CZ20002051A3 - Acylated hetero-alicyclic derivatives - Google Patents

Abstract

A compound of formula I, or a pharmaceutically acceptable salt thereof an acceptable salt, ester or other derivative wherein R 1 is optionally substituted cycloalkyl or optionally substituted saturated heterocyclic group; R2 is optionally substituted aryl or optionally substituted a heteroaryl group; A is methylene, carbonyl or a sulfonyl group; B is a single bond, alkylene or alkenyl; D is an oxygen atom or a sulfur atom; Gje an alkylene or alkenyl group; L is a generic group of formula -N (R 3) - or -C (R 4) (R 5) - wherein R 3 is optionally substituted aryl or optionally substituted a heteroaryl group; R 4 is hydrogen, optionally substituted aryl, optionally substituted heteroaryl a group, optionally substituted cycloalkyl or optionally substituted saturated heterocyclic group; R5 is an alkyl group optionally substituted by an amino group, amino, optionally substituted acylamino, hydroxy, optionally substituted hydroxyalkyl a group, alkoxy or -CO-R 6, wherein R 6 is alkyl a group, alkoxy or amino residue; or R 4 together with R 5 forms a cycloalkane ring, a cycloalkenyl ring, saturated heterocyclic ring; R 7 is alkyl; Z is two atoms hydrogen or oxygen; n is 0, 1 or 2. The compounds have selective antagonism against Nk2 receptors. Pharmaceutical composition and use of compounds for the manufacture of a medicament for the treatment of asthma, bronchitis, rhinitis, allergy or urinary incontinence.

Description

Technical field:

The present invention relates to compounds having a selective NK ₂ receptor antagonist activity.

BACKGROUND OF THE INVENTION:

It is known that NK receptors, _NK2 receptors and NK3 receptors act as tachykinin receptors. For tachykinin antagonists, compounds that demonstrate selective antagonist activity against NK ₁ , NK ₂ and NK ₃ receptors, and compounds that demonstrate antagonist activity against more than one of these receptor subtypes (eg, both NK ₁ and NK ₂ receptors) have been discovered in recent years. If it is intended to completely inhibit the action of tachykinins, it is important to use a compound that demonstrates an antagonistic effect against more than one of these receptor types.

However, since it is generally predicted that the frequency of occurrence of other than desirable pharmacological effects increases when a compound inhibits the action of more than one of certain receptor types, a compound that demonstrates a selective and potent antagonistic effect against specific receptors is also of interest.

Compounds which are considered structurally similar to the compounds of the present invention are disclosed in EP-776893, but these compounds demonstrate antagonistic activity against both NK ₁ and NK ₂ receptors and could therefore be considered completely different from the compounds of the present invention that selectively demonstrate antagonistic effect against NK ₂ receptors.

Regarding the selective NK ₂ receptor antagonist effect, clinical studies with SR48968 (a compound having Structural Formula A below) have been initiated. In addition, SR144190 (a compound having Structural Formula B below) is reported to have a NK ₂ receptor-selective antagonist effect that is more potent than SR48968 (X. Emonds-Alt et al., Tachykinins in Health and Disease, 7-11. October 1997, Caims, Australia, abstract p. 5).

• · · · · · · · · · · · · · ·

SUMMARY OF THE INVENTION:

As a result of conducting extensive research on tachykinin receptors, the present inventors have found that the novel acylated heteroalicyclic derivatives have an excellent NK2-selective antagonistic effect, leading to the completion of the present invention.

It is a further object of the present invention to provide a new medicament comprising the above compound as an active ingredient. Examples of diseases to which this drug may be administered include diseases of the central nervous system such as anxiety, depression, psychosis, and schizophrenia; neurodegenerative diseases such as AIDS dementia, Alzheimer's senile dementia, Alzeimer disease, Down's syndrome, demyelinating diseases, amyotrophic lateral sclerosis, neuropathy, peripheral neuropathy and neuralgia; respiratory diseases such as chronic obstructive pulmonary disease, bronchitis, pneumonia, bronchitis, asthma and cough; inflammatory diseases such as inflammatory bowel disease, psoriasis, fibrosis, arthosteosis, degenerative arthritis and rheumatoid arthritis; eczema; allergic diseases such as runny nose; hypersensitivity diseases such as hypersensitivity to grapevines; ophthalmological diseases such as conjunctivitis, conjunctivitis, spring catarrh, destruction of the blood-eye fluid barrier caused by various inflammatory eye diseases, increased intraocular pressure and miosis; skin diseases such as contact dermatitis, atopic dermatitis, urticaria and other eczematic dermatitis; dependencies such as alcohol dependence; somatic diseases caused by stress; involved in reflex dystrophy, such as shoulder-hand syndrome; dysthymia; undesirable immune responses, such as transplant defensive reactions, immunopotentiating diseases such as systemic lupus erythematosus, or immunosuppression; digestive diseases such as diseases caused by abnormalities of the nerves regulating organs, colitis, ulcerative colitis and Crohn's disease; vomiting such as vomiting induced by adverse effects of X-rays and chemotherapy, poisons, toxins, pregnancy, vestibular disorders, postoperative disease, gastrointestinal occlusion, decreased gastrointestinal activity, physical pain, migraine, increased intracranial pressure, decreased intracranial pressure or various drugs; bladder diseases such as cystitis and urinary incontinence; eosinophilia caused by collagen disease, scleroderma or Fasciola hepatica infection; diseases caused by abnormal blood flow due to vascular enlargement or vasoconstriction, such as angina, migraine and Reynauds disease; and pain or pain signals such as migraine, headache and toothache; and temporary sleep breathing. In particular, the novel medicament of the present invention can be used as a preventive or therapeutic agent against asthma and / or bronchitis, rhinitis, allergic diseases and urinary incontinence.

1) This invention relates to a compound of formula I and a pharmaceutically acceptable salt, ester or other derivative thereof:

R ²

or

where

R ¹ represents a (C ₃ -C 7) cycloalkyl group, a three to seven membered saturated heterocyclic group, a (C ₃ -C 7) cycloalkyl group substituted with 1 to 3 substituents selected from group A and B substituents, or a three to seven membered saturated heterocyclic group substituted 1 or 2 substituents selected from group A substituents and group B substituents,

R ² represents an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from group A substituents, or a heteroaryl group substituted with 1 to 3 substituents selected from group A substituents,

A represents a methylene group, a carbonyl group or a sulfonyl group,

B represents a single bond, a (C 1 -C 6 -alkylene group or a (C 2 -C 4) alkenylene group,

D represents an oxygen or sulfur atom,

G represents a (C 1 -C 4) alkylene group or a (C 2 -C 4) alkenylene group,

L is -N (R ³ ) - or -C (R ⁴ ) (R ⁵ ) wherein o

R represents an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from substituent group A, or a heteroaryl group substituted with 1 to 3 substituents selected from substituent group A,

R ⁴ represents a hydrogen atom, an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from group A substituents, a heteroaryl group substituted with 1 to 3 substituents selected from group A substituents, a (C 3 -C 7) cycloalkyl group, three to seven membered saturated (C 3 -C 7) cycloalkyl substituted with 1 to 3 substituents selected from group A substituents and group B substituents, or a three to seven membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents,

R ⁵ represents lower alkyl, amino, acylamino, lower acylaminoalkyl, acylamino in which the nitrogen atom is substituted by lower alkyl, hydroxy, lower hydroxyalkyl in which the oxygen atom is optionally substituted by arylalkyl, lower alkoxy or - CO-R ⁶ (wherein R ⁶ is lower alkyl, lower alkoxy, amino, aryl substituted with 1 to 3 substituents selected from group A substituents, or heteroaryl substituted with 1 to 3 substituents selected from group A substituents), or

R ⁴ and R ⁵ together with the carbon atom to which they are attached form a (C 5 -C 8 cycloalkane ring, (C 5 -C 8 cycloalkene ring), or a five to eight membered saturated heterocyclic ring (any of these rings may be optionally substituted with 1 or 2 substituents selected from A or A substituents, and may optionally be fused to an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from Group A substituents, or a heteroaryl ring substituted with 1 to 3 substituents selected from Group A substituents,

R ⁷ represents a lower alkyl group,

Z represents 2 hydrogen atoms or an oxygen atom, n represents 0,1 or 2.

• · φ · · φ · · φ · · φφ ··

Group A substituents;

Halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups, lower alkoxycarbonyl groups, carboxyl groups, hydroxy groups, lower aliphatic acyl groups, lower aliphatic acylamino groups, amino and cyano groups,

Group B substituents:

oxo and thiol groups; and as substituents on the nitrogen atom, lower alkyl, aryl and alkylaryl groups, which may optionally be substituted with a substituent selected from the substituents of the group A of the lower alkanesulfonyl group and the acyl group.

Among the compounds of formula (I), the following compounds and their pharmaceutically acceptable salts, esters and other derivatives are preferred:

2) compounds wherein R ¹ is a C 3 -C 6 cycloalkyl group, a five or six membered saturated heterocyclic group, a C 3 -C 6 cycloalkyl group substituted with 1 to 3 substituents selected from group A substituents and group B substituents, or a five or six membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents,

3) compounds wherein R ¹ is a C 3 -C 6 cycloalkyl group, a five or six membered saturated heterocyclic group, or a five or six membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents,

4) compounds wherein R ² is an aryl group, or an aryl group substituted with 1 to 3 substituents selected from substituents of group A

5) compounds wherein R ² is an aryl group substituted with 1 to 3 halogen atoms,

6) compounds wherein A is a methylene or carbonyl group,

7) compounds wherein A is a carbonyl group and Z is two hydrogen atoms, or wherein A is a methylene group and Z is an oxygen atom,

8) compounds wherein A is a carbonyl group,

9) compounds where B is a single bond,

(10) compounds where D is an oxygen atom,

11) compounds wherein G is a C 1 -C 4 alkylene group,

12) compounds wherein G is a C2-C3 alkylene group,

13) compounds wherein R ³ is a heteroaryl group, or an aryl group substituted with 1 to 3 substituents selected from substituents of group A,

14) compounds wherein L is -C (R ⁴ ) (R ⁵ ) -,

15) compounds wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a C 5 -C 8 cycloalkane ring, a C 5 -C 8 cycloalkene ring, or a five or eight membered saturated heterocyclic ring (any of these rings may optionally be substituted by 1) or 2 substituents selected from group A substituents and group B substituents and may optionally be fused with a saryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents or a heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents,

16) compounds wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a C 5 -C 6 cycloalkane ring, a C 5 -C 6 cycloalkene ring, or a five or six membered saturated heterocyclic ring (any of these rings may optionally be substituted with 1) or 2 substituents selected from group A substituents and group B substituents and may optionally be fused with a saryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents or a heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents,

17) compounds wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a cyclopentane ring, cyclopentene ring, tetrahydrothiophene ring, tetrahydrothiophenesulfoxide ring, tetrahydrothiophenesulfone ring or piperidine ring (either of which may be optionally substituted with 1 or 2) substituents selected from group A substituents and group B substituents and may optionally be fused to an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents, or a heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents,

18) compounds wherein Z is two hydrogen atoms,

19) compounds wherein n is 0 or 1,

20) compounds wherein n is 1.

9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9

In addition, compounds that comprise a combination of factors selected at random from each of the ten groups are 2) and 3); 4) and 5); 6) to 8); 9); 10); 11) and 12); 13); 14) to 17); 18); 19) and 20) are also preferred.

Particularly preferred compounds are:

21) a compound selected from the following compounds, or a pharmaceutically acceptable salt, ester, or other derivative thereof:

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'- piperidine] - (2S) -oxide, 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophene- 1- (2 H), 4'-piperidin] - (2 S) -oxide, 1- {2 - [(2/7) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophene-1 (3H), 4'-piperidine] - (2S) -oxide, 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- ( cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2 S) -oxide, 1- {2 - [(2 R) - ( 3,4-difluorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2, S) -oxide,

- {2 - ((2/7) - (3,4-difluorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine 1 - {2 - [(2/7) - (3,4-difluorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1] - (2S) -oxide (3 '), 4'-piperidine] - (2S) -oxide,

- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 '- piperidine] - (2S) -oxide,

- {2 - ((2/7) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [((2S) -hydroxy) indane-1,4'-piperidine ],

1- {2 - ((2/7) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [((2S) -hydroxy) indane-1,4'-piperidine ], 1- {2 - [(2/7) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [((2S) -hydroxy) indan-1, 4'-piperidine],

- {2 - ((2/7) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indan-1,4'-piperidine ], 1- {2 - [(2 H) - (3,4-difluorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indane-1,4 ' -piperidine], e tt tt tt tt ttt lt {2 - [(2 R) - (3,4-Difluorophenyl) -4- (cyclobutanecarbonyl) -orpholin-2-yl] ethyl} spiro [((2 R) -hydroxy) indan-1,4 '- piperidine], 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl) spiro [((2 S) -hydroxy) indane-1,4] '-piperidine],

- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indane-1,4'-piperidine ],

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} -4-phenylpiperidine-4-carboxamide, and

- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} -4- (2-pyridyl) piperidine-4-carboxamide.

In addition, the novel medicament of the present invention contains as an active ingredient a compound or a pharmacologically acceptable salt, ester or other derivative thereof described in any of the groups selected from groups 1) to 21). In particular, the medicament may be used as a preventive or therapeutic agent for tachykinin-mediated diseases (eg asthma and / or bronchitis, runny nose, allergic diseases and urinary incontinence).

In formula I:

"C3-C7 cycloalkyl" and C3-C7 cycloalkyl "C3-C7 cycloalkyl substituted with 1 to 3 substituents selected from substituents of group A and substituents of group B" as used in the definitions of R ¹ and R ⁴ includes cyclopropyl, cyclobutyl , cyclopentyl, cyclohexyl and cycloheptyl groups.

The "C 3 -C 7 cycloalkyl group" above may optionally be fused to an "aryl ring", "heteroaryl ring", "aryl ring substituted with 1 to 3 substituents selected from group A substituents" or "heteroaryl ring substituted with 1 to 3 substituents selected from substituents group A "(" aryl ring "and aryl ring" aryl ring optionally substituted with 1 to 3 substituents selected from substituents of group A "includes C 6 -C 10 aromatic hydrocarbon rings such as benezene ring, indene ring, naphthalene ring, phenanthrene ring and anthracene ring The "heteroaryl ring" and the heteroaryl ring of the "heteroaryl ring substituted with 1 to 3 substituents selected from the group A substituents" includes five to seven membered heteroaryl rings containing 1 to 3 sulfur, oxygen and / or nitrogen atoms such as e.g. furan ring, thiophene ring, pyrrole ring, azepine ring, pyrazole ring, imidazole ring β 9 9 9 * ♦ J 9 ·

I 9 9

9 9 · 9 ·

9 · 9 9

A ring, oxazole, isoxazole ring, thiazole ring, isothiazole ring, 1,2,3-oxadiazole ring, triazole ring, tetrazole ring, thiadiazole ring, pyran ring, pyridine ring, pyridazine ring, pyrimidine ring and pyrazine ring; preferred heteroaryl rings include five to seven membered heteroaryl rings having at least one nitrogen atom and optionally may also have a sulfur or oxygen atom, e.g., pyrrole ring, azepine ring, pyrazole ring, imidazole ring, oxazole ring, isoxazole ring, thiazole ring, isothiazole ring ring,

1,2,3-oxadiazole ring, triazole ring, tetrazole ring, thiadiazole ring, pyridine ring, pyridazine ring, pyrimidine ring and pyrazine ring; more preferred heteroaryl rings include pyridine ring, imidazole ring, oxazole ring, pyrazine ring and thiazole ring). Examples of C3-C7 cycloalkyl groups fused to one of these ring systems include benzocyclobutenyl, indanyl, 4,5,6,7-tetrahydroindanyl, tetrahydronaphthyl, 5,6,7,8-tetrahydroquinolyl and 5,6,7,8 -tetrahydroisoquinolyl.

"Three to seven membered saturated heterocyclic group" and three to seven membered saturated heterocyclic group "three to seven membered saturated heterocyclic group substituted with 1 or 2 substituents selected from substituents of group A and substituents of group B" in the definitions of R ¹ and R ⁴ mean three to seven membered non-aromatic heterocyclic a group containing 1 to 3 sulfur, oxygen and / or nitrogen atoms, preferably a 5 to 6 membered non-aromatic heterocyclic group containing 1 to 3 sulfur, oxygen and / or nitrogen atoms, more preferably a 5 to 6 membered non-aromatic group containing 1 or 2 sulfur, oxygen and / or nitrogen. Examples of such a group are pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, oxazolidinyl, thiazolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl and azepinyl groups.

These groups may optionally be fused with the same ring system as for "aryl ring", "heteroaryl ring", "aryl ring substituted with 1 to 3 substituents selected from group A substituents" and "heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents ", As described above. Examples of such a group include 1,2,3,4-tetrahydroisoquinolinyl and the like.

In addition, examples of a "5- to 7-membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A and group B substituents" include 2-oxooxazolidinyl, 2-oxothiazolidinyl, and the like.

"Aryl" in the definitions of R ² , R ³ and R ⁴ , "aryl" of "aryl groups substituted with 1 to 3 substituents selected from the substituents of group A" in the definitions of R, R, R, and

R ⁶ , and "aryl" As substituents on the nitrogen atom, an aryl group that may be

4

4-4 44 ·· ··

4 ·· 4 4 * · »• · 44

44 4 4 4 4 4 4 4 4 4 4 ·· «44 * •• 4 4 44 4 4 44 4» optionally substituted with a substituent selected from substituent group A 'in the definition of substituents group B means a C5-C14 aromatic hydrocarbon group such as a phenyl, indenyl, naphthyl, phenanthryl and anthracenyl group, preferably a phenyl group.

