CZ204897A3

CZ204897A3 - Peptide and the use thereof

Info

Publication number: CZ204897A3
Application number: CZ972048A
Authority: CZ
Inventors: Stefan Dr Dhein; Tatjana Tudyka
Original assignee: Basf Ag
Priority date: 1995-01-14
Filing date: 1996-01-04
Publication date: 1997-12-17
Also published as: EP0805818A1; IL116658A0; AU4483696A; WO1996021674A1; KR19980701397A; JPH11511727A; ZA96239B; FI972965A; BR9606756A; DE19500990A1; NO973230D0; CA2209496A1; FI972965A0; MX9704796A; CN1168142A; NO973230L

Abstract

The description relates to novel compounds of formula (I) in which R, X, Y and Z have the meanings given in the description and their production. The compounds are suitable for combatting diseases.

Description

- 1 - 1 • φ · φ φ

· Φ φ φ · · ((((φ φ .11,, ''''''''''',,,,

The present invention provides a novel process for the preparation of said compound; pdl.lž. .tU st U TI. Πι i.savadu; sbav tne: d i i n t know that piumdiy sih mi i tn < The rhythm of the most important cause of death in the idea of the inventive earth v. h. Big mail. Mail a special tons in snmaslizU with knnniárn imi diseases heart. a sohéiíi and I and I 'also higher her age well. Μι and dian and siny. kta ré vedi in ary lan ii. i smi P 'a ti iin ve i ni i od 1 i sne and Čásboně not is dli dnsml úlľia; Něiiy. Is ii st. That the train on the Piirk in is also very active. in ilii ni z.uaineii al. o xl.i 1i i i i i i i i i i i i i i i i i i i i i i e i i i i i i i i i i i i i i i li i i li li i i li li i i li k i i k i i i i i i e li to i go to go 1 ti pi i 1 ati: M1 'i Μ 1 ak en, kt.epá isi 111 then ι', ΐ'.Ι i πι · i nli > 1 to my heart, which makes it to O; t. to one laugh at the same time. K iin, id i > a · μ · e e e e e e e e e e e e e e e e e (kdi · .. pel zi) t, 1 of the action p < lun: i á! li, which. Ulil That is a: .i np.it. i iki uhy peenl.ry. The circuit excitement can then be carried out by the nitrous coil of the caraway, and the dian and sin i kra, in the man. to the hook i! ia · erz i 1 I v á 1! ! acre is driven by 11 11 ARE bil · "IIL'1 IIH i idpi i) iVdil i (and π., Th. I, -. La. 147 ·, I o :: ·),! r 1you se 1 »ak 1! | I I am pouring MI pouring I >. 1 1 in 1 &2; lil 1 i That i < dmi k vzn ik at. i pukračn i i i i ii i ii ri j i dti i s i 1 M'i; ijik 1 1 '. 1 .lUilll i v. Ii lili i li li., Iii (iii. K'tf :: j. I ', í iy,,: .dd «1 1, Γΐίίϋ) of the ship! if VI line: i lni ar k i ll i / i t i l i l i i i-l l une ci di spi < i li 1 k.aia! i: < jap ich ion) zak! ad 1 eg 1 ad i s i i i i i i i i i i i c e << i ί: tp .1 to 1 i " a! 1 C 1 li idnot v pil a ο las a hn A i ï (Am 1. Influence i 74! 1, t 1 - i 1V: i '· to II7 by 4. 1 etr;: (ai c. 4b, stas c! 4 l 07 * Up (iosud s 1 'ia k < i ary t ika p < i i vata t i l l i &i; iianidia! 1! | iti kana lii, kt.eia t.di kuji! i ans diaphragm 1 d tl é kaná * * * * * * * *

φ φ φ φ φ φ φ! γ (& kaná,,,,,,,,,,,,,,,,,,,,,,, n n n n kanály kanály kanály kanály kanály kanály kanály kanály kanály kanály kanály) i aklitu ich, ji zn tu > ta n.ij > i vs ir: h ριιπιι.Ί] and (rhythm.

However, the proclaimed occurrence occurred when all of the compounds were present (such as the blocking agents). < thread of your channel i / ysokt ρι im ry ln ii: kt · ik-! ii «i > Hi” í (Ihaiás klá. Snpl .4, skr. Ί3, ι ž 'M, 1 Mhb: Nov tnillaml J .

Honey MIM, Wed, Fri 1. Tri μ nu > π · ι that rights' by submitting V.! as irrigated in iIdI against < n yt.n < n > in pai < i < tb > Therefore, the prophylaxis of onmoxorio is suitable.

