DD161094A3 - METHOD FOR OBTAINING NARVEDINEENES AND THEIR DERIVATIVES - Google Patents

METHOD FOR OBTAINING NARVEDINEENES AND THEIR DERIVATIVES Download PDF

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Publication number
DD161094A3
DD161094A3 DD79216089A DD21608979A DD161094A3 DD 161094 A3 DD161094 A3 DD 161094A3 DD 79216089 A DD79216089 A DD 79216089A DD 21608979 A DD21608979 A DD 21608979A DD 161094 A3 DD161094 A3 DD 161094A3
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DD
German Democratic Republic
Prior art keywords
deep
alkyl group
obtaining
halogen
derivatives
Prior art date
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DD79216089A
Other languages
German (de)
Inventor
Radoslav J Vlachov
Dikran A Krikorjan
Maria S Sagorova
Maja C Chinova
Stojan P Paruschev
Original Assignee
Edinen Zentar Chim
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Application filed by Edinen Zentar Chim filed Critical Edinen Zentar Chim
Publication of DD161094A3 publication Critical patent/DD161094A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/23—Oxidation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Gewinnung von Narvedienon, die Ausgangsstoffe zur Gewinnung von Amarolidinalkaloiden sind. Die Aufgabe der Erfindung ist es, ein Verfahhren zur Gewinnung von Narvedinenonen mit einem hoeheren Reinheitsgrad und grosser Ausbeute zu entwickeln, de durch chemische Transformationen in Amarolidinalkaloide umgewandeldelt werden koennen. Durch das erfindungsgemaesse Verfahren werden Enone und ihre Derivate mit der allgemeinen FormelI, wobei A(siehe Rueckseite)R tief 3 _ Halogen, R tief 3 _ Halogen, R tief 4 _ niedrige Alkylgruppe, R tief 5 - HCIO tief 4 und andere aehnliche Salze anorganischer und organischer Saueuren X= O Y = H tief 2, X= H tief 2 Y = 0;X = H tief 2 Y = H tief 2 als Diphenolderivate mit der allgemeinen Formel II, wobei A( siehe Rueckseite), R tief 1 _niedrige Alkylgruppe, -CH tief2C tief6H tief 5,- CH tief2C tief 6H tief 4 OCH tief3, R tief2 _ niedrige Alkylgruppe, -CH tief 2C tief 6H tief 5 OCH tief3, Rtief 3 _ Halogen, Rtief 4 _ niedrige Alkylgruppe, Rtief5-HCIO tief4 und andere aehnliche Salze anorganischer und organischer Saeuren X = H tief2 Y a= o; X = OY = H tief 2Y = H tief 2 gewonnen undelektrochemisch oxydiert.The invention relates to a method for obtaining narvedienone, which are starting materials for the recovery of Amarolidinalkaloiden. The object of the invention is to develop a process for obtaining Narvedinenonen with a higher degree of purity and high yield, de can be converted by chemical transformations in Amarolidinalkaloide. By the process according to the invention, enones and their derivatives having the general formula I, where A is (see the reverse) R deep 3 _ halogen, R deep 3 _ halogen, R deep 4 _ lower alkyl group, R deep 5 - HCIO deep 4 and other similar salts inorganic and organic acids X = OY = H deep 2, X = H deep 2 Y = 0, X = H deep 2 Y = H deep 2 as diphenol derivatives having the general formula II, where A (see back page), R deep 1 _niedrige Alkyl group, -CH deep2C deep6H deep 5, - CH deep2C deep 6H deep 4 OCH deep3, R deep2 _ low alkyl group, -CH deep 2C deep 6H deep 5 OCH deep3, Rtief 3 _ halogen, Rtief 4 _ lower alkyl group, Rtief5-HCIO deep4 and other similar salts of inorganic and organic acids X = H deep2 Y a = o; X = OY = H deep 2Y = H deep 2 recovered and electrochemically oxidized.

Description

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Claims (1)

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DD79216089A 1978-11-21 1979-10-04 METHOD FOR OBTAINING NARVEDINEENES AND THEIR DERIVATIVES DD161094A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG7841458A BG28325A1 (en) 1978-11-21 1978-11-21 Method of obtaining of enons navedine type and their derivatives

Publications (1)

Publication Number Publication Date
DD161094A3 true DD161094A3 (en) 1984-10-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
DD79216089A DD161094A3 (en) 1978-11-21 1979-10-04 METHOD FOR OBTAINING NARVEDINEENES AND THEIR DERIVATIVES

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JP (1) JPS55107790A (en)
BG (1) BG28325A1 (en)
CH (1) CH642660A5 (en)
DD (1) DD161094A3 (en)
DE (1) DE2945161A1 (en)
FR (1) FR2442230A1 (en)
IT (1) IT1164751B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2203183C (en) * 1994-10-21 2008-04-08 Laszlo Czollner Process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine
US6407229B1 (en) 1994-10-21 2002-06-18 Sanochemia Pharmazeutika Ag Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
CN1875004B (en) * 2003-09-26 2010-06-23 台湾神隆股份有限公司 Resolution of a narwedine amide derivative

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DE2945161A1 (en) 1980-06-04
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IT7950771A0 (en) 1979-11-07
JPS55107790A (en) 1980-08-19
BG28325A1 (en) 1980-04-15
FR2442230A1 (en) 1980-06-20

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