In addition, the above-mentioned "aryl group" may optionally be condensed with a C 3 -C 10 cycloalkyl group, and examples of such a group include 5-indanyl group and the like.

"Heteroaryl" in the definitions of R ² , R ³ and R ⁴ and "heteroaryl" of "heteroaryl groups substituted with 1 to 3 substituents selected from the substituents of group A" in the definitions of R ² , R ³ , R ^{4 and} R ⁶ mean five to seven membered heteroaryl a group containing 1 to 3 sulfur, oxygen and / or nitrogen atoms, such as furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl,

A 1,2,3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl group, preferably a five to seven membered heteroaryl group containing at least one nitrogen atom and optionally containing a sulfur or oxygen atom, e.g., pyrrolyl, pyrazolyl, imidazolyl oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl groups, and more preferably pyridyl, imidazolyl, oxazolyl, pyrazinyl and thiazolyl groups.

In addition, the aforementioned "heteroaryl group" may optionally be condensed with another ring system and examples of such a group include indolyl, benzofuryl, benzothienyl, benzoxazolyl, benzimidazolyl, isoquinolyl, quinolyl and quinoxalinyl groups and the like.

"C1-C4 alkylene" in the definition of B and G means an unbranched or branched C1-C4 alkylene group such as methylene, methylmethylene, ethylene, propylene, trimethylene, tetramethylene, 1-methyltrimethylene, 2-methyltrimethylene and 3-methyltrimethylene.

With respect to B, a straight or branched C 1 -C 3 alkylene group is preferred.

As for G, a straight or branched C 1 -C 3 alkylene group is preferred, ethylene and trimethylene are more preferred, and ethylene is most preferred.

"C2-C4 alkenylene" in the definition of B and G means an unbranched or branched C2-C4 alkenylene group such as ethenylene, 2-propenylene,

8 · ···· ««

9 9 9

9 9 9 •

9 9 9

1-methyl-2-propenylene, 2-methyl-2-propenylene, 2-ethyl-2-propenylene and 2-butenylene, preferably ethenylene, 2-propenylene or 3-butenylene, and more preferably ethenylene or 2-propenylene.

"Lower alkyl" in the definition of R ⁵ , R ⁶ , R ^7, and A substituents; "Lower alkyl""acylamino wherein the nitrogen is substituted with a lower alkyl" in the definition of R ³ ; "Lower alkyl" means "lower hydroxyalkyl, wherein the oxygen atom is optionally substituted with an arylalkyl group" in the definition of R ⁵ ; "Lower alkyl" means "lower acylaminoalkyl" in the definition of R ⁵ ; "Lower alkyl group" As substituents on a nitrogen atom, a lower alkyl group which may be optionally substituted with a substituent selected from substituents of group A "in the definition of substituents of group B means an unbranched or branched C 1 -C 6 alkyl group such as methyl, ethyl," -propyl, isopropyl, n -butyl, isobutyl, sec-butyl, tert-butyl, n -pentyl, isopentyl, 2-methylbutyl, neopentyl, 1-ethylpropyl, n -hexyl, isohexyl, 4-methylpentyl, 3-methylpentyl, 2 -methylpentyl, 1-methylpentyl,

3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl,

2,3-dimethylbutyl and 2-ethylbutyl. More preferred is a straight or branched C1-C4 alkyl group.

"Acyl""acylamino","acyl""loweracylaminoalkyl" and "acyl""acylamino" in which the nitrogen atom is substituted by lower alkyl "in the definition of R ³ ; and "acyl" As substituents on the nitrogen atom, acyl groups "in the definition of group B substituents means, for example, an" aliphatic acyl group "including an alkylcarbonyl group such as formyl, acetyl, propionyl, butyryl, isobutyryl, pentynoyl, pivaloyl, valeryl, isovaleryl , octanoyl, nonylcarbonyl, decylcarbonyl, 3-methylnonylcarbonyl, 8-methylnonylcarbonyl,

Ethyloktylkarbonyl-3, 3,7-dimethyloctylcarbonyl, undecylcarbonyl, dodecylcarbonyl, tridecylcarbonyl, tetradecylkarbonyl, pentadecylcarbonyl, hexadecylcarbonyl, 1-methyl lpentadecylkarbonyl, 14-methylpentadecylcarbonyl, 13,13-dimethylethyl ltetradecylkarbonyl, heptadecylkarbonyl, 15-methylhexadecylcarbonyl, octadecylcarbonyl, 1-methylheptadecylcarbonyl, nonadecylcarbonyl, icosylcarbonyl, and henicosylcarbonyl; a halogenated alkylcarbonyl group such as chloroacetyl, dichloroacetyl, trichloroacetyl and trifluoroacetyl; a lower alkoxyalkylcarbonyl group such as methoxyacetyl; and an unsaturated alkylcarbonyl group such as acryliccarbonyl, propionylcarbonyl, methacrylcarbonyl, crotonylcarbonyl, isocrotonylcarbonyl, (A 2 -methyl-2-butenoyl) "aromatic acyl" including an arylcarbonyl group such as benzoyl, α-naphthoyl and β a halogenated arylcarbonyl group such as 2-bromobenzoyl and 4-chlorobenzoyl;

* · ·.

· • · * * * * · ·

2,4,6-trimethylbenzoyl and 4-toluoyl; an arylcarbonyl group substituted with a lower alkoxy group such as 4-anisoyl; nitrated arylcarbonyl group such as 4-nitrobenzoyl and 2-nitrobenzoyl; an arylcarbonyl group substituted with a lower alkoxycarbonyl group such as 2- (methoxycarbonyl) benzoyl; and an arylated arylcarbonyl group, such as e.g.

4-phenylbenzoyl; An "alkoxycarbonyl group" including a lower alkoxycarbonyl group such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl and isobutoxycarbonyl; and a lower alkoxycarbonyl group substituted with halogen atoms or a tri (lower alkyl) silyl group such as e.g.

2.2.2-trichloroethoxycarbonyl and 2-trimethylsilylethoxycarbonyl; "Alkenylcarbonyl" such as vinylcarbonyl and allylcarbonyl; An "arylalkylcarbonyl group" whose aryl ring may be optionally substituted by one or two lower alkoxy or nitro groups such as benzylcarbonyl, phenacyl, 4-methoxybenzylcarbonyl,

3,4-dimethoxybenzylcarbonyl, 2-nitrobenzylcarbonyl and 4-nitrobenzylcarbonyl; A "lower alkanesulfonyl group" such as methanesulfonyl, ethanesulfonyl and 1-propanesulfonyl; a fluorinated "lower alkanesulfonyl group" such as trifluoromethanesulfonyl and pentafluoroethanesulfonyl; and an "arylsulfonyl group" such as benzenesulfonyl and p-toluenesulfonyl. Among these groups, the following are preferred: "aliphatic acyl", "aromatic acyl" and "lower alkanesulfonyl".

"Lower alkoxy" in the definition of R ⁵ , R ⁶ and substituents of group A and "lower alkoxy" of "lower alkoxycarbonyl" in the definition of substituents of group A means a group in which the above-mentioned "lower alkyl" is attached to an oxygen atom, e.g. unbranched or branched C1-C6 alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, t-butoxy, n-pentoxy, isopentoxy, 2-methylbutoxy, neopentoxy, n-hexyloxy , 4-methylpentoxy, 3-methylpentoxy, 2-methylpentoxy, 3,3-dimethylbutoxy,

2,2-dimethylbutoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy and

2,3-dimethylbutoxy. Preferred is a straight or branched C1-C4 alkoxy group.

"Arylalkyl" means "lower hydroxyalkyl groups wherein the oxygen atom is optionally substituted with an arylalkyl group" in the definition of R ⁵ and "arylalkyl group" As substituents on the nitrogen atom, lower alkyl, aryl and alkylaryl groups which may be optionally substituted with a substituent selected from substituents group A 'in the definition of substituents of group B means a group in which the above-mentioned "aryl group" is attached to the above-mentioned "alkyl group", eg benzyl, α-naphthylmethyl, β-naphthylmethyl, indenylmethyl, phenanthrenylmethyl, anthracenylmethyl, diphenylmethyl, triphenylmethyl , 1-phenylethyl, aaa aaa aaa aa * * 9 9 9 9 9 a 9

2-phenylethyl, 1-naphthyl ethyl, 2-naphthylethyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenylpropyl,

1-naphthylpropyl, 2-naphthylpropyl, 3-naphthylpropyl, 1-phenylbutyl, 2-phenylbutyl, 3-phenylbutyl,

4-phenylbutyl, 1-naphthylbutyl, 2-naphthylbutyl, 3-naphthylbutyl, 4-naphthylbutyl, 1-phenylpentyl,

2-phenylpentyl, 3-phenylpentyl, 4-phenylpentyl, 5-phenylpentyl, 1-naphthylpentyl, 2-naphthylpentyl,

3-naphthylpentyl, 4-naphthylpentyl, 5-naphthylpentyl, 1-phenylhexyl, 2-phenylhexyl, 3-phenylhexyl,

4-phenylhexyl, 5-phenylhexyl, 6-phenylhexyl, 1-naphthylhexyl, 2-naphthylhexyl, 3-naphthylhexyl,

4-naphthylhexyl, 5-naphthylhexyl and 6-naphthylhexyl. Preferably it is a group in which the "aryl" moiety is a phenyl group and the "alkyl" moiety is a C 1 -C 4 alkyl group. More preferably, it is a benzyl or phenylethyl group.

The "C 5 -C 8 cycloalkane ring" which forms R ⁴ and R ⁵ together with the carbon atom to which they are attached means, for example, a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, a cyclohexane ring, a cycloheptane ring and a cyclooctane ring. Preferably it is a C5-C6 cycloalkane ring and more preferably it is a cyclopentane ring.

The "C 5 -C 8 cycloalkene ring" which forms R ⁴ and R ⁵ together with the carbon atom to which they are attached means, for example, a cyclopropene ring, a cyclobutene ring, a cyclopentene ring, a cyclohexene ring, a cycloheptene ring and a cyclooctene ring. Preferably it is a C5-C0 cycloalkene ring. More preferably, it is a cyclopentene ring.

"Five to eight-membered saturated heterocyclic ring" means the "five to eight-membered saturated heterocyclic ring", which forms R ⁴ and R ⁵ together with the carbon atom to which they are attached, means a five to eight-membered saturated heterocyclic ring containing 1 to 3 sulfur, oxygen and and / or nitrogen (where the sulfur atom, if it contains a ring, may be a sulfoxide or sulfone). It is preferably a 5- to 6-membered saturated heterocyclic ring containing 1 to 3 sulfur, oxygen and / or nitrogen atoms. More preferably, it is a five-membered saturated heterocyclic ring containing 1 to 2 sulfur, oxygen and / or nitrogen atoms such as an imidazolidine ring, oxazolidine ring, pyrrolidine ring, tetrahydrofuran ring, tetrahydrothiophene ring, tetrahydrothiophenesulfoxide ring, tetrahydrothiophenesulfone ring and piperidine ring.

The "C 5 -C 8 cycloalkane ring", "C 5 -C 8 cycloalkene ring" and "five to eight membered saturated heterocyclic ring" may further be optionally substituted with 1 or 2 substituents selected from group A substituents and group B substituents and may optionally be condensed as described above. "Aryl ring", "heteroaryl ring", "aryl ring substituted with 1 to 3 substituents selected from group A substituents and group B substituents" or "heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents and group B substituents". Examples of such a group include

Φ φ φ φ φ φ φ φ φ φ φ • • • • φ φ φ φ φ φ φ φ φ φ φ

4-οχο-1-phenylimidazolidine ring, 2-oxo-3-phenyloxazolidine ring, 3-benzyl-2-oxooxazolidine ring, 1-methylsulfonyl-2,3-dihydroindole ring, 1,3-dihydroisobenzofuran ring,

1-oxo-2,3-dihydrobenzo [i] thiophene ring, 1,3-dihydrobenzo [c] thiophene ring,

2-oxo-1,3-dihydrobenzo [c] thiophene ring, 2,2-dioxo-1,3-dihydrobenzo [c] thiophene ring, 1,4-dihydro-3-isoquinolone ring, indane ring, 1-hydroxyindane ring , 2-hydroxyindane ring, 1-oxoindane ring, 2-oxoindane ring, 1,2-dioxoindane ring, indene ring and the like.

"Amino radical" in the definition of R ⁶ means an amino radical that is bound by its nitrogen atom, including an amino group; amino substituted with 1 or 2 "lower alkyl" groups such as methylamino, ethylamino, isopropylamino, butylamino, dimethylamino, diethylamino, diisopropylamino and dibutylamino; amino substituted with 1 or 2 "C 5 -C 7 cycloalkyl groups" such as cyclopentylamino, cyclohexylamino, dicyclopentylamino and dicyclohexylamino; a saturated cyclic amino radical containing at least one nitrogen atom in the ring, such as pyrrolidine, piperidine, piperazine, N-methylpiperazine, morpholine and thiomorpholine; arylamino or arylalkylamino optionally substituted on a nitrogen atom with a "lower alkyl" such as aniline, benzylamino, N-methylaniline and N-methylbenzylamino; heteroarylamino optionally substituted on a nitrogen atom with a "lower alkyl" such as pyridylamino, N-methylpyridylamino and N-ethylpyridylamino; etc. Preferably it is an amino group; amino substituted with 1 or 2 "lower alkyl"groups; a saturated cyclic amino radical containing at least one nitrogen atom in the ring, such as pyrrolidine, piperidine, piperazine, N-methylpiperazine, morpholine and thiomorpholine; or arylamino or arylalkylamino optionally substituted on the nitrogen atom with a "lower alkyl" such as aniline, benzylamino, N-methylaniline and N-methylbenzylamino.

"Halogen atoms" in the definition of A substituents include fluorine, chlorine, bromine and iodine atoms, with fluorine and chlorine atoms being preferred.

"Lower haloalkyl" in the definition of the substituents of group A means a group in which the above-described "lower alkyl" is substituted with the above-described "halogen atoms" such as trifluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, dibromomethyl;

4 * 9 4 * 444 φ 4

4 9

4 • • 4 • 4 · 44 9 9 9 9 9 9 4

9 4 4

100 * 4 4 9

9 9 9

4 4 4 9

Fluoromethyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, 2-bromoethyl, 2-chloroethyl, 2-fluoroethyl or 2,2-dibromoethyl. Among these groups, the following are preferred: trifluoromethyl, 2-bromoethyl, 2-chloroethyl and 2-fluoroethyl.

"Lower aliphatic acyl" in the definition of A substituents and "lower aliphatic acyl" in the definition of A substituents means a C2-C7 aliphatic acyl group such as formyl, acetyl, propionyl, butyryl, isobutyryl, pentanoyl , pivaloyl, valeryl and isovarelyl. Among these groups, the following are preferred: acetyl and propionyl.

With respect to "aryl substituted with 1 to 3 substituents selected from substituents of group A" in the definition of R ² , an aryl group substituted with 1 to 3 "halogen atoms" is preferred, and a phenyl group substituted with 1 to 3 "halogen atoms" is more preferred.

Since the compound (I) of the present invention can be converted to a salt form, such a salt means a "pharmaceutically acceptable salt".

Preferable examples of salts consisting of a compound of formula I of the present invention and an acid include hydrohalic acid salts such as hydrofluoric acid salts, hydrochloric acid salts, hydrobromic acid salts and hydroiodic acid salts, inorganic acid salts such as acid salts nitric acid, chloroboric acid salts, sulfuric acid salts and phosphoric acid salts; lower alkylsulfonic acid salts such as methanesulfonic acid salts, trifluoromethanesulfonic acid salts and ethanesulfonic acid salts, arylsulfonic acid salts such as benzenesulfonic acid salts and / Moluenesulfonic acid salts; salts with organic acids such as acetic acid salts, malic acid salts, fumaric acid salts, succinic acid salts, citric acid salts, tartaric acid salts, oxalic acid salts and maleic acid salts; and amino acid salts such as giycin salts, lysine salts, arginine salts, omithine salts, glutamic acid salts and aspartic acid salts.

On the other hand, preferred examples of salts that consist of a compound of formula I of the present invention and a base include metal salts such as alkali metal salts such as sodium salts, potassium salts and lithium salts, alkaline earth metal salts such as e.g. calcium salts and magnesium salts, aluminum salts and iron salts; amine salts such as inorganic salts such as ammonium salts, organic salts such as tert-octylamine salts, dibenzylamine salts, morpholine salts, glucosamine salts, phenylglycine alkyl esters salts, ethylenediamine salts, N-methylglucamine salts, salts;

9999 «9 ·· · * 9 9 99

9 9 φ 9 9 9 • 99 9 9 9 9> 9999999 ♦ · 9999 9999 * ♦ * · 99 99 9 9 9 9 guanidine, diethylamine salts, triethylamine salts, dicyclohexylamine salts, Ν, Ν'-dibenzylethylenediamine salts, chloroprocaine salts, procaine salts, diethanolamine salts, N-benzylphenylethylamine salts, piperazine salts, tetramethylammonium salts, and tris (hydroxymethyl) aminomethane salts; and amino acid salts such as glycine salts, lysine salts, arginine salts, omithine salts, glutamic acid salts and aspartic acid salts.

In addition, a quaternary amine can be prepared from a compound of formula (I) of the present invention by modifying the nitrogen atom in the piperidine group molecule with R ⁷ , such a cation and anion (which is not limited provided it is an anion and halogen ion such as chloride or iodide, may be an example of this invention) may form a salt, and such a salt is also included in the present invention.

