CZ292191A3 - process for producing therapeutic plasters based on sulfonamide salts for the prevention and therapy of infections - Google Patents

Abstract

The present invention relates to a process for the production of medicated patches, of which the active ingredients are silver and zinc salts of sulfonamides, used for their high antimicrobial effectiveness to prevent and treat infections in severe burns and others skin injuries, or dental disinfection. They were prepared so that the textile or foil carrier that it is provided with an adhesive film, pressure-bonded to a high-speed film insert which is breathable or closed a textile or foil carrier provided with an adhesive layer together with pearl cellulose and the active salt of sulfonamides.

Description

A process for the manufacture of medicated plasters based on sulfonamide salts

Technical field

The present invention relates to a process for the manufacture of medicated plasters whose active ingredients are silver salts and zinc salts of sulfonamides, in particular sulfadimidine.

BACKGROUND OF THE INVENTION

Silver salts of sulfonamides are chemotherapeutics intended primarily for topical application. Their antibacterial activity is the result of the synergistic action of both the sulfonamide component and the silver ion. The most widely known and most widespread preparation of this class of drugs is the silver salt of sulf adiazine. CH. Foxam in 1968 and is used primarily for the prevention and treatment of infections in severe burns and other skin injuries, or for dental disinfection.

Sulfadiazine is known in the form of formulations under different designations, most of the formulations being cream-based with a concentration of 1% silver salt of sulf adiazine.

The use of cream sulfadiazine silver salt formulations is suitable for large-scale burns. However, it also has its drawbacks, which are mainly due to the fact that the cream is greasy due to the ingredients present and contaminates the patient's clothing and blanket.

SUMMARY OF THE INVENTION

SUMMARY OF THE INVENTION The present invention is based on a process for the manufacture of medicated plasters for the prevention and treatment of infections and is based on anchoring silver and / or zinc salts of sulfonamides, in particular sulf adimidine, sulf athiazole, sulf adiazine or sulfamet oxypyridazine.

They have found that these disadvantages can be eliminated by applying the silver and / or zinc salts of sulfonamides in a suitable manner to the carrier and forming a medicated plaster. * In addition to the silver sulfadiazine salt commonly used in creams, we used silver salt and zinc salt. other major sulfonamides such as suliadimidine, sulf athiazole and sulfamethosypyridazine

The antimicrobial activity of these silver and zirconium salts was verified in vitro by determining the minimum inhibitory concentration in 13 bacterial strains and the Candida albicana strain and compared and the efficacy of the respective free sulfonamides ·

The antimicrobial activity of the Ag salt is very high · Minimum inhibitory concentration values are more than 30 times lower than that of sulphonamides alone · The spectrum of activity also includes sulphonamide-resistant microbes Pseudomonas aeruginosa and Candida albioans · No significant difference in minimum inhibitory concentration values was found of the sulfonamides tested.

Measurement of antimicrobial activity was verified by diffusion plate method of antibiotic susceptibility test. Circular slices of prepared quick-banding pads with diameters of 5 »8 and 10 mm with different concentrations of active substances were tested. · From the observed average zones of inhibition in 13 bacterial strains and Candida strain Albinoans can be said that these zinc and especially silver salts of sulphonamides have very good antimlrobial activity nm all evaluated strains including strains of Pseudomonas alruginosa and Candida albioans ·

The following strains were used for testing:

Staphylococcue aureus 80/73 «· ^M « a 127/90 E 43/60 Streptococcus pyogenes Str 4/49 - - faecalia Str 17/78 Escherichia coli 324/70 w · 326/71 Pseudomonas aerug · 79/70

CKCTC

- - +

- - - - + - «

- * - +

126/78 CNCTC

11/70 - +

4/49 - «- +

VŮPB

- · 65 - Pseudomonas aerug · Proteus vulgaris Salmonella ® M. Enterobacter aerogenes Klebsiella pneumon. Candida albieans

F: International standard strains for testing disinfectants

A mixture of: Mueller-fiinton agar (Imuna) MHA was used as culture medium

Blood Agar No. 3 (Imuna) KA

0.1% glucose solution

Examples

Example 1

A homogeneous mixture of pearl cellulose 80 to 250 nm in size and active sulfonamide salts at the desired concentration, based on the basis weight of the quick-release liner, was anchored to a suitable, non-toxic, breathable or even closed textile or foil carrier provided with an adhesive adhesive layer. up to 3% based on pearl cellulose, basis weight of blends of both components was up to 70 g / m based on the liner

Example 2

A suitable non-toxic textile carrier with a high degree of water absorption is impregnated with an aqueous suspension of silver sulphonamide salt and pearl cellulose and dried after impregnation. · The desired concentration of the active substances was achieved by adjusting the concentration of the substances in the suspension and impregnation time.

