CZ234392A3 - Nutritive, prophylactic and therapeutical preparations for animals - Google Patents

Abstract

A feeding premix, additive or other concentrated preparation for poultry, pigs, ruminants and other farm animals on the basis of selenium, containing in 10 kg 2.5 to 65 mg of selenium, 0.5 to 50 g of vitamin E, 2 to 200 g of vitamin C, 0.5 g to 3 g of beta carotene, 1 to 5 g of zinc and possibly riboflavin, pyridoxine, pantothenic acid, vitamin B12, trihydroxybenzoic acid or its salts or esters, DL-methionine, choline, butylhydroxytoluene or other harmless synthetic antioxidants or other substances selected from the group including vitamins, provitamins, enzymes, amino acids, donators of methyl groups, lipotrophic substances, antibiotics and other chemotherapeutics, bioflavins, biogenic and trace elements, flavouring agents and substances increasing the ingestion and availability of feedstuffs.<IMAGE>

Description

Technical field

The invention relates to compositions made in solid and liquid form. These are formulated to contain, in addition to selenium, substances having a significant synergetic and potentiating effect in the disposal of toxic substances in the feed or directly in the body. These substances get into the body and exogenous

they are formed endogenously in the body. The complementary combination of products (containing selenium and other biologically active factors) eliminates, or significantly attenuates, the activity of these xenobiots.

BACKGROUND OF THE INVENTION

In the last ten years, some trace elements, biological catalysts doses far exceeded them initially attributed them to natural substances with a capacity. Among them, vitamin C and carotene, in particular, it has been shown that vitamins and many others applied in a higher range of action, which is mainly a group of different antioxidants, vitamin E, selenium, but also beta carotene.

The very serious antioxidant potency of vitamin E and its role in preventing the peroxidation process in cells has been elucidated relatively recently. However, doubts that the main function of vitamin E lies solely in its antisterial effect have been raised by ettrLOTeur of this patron in 1960.

The discovery that selenium is glutathione (GSH) i nd ivi dual, the interrelated function between vitamin E has been explained by high vitamin E and selenium in the living body due to their, once completely integral component of the peroxidase enzyme, elucidate 1 dependent and complementary selenium . By this discovery, the protective role, and yet unknown, important antioxidant ability to defuse or suppress the formation of free radicals that violate cellular integrity, as well as the management and utilization of oxygen by cells.

Recently, however, it has been found that there is a substantial difference in the need for these substances under normal living conditions and when the body is exposed to increased stress such as stress, disease or just flooding the body with free radicals, whether oxygen or otherwise, heavy metals (cadmium, lead, mercury, etc.), which are more intensively absorbed in their acid form. Some studies have shown that the optimal absorption of selenium, which disables the aforementioned xenobiotics, can be affected by the competitive effect of sulfur.

Epidemiological studies in animals have shown that there is a negative correlation between selenium deficiency and the occurrence of various diseases. The intensity of these disorders or diseases can be substantially enhanced by a lack of selenium in the body, as well as by factors that complement, complement or increase its absorption and utilization. The deficiency or low level of selenium in the body is a practical consequence of its low exogenous intake i.e. under normal feeding conditions.

The effect of selenium, vitamin E, and other natural and synthetic antioxidants on immunobiological functions has now been confirmed by extensive scientific work. Higher doses of these antioxidants have shown unequivocal results in the prevention and treatment of itis-metritis-agalactia ointment complex and a significant increase in primary immunity in a variety of diseases.

The formation of free radicals as well as non-radical oxidative intermediates of intermediate metabolism can, in addition to the already mentioned consequences for the organism, have a strong genotoxic effect despite cell-induced disorders. This interference with the DNA organizational system can endanger the functioning of a significant number of cells.

Extensive animal studies have also found that selenium, vitamin E, beta carotene, vitamin C and other antioxidant compounds prolong the reproduction and life span of animals.

Fortification by antixidants is highly dependent on their intake by feed and mainly by the presence of subtoxic and toxic substances contained in the ration.

As in humans, an important role is represented by the content of free fatty acids in feed, heavy metals, aflatoxicosis and the presence of other xenobiotic factors.

SUMMARY OF THE INVENTION

The present invention relates to feed premixtures, supplements 6 and other forms of concentrated livestock formulations, characterized in that: The composition is characterized in that it contains 2.5-65 mg by weight of parts of CdH selenium, 0.5-50 g by weight in 10 kg of the premix of the supplement. vitamins E, 2-100 g by weight ·. of vitamin C, 0.5-3 g wt. d <beta carotene, 1-5 g .wt. d-. zinc and optionally containing 200-1000 mg by weight drofoflavin,

100-1000 g wt. d. pyridoxine, 0.5-2 g of pantothenic acid, 1-5 mg h. Vitamin B 12, 10-50 g -h, d. mono- to trihydroxibenzoic acid or its harmless salts and esters, 10-30 g Jh. d ·. synthetic antioxidants, up to 6-30 g Jb-r of sulfur amino acids, 2-10 g Jb-r. choline or other methyl group donors, and optionally other substances from the group of vitamins, antibiotics, anticoccidiotics, chemotherapeutics, amino acids, lipotropic substances, methyl group donors, enzymes, bioflavins, biogenic and trace elements, artificial sweeteners and nutrient stimulating substances in feed .