A compound of formula I of the present invention can sometimes be converted to a hydrate due to water absorption or adhesion of absorbed water when left in the open environment, and such a hydrate is also included in the present invention.

"Ester" means an ester to which a compound of formula (I) of the present invention can be converted and includes "ester of hydroxy" and "ester of carboxyl" and indicates an ester where the ester-forming group is "general protecting group" or "protecting group it may be cleaved by biological means such as in vivo hydrolysis'.

"General protecting group" means a protecting group that can be removed by chemical means such as hydrogenolysis, hydrolysis, electrolysis and photolysis.

Preferable examples of the "general protecting group" for the "hydroxy ester group" include the above-mentioned "lower aliphatic acyl group"; the aforementioned "aromatic acyl group"; "Tetrahydropyranyl or tetrahydrothiopyranyl groups" such as tetrahydropyran-2-yl, 3-bromotetrahydropyran-2-yl, 4-methoxytetrahydropyran-4-yl, tetrahydrothiopyran-2-yl and 4-methoxytetrahydrothiopyran-4-yl; "Silyl groups" such as tri (lower alkyl) silyl groups such as trimethylsilyl, triethylsilyl, isopropyldimethylsilyl, tert-butyldimethylsilyl, methyldiisopropylsilyl, di-tert-butylmethylsilyl and triisopropylsilyl, and tri (lower alkyl) silyl groups substituted with 1 or 2 groups such as diphenylmethylsilyl, diphenylbutylsilyl, diphenylisopropylsilyl and phenyldiisopropylsilyl; "Alkoxymethyl groups" such as lower alkoxymethyl groups such as methoxymethyl, 1,1-dimethyl-1-methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, butoxymethyl and tert-butoxymethyl, lower alkoxymethyl groups alkoxylated with a lower alkoxy group such as 2-methoxyethoxymethyl , and lower haloalkoxymethyl groups, e.g.

• 4

4444 4

4 • · 4

4 4

4 44

4 4

4 4 4

44

4 «44

4 4

4 4

4 4

4 4 4

2,2,2-trichloroethoxymethyl and bis (2-chloroethoxy) methyl; "Substituted ethyl groups" such as lower alkoxyethyl groups such as 1-ethoxyethyl and 1- (isopropoxy) ethyl, and haloethyl groups such as 2,2,2-trichloroethyl; "Arylalkyl groups" such as a lower alkyl group substituted with 1 to 3 aryl groups such as benzyl, α-naphthylmethyl, β-naphthylmethyl, diphenylmethyl, triphenylmethyl, α-naphthyl-diphenylmethyl or 9-anthrylmethyl, and a lower alkyl group substituted with 1-3 aryl groups which are substituted by lower alkyl, lower haloalkyl, lower alkoxy or nitro, halogen or cyano, e.g. 4-methylbenzyl, 2,4,6-trimethylbenzyl, 3,4,5-trimethylbenzyl, 3,5-di (trifluoromethyl) benzyl, 4-methoxybenzyl,

4-methoxyphenyldiphenylmethyl, 2-nitrobenzyl, 4-nitrobenzyl, 4-chlorobenzyl, 4-bromobenzyl and

4-cyanobenzyl; the aforementioned "lower alkoxycarbonyl group"; and the above-mentioned "arylalkoxycarbonyl group".

Preferable examples of the "general protecting group" for the "carboxyl group of the ester" include the above-mentioned "lower alkyl group"; lower alkenyl groups such as ethenyl,

1-Propenyl, 2-propenyl, 1-methyl-2-propenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl,

2-methyl-2-propenyl, 2-ethyl-2-propenyl, 1-butenyl, 2-butenyl, 1-methyl-2-butenyl,

1-methyl-1-butenyl, 3-methyl-2-butenyl, 1-ethyl-2-butenyl, 3-butenyl, 1-methyl-3-butenyl,

2-Methyl-3-butenyl, 1-ethyl-3-butenyl, 1-pentenyl, 2-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-pentenyl, 1-methyl-3- pentenyl, 2-methyl-3-pentenyl, 4-pentenyl,

1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, and

5-hexenyl; lower alkynyl groups such as ethynyl, 2-propynyl, 1-methyl-2-propynyl,

2-butynyl, 1-methyl-2-butynyl, 2-methyl-2-butynyl, 1-ethyl-2-butynyl, 3-butynyl,

1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-ethyl-3-butynyl, 2-pentynyl, 1-methyl-2-pentynyl,

2-methyl-2-pentynyl, 3-pentynyl, 1-methyl-3-pentynyl, 2-methyl-3-pentynyl, 4-pentynyl,

1-methyl-4-pentynyl, 2-methyl-4-pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl and 5-hexynyl; the aforementioned "lower haloalkyl group"; &Quot; lower hydroxyalkyl groups "

2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 3,4-dihydroxybutyl and 4-hydroxybutyl; "Lower aliphatic acyl" - "lower alkyl groups" such as acetylmethyl; the above-mentioned "arylalkyl group"; and the aforementioned "silyl group".

"Protecting group that can be cleaved by a biological process, such as in vivo hydrolysis" means a group that cleaves in the human body by a biological process to provide the free acid or its salt. Whether a compound is or is not a derivative can be determined as follows: the compound is administered intravenously to the test animal, and the compound is administered intravenously to the test animal. 4 * * * * * φ φ φ * * * ΦΦ <Φ ΦΦ Φ such as rat or mouse, and then the body fluids of the animal are studied. If the parent compound or a pharmacologically acceptable salt thereof can be detected in body fluids, then the compound under study is considered a derivative.

Preferable examples of a "protecting group that can be cleaved by a biological means such as in vivo hydrolysis" for a hydroxy group include a "carbonyloxyalkyl" such as 1- (acyloxy) "lower alkyl" including 1- ("lower aliphatic acyl") oxy) "lower alkyl" groups, such as formyloxymethyl, acetoxymethyl, dimethylaminoacetoxymethyl, propionyloxymethyl, isovaleryloxymethyl,

-propionyloxyethyl,

-isovaleryloxyethyl,

-propionyloxypropyl, 1-isovaleryloxypropyl, 1-butyryloxybutyl,

-butyryloxypentyl, butyryloxymethyl, hexanoyloxymethyl,

1-butyryloxyethyl,

-hexanoyloxyethyl,

-Butyryloxypropyl

-hexanoyloxypropyl,

-pivaloyloxybutyl, pivaloyloxymethyl,

-formyloxy ethyl,

-pivaloyloxyethyl,

-formyloxypropyl,

-pivaloyloxypropyl, 1-acetoxybutyl,

1-acetoxypentyl, valeryloxymethyl, 1-acetoxyethyl,

1-valeryloxyethyl, 1-acetoxypropyl, 1 -valeryloxypropyl, 1-propionyloxybutyl, 1-propionic loxypentyl, 1-pivaloyloxyhexyl, 1-pivaloyloxypentyl and 1- ("cycloalkyl" carbonyloxy) "lower alkyl" groups, such as cyclopentylcarbonyloxymethyl, 1-pivaloyloxyhexyl, -cyclopentylcarbonyloxyethyl, 1 -cyclohexylcarbonyloxyethyl, 1 -cyclopentylcarbonyloxypropyl, 1 -cyclohexylcarbonyloxypropyl,

1-cyclopentylcarbonyloxybutyl and 1-cyclobexylcarbonyloxybutyl; 1- ("aromatic acyl" oxy) "lower alkyl" such as benzoyloxymethyl; (lower alkoxycarbonyloxy) alkyl groups such as methoxycarbonyloxymethyl, ethoxycarbonyloxymethyl, propoxycarbonyloxymethyl, isopropoxycarbonyloxymethyl, butoxycarbonyloxymethyl, isobutoxycarbonyloxymethyl, pentyloxycarbonyloxymethyl, hexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxymethyl

- (methoxycarbonyloxy) ethyl, 1- (ethoxycarbonyloxy) ethyl, 1- (propoxycarbonyloxyethyl, 1- (isopropoxycarbonyloxy) ethyl, 1- (butoxycarbonyloxy) ethyl, 1- (isobutoxycarbonyloxy) ethyl,

- (tert-butoxycarbonyloxy) ethyl,

- (hexyloxycarbonyloxy) ethyl 1,1- (cyclopentyloxycarbonyloxy) propyl, 1- (cyclopentyloxycarbonyloxy) butyl, 1- (cyclohexyloxycarbonyloxy) ethyl,

- (pentyloxycarbonyloxy) ethyl, 1- (cyclopentyloxycarbonyloxy) ethyl, 1- (cyclohexyloxycarbonyloxy) propyl, 1- (cyclohexyloxycarbonyloxy) butyl, 1- (ethoxycarbonyloxy) propyl,

2- (methoxycarbonyloxy) ethyl, 2- (ethoxycarbonyloxy) ethyl, 2- (propoxycarbonyloxy) ethyl,

2- (isopropoxycarbonyloxy) ethyl, 2- (butoxycarbonyloxy) ethyl, 2- (isobutoxycarbonyloxy) ethyl, • 4

• 9 • 9 • 9 • 9 • 9

2- (methoxycarbonyloxy) ethyl, 2- (pentyloxycarbonyloxy) ethyl, 2- (hexyloxycarbonyloxy) ethyl, 1- (methoxycarbonyloxy) propyl, 1- (ethoxycarbonyloxy) propyl, 1- (propoxycarbonyloxy) propyl,

- (isopropoxycarbonyloxy) propyl, 1- (isobutoxycarbonyloxy) propyl,

- (butoxycarbonyloxy) propyl, 1- (pentyloxycarbonyloxy) propyl,

- (hexyloxycarbonyloxy) propyl, 1- (methoxycarbonyloxy) butyl, 1- (ethoxycarbonyloxy) butyl, 1- (propoxycarbonyloxy) butyl, 1- (isopropoxycarbonyloxy) butyl, 1- (butoxycarbonyloxy) butyl, 1- (isobutoxycarbonyloxy) butyl butyl, 1- (methoxycarbonyloxy) pentyl, 1- (ethoxycarbonyloxy) pentyl, 1- (methoxycarbonyloxy) hexyl and 1- (ethoxycarbonyloxy) hexyl; oxodioxolenylmethyl groups, e.g.

[5- (4-Methylphenyl) -2-oxo-1,3-dioxolen-4-yl] methyl, [5- (4-Methoxyphenyl) -2-oxo-1,3-dioxolen-4-yl] methyl, [5- (4-Fluorophenyl) -2-oxo-1,3-dioxolen-4-yl] methyl, [5- (4-chlorophenyl) -2-oxo-1,3-dioxolen-4-yl] methyl (5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl, (5-phenyl-2-oxo-1,3-dioxolen-4-yl) methyl, (2-oxo-1), 3-dioxolen-4-yl) methyl, (5-ethyl-2-oxo-1,3-dioxolen-4-yl) methyl, (5-propyl-2-oxo-1,3-dioxolen-4-yl) methyl, (5-isopropyl-2-oxo-1,3-dioxolen-4-yl) methyl and (5-butyl-2-oxo-1,3-dioxolen-4-yl) methyl; and groups such as "phthalidyl groups" such as phthalidyl, dimethylphthalidyl and dimethoxyphthalidyl; the aforementioned "lower aliphatic acyl group"; the aforementioned "aromatic acyl group"; 'Half-succinic acid ester residue'; 'Phosphate ester salt residues'; 'Ester forming amino acid residues or the like'; carbamoyl groups: carbamoyl groups substituted with 1 or 2 lower alkyl groups; and "1- (acyloxy) alkyloxycarbonyl groups", e.g., pivaloyloxymethyloxycarbonyl. Among these groups, a "carbonyloxyalkyl group" is more preferred.

Preferable examples of a "protecting group that can be cleaved by a biological means such as in vivo hydrolysis" for a carboxyl group include "lower alkoxyalkyl groups" such as lower alkoxy lower alkyl groups such as methoxyethyl, 1-ethoxyethyl,

1-Methyl-1-methoxyethyl, 1- (isopropoxy) ethyl, 2-methoxyethyl, 2-ethoxyethyl,

1,1-dimethyl-1-methoxyethyl, ethoxymethyl, n-propoxymethyl, isopropoxymethyl, n-butoxymethyl or t-butoxymethyl; (lower alkoxy lower alkoxy) alkyl groups such as e.g.

2-methoxyethoxymethyl; lower alkoxy lower alkyl groups alkoxylated with lower alkoxy groups such as 2-methoxyethoxymethyl; "Aryl" oxy "lower alkyl" such as phenoxymethyl; and lower haloalkoxy lower alkyl such as 2,2,2-trichloroethoxymethyl and bis (2-chloroethoxy) methyl; "Lower cyanoalkyl groups" such as cyanomethyl or 2-cyanoethyl; "Lower alkylthiomethyl groups", such as methylthiomethyl or ethylthiomethyl;

Tt tttttt tt tt t······················ · · · · · · · · · · · · · · · · · · · "Arylthiomethyl groups", such as phenylthiomethyl or naphthylthiomethyl; "Lower alkanesulfonyl (lower alkyl) groups optionally substituted with halogen atoms, such as 2-methanesulfonylethyl or 2-trifluoromethanesulfonylethyl; Arenesulfonyl (lower alkyl) groups, such as 2-benzenesulfonylethyl or 2-toluenesulfonylethyl; the above-mentioned 1- (acyloxy) lower alkyl groups; the aforementioned "phthalidyl groups"; the aforementioned "aryl groups"; the aforementioned "lower alkyl groups"; "Carboxyalkyl groups", such as a carboxymethyl group; and "amide-forming amino acid residues" such as phenylalanine.

When a compound of formula (I) of the present invention has an amino group and / or a carboxyl group, it may be converted to a derivative other than the above-mentioned "pharmaceutically acceptable salt" and the above-mentioned "ester", and Another derivative "means that derivative. An example of such a derivative includes an amide.

The compound of formula (I) of the present invention has some asymmetric centers and therefore, due to the R or S configuration, stereoisomers may exist at each asymmetric center. The present invention includes all individual isomers and mixtures of these isomers in any proportions.

Technique for carrying out the invention:

The acylated heteroalicyclic derivatives of the present invention can be prepared as follows.

Method A

Process A is a process for the preparation of a compound of formula I wherein Z is two hydrogen atoms.

R ⁸ —OG (II) ·

-r nh

Step A2

Step A1

R ²

YABR ¹ (III) ⁸ -o-g'N-A-B-R ¹¹

Y'-GR ² 'N — A — B — R ¹

Step A3

L N-G'NA — BR ¹ , _T , I (Ia)

L NH (V) (VI) • 4 ·· 44 ♦ «* 4 ♦ · · · 4 4 · 9 * 44

Ol · 4 · 4449 4 9 4

Z1 * 4494 44 44 444 44 4 • 4 4449 9444 •• 4 4 94 44

In the above scheme, R ¹ , R ² , A, B, D, G, L, and ^{n are the} same as defined above.

Y and Y &apos; preferably represent, although there is no limitation provided that they are groups capable of withdrawal as nucleophilic groups, halogen atoms such as chlorine, bromine and iodine atoms; trihalomethyloxy groups such as trichloromethyloxy; lower alkanesulfonyloxy groups such as methanesulfonyloxy and ethanesulfonyloxy; lower haloalkanesulfonyloxy groups such as trifluoromethanesulfonyloxy and pentafluoroethanesulfonyloxy; and arensulfonyloxy groups such as benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy. Among these groups, halogen atoms and lower alkanesulfonyloxy groups are more preferred.

R ⁸ represents a hydrogen atom or a hydroxyl protecting group. A protecting group on a hydroxyl group means a "protecting group in the reaction" which can be removed by chemical means such as hydrogenolysis, hydrolysis, electrolysis and photolysis, examples of which include the same groups as for the "general hydroxy group protecting group".

Step A1 is a reaction wherein a compound of formula II is reacted with a compound of formula ΠΙ in a solvent and in the presence of a base to form a compound of formula IV wherein the amino group of the compound of formula Π is modified with a group having the formula -ABR ¹ and R ¹ are as defined above).

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds such as nitroethane and nitrobenzene; and nitriles such as acetonitrile and isobutyronitrile. Among these solvents, halogenated hydrocarbons and ethers are more preferred, and dichloromethane and tetrahydrofuran are most preferred.

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferable examples include organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine;

· • • • · «• • • • · · · · · · · · · ·

99

2,6-di (tert-butyl) -4-methylpyridine, quinoline, Ν, Ν-dimethylaniline, N, N-diethylaniline, 1,5-diazabicyclo [4,3,0] non-5-ene (DBN), 1,4-diazabicyclo [2.2.2] octane (DABCO) α1,8-diazabicyclo [5.4.0] undec-7-ene (DBU). Among these bases, triethylamine and diisopropylethylamine are more preferred.

The reaction is carried out at a temperature of -20 to 100 ° C, preferably at a temperature of 0 to 20 ° C.

The reaction times vary depending on the reaction temperature, starting materials, reagents and solvent, and are usually 5 minutes to 24 hours, preferably 10 minutes to 12 hours.

In addition, when the compound of formula (II) is reacted with a compound of formula (III) in which A is a carbonyl group, this process is carried out by reacting a compound of formula (R ^A) -OH (where A, B and R ¹ are as defined above); a condensing agent in a solvent in the presence or absence of a base.

