CZ309926B6 - Vitamin ointment - Google Patents

Abstract

Vitamin ointment consists of shea butter in the amount of 25 to 35 wt. %, coconut oil in the amount of 25 to 35 wt. %, almond oil in the amount of 12 to 18 wt. %, cetearyl alcohol in the amount of 8 to 12 wt. %, babassu oil in the amount of 4 to 6 wt. %, bleached beeswax in the amount of 4 to 6 wt. %, tocopherol in the amount of 0.8 to 1.2 wt. %, calcium pantothenate in the amount of 0.15 to 0.25 wt. %, tocopherol acetate in the amount of 0.07 to 0.13 wt. %, guaiazulene in the amount of 0.07 to 0.13 wt. %, retinyl palmitate in the amount of 0.02 to 0.05 wt. % and sunflower seed oil in the amount of 0.02 to 0.05 wt. %The ointment is suitable for the treatment of dry skin prone to cracks, fissures and erosive eczemas. It facilitates skin epithelization.

Description

Vitamin ointment

Field of technology

The proposed invention is a vitamin ointment for the support of epithelization of the skin. The ointment is suitable for the care of dry skin prone to cracks, fissures and erosive eczema. Helps epithelize the skin.

Current state of the art

Medical white vaseline (vaselinum album) is currently used in the care of dry or otherwise damaged skin. It does not contain any active substances, so it has no epithelizing abilities. It is only used for lubrication and has only an occlusive effect.

Another well-known remedy is an ointment known under the trade name Infadolan. The ointment contains retinol acetate and ergocalciferol (vitamin D2) and as excipients white wax, fat from sheep's wool and white petroleum jelly. Thanks to its composition, the ointment provides an epithelization effect, but it is not very pronounced.

The task of the invention is to provide a means (ointment) that provides a strong epithelizing effect and improves the condition of the skin in common dermatological diagnoses.

The essence of the invention

The essence of the invention is the composition of vitamin ointment. The ointment is used to support epithelization of the skin. The ointment consists of shea butter (Butyrospermum Parkii Butter) 25 to 35% by weight, coconut oil (Cocos Nucifera Oil) 25 to 35% by weight, almond oil (Prunus Amygdalus Dulcis Oil) 12 to 18% by weight, fatty alcohol (Cetearyl Alcohol) 8 to 12% by weight, babassu oil (Orbignya Oleifera Seed Oil) 4 to 6% by weight, bleached beeswax (Cera Alba) 4 to 6% by weight, tocopherol (Tocopherol) - natural vitamin E 0.8 to 1.2% by weight, calcium pantothenate 0.15 to 0.25% by weight, tocopheryl acetate - synthetic vitamin E 0.07 to 0.13% by weight, guaiazulen 0 .07 to 0.13% by weight, retinyl palmitate (Retinyl Palmitate) - a combination of vitamin A1 and palmitic acid 0.02 to 0.05% by weight. and sunflower oil (Helianthus Annuus Seed Oil) 0.02 to 0.05 wt.%

Retinyl palmitate is a stabilized vitamin A, an ester of retinol (vitamin A) and palmitic acid, a saturated fatty acid that is the main component of palm oil. It has an epithelializing effect and accelerates granulation. It has a beneficial effect on dry skin in chronic dermatitis (especially atopic), burns, erosions, rashes, ichthyosis vulgaris, pityriasis rubra pilaris, Morbus Darier. It is also suitable for non-healing wounds with insufficient epithelization, such as fistulas, leg ulcers and pressure ulcers. Compared to retinol, it is more stable and non-toxic, it breaks down enzymatically in the body.

Tocopherol acetate (vitamin E) has significant antioxidant effects. It has a beneficial effect in the local therapy of trophic and leg ulcers, sclerodermia circumscripta, lichen sclerosus et athrophicus, lichen planus, balanitis obliterans, craurosis vulvae, induratio penis plastica and xerotica obliterans.

The combination of tocopherol (natural vitamin E) and tocopherol acetate (synthetic vitamin E) ensures a high level of antioxidant effects. Tocopherol protects the ointment itself and slows its deterioration in time before application to the skin. Tocopherol acetate is

- 1 CZ 309926 B6 stabilized form of vitamin E, which does not have stabilizing effects in the substance (in the ointment as such). It works after enzymatic decomposition in the skin. The advantage of tocopherol acetate is that it shows long-term stability in the mass, and the antioxidant effect is only manifested in the skin.

Guajazulene is a mixture of alkylated azulenes. Guajazulen has a weak antipruritic, astringent, anti-inflammatory and bacteriostatic effect. It supports granulation and epithelialization.

Calcium pantothenate is the calcium salt of water-soluble vitamin B5. It has a granulating and epithelizing effect. It has a beneficial effect on the healing of burns, fissures and ragades as well as leg ulcers, pressure ulcers and post-radiation dermatitis, including X-ray ulcers.

Babassu oil (Orbignya Oleifera Seed Oil) hydrates the skin and thus prevents it from drying out. It contains lauric acid, which has antimicrobial and anti-inflammatory effects. Furthermore, the oil contains antioxidants similar to tocopherol, which have a protective effect on the skin.

The mentioned combination of ingredients forms a vitamin ointment, which is particularly suitable for the care of dry skin prone to cracks (ragadas), cracks (fissures) and erosive eczema. The ointment helps epithelize the skin. It is very gentle and does not contain parabens or lanolin and is free of added dyes and perfumes. Thanks to this, it can also be applied to his lips and can be used from newborn age.

Tests have shown that when a thin layer of ointment is applied to the affected area 2 to 5 times a day, the healing of the skin is noticeably accelerated in most cases. The synergistic effect of the components used in the given ratio ensures faster healing, even when compared to previously known preparations.