Example 3

A suitable non-toxic textile carrier and a high degree of water absorption were impregnated with aqueous suspension of zinc sulionamide salt and pearl eeliosis and dried after impregnation. The desired active substance concentration was achieved by adjusting the concentration of the substances in the suspension and the impregnation time;

Example 4

A carrier similar to Example 2 was impregnated first in an alkaline aqueous sulfonamide solution, then in an equivalent amount of an aqueous silver nitrate solution, washed with water, impregnated with a pearl eeluiosis solution and dried.

Example 5

A carrier similar to Example 2 was first impregnated in an alkaline aqueous solution of sulfonamide, then in an equivalent amount of aqueous zinc chloride solution, washed with water, impregnated with a solution of pure eeluiosis and dried.

Example 6

A similar carrier to that of Example 2 was impregnated in an ammoniacal solution of silver and zinc sulfonamide salts with the addition of pearl eeliosis and dried after impregnation. The desired concentration of the active ingredients was obtained similarly to Example 2.

Utility of the invention

The preparation of the medicated patch consists of three operations:

In the first operation, a non-toxic adhesive film is anchored onto a suitable] textile carrier or foil as the basis for the medical patch.

In a second operation, a quick-release liner with active ingredients is prepared

- 5 substances.

The anchoring of the active substance on the carrier ee shall be carried out by one of the following methods:

As a carrier of the active substances we have chosen and preferably a breathable textile insert on which the active substance is anchored together with an adsorbent, which allows perfect homogeneity prepared. inserts for the patch. Among the adsorbing agents, the use of non-toxic pearl cellulose has proven to be the best. The insert thus prepared is part of the overall composition of the medicated plaster and the active substance diffuses easily from the bead cellulose into the environment. The anchoring of the active substance can be carried out in other ways:

The insoluble Ag and Zn salts of the sulfonamides, together with the bead cellulose, are suspended in water, the resulting suspension is impregnated and dried.

The carrier is impregnated first with an aqueous, alkaline sulfonamide solution, then with an aqueous solution of Ag NO2 or ZnCl2, washed with water and dried after stirring in a suspension of pearl cellulose.

The silver and zinc sulfonamide salts are dissolved in dilute ammonia, pearl cellulose is added and, after impregnation of the carrier _{and the} mixture, the carrier is dried.

In the third operation, the rapid dressing pad is pressurized to the patch itself.

Claims (3)

PATENT N 2 2 O ΚΓ T3 D Λ r- > O O <O ra xx * - ς-> <r ~ - <m N · < 1. A process for the manufacture of medicated plasters for the prevention and treatment of sulphonamide salt infections, characterized in that silver or / and zinc salts of sulphonamides are anchored individually or in a pearl eeluloe mixture on a breathable or even closed textile or film carrier. 2. A process according to claim 1, characterized in that the silver and / or zinc salts of sulfonamides, together with the pearl eelulola, are suspended in water, and the resulting suspension is impregnated and subsequently dried. 3. A process according to claim 1, wherein the carrier aa is first impregnated with an aqueous alkaline solution of sulfonamides, followed by a solution of silver nitrate and / or zinc chloride, and then washed with water and dried after stirring in a suspension of pearl eeluloi. 2. The process of claim 1 wherein the silver and / or zinc sulfonamide salts are dissolved in an ammonia solution to a complex, to which a bead cellulose is added, and then impregnated with said carrier and then dried. 5. The method according to the points of the component will be used dinu · Process according to claims 1 to 4, characterized in that the silver and / or zinc salts of aulfadimi6 are used as active silver.