Examples of "condensing agent" used include:

1) a combination of a phosphonate (eg, diethyl cyanophosphate or diphenylphosphoryl azide) and a base described below;

2) carbodiimide (eg, 1,3-dicyclohexylcarbodiimide, 1,3-diisopropylcarbodiimide or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide); a combination of one of said carbodiimides and a base described below; or a combination of one of said carbodiimides and an N-hydroxy compound (eg, N-hydroxysuccinimide, 1-hydroxybenzotriazole or N-hydroxy-5-norbomen-2,3-dicarboxyimide);

3) a combination of a disulfide (eg 2,2'-dipyridyldisulfide or 2,2'-dibenzothiazolyl disulfide, etc.) and a phosphine (eg triphenylphosphine or tributylphosphine);

4) carbonate (eg, N, N'-disuccinimidyl carbonate, di-2-pyridyl carbonate or S, S'-bis (1-phenyl-1 H -tetrazol-5-yl) dithiocarbonate);

5) phosphine chloride (eg, N, N'-bis (2-oxo-3-oxazolidinyl) phosphine chloride);

6) oxalate (eg, Ν, Ν-disuccinimidyl oxalate, N, N ’-diphthalimidyl oxalate,

N, N'-bis (5-norbomen-2,3-dicarboxyimidyl) oxalat, 1,1'-bis (benzotriazolyl) oxalat,

1,1'-bis (6-chlorobenzotriazolyl) oxalate or 1,1'-bis (6-trifluoromethylbenzotriazolyl) oxalate);

7) a combination of the aforementioned phosphine and azodicarboxylate or azodicarboxamide (eg, diethyl azodicarboxylate, 1,1 '- (azodicarbonyl) dipiperidine); or a combination of the above phosphine and a base described below;

8) N-lower alkyl-5-arylisoxazolium-3'-sulfonate (eg, N-ethyl-5-phenylisoxazolium-3'-sulfonate);

9) diheteroaryldiselenide (eg, di-2-pyridyldiselenide);

10) arylsulfonyltriazolidine (eg, p-nitrobenzenesulfonyltriazolidine);

· · Φ · · · · · · · · · · · · · · · · ·

11) 2-halo-1-lower alkylpyridinium halide (eg, 2-chloro-1-methylpyridinium iodide);

12) imidazole (eg Ι, Γ-oxalyldiimidazole or Ν, Ν-carbonyldiimidazole);

13) 3-lower alkyl-2-halobenzothiazolium fluoroborate (eg, 3-ethyl-2-chlorobenzothiazolium fluoroborate);

14) 3-lower alkylbenzothiazole-2-serone (eg, 3-methyl benzothiazole-2-serone);

15) phosphate (e.g., phenyldichlorophosphate or polyphosphate);

16) halosulfonyl isocyanate (eg, chlorosulfonyl isocyanate);

17) halosilane (eg, trimethylsilyl chloride or triethylsilyl chloride);

18) a combination of a lower alkanesulfonyl halide (eg, methanesulfonyl chloride) and a base described below; and

19) N, N, N,, N--tetra (lower alkyl) haloformamidium chloride (eg Ν, Ν, Ν,, etr-tetramethylchlorformamidium chloride).

Of these condensing agents, the above 1) is more preferred.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferable examples include organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine; 2,6-di (tert-butyl) -4-methylpyridine, quinoline, Ν, Ν-dimethylaniline and Ν, Ν-diethylaniline.

In addition, a catalytic amount of 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in combination with another base, and a dehydrating agent such as molecular sieves, quaternary ammonium salts such as e.g. benzyltriethylammonium chloride and tetrabutylammonium chloride, crown ethers such as dibenzo-18-crown-6, and acidic carriers such as 3,4-dihydro-2H-pyrido [1,2-a] pyrimidin-2-one.

• «·

4 4

9944 · 9 ·· 99 99 99

9 * 999

99 9 9 9 9 • 9 999 99 9 • 9

9 · «9 99 99

The reaction is carried out at a temperature of -20 to 80 ° C, preferably at 0 ° C to room temperature.

The reaction time varies mainly depending on the reaction temperature, starting materials, reagents and solvent, and is usually 10 minutes to 3 days, preferably 30 minutes to day.

Step A2 is a process for preparing a compound of formula V by removing an R ⁸ group from a compound of formula IV and then converting the hydroxy group to a leaving group Y 'in the presence or absence of a base.

The removal reactions of the R ⁸ group vary depending on the nature of the group and are carried out as shown below in a manner known to the person skilled in the art.

In the case where R ⁸ is a silyl group, it may be removed by treatment with a fluoride anion forming compound such as tetrabutylammonium fluoride, hydrogen fluoride, pyridinium fluoride or potassium fluoride; or by treatment with an organic acid such as acetic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid, trifluoromethanesulfonic acid or β-bromocatecholborane, or with an inorganic acid such as hydrochloric acid.

In the case of removal by fluoride anion, the reaction may occasionally be aided by the addition of an organic acid such as formic acid, acetic acid or propionic acid.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; water; organic acids such as acetic acid; and mixtures thereof.

The reaction is carried out at a temperature of 0 to 150 ° C (preferably 10 to 100 ° C) in an interval of 1 to 48 hours (preferably 2 to 12 hours).

When R is an arylalkyl or arylalkoxycarbonyl group, it is preferable to remove it with a reducing agent (preferably catalytic hydrogenation at room temperature in the presence of a catalyst) in a solvent or with an oxidizing agent.

The solvent to be used for the removal by catalytic hydrogenation is not particularly limited provided that it has no adverse effect on the reaction, and preferred examples include alcohols such as methanol, ethanol and isopropanol, ethers such as diethyl ether, tetrahydrofuran and dioxane, aromatic. hydrocarbons, such as toluene, benzene and xylene, aliphatic hydrocarbons, such as hydrocarbons, such as toluene, benzene and xylene; 9, eg hexane and cyclohexane, esters such as ethyl acetate and propyl acetates, amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone and hexamethylphosphoric triamide, aliphatic acids such as formic acid and acetic acid, water and mixtures thereof. Among these solvents, alcohols, aliphatic acids, mixtures of alcohol and ether, mixtures of alcohol and water or mixtures of aliphatic acids and water are preferred.

There are no particular limitations to the catalyst used, provided that it is commonly used in catalytic hydrogenation, and preferred examples include palladium on activated carbon, palladium black, Raney nickel, platinum oxide, platinum black, rhodium aluminum oxide, triphenylphosphine-rhodium chloride and palladium barium sulfate.

The pressure is not particularly limited and is usually 101.325 to 1013.250 kPa.

The reaction time and temperature vary depending on the starting materials, solvent and catalyst, but the reaction is usually carried out at a temperature of 0 to 100 ° C (preferably 20 to 70 ° C) in an interval of 5 minutes to 48 hours (preferably 1 to 24) hours).

The solvent to be used in the oxidation removal is not particularly limited provided that it has no adverse effect on the reaction, and preferably an organic solvent containing water is used.

Preferable examples of such organic solvents include ketones such as acetone, halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride, nitriles such as acetonitrile, ethers such as diethyl ether, tetrahydrofuran and dioxane, amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide, and sulfoxides such as dimethylsulfoxide.

There is no particular limitation on the requirements for the oxidizing agent used, provided that it is usually used in oxidation reactions, and preferred examples include potassium persulfate, sodium persulfate, cerium ammonium nitrate (CAN) and 2,3-dichloro-5. 6-dicyano-p-benzoquinone (DDQ-2,3-dichloro-5,6-dicyano-p-benzoquinone).

The reaction time and temperature vary depending on the starting materials, solvent and catalyst, but the reaction is usually carried out at 0 to 150 ° C over a period of 10 minutes to 24 hours.

The group may also be removed with an alkali metal such as lithium metal or sodium in liquid ammonia or an alcohol such as methanol or ethanol at a temperature of -78 to -20 ° C.

• · • ·

In addition, the group can be removed with aluminum chloride-sodium iodide, or with an alkylsilyl halide such as trimethylsilyl iodide, in a solvent.

The solvent to be used is not particularly limited provided that it does not adversely affect the reaction, and nitriles such as acetonitrile, halogenated hydrocarbons such as dichloromethane or chloroform, or mixtures thereof, are preferably used.

The reaction time and temperature vary depending on the starting materials and solvent, but the reaction is usually carried out at 0 to 50 ° C over a period of 5 minutes to 3 days.

When the substrate contains a sulfur atom in the reaction, aluminum chloride sodium iodide is preferably used.

In the case where R ⁸ is an aliphatic acyl group, an aromatic acyl group or a lower alkoxycarbonyl group, it may preferably be removed by treatment with a base in a solvent.

The base used is not particularly limited provided that it does not affect any other part of the compound, and preferred examples include metal alkoxides such as sodium methoxide; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, lithium hydroxide and barium hydroxide; and ammonia such as aqueous ammonia solution and concentrated ammonia solution in methanol.

There is no particular limitation on the solvent requirements provided that it is usually used in hydrolytic reactions, and preferred examples include water; organic solvents such as alcohols (e.g. methanol, ethanol and n-propanol) and ethers (e.g. tetrahydrofuran and dioxane); or a mixture of water and an organic solvent as described above.

The reaction time and temperature vary depending on the starting materials, solvent and base used, but the reaction is usually carried out at 0 to 150 ° C in an interval of 1 to 10 hours to avoid side reactions.

In the case where R ⁸ is lower alkoxymethyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrofuranyl, tetrahydrothiofuranyl or substituted ethyl, it can usually be removed by treatment with an acid in a solvent.

The acid used is not particularly limited provided that it is commonly used as Bronstead or Lewis acid, and preferred examples include Brenstead acids such as hydrogen chloride; an inorganic acid (eg, hydrochloric acid, sulfuric acid or nitric acid) and an organic acid (eg, acetic acid, trifluoroacetic acid, methanesulfonic acid or p-toluenesulfonic acid); and Lewis acids such as boron trifluoride. Strongly acidic cation exchangers, such as Dowex 50W, can also be used.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutyl alcohol, tert-butyl alcohol, isoamyl alcohol, diethylene glycol, glycerin, octanol, cyclohexanol and methyl cellosolv; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; water; and mixtures thereof. Among these solvents, halogenated hydrocarbons, esters and ethers are more preferred.

The reaction temperature and time vary depending on the starting materials, solvent and the nature and concentration of the acid used, but the reaction is usually carried out at a temperature of -10 to 100 ° C (preferably -5 to 50 ° C) over a period of 5 minutes to 48 hours (preferably 30 minutes to 10 hours).

In the case where R ⁸ is an alkenyloxycarbonyl group, it may be removed by treatment with a base under reaction conditions similar to those described above for the case where R ⁸ is an aliphatic acyl group, an aromatic acyl group or a lower alkoxycarbonyl group.

In the case of an allyloxycarbonyl group, a process using palladium and triphenylphosphine or bis (methylphenylphosphine) (1,5-cyclooctadiene) hexafluorophosphate (1,5-cyclooctadiene) is also iridious and the reaction can be carried out with minimal side reactions.

The solvent used in the last step of Step A2 is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane and chloroform; ethers such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; nitriles such as acetonitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide. Of these solvents, amides are more preferred.

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·> ··

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferable examples include organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine; 2,6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, Ν, Ν-diethylaniline, 1,5-diazabicyclo [4.3.0] non-5-ene (DBN), 1,4-diazabicyclo [2.2.2] octane (DABCO) α1,8-diazabicyclo [5.4.0] undec-7-ene (DBU). Among these bases, triethylamine, pyridine and 4- (N, N-dimethylamino) pyridine are more preferred, and most preferably the reaction is performed with pyridine as solvent and with the addition of a catalytic amount of 4- (N, N-dimethylamino) pyridine.

The reaction is carried out at a temperature of -20 to 50 ° C, preferably at a temperature of -10 to 20 ° C.

The reaction times vary depending on the reaction temperature, starting materials, reagents and solvent, and are usually 15 minutes to 24 hours, preferably 30 minutes to 6 hours.

For the reagent that forms a leaving group Y ', the corresponding halide is used, and examples of such reagent include a sulfonyl halide such as methanesulfonyl chloride or p-toluenesulfonyl chloride.

Step A3 is a process for preparing a compound of formula I of the present invention by reacting a compound of formula V with a compound of formula VI in a solvent and in the presence of a base.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds such as nitroethane and nitrobenzene; nitriles such as acetonitrile and isobutyronitrile; amides such as formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; and sulfoxides such as dimethylsulfoxide and sulforane. Of these solvents, amides, ethers and nitriles are more preferred, and amides are most preferred.

·> • • • •

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferable examples include: a combination of a metal iodide (e.g. potassium iodide) and an inorganic base such as an alkali metal carbonate (e.g. sodium carbonate, potassium carbonate or lithium carbonate), an alkali metal bicarbonate (e.g. sodium bicarbonate, potassium bicarbonate or lithium bicarbonate) ), an alkali metal hydride (eg lithium hydride, sodium hydride or potassium hydride), an alkali metal hydroxide (eg sodium hydroxide, potassium hydroxide, barium or lithium hydroxide) or an alkali metal fluoride (eg sodium fluoride or potassium fluoride); or an organic base such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine; 2,6-di (tert-butyl) -4-methylpyridine, quinoline,

N, N-dimethylaniline, Ν, Ν-diethylaniline, 1,5-diazabicyclo [4.3.0] non-5-ene (DBN), 1,4-diazabicyclo [2.2.2] octane (DABCO) al 8-diazabicyclo [5.4.0] undec-7-ene (DBU). Between these bases, a combination of metal iodide and an inorganic base is more preferred, and a combination of metal iodide and alkali metal bicarbonate is most preferred.

The reaction may be carried out at 0 to 150 ° C, preferably at 20 to 120 ° C.

The reaction time varies depending on the reaction temperature, starting materials, reagents and solvents, and is usually 30 minutes to 48 hours, preferably 1 to 12 hours.

Method B

A compound of formula I wherein n is 0 and Z is an oxygen atom may be prepared by Method B.

OH

DH-G-OR ⁹ (VIII)

Step B1

H

N-A-B-R

H ₂ N ~ A — BR ¹ (ix)

R ² '

DH-G-OR (X) 10

Step B2 ->

DH

AND

NA — B — R 'G-OR ⁹

Step B3 γ'-G_γ'Χ i NA — BR ¹

- o (xn;

Step B2

Step B4 - _x * _L NG-r

NA — B — R ¹ (I-b)

L NH \ _ /

R ¹ , R ² , A, B, D, G, L, and Y 'in the above scheme are as defined above.

R ⁹ represents a hydroxyl protecting group as defined in the definition of R ⁸ as a "protecting group in the reaction".

R ¹⁰ represents an imino protecting group, and examples include the above-mentioned "aliphatic acyl groups"; the aforementioned "aromatic acyl groups"; the aforementioned "lower alkoxycarbonyl groups"; the above-mentioned "alkenyloxycarbonyl groups"; the above-mentioned "arylalkyloxycarbonyl groups" and the above-mentioned "silyl groups". Of these, the lower alkoxycarbonyl group is more preferred and the t-butoxycarbonyl group is most preferred.

Step B1 is a process for preparing an amino compound of formula X by converting the primary hydroxy group of a diol compound of formula VIIIa to a leaving group and then replacing the group with an amino group of the compound of formula IX.

Conversion of the primary hydroxyl group of the diol compound of formula (VIII) to a leaving group is carried out in a manner similar to that described in the last reaction of Step A2.

The last exchange reaction is usually carried out using a metal salt in a solvent.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitriles such as acetonitrile, propionitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide. Of these solvents, nitriles are more preferred and acetonitrile is most preferred.

Examples of metal salts used include metal perchlorates such as lithium perchlorate, magnesium perchlorate and sodium perchlorate; metal chlorides such as calcium chloride, zinc chloride and cobalt chloride; metal tetrafluoroborates such as lithium tetrafluoroborate and potassium tetrafluoroborate; and zinc trifluoromethanesulfonate. Of these salts, metal perchlorates are more preferred and lithium perchlorate is most preferred.

The reaction may be carried out at a temperature of -20 to 150 ° C, preferably at room temperature to -20 ° C

Mp 100 ° C.

The reaction time varies depending on the reaction temperature, starting materials, reagents and solvents, and is usually 30 minutes to 2 days, preferably 2 hours to 1 day.

Coke B2 is a process for preparing a compound of formula XI by protecting the secondary amino group of the resulting amino compound of formula X and subsequent cyclization.

The protection of the secondary amino group R ¹⁰ by the group can be carried out as follows: [Method 1]

A method wherein the resulting compound is reacted with 1-4 equivalents (preferably 2-3 equivalents) of a compound of formula R ¹⁰ -X or a compound of formula R ¹⁰ -OR ¹⁰ (when R ¹⁰ is an acyl group) in a solvent in the presence or absence of a base; where

R ¹⁰ is as defined above and

X represents a leaving group, and this leaving group is not particularly limited provided that it can usually leave as a nucleophilic group. Preferable examples include halogen atoms such as chlorine, bromine and iodine; lower alkoxycarbonyloxy groups such as methoxycarbonyloxy and ethoxycarbonyloxy; halogenated alkylcarbonyloxy groups such as chloroacetyloxy, dichloroacetyloxy, trichloroacetyloxy and trifluoroacetyloxy; lower alkanesulfonyloxy groups such as methanesulfonyloxy and ethanesulfonyloxy; halogenated lower alkanesulfonyloxy groups such as trifluoromethanesulfonyloxy and pentafluoroethanesulfonyloxy; and arylsulfonyloxy groups such as benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy. Among these groups, halogen atoms, halogenated lower alkanesulfonyloxy and arylsulfonyloxy groups are preferred, [Method 2].

A method wherein the resulting compound is reacted with a compound of formula R ¹⁰ -OH (when R ¹⁰ is an acyl group) in a solvent in the presence or absence of the aforementioned "condensing agent" and a catalytic amount of a base.

