphates and as carbon dioxide carriers mostly alkali carbonates and bicarbonates are used;

Despite the variety of still to tablet disintegrants, extenders, surfactants, flavors, fragrances, antibacterial substances and dyes to be expanded feedstocks and the resulting Kombinatierismoglichkeiten, such prosthesis cleaners inadequate cleaning effect against tartar-like coverings is a crucial disadvantage. Alkali polyphosphates, thioureas, ethylenediaminetetraacetic acid, nitrilotriacetic acid and the like. Compounds that are added to the cleaners to remedy this disadvantage, have not been proven.

Object of the invention

The aim of the invention is thus a cleaning product for dental prostheses, which, having overcome the decisive disadvantage of all other cleaners, has detectable tartar-dissolving properties.

Essence of the invention

The invention has for its object to develop a stable, possibly tablettable, but also usable as granules or as a powder, strongly bubbling prosthesis cleaner with pronounced calculus-dissolving properties.

The object is achieved in that the largely conventional, carbon dioxide-releasing detergent compositions 0.5 to 10 % of an N-disubstituted 1-aminoalkane-1,1-diphosphonic acid of the general formula X.

HC - PO ₃ H ₂

where R and R are alkyl radicals having 1-10 C atoms, optionally substituted aryl radicals, aralkyl or sycloalkyl radicals which may be the same (R = R) or different (R 4 R), and R ^ = hydrogen or a G.-Go alkyl radical. It has surprisingly been found that such aminophosphonic acids are able to dissolve the particularly firmly bound calcium from the natural tartar in neutral and alkaline solution. In alkaline solution, the dissolution is supported by a simultaneous saponification of the organic tartar matrix. By dissolving out the calcium, the calculus structure is so loosened that even heavy deposits are easily removed. Durch'die regular application of erfindungügemäßen detergent, of course, the formation of tartar on the prostheses is avoided.

The calculus dissolution by the aminoalkane-1, i-diphosphonic acids of the general formula I and by the detergents containing them according to the invention was unequivocally nach.-pointed by appropriate extraction experiments on natural calculus ^ as clearly evident from the FT-P ~ nmr spectra of the extraction solutions, do they contain that from the

 - · 4

Hydroxylapatite of the tartar As a result of the Galcium bond dissolving in the "Phosphation ,, which is not detectable with I-free Heiniger solutions", Also the gravimetric © control of the extraction material confirms the dissolution process ·,

Surprisingly, the use of the aminoalkane-1,1-diphosphonic acids of general formula I in / largely customary detergent compositions has further positive effects. The detergents according to the invention have a significantly increased oxidation stability compared to analogous I-free compositions even when using not specifically predried Raw materials5 the relative loss of active oxygen is, for example, by 0.5 -10 % dimethylaminomethane

12 "λ 1,1-diphosphonic acid (Is R = R = GH ^, R ^ = H) at least um

20 - 30 % lowered. '.

The composition of the denture cleansing compositions of the invention and their efficacy are shown in the following typical examples.

Note ₁ 1 _: '

Cleaning preparations for dentures in tablet, granule or powder form, consisting of (parts by weight)

10.0 potassium peroxodisulfate

25.0 sodium percarbonate

10.0 sodium bicarbonate _:

24.6 sodium carbonate

20.0 tartaric acid

0.4 Cetyltrimethylammonium bromide 0.2 Dye Blue (with indigotine) ../ 1,8 Hatrium sulfate '

8.0 N-myristyl-N-propyl-aminomethanediphosphonic acid

Example 2 · '...

Cleaning preparations for dentures in tablet, granule or powder form consisting of (parts by weight)

25.0 sodium perborate; 44.0 Sodium carbonate 2OjO Citric acid 0.2 Sodium alkylarylsulfonate: \ 0.4 Magnesium stearate

0.1 peppermint oil

10.3 1- (N-methyl-N-phenylamino) ethane-1,1-diphosphon; acid

Example 3 '. '

Detergent for dentures in tablet, granule or powder form, consisting of (parts by weight).

^: 25.0 potassium peroxodisulfate.

10.0 sodium perborate

20.0 sodium bicarbonate

20.0 sodium carbonate, 20.0 adipic acid

0.5 SiIgiumdioxid '

0.2 peppermint oil.

0.1 sodium lauryl sulfate

0.1 dye blue · (with indigotine) 4,1 dimethylamino-methane-diphosphonic acid

Example, 4..

Calculus solution by a cleaning agent of the composition given in Example 3,

0.1 g of powdered natural tartar are placed with the 3% aqueous cleaning solution for 10 hours at 4-0 ⁰ C

?1

Leave? 1. Thereafter, the solution is filtered and analyzed by PT - P Spectrosfcopy (reference substance: phosphoric acid, external) s = 6.9 ppm. (Phosphonate), · Γ = 2.7 ppm (phosphate). In the range of the similarly tested cleaning solution the peak at 6 ' = 2.7 ppm is missing. . '. ·

Example 5.

Active substance content of the tabletted, and sealed in Thermonylpapier cleaning agent of the composition given in Example 3 (A) after different Lagerze.iten at 20 and 40 ⁰ C compared to an analog detergent without dimethylamino-methane-diphosphonic acid (B):

The content of finely pulverized tablets of perborate is determined by mangoimetry and the content of peroxodisulfate iodometrically and summarily converted to the content of active oxygen. The following figures are average values of 10 individual determinations:

Warehouse- 2 Active oxygen content (Jo) at 20 ⁰ C B 40 ⁰ C A B Time "2 2,908 2,908 2,904 (Months) 2 A • 2,866 2,900 2,872 0th 2 , 908  '.. 2,804 2,904 2,810 '1 ' 2 , 898 2,701 2,898 2,718 3 , 910 2,581 2,822 2,570 6. , 881 12 , 813

Claims (2)

claims At the cleaning agent for dentures, in tablet, granular or powder form, applicable characterized in 'that the largely conventional, carbon dioxide-releasing''cleaner compositions for tartar solution an ^N: disubstitütierte 1-amino ^ alkane-i, 1 ~ dit> hosphonsäure the general formula , _R 1 _R 3. N-C-PO₃H₂  . R² 1 p is added, wherein R 'and R are alkyl radicals having Λ - 10 C atoms, optionally substituted aryl radicals, aralkyl or cycloalkyl radicals which are identical (R = R) or '' 'Ί 2 ^' may be different (R φ R) and R - \ = \ ¥ oxygen or a C _x . - Oo-alkyl radical is. 2. Cleaning agent for dental prostheses according to claim Λ , characterized in that the most common cleaning compositions are added 0.5 - 10% dimethylaminomethane ~ 1,1-diphosphonic acid.