Proku: a: still looking | The new principles of action, which no longer show a lot of proarrhythmic activity, have been found to have 1 cell / cell cell kick. lat Ό

Clinical and experimental results with well-known nor. The ary kms have shown that it is hardly possible for a high fnoary to have some side effects that can also be proved by the pn-kllSem invi thorn (New Thorns I and .1. Med. 3 skr4. Scr. '/! &Gt; 1, 1 1T Π - Pir- cn.Iati.un b7, Scr. F.1.7, I o > i: <> where p was iwviýfii and π kia ry km o k n c o 1 d a, d, u 174, l'j4. & gt, which leads ován i | i i i i i i i i i i i i i i i i i i i i i i i i i i místní místní místní ala místní ala ala ala ala Iί I experiments in vi t.ro na izolnvanái; iki á 1 ičím suli: i 111 1 vy ka Z! lie ka kn · -;! t mát mi i na prak! íčky zadut 'ja; ri ry iiii ΐ * The primary effect of the compound is to change the effect of the effect of the compound, in that it differs from the point of view of the device. i i: i i 1 n i di iby. i '(&d; ta d i t i i; i);

of Formula I

The essence of the present invention is the oil-based poppy.

- NO!, -

IbN - X - Ala - kly - Hyp - V - HH - kil i

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/ iiHjiia j η η, ir y! i í m k71i < im *! »v-ipt * r ((i > ι nlrj111n i-, t» v l ?mylpl i pt 11 »l lil i / m itj | K ij f'i 111, i tu j ii kiinkii pu .iin kru an]] h ú ú ú ú ú - - - - - -,,,,,,,, 1 1 1 1 11 11 1.1 /.17, 1 XXX 1 ps ps * pk i ilii i if 1 11 vyna 11 νιι, I j di ika i nu a 1 1 f -k; ijn 11111 v (mX-- nyrh I im · -1 ι -iifi · i · vi li ki Uiri M ι kl let ii: h Cviiltiá lt < ίιμι · ι'νΙ γρι'τ · vp!; J · .iíj < * 11 Jp Κηιιπ: J Γ 1 1 f V í ii ΛΑΡ1 Π ΑΑΙΊ xrr kil It} k .ijn F 11 k vlili · kf ni 1 rn 1 and XX + / -: i XX / - th XX / - • ls XX ¥ / · * > -lil, 1 lili! X4 + / -: -1 ·) ·) r-. . 1 ¥ / - 4 - 'k 0 (lil XX + / -:) ni / - X (»ΓΊ, ni ií i XX + / -: 1 1 7 -l · · / - X •? (, Nun' X . 1 + / -:) 17 - + / - (> xr, + - / - X < 7.: Inu 1 x i- / - X - 'i, f, X!? Xr, · + / -; > 1 '1, iX4 1! i 4 "/ - X - X,: ii μ i XX / - 1 - X, (1111) 17 + / - tu · .1 .1 s | m ut- .um;; gt ;; ί i li tkni 1 I. í vi 'ktiiii! V t?! mt pn - 1 f, t. í í í í 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 \ t li - 1 i i i Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr Dr - - vi vi vi vi vi vi vi vi ι ι i 1 i.lik -ι ι nk ι it · i Μ X. Π 1V i: t τ π * 17 i ii, jr sic i mni i 11 / > fl η 1 ý iU p) - r íl ·) im lii ii: kkln ϊ nilSF'1 l | 1 * Ί 1 iy, s | fΠ ry: ['! = L ií ni r! 1 mi 1! i iil three ik: l li < i li i i; ί ti iry kapii j &r;< i ikííí li 1, -1 ry ii; ncl π i; : i II: iTtlF1 V; j in, 'fi · ,: IV I 1 I ·! inivt. 1V | . II 111 ι i ι i i i i i i i i n i i n i i c i c i c i c i i c i i, i n > -lii ii in pi nk ii il · τίμ. 11. ·! < · I.

Claims

φ •φφφ • • • • • • • •φφφφφφφφφφφφφφφφφφφφ

φφ - Ί 1 'Λ! i: II r II V 1 Ν Λ Ρ II Κ V 1. Poj >! i 11 i Ί) ί ί κ κ κ κ κ κ κ κ II X X X X X X X X X X X X X X X X η η η CM η η η lil! · 11. i R 11. UM Vild i 11 Iiol II 1 hyi 1 r ι & xy 11 IVOU 1,; kiip inu XA] a, Ary, li 1 v π i1 P. i V a 1. N av Μ av t n ii nil í n n n oi n n n n n n n n n n n n n n n n n n n n av av av av av av 11 ill l l v v v le z z z z z z y y y y y y y y y y y y y y y z z z z y y y y y y The composition of claim 1 is not known in the art. Ily N - lily - Ala - f 11 y - llyii - Pro 'ι οι 11 ytoin · π ι · I d. Popkjd i > ι κ 1 le claim 1 ulmrnélio U7nn: i ·' I pm jnmžikí ι! i imi m · i-i i