[Method 3]

Particularly in the case where R ¹⁰ is a tert-butoxycarbonyl or benzyloxycarbonyl group, the protection of the amino group by R ¹⁰ can be carried out by reacting the tert-butoxycarbonylating agent or the benzyloxycarbonylating agent with the resulting compound in a solvent in the presence of a base.

• ·

The solvent used in [method 1] is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base used in [Method 1] is not particularly limited provided that it is one of the commonly used bases. Preferable examples include organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine; 2,6-di (tert-butyl) -4-methylpyridine, quinoline, Ν, Ν-dimethylaniline, Ν, Ν-diethylaniline.

In addition, a catalytic amount of 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in combination with another base. In addition, a quaternary ammonium salt such as benzyltriethylammonium chloride or tetrabutylammonium chloride, or a crown ether such as dibenzo-18-crown-6 can be added to effect the reaction.

The reaction can be carried out at -20 ° C to the boiling point of the solvent, preferably at 0 ° C to room temperature.

The reaction time varies depending on the reaction temperature, starting materials, base and solvent, and is usually 10 minutes to 3 days, preferably 1 hour to 1 day.

Examples of the compound of formula R -X ^lo include acyl halides such as e.g. aliphatic acyl halides (e.g. acetyl chloride, propionyl chloride, butyryl chloride, valeryl chloride and hexanoyl chloride); lower alkoxycarbonyl halides (eg, methoxycarbonyl chloride, methoxycarbonyl bromide, ethoxycarbonyl chloride, propoxycarbonyl chloride, butoxycarbonyl chloride and hexyloxycarbonyl chloride); arylcarbonyl halides (e.g., benzoyl chloride, benzoyl bromide and naphthoyl chloride); silyl halides such as tert-butyldimethylsilyl chloride, trimethylsilyl chloride, triethylsilyl chloride, triethylsilyl bromide, triisopropylsilyl chloride, dimethylisopropylsilyl chloride, diethylisopropylsilyl chloride, tert-butyldiphenylsilyl chloride, diphenylmethylsilyl; the corresponding silyl trifluoromethanesulfonates; arylalkyl halides such as benzyl chloride and benzyl bromide; a a · a · a · a · a · a · a · a · aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Lower carbonyloxyalkylhaiogenides such as pivaloyloxymethyl chloride and ethoxycarbonyioxymethyl chloride.

Examples of the compound of formula R ¹⁰ -OR ¹⁰ include aliphatic carboxylic acid anhydrides such as acetic anhydride, propionic anhydride, valeric anhydride or hexanoic anhydride; and mixed anhydrides such as mixed formic and acetic anhydride.

The solvent used in [method 2] is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethyl acetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base described in Method 1 may be used as the base in Method 2.

The reaction may be carried out at a temperature of -20 to 80 ° C, preferably at 0 ° C to room temperature.

The reaction time varies depending on the reaction temperature, starting materials, base and solvent, and is usually 10 minutes to 3 days, preferably 30 minutes to 1 day.

The solvent used in [Method 3] is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; water; and a mixture of water and one of the above organic solvents.

The base described in Method 1 may be used as the base in Method 3.

• • • «9

9 9 9 9 9 9

Preferred examples of the tert-butoxycarbonylating agent include di-tert-butyl dicarbonate, 2- (tert-butoxycarbonyloxyimino) -2-phenylacetonitrile, tert-butyl-S- (4,6-dimethylpyridin-2-yl) thiol carboxylate, 1,2, 2,2-tetrachloroethyl carbonate and tert-butyl carbonate. Of these reagents, di-tert is more preferred. butyl dicarbonate.

Preferable examples of the benzyloxycarbonylating agent include benzyloxycarbonyl chloride, benzyloxycarbonyl cyanide and dibenzyl dicarbonate.

The reaction may be carried out at a temperature of -20 to 80 ° C, preferably at 0 ° C to room temperature.

The reaction time varies depending on the reaction temperature, starting materials, base and solvent, and is usually 10 minutes to 3 days, preferably 30 minutes to 1 day.

The cyclization reaction of the last step is usually carried out in a solvent in the presence of a base.

The solvent to be used is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferred examples include inorganic bases such as alkali metal carbonates (eg sodium carbonate, potassium carbonate or lithium carbonate), alkali metal bicarbonates (eg sodium bicarbonate, potassium bicarbonate and lithium bicarbonate), alkali metal hydrides (eg lithium hydride, sodium hydride and potassium hydride), alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide); and alkali metal fluorides (e.g., sodium fluoride and potassium fluoride); and alkali metal alkoxides such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium tert-butoxide and lithium methoxide. Of these, alkali metal hydrides and alkali metal alkoxides are more preferred.

The reaction may be carried out at a temperature of -20 to 80 ° C, preferably at 0 ° C to room temperature.

The reaction time varies depending on the reaction temperature, starting materials, base and solvent, and is usually 10 minutes to 3 days, preferably 30 minutes to 1 day.

Step B3 is a process for preparing a compound of formula ΧΠ by deprotecting the hydroxy group of the compound of formula XI and then converting the resulting hydroxy group into a leaving group and may be carried out in the same manner as described in the last step of step A2.

Step B4 is a process for preparing a compound of formula I-b of the present invention by a condensation reaction between a compound of formula ΧΠ and a compound of formula VII and can be carried out in the same manner as described in Step A3.

Method C

A compound of formula I wherein n is 1 or 2 and Z is an oxygen atom may be prepared by Method C.

R

H

N-A-B-R

Step C1

R ^and —OG

N — A — B — R

DH 'G-OR ⁹ µ Z (X) (XIV)

Step C2

->.

Y’-G'N — A — B — R (XV)

Step C3

R ²

L N-GNH

N — A — B — R '0 (I-c) (VII) • 9 9 9 9 • 9 9 99 9 9 9 9

9999 99 99 9 9 9 99 · 9 9 9 9 9 9 9 9

99 99 99 99

Wherein R ¹ , R ² , R ⁹ , A, B, D, G, L and Y 'are as defined above;

X and X 'are outgoing groups that have the same meaning as Y' defined above; and n 'is 1 or 2.

Step C1 is a process for preparing a cyclic amide compound of formula XIV by reacting a secondary amine of an amino compound of formula X with a compound of formula ΧΤΠ in a solvent in the presence of a base and then alkylating the DH group.

The solvent used in the first step is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorhenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyronitrile; and amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferable examples include organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine; 2,6-di (tert-butyl) -4-methylpyridine, quinoline, Ν, Ν-dimethylaniline, N, N-diethylaniline.

In addition, a catalytic amount of 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in combination with another base, and a dehydrating agent such as molecular sieves, quaternary ammonium salts such as e.g. benzyltriethylammonium chloride and tetrabutylammonium chloride, crown ethers such as dibenzo-18-crown-6, and acidic carriers such as 3,4-dihydro-2H-pyrido [1,2-a] pyrimidin-2-one.

The reaction may be carried out at a temperature of -20 to 80 ° C, preferably at 0 ° C to room temperature.

The reaction time varies depending on the reaction temperature, the starting materials, the reagent and the solvent and is usually 10 minutes to 3 days, preferably 30 minutes to 1 day.

• 4 44 4 4 · 4 • 4 4 4 4 9 4 4 • 4 44 4 4 4 9 • 99 999 49 4 • 44 4 4 94 9 ·· 4 · 44 44

The solvent used in the alkylation reaction of the last step is not particularly limited provided that it has no adverse effect on the reaction and that it can dissolve the starting materials to some extent, and preferred examples include aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile, propionitrile and isobutyronitrile; amides such as formamide, Ν, Ν-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Of these solvents, ethers and amides are more preferred, and tetrahydrofuran and Ν, Ν-dimethylformamide are most preferred.

The base to be used is not particularly limited provided that it is one of the commonly used bases. Preferred examples include inorganic bases such as alkali metal carbonates (e.g. sodium carbonate, potassium carbonate and lithium carbonate), alkali metal bicarbonates (e.g. sodium bicarbonate, potassium bicarbonate and lithium bicarbonate), alkali metal hydrides (e.g. lithium hydride, sodium hydride and potassium hydride), alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide); and alkali metal fluorides (e.g., sodium fluoride and potassium fluoride); and alkali metal alkoxides such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium tert-butoxide and lithium methoxide. Of these, alkali metal hydrides and alkali metal alkoxides are more preferred.

The reaction may be carried out at a temperature of -20 to 100 ° C, preferably at 0 to 50 ° C.

The reaction time varies depending on the reaction temperature, starting materials, base and solvent, and is usually 10 minutes to 24 hours, preferably 30 minutes to 12 hours.

Step C2 is a process for preparing a compound of formula XV of the present invention by deprotecting the hydroxy group of a compound of formula XIV and then converting the resulting hydroxy group to a leaving group and may be carried out in the same manner as described in the last step of step A2.

Step C3 is a process for preparing a compound of formula I-b of the present invention by a condensation reaction between a compound of formula XV and a compound of formula VII and can be carried out in the same manner as described in step A3.

• · ····

99 99 99

9 9 9 9 9 9

9 9 9 9 9 9 • 9 9 9 9 9 9 9 9 9

9 9 9 9 9

After each reaction described above, the desired compound is isolated from the reaction mixture by conventional means.

For example, it is obtained, if desired, by a neutralization reaction, removing insoluble matter by filtration, if any, by adding organic solvents that are not miscible with the second solvent, such as ethyl acetate and water, by rinsing with water or the like, separating the organic layer containing the desired drying the compound over anhydrous magnesium sulfate or the like and then distilling off the solvent.

If necessary, the desired compound thus obtained can be isolated and purified by conventional means, such as recrystallization or precipitation and chromatography, in which the method generally uses elution to purify and purify the organic compound in the combination that is desired. Examples of chromatography include adsorption column chromatography using a carrier such as silica gel, alumina or magnesium silica type Florisil, chromatography using synthetic adsorbents, such as a column chromatography using a carrier such as Sephadex LH-20 (product of Pharmacia), Amberlite XAD- 11 (a product of Rohm & Haas) or Diaion HP-20 (a product of Mitsubishi Chemical), ion exchange chromatography, or normal or reverse phase high performance liquid chromatography using silica gel or alkylated silica gel.

In addition, the starting materials are either commercially available or can be readily prepared by known techniques (eg, EP-776893 and USP-5,641,777 and the like) from commercially available starting materials.

The novel acylated hetero-alicyclic derivatives of the present invention have excellent NK2-selective antagonistic activity and low toxicity and may therefore be useful as a medicament. For example, they may be useful as a preventive and therapeutic agent for diseases of the central nervous system, such as anxiety, depression, psychosis, and schizophrenia; neurodegenerative diseases such as AIDS dementia, Alzheimer's senile dementia, Alzeimer disease, Down's syndrome, demyelinating diseases, amyotrophic lateral sclerosis, neuropathy, peripheral neuropathy and neuralgia; respiratory diseases such as chronic obstructive pulmonary disease, bronchitis, pneumonia, bronchoconstriction, asthma and cough; inflammatory diseases such as inflammatory bowel disease, psoriasis, fibrosis, bone and joint inflammation, degenerative arthritis and rheumatoid arthritis; eczema; allergic diseases such as runny nose; hypersensitive 9 9 9 9 9 9 9 9 9 4 4 4 4 4

4 · 9 4 44 94 4 4 4 4 diseases such as vine hypersensitivity; ophthalmological diseases such as conjunctivitis, conjunctivitis, spring catarrh, destruction of the blood-eye fluid barrier caused by various inflammatory eye diseases, increased intraocular pressure and miosis; skin diseases such as contact dermatitis, atopic dermatitis, urticaria and other eczematic dermatitis; dependencies such as alcohol dependence; stress-induced somatic diseases; involved in reflex dystrophy, such as shoulder-hand syndrome; dysthymia; undesirable immune responses, such as transplant defensive reactions, immunopotentiating diseases such as systemic lupus erythematosus, or immunosuppression; digestive diseases such as diseases caused by abnormalities of the nerves regulating organs, colitis, ulcerative colitis and Crohn's disease; vomiting such as vomiting due to adverse effects of X-ray radiation and chemotherapy, poisons, toxins, pregnancy, vestibular disorders, postoperative disease, gastrointestinal occlusion, decreased gastrointestinal activity, physical pain, migraine, increased intracranial pressure, decreased or intracranial pressure various drugs; bladder diseases such as cystitis and urinary incontinence; eosinophilia caused by collagen disease, scleroderma or Fasciola hepatica infection; diseases caused by abnormal blood flow due to vascular enlargement or vasoconstriction, such as angina, migraine and Reynauds disease; and pain or pain signals such as migraine, headache and toothache.

The route of administration of a compound of formula I of the present invention comprises oral administration in the form of tablets, capsules, granules, powder or syrup, or parenteral administration in the form of injections or suppositories. These formulations can be prepared by known methods using additives such as excipients (eg, organic excipients including carbohydrate derivatives such as lactose, sucrose, glucose, mannitol or sorbitol; starch derivatives such as corn starch, potato starch, α- cellulose derivatives such as crystalline cellulose, less substituted hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, calcium carboxymethylcellulose, or internally cross-linked sodium carboxymethylcellulose; slightly anhydrous orthosilicic acid, synthetic aluminum silicate or magnesium metasilicate aluminate; phosphates such as calcium phosphate; carbonates such as calcium carbonate; and sulfates such as calcium sulfate); lubricants (eg, stearic acid and metal stearates such as calcium stearate and magnesium stearate; talc; colloidal silicon dioxide; waxes such as bees.) wax and spermaceti wax and orthoboric acid; adipic acid; sulphates such as sodium sulphate; glycol; fumaric acid; sodium benzoate; DL-leucoate; DL-leucoate; DL-leucoate; DL-leucoate; DL-leucoate; DL-leucoate; DL-leucoate; sodium salts of aliphatic acids; lauryl sulphates such as sodium lauryl sulphate and magnesium lauryl sulphate; orthosilicic acids such as anhydrous orthosilicic acid and silicate hydrate; and starch derivatives described above); binders (e.g., polyvinylpyrrolidone, macrogol, and the same compounds as the above excipients); disintegrants (e.g., the same compounds as the above excipients and chemically modified cellulose starches such as croscarmellose sodium, sodium carboxymethyl starch and cross-linked polyvinylpyrrolidone); stabilizers (e.g., paraoxybenzoates such as methyl-p-hydroxybenzoate and propyl-p-hydroxybenzoate; alcohols such as chlorobutanol, benzyl alcohol and phenylethyl alcohol; benzalkonium chloride; phenols such as phenol and cresol; thimerosal; dehydroacetic acid; and sorbic acid); corrigents (e.g., commonly used sweeteners, acidic agents and perfumes) and diluents.

The dosage of the compound of formula I will vary depending on the condition of the disease, the age of the patient and the mode of administration. A suitable single dose of a compound of formula I for oral administration is from 0.01 mg / kg body weight (preferably 0.1 mg / kg body weight), as a lower limit, to 100 mg / kg body weight (preferably 50 mg / kg). kg body weight) as the upper limit. For intravenous administration, it is from 0.01 mg / kg body weight (preferably 0.05 mg / kg body weight), as a lower limit, to 100 mg / kg body weight (preferably 50 mg / kg body weight), such as upper limit. It is desirable to administer the aforementioned single dose several times a day depending on the condition of the disease.

Examples:

The following examples, reference examples, formulation examples and test examples are intended to further illustrate the present invention and are not intended to limit the scope of the invention in any way.

Example 1

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 ' -piperidine] - (2S) -oxide

Example 1 (a)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethanol

9

9 ··· • · 9 · 9 ·

9 9 9 9 Λ 9 • 9 9 9 9 99 99

Water soluble carbodiimide hydrochloride (WSC.HCl) (166 mg; 0.87 mmol), 1-hydroxybenzotriazole (117 mg; 0.87 mmol) and triethylamine (0.15 mL; 1.09 mmol) were added sequentially at 0 ° C under nitrogen to a solution of cyclobutanecarboxylic acid (80 mg; 0.80 mmol) in dichloromethane (5 mL) and to this mixture was added 2 - [(2 R) - (3,4-dichlorophenyl) morpholine -2-yl] ethanol (200 mg; 0.72 mmol), which was obtained in Reference Example 1. The mixture was stirred at room temperature for 6 hours. The reaction mixture was washed successively with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was then distilled off under reduced pressure. The residue was purified by preparative TLC silica gel chromatography using n -hexane / ethyl acetate = 1/4 as eluent to give the title compound (254 mg, 98%) as a white amorphous solid.

¹ H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.59 (1¾ bs); 7.44 (1H, d, J = 8.4 Hz); 7.29 (1H, bd, J = 8.4 Hz); 4.55 (1H, d, J = 13.9 Hz); 3.71-3.80 (1¾ m); 3.32-3.62 (6¾ m); 3.09-3.22 (1¾ m); 2,282.42 (1¾ m); 1.79-2.18 (8¾ m).

IR spectrum υ max cm ^-1 (CHC1 _3): 3624, 2954.1640, 1,441th

MS spectrum (FAB) m / z: 358 (M + H) &lt; + & gt ^; ).

Example 1 (b)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl methanesulfonate

Methanesulfonyl chloride (0.071 mL; 0.92 mmol) and 4-dimethylaminopyridine (catalytic amount) were added to a solution of 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholine under ice-cooling under nitrogen. -2-yl] ethanol (219 mg; 0.61 mmol), which was prepared in Example 1 (a), in pyridine (2 mL). The mixture was stirred at the same temperature for 30 minutes. The reaction mixture was acidified with glacial hydrochloric acid (10%) and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residue was purified by preparative TLC silica gel chromatography using n-hexane / ethyl acetate = 1/4 as eluent to give the title compound (255 mg, 96%) as a white amorphous solid.