An example of the implementation of the invention

Vitamin ointment for the support of epithelization of the skin in a specific embodiment consists of:

shea butter (Butyrospermum Parkii Butter) 31.8% by weight, coconut oil (Cocos Nucifera Oil) 31.8% by weight, almond oil (Prunus Amygdalus Dulcis Oil) 14.878% by weight, cetearyl alcohol (Cetearyl Alcohol) 10% by weight ., babassu oil (Orbignya Oleifera Seed Oil) 5% by weight, bleached beeswax (Cera Alba) 5% by weight, tocopherol (Tocopherol) 1.05% by weight, calcium pantothenate (Calcium Pantothenate) 0.204% by weight, tocopherol acetate (Tocopheryl Acetate) 0.102% by weight, guaiazulen (Guaiazulen) 0.1% by weight, retinyl palmitate (Retinyl Palmitate) 0.036% by weight, sunflower oil (Helianthus Annuus Seed Oil) 0.03% by weight.

The mentioned components in this particular representation show the greatest contribution to the healing of damaged skin and the care of dry damaged skin. With this composition, tests of biological effectiveness were carried out in clinical practice for four frequent dermatological diagnoses - atopic eczema, psoriasis, microbial eczema and red lip inflammation. The collection of clinical data was carried out in the clinics of a specialist dermatologist and a total of 246 patients were evaluated.

The effect of using the ointment was monitored in the study using three criteria assessed by the attending physician and one criterion assessed by the patient. The doctor evaluated the change in inflammation (or redness), dryness and integrity of the skin (i.e. the effect on epithelization of the skin). The patient assessed subjective itching (pruritus). After establishing the diagnosis and consent of the patient or him

- 2 CZ 309926 B6 legal representative, the patient received a sample of the ointment and was instructed on the application. The method of application was shown by the doctor to all patients directly in the doctor's office on their skin so that the application was identical for all patients. The patient applied the ointment to the designated areas twice a day in the morning and evening after hygiene.

In the atopic eczema group, out of a total of 106 patients, there was a significant improvement in the clinical picture in 95 patients. In 9 patients there was no change after a week and in 2 patients the condition worsened and local corticoid extemum had to be applied (Table 1).

Tab. 1 Atopic eczema Age (years) improvement without change deterioration 0-3 39 0 0 3-6 24 0 0 6-15 13 4 1 15-30 14 3 1 30-38 5 0 Total 95 9

In the group of psoriasis (Psoriasis vulgaris), there was improvement in 33 of the total number of 46 patients. The application showed no change in 10 patients and in 3 there was a deterioration and an extemum containing calcipotriol and a corticoid had to be used. One deteriorated patient was later diagnosed with Co vid 19 (Table 2).

Tab. 2 Psoriasis Age (years) improvement without change deterioration 0-10 0 0 0 10-20 3 0 0 20-30 8 3 0 30-50 10 5 -> 50-66 12 1 Total 33 10 3

In the microbial eczema group, out of the total number of 45 patients evaluated, 39 of them improved. In 4 patients there was no change and in 2 patients there was a deterioration and corticoid extemum had to be used (Table 3).

Tab. 3 Microbial eczema Age (years) improvement without change deterioration 0-30 0 0 0 30-50 18 3 0 50-88 21 1 -> Total 39 4 ->

-3 CZ 309926 B6

In the group with red lip inflammation (Cheilitis sicca), there were a total of 49 patients, of which 30 cases involved cheilitis as part of treatment with total retinoids for the underlying disease of Acne conglobata. In all 49 patients, there was a significant improvement in the condition of the lips and practically healing of the deposits. No patient experienced a persistent condition or deterioration (Table 4).

Tab. 4 Inflammation of the lips red Age (years) improvement without change deterioration 0-10 9 0 0 10-20 34 0 0 20-30 4 0 0 30-52 2 0 0 Total 49 0 0

Of the total number of 246 patients included in the study, there was a significant improvement in the clinical condition of 216 of them, which represents 88%. The presented vitamin ointment ίο demonstrated an excellent effect in a clinical study and confirmed the declared biological effectiveness.

Claims (1)

PATENT CLAIMS 1. Vitamin ointment consisting of Cocos Nucifera Oil, Prunus Amygdalus Dulcis Almond Oil, Cetearyl Alcohol, Babassu Orbignya Oleifera Seed Oil, Tocopherol Tocopherol, Sunflower Helianthus Annuus Seed Oil, Vitamin A, Vitamin E, characterized by , that: the amount of coconut oil Cocos Nucifera Oil is in the range of 25 to 35% by weight, the amount of almond oil Prunus Amygdalus Dulcis Oil is in the range of 12 to 18% by weight, the amount of cetearyl alcohol is in the range of 8 to 12% by weight, the amount of oil babassu Orbignya Oleifera Seed Oil is in the range of 4 to 6% by weight, the amount of Tocopherol is in the range of 0.8 to 1.2% by weight, the amount of Helianthus Annuus Seed Oil is in the range of 0.02 to 0.05% wt., while it also consists of shea butter Butyrospermum Parkii Butter in the amount of 25 to 35% by weight, bleached beeswax Cera Alba in the amount of 4 to 6% by weight, calcium pantothenate in the amount of 0.15 to 0.25% by weight ., guaiazulen Guaiazulen in an amount of 0.07 to 0.13% by weight, while at least part of vitamin A is formed by retinyl palmitate Retinyl Palmitate contained in an amount of 0.02 to 0.05% by weight. and at least part of vitamin E is made up of tocopherol acetate Tocopheryl Acetate contained in an amount of 0.07 to 0.13% by weight.