1! $ D, AS ^! rgov OHd dvgc o ΙΛ LZ co

This premix or supplement is used as part of a compound feed, or protein or other concentrate (supplementary forage or other farmed feed) in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of the feed compound or directly fed protein or other seed concentrate .

These concentrates or supplements containing! selenium and combinations thereof with other anti-oxidizing agents which may be further enriched with such compounds that complement, enhance or stimulate their activity in the body or increase the absorption of these substances. Although selenium, vitamin E, vitamin C and beta carotene and zinc are both individually and in combination, the essential components of preparations, there is no doubt that other compounds (listed in the formulations and in the examples) significantly enhance the effect or assimilation and thus the effectiveness of their nutritional, prophylactic or therapeutic effect.

Accordingly, the present invention provides formulations containing, in addition to selenium, other natural (but also synthetic) antioxidant and trace and biogenic elements, vitamins, amino acids, methyl group donors, glutathione, enzymes, and other compounds that complement1, and enhance their efficacy and absorbed i.

The dosage range of selenium for each species and category of livestock in 1 kg of complete feed weight is given below:

POULTRY

Category poultry Medical situation Range (pg) Chickens normal 75-150 Nosn i ce normal heat stress infectious stress 75 - 150 100 - 200 125 - 200 mechanical stress 125-200 Bro i 1e i normal infectious stress aflatoxicosis 75 - 150 150 - 200 150 - 250 Turkeys normal infectious stress 175-225 200-300 Breeding turkeys normal 150-250

PIGS

Category Range (jag) Morning weaning 200 - 400 Piglets 200-250 Growing pigs 150 - 200 Fattening 25 - 200 Lactation 150 - 200

RUMINERS Category Range (pg) Dairy cattle 200-300 Fattening cattle 50 - 650 Sheep DOO - 200

Note that the above ranges are 25 krAt and S

LisrrAL higher in premixes, supplements or other more concentrated preparations intended for in-feed or direct application.

DETAILED DESCRIPTION OF THE INVENTION

Only a few typical examples are given. This is because different species and categories of livestock, as well as the wide variation in their production conditions and health situations, may require a number of other formulations. Also, the composition and type of the individual components in the formulations may be considerably broader and may include individual classes of antioxidant substances or substances having the same or similar nutritional, preventive or therapeutic effect. Synergistic agents such as combinations with mono-trihydrobenzoic acid, glutathione, sulfur amino acids, choline with betaine or other methyl group donors, SOD, superoxide dismutase, bioflavins and their co-enzymes, as well as a number of other substances having a related or similar effect.

The examples given refer to 1 kg of feed weight in the starting feed ration, so that in premixtures, supplements or other concentrated preparations their content may be, for example, 25 to 1000 times higher. This depends on the amount of concentrate used either to directly feed the feeders or to enrich the industrial compound feed produced.

1.Wood

Examples of composition

Ingredients 1 2 Example 3 4 Selenium (pg) 25 75 125 250 Vitamin E (mg) 5 100 ALIGN! 250 500 Vitamin C (mg) 50 250 500 1000 Beta-carotene (mg) 5 10 15 Dec 30 Zinc (mg) 10 15 Dec 20 May 30

The results of extensive practical application with various antioxidant supplements in broilers are demonstrated in Table 1.

Table 1

Effect of various antioxidant and synergistic substances on broiler mortality in industrial farms

............. Mortality (%) ..................

Health status Negative 12 34 control Se + E 1 + C + BHT 2 + Zn + M + C 3 + ASC

Normal Aflatoxicosis subcl. Heat stress

6.7

12.6

29.2

8.6

4.2 6.9

14.8

5.3

3.9

5.7 14.9

4.7

3.9

5.8

11.4

5.2

3.9

5.2

11.7

4.3

Continuation Tab 1

Composition of experimental supplements per 1 kg weight i forage mixtures ·· Selenium (pg) - 150 150 150 150 Vitamin E (mg) - 400 400 400 400 Vitamin C (mg) - - 1OOO 1000 1000 BHT (mg) - - 125 125 125 Zinc (mg) - - - 40 40 Methionine (mg) - - - 100 ALIGN! 100 ALIGN! Choline (mg) - - - 50 50 Aspirin (mg) - - - 300 Riboflavin (mg) - 8 8 8 8 Pyridoxine (mg) - 5 5 5 5 Acidic acid (mg) - 15 Dec 15 Dec 15 Dec 15 Dec Vitamin B12 (pg) - 50 . 50 50 50

Note to Tab i ^:

The negative control and all experimental groups were fed the same standard mixture normally fortified with vitamins, coccidiostats and other specifically active substances. In each group there were a total of 0,000 pieces divided in four repetitions. \

Table 2 shows the results with the application of antioxidant and synergistic agents in heavy breeds of laying hens in infested holdings.