Ή NMR Spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.57 (1H, bs); 7.46 (1H, d, J = 8.5Hz); 7,207.30 (1¾ m); 3.14-4.31 (9¾ m); 2.93 (3¾ s); 2.26-2.42 (2¾ m); 1.82-2.22 (6¾ m).

IR spectrum υ max cm ^-1 (CHCl 3): 2971, 1641, 1440th

* · ·

• 9 9 9 9 99 99

MS spectrum (FAB) m / z: 436 (M + H) &lt; + & gt ^; ).

Example 1 (c) 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophene-1 (3 ') 1,4'-piperidine] - (2S) -oxide

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl] methanesulfonate (114 mg; 0.26 mmol), which was prepared in Example 1 (b) ), spiro [benzo [e] -thiophene-1 (3 H), 4'-piperidine] - (2 S) -oxide hydrochloride (74 mg; 0.29 mmol), sodium bicarbonate (66 mg; 0.78 mmol) ) and potassium iodide (65 mg; 0.39 mmol) were suspended in anhydrous dimethylformamide (2 mL) and the mixture was stirred under nitrogen at 80 ° C for 8 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by preparative TLC silica gel chromatography using dichloromethane / methanol - 10/1 as eluent to give the title compound (111 mg, 76%) as a white crystalline solid.

Melting point: 99 - 101 ° C [α] ²⁴ + 65.4 ° (c = 0.54, chloroform) 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.22-7.59 (7H) , m); 4.52 (1H, d, > 13.8 Hz); 4.31 (1H, d,> 16.8 Hz); 3.99 (1H, d,> 16.8 Hz); 3.13-3.83 (6 H, m); 2.72-2.96 (2 H, m); 2,022.45 (11 H, m); 1.82-1.99 (4 H, m); 1.52-1.56 (1 H, m).

IR spectrum ν max cm ^-1 (KBr): 3432, 2949, 1643, 1436.

MS spectrum (FAB) m / z: 561 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calcd for C24H34N2O3SCl2.0.5H2O 61.04% C; 6.18% H; 4.90% N; 5.61% S; 12.43% C1; found: 61.75% C; 6.40% H; 4.86% N; 5.52% S; 11.72% C1.

Example 2

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 ' -piperidine] - (2S) -oxide

Example 2 (a)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethanol

The title compound (230 mg, 92%) was obtained as a white amorphous solid according to the procedure described in Example 1 (a) using cyclopropanecarboxylic acid (69 mg;

0.80 mmol) and 2 - [(2R) - (3,4-dichlorophenyl) morpholin-2-yl] ethanol (200 mg; 0.72 mmol).

• · φφφφ φφφφ * ··· ·· φφ φφ φφ 'Η NMR (270 MHz, CDC1 ₃₎ δ ppm; 7.58 (1Η, bs); 7.43 (1Η, d,> 8.7 Hz); 7.28 (1H, bd, > 8.7 Hz); 4.54 (1H, d, > 13.9 Hz); 3.5-3.9 (8 H, m); 1.9-2.2 (2 H, m); 1.5-1.7 (1 H, bs); 0.7-1.0 (4H, m),

IR spectrum .nu.max cm @ ^-1 (CHCl3): 3623, 2968, 1732, 1637, 1471.

MS (FAB) m / z: 344 (M + H) ^4}.

Example 2 (b)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (257 mg, 95%) was obtained as a white amorphous solid according to the procedure described in Example 1 (b) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholine -2-yl] ethanol (220 mg; 0.64 mmol).

¹ H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm; 7.57 (1 H, bs); 7.45 (1H, d, > 7.9 Hz); 7,257.32 (1 H, m); 3.48-4.30 (8 H, m); 2.92 (3H, s); 2.09-2.49 (2 H, m); 0.65-1.12 (4 H, m).

IR spectrum υ max cm ^-1 (CHC1 _3): 2973, 1731, 1678.1471.

MS spectrum (FAB) m / z: 422 (M + H) &lt; + & gt ^; ).

Example 2 (c) 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophene-1 (3 ') N, 4'-piperidine] - (2 S) -oxide

The title compound (63 mg, 45%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2A) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholine-2- yl] ethyl methanesulfonate (109 mg; 0.26 mmol) and spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2 S) -oxide hydrochloride (71 mg; 0.28 mmol).

Melting point: 96 - 99 ° C [α] D ²⁴ + 56.7 ° (c = 0.30, chloroform) 1 H NMR spectrum (400 MHz, CDCl 3) δ ppm: 7.23-7.59 (7H, m); 4.31 (1H, d,> 16.8 Hz); 3.99 (1H, d,> 16.8 Hz); 3.44-4.52 (5 H, m); 2.73-2.96 (2 H, m); 1.52-2.40 (12H, m); 0.75-1.15 (4 H, m).

IR spectrum ν max cm ^-1 (KBr): 3414, 2922, 1639, 1470.

MS spectrum (FAB) m / z: 547 (M + H) &lt; + & gt ^; ).

Elementary analysis (%) for C28H ₃₂ N2O3SCl2.0,5H20 calculated 60.42% C; H, 5.98; 5.03% N;

5.76% S; 12.74% Cl; Found: C, 60.92; H, 6.32; 4.84% N; 5.71% S; 12.35% C1.

ft »»

Example 3

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 ⁵ -piperidine] - (2 S) -oxide

Example 3 (a)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethanol

The title compound (389 mg, 96%) was obtained as a white amorphous solid according to the procedure described in Example 1 (a) using cyclopentanecarboxylic acid (186 mg; 1.63 mmol) and 2 - [(2R) - (3,4) (dichlorophenyl) morpholin-2-yl] ethanol (300 mg; 1.09 mmol).

¹ H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.59 (11¾ d, J = 20 Hz); 7.43 (1H, d, J = 8.4 Hz); 7.28 (1H, dd, J = 8.4 and 2.0 Hz); 4.62 (1H, d, J = 13.9 Hz); 3.3-3.9 (7¾ m); 3.37 (1H, d, J = 13.9 Hz); 2.78 (1 m); 1.4-2.1 (9 H, m).

LR spectrum .nu.max cm @ ^-1 (CHCl3): 3622, 2960, 1732, 1637, 1440.

MS spectrum (FAB) m / z: 372 (M + H) &lt; + & gt ^; ).

Example 3 (b)

2 - [(2R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (435 mg, 95%) was obtained as a white amorphous solid according to the procedure described in Example 1 (b) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholine -2-yl] ethanol (380 mg; 1.02 mmol).

Ή NMR Spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.57 (1¾ d, J = 2.0 Hz); 7.45 (1H, d, J = 8.4 Hz); 7.27 (1H, dd, J = 8.4 and 2.0 Hz); 4.38 (1H, d, J = 3.9 Hz); 4.19-4.25 (1¾ m); 3.94-4.00 (1H, m); 3,743.79 (1¾ m); 3.45-3.62 (4¾ m); 2.89-2.94 (4¾ m); 2.79 (1¾ m); 2.27-2.34 (1¾ m); 2,132.21 (1¾ m); 1.53-1.91 (7¾ m).

IR spectrum υ max cm ^-1 (CHC1 _3): 2964,1640,1440, 1362, 1175th

MS spectrum (FAB) m / z: 450 (M + H) &lt; + & gt ^; ).

Example 3 (c)

- {2 - [(2H-3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (25) -oxide

The title compound (132 mg, 49%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2A) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholine-2- yl] ethyl methanesulfonate (210 mg; 0.47 mmol) and spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2 S) -oxide hydrochloride (144 mg; 0.56 mmol).

tttt tttt tttt ttt tt tt tt tt tt

«· Ttttt • tt tt tt •

ttt ttt ttt ttt ttttt ttt ttt

Melting point: 99 - 100 ° C [α] _D ²⁴ + 55.0 ° (c - 0.50, chloroform) 1 H NMR spectrum (400 MHz, CDCl 3) δ ppm: 7.55-7.59 (1H, m); 7.41-7.48 (1 H, m); 7,207.36 (5 H, m); 4.59 (1H, d, &gt; 13.8 Hz); 4.31 (1H, d,> 16.8 Hz); 3.98 (1H, d,> 16.8 Hz); 3,433.82 (4 H, m); 3.36 (1H, d, > 13.8 Hz); 2.89-2.94 (1H, m); 2.73-2.84 (2 H, m); 2.17-2.43 (6 H, m); 2.04-2.15 (1 H, m); 1.48-1.99 (1H, m).

IR spectrum ν max cm ^-1 (KBr): 3441, 2952, 1640, 1435, 1227.

MS (FAB) m / z 575 (M + H) &lt; + &^gt;

Elementary analysis (%): for C3oH36N203SCl2.0,5H ₂ 0 Calculated C 61.63%; H, 6.38; 4.79% N; 5.49% S; 12.13% C1; Found: C, 61.46; 6.28% H; 4.69% N; 5.40% S; 11.57% C1.

Example 4

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 ' -piperidine] - (2S) -oxide

Example 4 (a)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethanol

The title compound (405 mg, 96%) was obtained as a white amorphous solid according to the procedure described in Example 1 (a) using cyclohexanecarboxylic acid (147 mg; 1.15 mmol) and 2 - [(2A) - (3,4) (dichlorophenyl) morpholin-2-yl] ethanol (300 mg; 1.09 mmol).

¹ H NMR spectrum (400 MHz, CDCl 3) δ ppm: 7.58 (1H, d,> 20 Hz); 7.42 (1H, d,> 8.0 Hz); 7.28 (1 H, m); 4.63 (1H, d, > 14.0 Hz); 3.40-3.93 (6 H, m); 3.34 (1H, d, > 14.0 Hz); 1.15-2.55 (13 H, m).

IR spectrum .nu.max cm @ ^-1 (CHCl3): 3623, 3536, 2936, 2858, 1711, 1634.

MS spectrum (FAB) m / z: 386 (M + H) &lt; + & gt ^; ).

Example 4 (b)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (450 mg, 94%) was obtained as a white amorphous solid according to the procedure described in Example 1 (b) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholine -2-yl] ethanol (400 mg; 1.04 mmol).

1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.56 (1H, d,> 2.0 Hz); 7.44 (1H, d,> 8.0 Hz);

7.26 (1H, dd, > 8.0 and 2.0 Hz); 4.39 (1H, d, > 14.0 Hz); 4.22 (1 H, m); 3.97 (1H, dt,> 10.0 and • ·

Ad · · · · · · · · · 4 · 4 · * · 4 · 4 · 4 · 4 · 4

7.0 Hz); 3.77 (1¾ dt,> 12.0 and 4.0 Hz); 3.60 (1¾ m); 3.48 (1 m); 3.43 (1H, d, > 14.0 Hz); 2.94 (3¾ s); 2.12-2.60 (3 H, m); 1.15-1.85 (10¾ m).

IR spectrum .nu.max cm @ ^-1 (CHCl3): 2936, 2858, 1634.

MS spectrum (FAB) m / z: 464 (M + H) &lt; + & gt ^; ).

Example 4 (c)

- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (377), 4'-piperidine] - (2 ') - oxide

The title compound (168 mg, 70%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholine- 2-yl] ethyl methanesulfonate (190 mg; 0.41 mmol) and spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2 S) -oxide hydrochloride (127 mg; 0) , 49 mmol). Melting point: 119-123 ° C [α] D ²⁴ + 50.1 ° (c = 0.44, chloroform)

Ή NMR Spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.25-7.60 (7¾ m); 4.60 (1¾ d,> 14.0 Hz); 4.30 (1H, d,> 17.0 Hz); 3.99 (1¾ d,> 17.0 Hz); 3.40-3.90 (4¾ m); 3.32 (1¾ d,> 14.0 Hz); 2.94 (1¾ m); 2.74 (1¾ m); 1.15-2.60 (21¾ m).

IR spectrum ν max cm ^-1 (KBr): 3438, 2928, 2855, 1642.

MS spectrum (FAB) m / z: 589 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calculated for C ₃₁ H 38 N ₂ O ₃ SC 12.0.2H ₂ O 62.96%; H, 6.51; 4.74% N; 5.42% S; 11.99% C1; found: 62.80% C; H, 6.69; 4.65% N; 5.39% S; 12.07% C1.

Example 5

- {2 - [(2 R) - (3,4-Dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl-ethyl} -4-phenylpiperidine-4-carboxamide

The title compound (93 mg, 69%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholine- 2-yl] ethyl methanesulfonate (107 mg; 0.25 mmol) and 4-phenylpiperidinecarboxamide hydrochloride (67 mg; 0.30 mmol).

Melting point: 94 - 96 ° C [α] D ²³ + 39.6 ° (c = 0.54, methanol) 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.22-7.55 (8¾ m); 5.17 (2¾ s); 1.85-4.43 (19¾

m); 0.65-1.15 (4¾ m).

• ·

IR spectrum ν max cm ^-1 (KBr): 3350, 2927, 1676, 1633, 1470.

MS spectrum (FAB) m / z: 530 (M + H) &lt; + & gt ^; ).

Elementary analysis (%) for C28H33N3O ₃ Cl ₂ .0,5H20 calculated 62.34% C; 6.35% H; 7.79% N; 13.14% C1; Found: C, 62.40; H, 6.54; 7.47% N; 13.81% C1.

Example 6

- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl) -4- (2-pyridyl) piperidine-4-carboxamide

The title compound (129 mg, 69%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 H) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholine- 2-yl] ethyl methanesulfonate (150 mg; 0.33 mmol) and 4- (2-pyridyl) piperidine-4-carboxamide hydrochloride (102 mg; 0.37 mmol).

Melting point: 189-190 ° C [(x] d ²³ + 43.3 ° (c = 0.53, methanol)

Ή NMR Spectrum (400 MHz, CDCl ₃ ) δ ppm: 8.57 (1H, d, J = 4.7 Hz); 7.15-7.68 (6 H, m); 6.40 (1 H, brs); 5.14 (1 H, brs); 4.57 (1H, d, J = 13.5Hz); 3.20-3.95 (5 H, m); 1.45-2.98 (21 H, m).

IR spectrum ν max cm ^-1 (KBr): 3412, 2953, 1679, 1639, 1468, 1433.

MS spectrum (FAB) m / z: 559 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calc'd for C29H36N4O3Cl2, 62.25% C; 6.49% H; 10.01% N; 12.67% C1; found: 62.06% C; 6.43% H; N, 9.89; 12.67% C1.

Example 7

Ν, Ν-Dimethyl-1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} -4- (cyclohexyl) piperidine-4-carboxamide

The title compound (152 mg, 77%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholine-2- yl] ethyl methanesulfonate (150 mg; 0.33 mmol) and N, N-dimethyl-4- (cyclohexyl) piperidine-4-carboxamide hydrochloride (101 mg; 0.37 mmol). Melting point: 98-102 ° C [α] _D ²³ + 40.9 ° (c - 0.52, methanol) ¹ H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.21-7.53 (3H) , m); 4.53 (1H, d, J = 13.8Hz); 2.603.95 (8 H, m); 3.02 (6 H, s); 1.40-2.35 (22H, m); 1.00-1.35 (7H, m).

IR spectrum ν max cm ^-1 (KBr): 3441, 2932, 2855, 1630, 1450.

MS spectrum (FAB) m / z: 591 (M + H) &lt; + & gt ^; ).

Elementary analysis (%): for C32H47N ₃ O3Cl .0,5H2O ₂ Calculated% C, 63.88; 8.04% H; 6.98% N; 11.79% C1; found 64.06% C; H, 7.97; 6.84% N; 11.72% C1.

Example 8 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indan-1,4 ' -piperidine]

The title compound (817 mg, 78%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholine- 2-yl] ethyl methanesulfonate (850 mg; 1.89 mmol) and [((2S) -hydroxy) indan-1,4'-piperidine] hydrochloride (497 mg; 2.08 mmol).

Melting point: 192-193 ° C [α] _D ²³ + 63.1 ° (c = 0.52, methanol) 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.16-7.58 (7H) , m); 4.6O (1H, d, J = 13.6Hz); 4.4O (1H, d, J = 3.3Hz); 3.24-3.98 (7H, m); 2.64-3.01 (4 H, m); 1.42-2.43 (18 H, m).

IR spectrum ν max cm ^-1 (KBr): 3423, 2949, 1640, 1434.

MS spectrum (FAB) m / z: 557 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calculated for C31H38N2O3Cl2: 66.78% C; H, 6.87; 5.02% N; 12.72% C1; Found: C, 66.77; H, 6.79; 5.07% N; 12.41% C1.

Example 9

1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (L-prolyl) morpholin-2-yl] ethyl] spiro [((2 R) -hydroxy) indane-1,4 ' -piperidine] dihydrochloride

Example 9 (a)

2 - [(2 R) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-L-prolyl) morpholin-2-yl] ethanol

The title compound (314 mg, 92%) was obtained as a white amorphous solid according to the procedure described in Example 1 (a) using 2 - [(2 R) - (3,4-dichlorophenyl) morpholin-2-yl] ethanol (200 mg; 0.72 mmol) and N-tert-butoxycarbonyl-L-proline (171 mg; 0.80 mmol).

¹ H NMR spectrum (270 MHz, CDCl 3) δ ppm: 7.20-7.62 (3H, m); 3.98-4.94 (2 H, m); 3,103.91 (9 H, m); 1.55-2.25 (7 H, m); 1.46 (3 H, s); 1.38 (3 H, s); 1.14 (3 H, s).

IR spectrum ν max cm ^-1 (KBr): 3442, 2975, 2876, 1695, 1401.

MS spectrum (FAB) m / z: 473 (M + H) &lt; + & gt ^; ).

