CZ308102B6 - Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk - Google Patents

Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk

Info

Publication number
CZ308102B6
CZ308102B6 CZ2018-595A CZ2018595A CZ308102B6 CZ 308102 B6 CZ308102 B6 CZ 308102B6 CZ 2018595 A CZ2018595 A CZ 2018595A CZ 308102 B6 CZ308102 B6 CZ 308102B6
Authority
CZ
Czechia
Prior art keywords
cardiovascular
micrornas
postpartal
children born
new biomarkers
Prior art date
Application number
CZ2018-595A
Other languages
Czech (cs)
Other versions
CZ2018595A3 (en
Inventor
Ilona Hromadníková
Original Assignee
Univerzita Karlova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerzita Karlova filed Critical Univerzita Karlova
Priority to CZ2018-595A priority Critical patent/CZ308102B6/en
Priority to PCT/CZ2019/050050 priority patent/WO2020088703A1/en
Publication of CZ2018595A3 publication Critical patent/CZ2018595A3/en
Publication of CZ308102B6 publication Critical patent/CZ308102B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Method for in vitro detection of potential cardiovascular risk in children born of a complicated pregnancy based on the presence of an aberrant expression profile of selected microRNAs throughout the peripheral venous blood.
CZ2018-595A 2018-10-31 2018-10-31 Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk CZ308102B6 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ2018-595A CZ308102B6 (en) 2018-10-31 2018-10-31 Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk
PCT/CZ2019/050050 WO2020088703A1 (en) 2018-10-31 2019-10-30 A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2018-595A CZ308102B6 (en) 2018-10-31 2018-10-31 Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk

Publications (2)

Publication Number Publication Date
CZ2018595A3 CZ2018595A3 (en) 2020-01-02
CZ308102B6 true CZ308102B6 (en) 2020-01-02

Family

ID=69063489

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2018-595A CZ308102B6 (en) 2018-10-31 2018-10-31 Postpartal epigenetic profile of cardiovascular microRNAs in children born of complicated pregnancies - new biomarkers of cardiovascular risk

Country Status (2)

Country Link
CZ (1) CZ308102B6 (en)
WO (1) WO2020088703A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023109988A1 (en) 2021-12-13 2023-06-22 GeneSpector Innovations s.r.o. Method of prediction of pregnancy complications based on the expression profile of cardiovascular mirnas

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114600832B (en) * 2022-04-01 2023-07-25 西南医科大学 Mice heart failure model and preparation method thereof

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
DK144771C (en) 1979-07-10 1982-10-25 V B K Rasmussen HINGING FITTINGS FOR LINEN WINDOWS, NAMELY LARGE BUILT-IN ROOF WINDOWS
US4318157A (en) 1980-06-06 1982-03-02 Control Data Corporation Apparatus for mounting circuit cards
US20140274923A1 (en) * 2013-03-14 2014-09-18 The Regents Of The University Of Colorado, A Body Corporate Mirnas as a prognostic biomarker in pediatric heart failure
CN108350501A (en) * 2015-08-20 2018-07-31 塞雷尼姆有限公司 Circular rna makees the system and method for biomarker diagnosis Endothelial Dysfunction
CN108165623A (en) * 2018-01-02 2018-06-15 青岛大学 Application of miRNA, product using miRNA and detection method

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FLORIS I. et al.: „Roles of microRNA across prenatal and postnatal periods," International Journal of Molecular Sciences, vol. 17, no. 12, 2016, ISSN 1422-0067 *
HROMADNÍKOVÁ I. et al.: „Cardiovascular and cerebrovascular disease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction," Plos One, vol. 10, no. 9, 2015, str. e0138383, ISSN 1932-6203 *
HROMADNÍKOVÁ I. et al.: „Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood," Trombosis Research, vol. 137, 2016, str. 126 - 140, ISSN 0049-3848 *
HROMADNÍKOVÁ I. et al.: „Profiling of cardiovascular and cerebrovascular disease associated microRNA expression in umbilical cord blood in gestational hypertension, preeclampsia and fetal growth restriction," International Journal of Cardiology, vol. 249, 2017, str. 402 - 409, ISSN 0167-5273 *
JIAO M. et al.: „Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy," Scientific Reports, vol. 8, 15.1.2018, str. 1 – 9, ISSN 2045-2322 *
YU P. et al.: „Deregulated cardiac specific microRNAs in postnatal heart growth," BioMed Research International, vol. 2016, 2016, str. 6241763, ISSN 2314-6133 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023109988A1 (en) 2021-12-13 2023-06-22 GeneSpector Innovations s.r.o. Method of prediction of pregnancy complications based on the expression profile of cardiovascular mirnas

Also Published As

Publication number Publication date
WO2020088703A1 (en) 2020-05-07
CZ2018595A3 (en) 2020-01-02

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