Table 2

Productivity of heavy breed laying hens infested with subclinical infections and occasional aflatoxicosis in feed

Produkčn i Negative 1 2 3 4 Diameter parameters control Se + E 1 + C + BHT 2 + Zn + M + C 3 + ASK 1 to 4 Load capacity % 67.4 81.1 86.9 87.9 88.3 86. 1 Lihnivost % 69.5 81.6 86.4 87.8 88.2 86.0 Morta1 ita % 11.2 3.0 2.6 2.6 2.4 2.7 Brakován i % 14.6 12.6 12.6 12.7 12.5 12.6

Continued Tab 2 on page 9

Composition of feed supplements per 1 Selenium (pg) - 150

Vitamin E (mg) - 400

Vitamin C (g) -.

BHT (mg)

Zinc (mg)

DL-met (mg)

Choline (mg)

Aspirin (mg)

g of feed weight benefits 150 150 150 400 400 400 1 1 1 150 150 150 - 40 40 - 150 150 - 50 50 - - 500

Note The negative control had 35,000 laying hens in three replicates and 35 subgroups. The experimental groups each had 10000 laying hens of 1 subgroup.

2.Pigs Examples of composition

Ingredients 1 2 3 4 Se flax (pg) 25 150 175 250 Vitamin E (mg) 5 50 400 500 Vitamin C (mg) 50 100 ALIGN! 200 400 Beta-carotene (mg) 5 15 Dec 20 May 30 Zinc (mg) 10 15 Dec 25 50

3.Ruminants i

Examples of composition Composition 1 2 3 4 Selenium (pg) 50 150 250 500 V i tam i η E (mg) 5 50 350 500 Beta-carotene (mg) 5 10 15 Dec 20 May Zinc (mg) 10 20 May 25 50

Specific results of the application of the supplement to high-breeding dairy cows are shown in Table 3.

Table 3

Health status of dairy calves from mothers fed with antioxidants 30 days before calving

Parameter Negative Experimental control group

Number of calves 127 121 Increment / piece / day / g 742 837 Mortality until 45 days /% 7.4 4. 1 Revenue% 12.8 11.0 Experimental supplement groups per mother and day: Selenium (mg) - 3.0 Vitamin E (g) - 40.0 BHT (g) - 1.5

Table 4 shows the results with the application of selenium and vitamin E in hydrophilic form in calves fed with milk replacer.

Table 4

Effects of selenium and vitamin E for rearing calves fed on milk replacer ^Λ

Parameter Negative Experimental control group

Number of calves 675 1 285 Increment piece / day / g 674 726 Mortality in% 5.4 4.8 Occurrence of diarrhea in% 14.6 12. 1

Test Group Supplement at. piece and day ·

Se fief (yug) - 120

Vitamin E (mg) - 300 mg

Claims (2)

PATENT CLAIMS 1. A premix feed, supplement di other concentrated preparation for poultry, pigs, ruminants and other selenium-based livestock, characterized in that it contains in 10 kg 65 mg, weight ^f hha selenium vitamin E vitamin C beta carotene zinc riboflavin pyridoxine pantothenic acid vi tam i nu Bl2 ------------------------ 2.5 - 0,5 - 50 G 2 100 ALIGN! G , <· 0,5 - 3 g ^: 1 5 G 200 - íooo mg 100 - 1ΟΟΟ mg 0,5 - 2 G r - 1 5 mg 10 - 50 G and optionally trihydroxybenzoic acid, their harmless salts and esters of 6-30 g of DL-methionine 2 - 10 g choline 10-30 g ----- butyl hydroxy toluene, other harmless synthetic antioxidants, and optionally other active substances selected from the group consisting of vitamins, provitamins, enzymes, amino acids, methyl group donors, lipotropic substances, antibiotics and other chemotherapeutics, bioflavins, biogenic and trace elements, flavoring substances and substances that increase feed intake and use IQ feed, Feed premix, concentrate di supplement for poultry, pigs, ruminants and other monogastric di polygastric animals, characterized in that it contains the preparations mentioned in claim 1 in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of the feed. t. j. eg complete feed mixtures of directly fed protein or other core concentrate