··· · · I »9 · ·

9

Example 9 (b)

2 - ((2H) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-L-prolyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (313 mg, 94%) was obtained as a white amorphous solid according to the procedure described in Example 1 (b) using 2 - ((2 H) - (3,4-dichlorophenyl) -4- (N-tert). butoxycarbonyl-L-prolyl) morpholin-2-yl] ethanol (286 mg; 0.60 mmol).

^! 1 H NMR spectrum (270 MHz, CDCl 3) δ ppm: 7.20-7.60 (3H, m); 4.10-4.77 (2 H, m); 3.304.00 (9 H, m); 2.93 (3 H, s); 1.75-2.40 (6 H, m); 1.46 (3 H, s); 1.40 (3H, s); 1.16 (3 H, s).

IR spectrum ν max cm ^-1 (KBr): 2976, 1695, 1659, 1401, 1359, 1175.

MS spectrum (FAB) m / z: 551 (M + H) &lt; + & gt ^; ).

Example 9 (c) 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-L-prolyl) morpholin-2-yl] ethyl} spiro [(( 25) -hydroxyindan-1,4'-piperidine]

The title compound (175 mg, 73%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (N-tert. butoxycarbonyl-L-prolyl) morpholin-2-yl] ethyl methanesulfonate (200 mg; 0.36 mmol) and [((2S) -hydroxy) indan-1,4'-piperidine] hydrochloride (95 mg; 0.40 mmol).

Melting point: 108-110 ° C [α] D ²⁴ + 21.5 ° (c = 0.52, methanol) ^! 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.20-7.62 (7H, m); 4.30-4.84 (3 H, m); 3.203.98 (10H, m); 1.58-2.90 (16 H, m); 1.46 (3 H, s); 1.40 (3H, s); 1.17 (3 H, s).

IR spectrum ν max cm ^-1 (KBr): 3442, 2928, 1696, 1661, 1400.

MS spectrum (FAB) m / z: 658 (M + H) &lt; + & gt ^; ).

Elementary analysis (%): calculated for C, 62.96; H, 6.94; 6.29% N; 10.62% C1; found 63.09% C; 7.10% H; 6.27% N; 10.50% C1.

Example 9 (d) 1- {2 - [(2 H) - (3,4-dichlorophenyl) -4- (L-prolyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indane -1,4'-piperidine] dihydrochloride

To a solution of 1- {2 - ((2 H) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-L-prolyl) morpholin-2-yl] ethyl} spiro [((2 (R) -hydroxyindan-1,4'-piperidine], which was prepared in the example

9 (c), (131 mg; 0.20 mmol) in ethanol (2 mL) was added dioxane hydrogen chloride (4 mol / L; 1.5 mL) under ice-cooling. The solution was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure. Diethyl ether was added to the residue. After drying to dryness, the title compound (127 mg; 100%) was obtained as a white crystalline solid.

Melting point: 290-294 ° C

Mp ²³ + 24.7 ° (c = 0.52, methanol) 1 H NMR spectrum (400 MHz, DMSO-d ₆ ) δ ppm: 9.83-11.20 (2¾ m); 8.45-8.63 (1¾ m); 7,437.98 (3¾ m); 7.05-7.25 (4 H, m); 3.60-5.05 (8¾ m); 2.85-3.58 (8¾ m); 1.48-2.80 (13¾ m).

IR spectrum ν max cm ^-1 (KBr): 3350, 2925, 2677, 2574, 1653, 1476.

MS spectrum (FAB) m / z: 558 (M + H) &lt; + & gt ^; , free form).

Elemental analysis (%): calculated for C30H37N3O3Cl2.2HCl.0.5H2O 56.26% C; H, 6.29; 6.56% N; 22.14% CI; Found: 56.02% C; H, 6.31; 6.55% N; 21.94% C1.

Example 10

1- (2 - ((2/7) - (3,4-dichlorophenyl) -4- (4-piperidinecarbonyl) morpholin-2-yl) ethyl} spiro [((2S) -hydroxy) indane-1,4 ' -piperidine] dihydrochloride

Example 10 (a)

2 - ((2/7) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl3ethanol

The title compound (226 mg, 85%) was obtained as an amorphous solid according to the procedure described in Example 1 (a) using 2 - [(2H-3,4-dichlorophenyl) morpholin-2-yl] ethanol (150 mg; 0.54 mmol) and N-tert-butoxycarbonyl-4-piperidinecarboxylic acid (137 mg; 0.60 mmol).

1 H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.57 (11¾ d,> 1.9 Hz); 7.43 (1¾ d,> 8.5 Hz); 7.26 (1¾ dd,> 8.5 and 1.9 Hz); 4.69 (1H, d, 14.2 Hz); 3.99-4.22 (2¾ m); 3.73-3.85 (1¾ m); 3,403.64 (5¾ m); 3.32 (1¾ d,> 14.2 Hz); 2.60-2.82 (2¾ m); 2.45-2.58 (1¾ m); 1.88-2.12 (2¾ m); 1.50-1.85 (3¾ m); 1.45 (9¾ s); 1.30-1.50 (2¾ m).

IR spectrum ν max cm ^-1 (KBr): 3447, 2930, 1690, 1640, 1427.

MS spectrum (FAB) m / z: 487 (M + H) &lt; + & gt ^; ).

Example 10 (b)

2 - ((2/7) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (216 mg, 93%) was obtained as a white amorphous solid according to the procedure described in Example 1 (b) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (N-tert-butyl). butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl] ethanol (200 mg; 0.41 mmol).

Ή NMR Spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.55 (1H, d, J = 1.8 Hz); 7.45 (1H, d, J = 8.3Hz); 7.26 (1H, dd, J = 8.3 and 1.8 Hz); 4.43 (1H, d, J = 13.9Hz); 3.43 (1H, d, J = 13.9Hz); 3.40-4.30 (8 H, m); 2.94 (3 H, s); 2.60-2.82 (2 H, m); 2.45-2.60 (1 H, m); 2.10-2.35 (2 H, m); 1.50-1.80 (2H, m); 1.46 (9 H, s); 1.35-1.50 (2H, m).

IR spectrum ν max cm ^-1 (KBr): 2974, 2932, 1689, 1642, 1175.

MS spectrum (FAB) m / z: 565 (M + H) &lt; + & gt ^; ).

Example 10 (c) 1- {2 - [(2R) - (3,4-dichlorophenyl) -4- (N-tert-butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl] ethyl} -spiro [((25) 1-Hydroxyindane-1,4'-piperidine]

The title compound (193 mg, 83%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (N-tert. butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl] ethyl methanesulfonate (195 mg, 0.35 mmol) and [((2 _i S) -hydroxy) indane-l, 4'-piperidine] hydrochloride (91 mg; 0.38 mmol).

Melting point: 105-107 ° C [α] D ²³ + 59.0 ° (c = 0.53, methanol)

1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.56 (1H, d, J = 1.7 Hz); 7.42 (1H, d, J = 8.5Hz); 7.20-7.30 (5 H, m); 3.20-4.75 (8 H, m); 2.45-2.90 (6 H, m); 1.46 (9 H, s); 1.35-2.40 (15 H, m);

IR spectrum ν max cm ^-1 (KBr): 3448, 2926, 1693, 1644, 1426, 1169.

MS spectrum (FAB) m / z: 672 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calculated C, 63.77; H, 7.08; 6.20% N; 10.46% C1; found 63.81% C; H, 7.04; 6.05% N; 10.56% C1.

Example 10 (d) 1- {2 - [(2R) - (3,4-Dichlorophenyl) -4- (4-piperidinecarbonyl) morpholin-2-yl] ethyl} spiro [((2S) -hydroxy) indan-1] 4'-piperidine] dihydrochloride

The title compound (141 mg, 100%) was obtained as a white crystalline solid according to the procedure described in Example 9 (d), using 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (N) - (N -)]. tert-butoxycarbonyl-4-piperidinecarbonyl) morpholin-2-yl] ethyl} spiro [((2S) -hydroxy) indane-1,4'-piperidine] (147 mg; 0.22 mmol).

• ·

Melting point: 216-220 ° C [α] _D ²³ + 45.6 ° (c = 0.53, methanol) ^{] 1} H NMR spectrum (400 MHz, DMSO-d ₆ ) δ ppm: 10.40-11.93 (1¾ m); 8.60-9.27 (1¾ m); 7,407.90 (3¾ m); 7.05-7.25 (4¾ m); 4.99 (1¾ brs); 2.40-4.43 (22¾ m); 2.12-2.40 (2¾ m); 1,752.12 (4¾ m); 1.48-1.75 (3¾ m).

IR spectrum .nu.max cm @ ^-1 (KBr): 3381, 2933, 2712, 1636, 1457.

MS spectrum (FAB) m / z: 572 (M + H) &lt; + & gt ^; , free form).

Elementary analysis (%): for ₃₉ N ₃ C3iH O3Cl .2HCl.l _2, 5H ₂ 0 Calculated C 55.36%; H, 6.59; 6.25% N; 21.09% C1; Found: C, 55.65; H, 6.89; 6.19% N; 20.70% C1.

Example 11

- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (2-oxo- (4 R) -thiazolidinecarbonyl) morpholin-2-yl] ethyl} spiro [((2 R) -hydroxy) indan-1,4'-piperidine]

Example II (a)

2 - [(2R) - (3,4-dichlorophenyl) -4- (2-oxo- (4R) -thiazolidinecarbonyl) morpholin-2-yl] ethanol

The title compound (92 mg, 31%) was obtained as a white solid according to the procedure described in Example 1 (a) using 2-oxo- (4 R) -thiazolidinecarboxylic acid (107 mg; 0.724 mmol) and 2 - [( (R) - (3,4-dichlorophenyl) morpholin-2-yl] ethanol (200 mg; 0.724 mmol).

1 H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.53 (11¾ d, J = 2.0 Hz); 7.46 (11¾ d,> 8.3 Hz); 7.28 (1¾ dd,> 8.3 and 2.0 Hz); 5.85 (1¾ brs); 4.53-4.81 (2¾ m); 3.28-3.91 (9¾ m); 1.93-2.10 (2¾ m).

IR spectrum ν max cm ^-1 (KBr): 3251, 1680, 1470, 1375, 1239, 1092.

MS spectrum (FAB) m / z: 405 (M + H) &lt; + & gt ^; ).

Example II (b)

2 - [(2R) - (3,4-dichlorophenyl) -4- (2-oxo- (4R) -thiazolidinecarbonyl) morpholin-2-yl] ethyl methanesulfonate

The title compound (62 mg, 61%) was obtained as a white solid according to the procedure described in Example 1 (b) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (2-oxo-) (R) -thiazolidinecarbonyl) morpholin-2-yl] ethanol (85 mg; 0.21 mmol).

1 H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.56 (11¾ d,> 1.9 Hz); 7.48 (1¾ d,> 8.3 Hz);

7.27 (1¾ dd,> 8.3 and 1.9 Hz); 5.78 (1¾ brs); 4.18-4.66 (3¾ m); 3.37-3.96 (8¾ m); 2.96 (3¾ s);

2.13-2.32 (2¾ m).

• · ···· · · · ·

IR spectrum ν max cm ⁴ (KBr): 2934, 1687, 1468, 1352, 1241, 1174, 1095.

MS (FAB) m / z 483 (M + H) &lt; + & gt ^; );

Example II (c)

- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (2-oxo- (4 R) -thiazolidinecarbonyl) morpholin-2-yl] ethyl} spiro [((25) - hydroxy) indan-1,4'-piperidine]

The title compound (32 mg, 44%) was obtained as a white solid according to the procedure described in Example 1 (c) using 2 - [(2 R) - (3,4-dichlorophenyl) -4- (2-oxo-) (4 H) -thiazolidinecarbonyl) morpholin-2-yl] ethyl methanesulfonate (60 mg; 0.124 mmol) and [((2 S) -hydroxy) indane-1,4'-piperidine] hydrochloride (31 mg; 0.130 mmol) .

Melting point: 155 - 156 ° C [α] D ²³ + 41.6 ° (c = 0.38, methanol) ¹ H NMR spectrum (400 MHz, CDCl 3) δ ppm: 7.57 (1¾ d,> 2 , 1 Hz); 7.44 (11¾ d,> 8.3 Hz); 7.14-7.29 (5¾ m); 5.68 (1¾ brs); 4.32-4.76 (3¾ m); 3.22-3.85 (8¾ m); 2.57-2.83 (3¾ m); 1,412.43 (1H, m).

IR spectrum ν max cm ^-1 (KBr): 3400, 2924, 1683, 1472, 1238, 1090, 759.

MS spectrum (FAB) m / z: 590 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): Calc'd for C29H33N3O4SCl2.H2O 57.23% C; 5.80% H; 6.90% N; 11.65% C1; 5.27% S, found 56.54% C; 5.73% H; 6.53% N; 11.48% C1; 5.61% N.

Example 12 1- {2- [4-Cyclohexylmethyl) - (2 R) - (3,4-dichlorophenyl) -5-oxomorpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indan-1] 4'-piperidine]

Example 12 (a) (2 R) - (3,4-dichlorophenyl) -4- (triphenylmethoxy) butane-1,2-diol

To a mixture of tert-butanol (200 mL) and water (200 mL) was added (DHQDbPHAL (85 mg; 0.11 mmol), potassium ferricyanide (10.75 g; 32.7 mmol) and potassium carbonate (4.51 g). To this mixture was added osmium tetroxide (55 μΐ (0.02 mmol) of 0.393 mol / L toluene solution) followed by 3- (3,4-dichlorophenyl) -3-buten-1-ol triphenylmethyl ether (5.00 g; 10.9 mmol) The mixture was stirred at room temperature for three days After addition of sodium sulfite (15 g), the mixture was stirred at room temperature for one hour The reaction mixture was extracted with ethyl acetate The organic layer was dried anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure, and the residue was purified by flash chromatography on silica gel using hexane / ethyl acetate = 50/1 - 2/1 as eluent to give the title compound (3.56 g, 66%) as a white crystalline solid.

Ή NMR Spectrum (270 MHz, CDCl 3) δ ppm: 7.43 (1H, d, J = 2.0 Hz); 7.19-7.39 (16 H, m); 7.03 (1H, dd, J = 8.5 and 2.0 Hz); 4.69 (1 H, s); 3.48-3.66 (2 H, m); 3.34-3.45 (1H, m); 2.94 (1 H, m); 2.49 (1 H, m); 2.32 (1 H, m); 1.92 (1 H, m).

IR spectrum ν max cm ^-1 (KBr): 3446, 3059, 2932, 1449, 1062.

MS (FAB) m / z 515 (M + Na) &lt; + &^gt;

Example 12 (b)

4- (triphenylmethoxy) - (2 R) - (3,4-dichlorophenyl) -1- [N- (chloroacetyl) -N- (cyclohexylmethyl) amino] -2-butanol

To a solution of (2A) - (3,4-dichlorophenyl) -4- (triphenylmethoxy) butane-1,2-diol (3.51 g; 7.11 mmol) prepared in Example 12 (a) in pyridine. (17 mL) was added p-toluenesulfonyl chloride (2.03 g; 10.7 mmol). The mixture was stirred overnight at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was dissolved in acetonitrile (50 mL) and lithium perchlorate trihydrate (3.42 g; 21.3 mmol) and cyclohexylmethylamine (2.78 mL; 21.3 mmol) were added. The mixture was stirred overnight at 100 ° C. Ethyl acetate was added to the reaction mixtures, and the mixture was washed with a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 50% by weight of the residue was dissolved in dichloromethane (30 ml). To this solution was added triethylamine (2.48 mL; 17.8 mmol) and chloroacetyl chloride (1.42 mL; 17.8 mmol) under ice-cooling. The mixture was stirred for one hour at 0 ° C. Dichloromethane was added to the reaction mixture, and the organic layer was washed with water and then with a saturated aqueous sodium chloride solution, and then dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the resulting residue was purified by silica gel column chromatography using n-hexane / ethyl acetate = 20/1 - 10/1 as eluent to give the title compound (1.49 g, 63%).

¹ H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 6.98-7.62 (18H, m); 4.84 and 4.99 (total 1H, both brs); 3.97-4.38 (3 H, m); 2.81-3.72 (5 H, m); 1.93-2.37 (2 H, m); 1.40-1.80 (6H, m); 1.10-1.30 (3H,

m); 0.75-1.00 (2H, m).

IR spectrum ν max cm ^-1 (KBr): 3455, 2926, 2853, 1649, 1469, 1449, 1073, 1029.

MS spectrum (FAB) m / z: 664 (M + H) &lt; + & gt ^; ).

• ·

Example 12 (c)

2- [4-cyclohexylmethyl) - (2R) - (3,4-dichlorophenyl) -3-oxomorpholin-2-yl] ethyltriphenylmethyl ether

To a solution of 4- (triphenylmethoxy) - (2 R) - (3,4-dichlorophenyl) -1- [N- (chloroacetyl) -N- (cyclohexylmethyl) amino] -2-butanol (1.41 g; 2.12 mmol), prepared in Example 12 (b), in dimethylformamide (15 mL) was added sodium hydride (127 mg (3.18 mmol) of a 60% suspension in oil) under ice-cooling. The mixture was stirred overnight at room temperature. The reaction mixture was poured into ice water and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by flash chromatography on silica gel using n -hexane / ethyl acetate = 10/1 - 5/1 as eluent to give the title compound (1.08 g, 81%).

1 H NMR spectrum (270 MHz, CDCl ₃ ) δ ppm: 7.19-7.35 (17¾ m); 6.89 (1H, dd, J = 8.4 and 2.2 Hz); 4.13 (1H, d, J = 17.0 Hz); 3.88 (1¾ d, J = 17.0 Hz); 3.80 (1H, d, J = 13.4 Hz); 3.70 (1H, d, J = 13.4 Hz); 3.39 (1H, dd, J = 13.4 and 7.0 Hz); 3.18 (1¾ m); 3.02 (1¾ dd, J = 13.4 and 7.3 Hz); 2.67 (1¾ m); 2.13-2.24 (2¾ m); 1.10-1.80 (9¾ m); 0.85-1.08 (2¾ m).

IR spectrum ν max cm ^-1 (KBr): 2924, 2852, 1664, 1490, 1449.

MS (FAB) m / z 628 (M + H) &lt; + & gt ^; );

Example 12 (d)

2- [4-cyclohexylmethyl] - (2 R) - (3,4-dichlorophenyl) -3-oxomorpholin-2-yl] ethyl methanesulfonate

To a solution of 2- [4-cyclohexylmethyl) - (2 R) - (3,4-dichlorophenyl) -3-oxomorpholin-2-yl] ethanol triphenylmethyl ether (1.04 g; 1.65 mmol) which was prepared in of Example 12 (c), in ethanol (10 mL), a solution of hydrogen chloride in dioxane (4 mol / l; 4.1 mL) was added under ice-cooling. The mixture was stirred for one hour at room temperature. Water was added to the reaction mixture, and the mixture was then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by flash chromatography on silica gel using n-hexane / ethyl acetate = 10/1 - 0/1 as eluent to afford the alcohol derivative (440 mg, 69%). The alcohol derivative (418 mg; 1.08 mmol) was dissolved in dichloromethane (10 mL) and to this was added triethylamine (0.23 mL; 1.62 mmol) and methanesulfonyl chloride (0.10 mL; 1.30 mmol). The mixture was stirred at room temperature for 2 days. Dichloromethane was added to the reaction mixture, and the organic layer was washed with water and then with a saturated aqueous sodium chloride solution, and then dried over anhydrous magnesium sulfate. After distillation 44 4444 4444 • 44 44 44 4444

The solvent was removed under reduced pressure, and the residue was purified by flash chromatography on silica gel using n-hexane / ethyl acetate = 1/1 - 1/3 as eluent to give the title compound (500 mg, 99%). %).

1 H NMR spectrum (270 MHz, CDCl 3)? Ppm: 7.49 (1H, d, J = 8.4 Hz); 7.46 (1¾ d,> 2.1 Hz); 7.20 (1¾ dd,> 8.4 and 2.1 Hz); 4.27 (1H, d, > 17.0 Hz); 4.23 (1¾ m); 4.15 (1H, d, > 17.0 Hz); 4.00 (1¾ ddd,> 10.5; 7.3 and 7.3 Hz); 3.69 (1¾ d,> 13.2 Hz); 3.61 (1¾ d,> 13.2 Hz); 3.28 (1¾ dd,> 13.6 and 7.0 Hz); 3.22 (1¾ dd,> 13.6 and 7.7 Hz); 2.92 (3¾ s); 2.40 (1¾ ddd,> 14.6; 6.4 and 6.4 Hz); 2.26 (1¾ ddd,> 14.6; 7.3 and 7.3 Hz); 1.46-1.78 (6¾ m); 1.12-1.29 (3¾ m); 0.881.04 (2¾ m).

IR spectrum .nu.max cm @ ^-1 (neat): 2926, 2853, 1657, 1474, 1450, 1356, 1176.

MS spectrum (EI) m / z: 463 (M) &lt; ^{+ &gt;} .

Example 12 (e) 1- {2- [4-Cyclohexylmethyl) - (2 R) - (3,4-dichlorophenyl) -5-oxomorpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indane -1,4 '-p iperidine]

The title compound (94 mg, 76%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2- [4-cyclohexylmethyl) - (2 R) - (3,4-dichlorophenyl) -3- oxomorpholin-2-yl] ethyl methanesulfonate (100 mg; 0.22 mmol) and [((2S) -hydroxy) indan-1,4'-piperidine] hydrochloride (57 mg; 0.24 mmol).

Melting point: 84 - 86 ° C [α] _D ²³ + 35.8 ° (c = 0.52, methanol) 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.47 (1H, d,> 2.1 Hz); 7.47 (11¾ d,> 8.5 Hz); 7.17-7.24 (5¾ m); 4.41 (1H, dd,> 5.2 and 1.8 Hz); 4.24 (1H, d, > 17.0 Hz); 4.12 (11¾ d,> 17.0 Hz); 3.78 (1¾ d,> 12.9 Hz); 3.58 (1H, d, > 12.9 Hz); 3.23-3.31 (3¾ m); 2.55-2.87 (3¾ m); 1,452.40 (17¾ m); 1.15-1.32 (3¾ m); 0.91-1.08 (2¾ m).

IR spectrum ν max cm ^-1 (KBr): 3417, 2924, 2851, 1654, 1474, 1450, 1381.

MS spectrum (FAB) m / z: 571 (M + H) &lt; + & gt ^; ).

Elementary analysis (%) for ₂ C32H4oN 03Cl2.0,3H20 calculated 66.61% C; H, 7.09; 4.86% N; 12.29% C1; Found: C, 66.89; H, 6.85; 4.83% N; 11.83% C1.

Example 13

- {2- [3-Cyclohexylmethyl) - (S) - (3,4-dichloro-phenyl) -2-oxooxazolidin-5-yl] -ethyl} spiro [((2 S) -hydroxy) indane-1,4 ' -piperidin] • 4 · 44 · 44 · 4 9 · 4 · 4 · 4 · 4 9 4 •• 4 4 9 44 9 ··· * 4 · 49 ··

Example 13 (a)

2- [3-Cyclohexylmethyl] - (5 R) - (3,4-dichlorophenyl) -2-oxooxazolidin-5-yl] ethyltriphenylmethyl ether To a solution of (R) - (3,4-dichlorophenyl) -4- (triphenylmethoxy) butane-1,2-diol (3.51 g;

7.11 mmol), which was prepared in Example 12 (a), in pyridine (17 mL) was added p-toluenesulfonyl chloride (2.03 g; 10.7 mmol). The mixture was stirred overnight at room temperature.

Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was dissolved in acetonitrile (50 mL) and lithium perchlorate trihydrate (3.42 g; 21.3 mmol) and cyclohexylmethylamine (2.78 mL; 21.3 mmol) were added. The mixture was stirred overnight at 100 ° C. Ethyl acetate was added to the reaction mixture, and the mixture was washed with saturated aqueous sodium chloride, and the solvent was distilled off under reduced pressure. 50% by weight of the residue was dissolved in dichloromethane (30 ml) and triethylamine (2.48 ml; 17.8 mmol) and di-tert-butyl dicarbonate (3.88 g; 17.8 mmol) were added under ice-cooling. ). The mixture was stirred overnight at room temperature. Dichloromethane was added to the reaction mixture, and the organic layer was washed with water and then dried over anhydrous magnesium sulfate. After distilling off the solvent, the resulting residue was dissolved in dimethylformamide (30 mL). To this solution was added sodium hydride (213 mg (5.34 mmol) of a 60% suspension in oil) under ice-cooling. The mixture was stirred at room temperature for 4 hours. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by flash chromatography on silica gel using n -hexane / ethyl acetate = 20/1 - 5/1 as eluent to give the title compound (1.76 g, 81%).

^! 1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.21-7.37 (17¾ m); 7.04 (1H, dd, J = 8.3 and 2.3 Hz); 3.90 (1H, d, J = 8.8 Hz); 3.53 (1¾ d,> 8.8 Hz); 3.31 (1¾ ddd,>10.9; 5.4 and 5.4 Hz); 3.07 (1¾ dd,> 13.9 and 7.3 Hz); 2.93-3.00 (2¾ m); 2.29 (1H, ddd, J = 14.0, 7.0 and 7.0 Hz); 2.15 (1H, ddd, J = 14.0, 5.4 and 5.4 Hz); 1.44-1.76 (6¾ m); 1.07-1.22 (3¾ m); 0.84-0.99 (2¾ m).

IR spectrum ν max cm ^-1 (KBr): 3059, 2924, 2852, 1759, 1449, 1265, 1064.

MS (FAB) m / z 612 (M + H) &lt; + & gt ^; );

Example 13 (b)

2- [3-cyclohexylmethyl) - (5A) - (3,4-dichlorophenyl) -2-oxooxazolidin-5-yl] ethyl methanesulfonate

The alcohol derivative (930 mg, 91%) was prepared as described in Example 12 (d) using 2- [3-cyclohexylmethyl) - (5 R) - (3,4-dichlorophenyl) -2-oxooxazolidin-5-yl] ethyltriphenylmethyl ether (1.69 g; 2.75 mmol) and a solution of hydrogen chloride in dioxane (4 mol / L; 6.9 mL). The alcohol derivative (880 mg; 2.36 mmol) was dissolved in dichloromethane (18 mL) and to this was added triethylamine (0.50 mL; 3.55 mmol) and methanesulfonyl chloride (0.22 mL; 2.84 mmol). The mixture was stirred overnight at room temperature. Dichloromethane was added to the reaction mixture and the mixture was washed with water and then with a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by flash chromatography on silica gel using n-hexane / ethyl acetate = 4/1 - 1/1 as eluent to give the title compound (1.03 g, 97%).

1 H NMR spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.52 (11¾ d,> 8.4 Hz); 7.51 (1H, d, J = 2.3 Hz); 7.22 (1¾ dd,> 8.4 and 2.3 Hz); 4.33 (1¾ ddd,>10.7; 6.7 and 6.7 Hz); 4.10 (1H, ddd, &gt;10.7; 6.9 and 6.9 Hz); 3.79 (1¾ d,> 8.9 Hz); 3.59 (1¾ d,> 8.9 Hz); 3.13 (1¾ dd,> 13.9 and 7.3 Hz); 3.05 (1¾ dd,> 13.9 and 7.1 Hz); 2.94 (3¾ s); 2.48-2.54 (2¾ m); 1.48-1.78 (6¾ m); 1.12-1.28 (3¾ m); 0.861.02 (2¾ m).

IR spectrum υ max cm ^-1 (CHC1 _3): 2927, 2856, 1757, 1365,1264,1176.

MS (FAB) m / z 450 (M + H) &lt; + & gt ^; );

Example 13 (c) 1- {2- [3-Cyclohexylmethyl) - (5 R) - (3,4-dichlorophenyl) -2-oxooxazolidin-5-yl] ethyl} spiro [((2 R) -hydroxy) indan-1,4'-piperidine]

The title compound (85 mg, 69%) was obtained as a white crystalline solid according to the procedure described in Example 1 (c) using 2- [3-cyclohexylmethyl) - (5 R) - (3,4-dichlorophenyl) -2- oxo-oxazolidin-5-yl] ethyl methanesulfonate (100 mg; 0.22 mmol) and [((2o ^T) -hydroxy) indane-l, 4'-piperidine] hydrochloride (58 mg, 0.24 mmol).

Melting point: 67-69 ° C [α] _D ²⁴ -2.2 ° (c = 0.50, methanol)

Ή NMR Spectrum (400 MHz, CDCl ₃ ) δ ppm: 7.50 (1¾ d,> 2.2 Hz); 7.48 (1H, d, J = 8.4 Hz);

7.16-7.23 (5¾ m); 4.43 (1¾ dd,> 5.4 and 2.0 Hz); 3.80 (1¾ d,> 8.8 Hz); 3.56 (1¾ d,> 8.8 Hz);

3.28 (1¾ dd,> 16.6 and 5.4 Hz); 3.14 (1¾ dd,> 13.9 and 7.4 Hz); 3.02 (1¾ dd,> 13.9 and 6.8 Hz);

2.82 (1¾ dd,> 16.6 and 2.0 Hz); 2.15-2.90 (8¾ m); 1.47-2.10 (11¾ m); 1.10-1.30 (3 m); 0.851.02 (2¾ m).

«* ♦ ··· • · · ♦ ·

IR spectrum ν max cm ^-1 (KBr): 3437, 2924, 2852, 1752, 1475, 1449, 1268.

MS spectrum (FAB) m / z: 557 (M + H) &lt; + & gt ^; ).

Elemental analysis (%): calculated for C 31 H 38 N 2 O 3 Cl 2. H, 6.94; 4.94% N; 12.51% C1; found: 65.75% C; 6.70% H; 5.20% N; 12.72% C1.

In a manner similar to that described in the above examples, the compounds shown in Table 1 can be prepared.

R ²

Q-G

(1-1)

Each substituent (referred to in the table as "sub") in Table 1 represents the following group.

sub.l sub.2 MeSc + O sub.3 Ph. / - \ X 7 (Me) ₂ NCO ^x ' sub.4 c-X- 0 sub. 5 c; c- 0 sub.6 ^Ph O AcNH ^λ ' sub. 7 ^Ph O MeCO - / sub. 8 ^Ph o HO - ^/ sub. 9 it sub. 10 Ph-SO \ / - \ X / ^N sub. 11 PhHNCO- ^ \ sub. 12 NCO ~ N Me \ ' sub. 13 sub. 14 ^{Prf / X} NCO - / N Me - / sub. 15 Dec PhCONHH ^ \

Tt tt tt tt ttt

Ttt ttt ttt ttt tttt tttt ttt ttt

sub. 16 Ph sub. 17 ^ac O - / X sub. 18 _n f7 O sub. 19 Dec 7: Ph > sub.20 Ph 3 ⁿ sub.21 pQTQ O sub.22 A MeSO ₂ ~ N '^ / \ ^N sub.23 % Λ sub.24 7c > Qz- Qz Q sub.25 QC \\ 0 q sub.26 7 Λ sub.27 _O , s77 N 7c Q sub.2 8 Υ-νηΝ- O N sub.29 7 ⁿ sub.30 XX HIM 7 ⁿ Qz- Π Qz- sub.31 7: OH λ sub.32 „7+ X sub.33 7: 0 Qz- 7: sub.34 0 _ / ^N sub.35 7 ⁿ

• 9 9 9 9 9 9 • 8 9 a a 9 9 a

989 and 88 98 89 89

The following abbreviations are used in Table 1.

Ph: phenyl; Me: methyl; Ac: acetyl; cPr: cyclopropyl; cBu: cyclobutyl; cPn: cyclopentyl; cHex: cyclohexyl; cHep: cycloheptyl; Pyrd: pyrrolidinyl; Oxa: oxazolidinyl;

Thi: thiazolidinyl; Oxa: 2-oxooxazolidinyl;

OThi: 2-oxothiazolidinyl; Pip: piperidinyl; Plague: morpholinyl;

Thmor: thiomorpholinyl; Piz: piperazinyl; Aze: azepinyl.

Table 1

Compound in C. R ¹ R ² AND (B) N D G Q 1 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l 2 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 4 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 5 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 6 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 7 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 8 4-0xa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 9 5-0xa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l

• 9 9

9999 · 8 ·· ·

99

9 »9 ·

99 * «8 * · ·

9 9 9

9 · 9

9 9 9

99

10 4-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 11 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 12 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 13 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 14 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 15 Dec 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 16 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 17 3-Pip 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 18 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 19 Dec 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 20 May 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 21 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 22nd 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 23 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 24 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 25 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 26 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 27 Mar: 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ 1 sub.l 28 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 29 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 30 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 31 cPr 3,4-diClPh what simple binding. 1 0 ch ₂ ch ₂ sub. 2 32 cBu 3,4-diClPh what simple custody 1 0 CHoCH? 1 sub. 2

44

4 9

9 4 • 4

4 4 4

44 • 4 • 49 • 49 •

44

33 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 34 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 35 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 36 2-Pyrd 3.4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 37 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 38 4-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 39 5-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 40 4-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 41 5-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 42 4-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 43 5-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.2 44 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 45 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 46 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 47 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.2 48 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 49 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 50 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 51 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 52 2-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 53 3-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 54 4-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 55 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.2 56 3-Piz 3,4-diClPh what simple vazha. 1 0 ch ₂ ch ₂ sub.2

• 9 • ·· «9

9 9 ·

9 9 9

9 9 9

9 9 9

99 • 9

9 9 9

99

57 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.2 58 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub .2 59 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.2 60 4-Aze 3,4-diClPh WHAT simple 'Binding 1 0 ch ₂ ch ₂ sub.2 61 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 62 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 63 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 64 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 65 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 66 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 67 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 68 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 69 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 70 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 71 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 72 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 73 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 74 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 75 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 76 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 77 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 78 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 79 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3

• · · φ · Φ · • · • · · • · · · · · ·. · · · · · · · · · ΦΦ · ΦΦ · φ φ φ φ φ φφ · Φ

80 3-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 81 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.3 82 2-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 83 3-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 84 4-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 85 2-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 86 3-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 87 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 88 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 89 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub, 3 90 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.3 91 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.4 92 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.4 93 cPn 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 94 cHex 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 95 cHep 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 96 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 97 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 98 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 99 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 100 ALIGN! 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 101 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4 102 4-OOxa 3,4-diClPh what simple custody' 1 0 CH2CH2 sub.4 103 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.4

• · 99 99 99 99 99 9 9 9 9 9 9 9 9 9 9 9 9 9 9 99 • 9 9 9 9 9999 9 9 9 9 9 9 9 9 9 • 9 9 9 9 9 9 9 9 • • 999 9 99 99 99

104 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 105 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 106 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 107 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 108 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 109 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 110 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 111 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 112 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 113 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 114 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 115 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 116 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 117 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 118 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 119 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 120 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.4 121 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.5 122 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.5 123 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.5 124 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.5 125 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.5 126 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.5

• ·

127 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 128 4-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 129 5-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 130 4-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 131 5-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 132 4-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 133 5-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 134 4-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 135 5-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 136 2-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 137 3-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 138 4-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.5 139 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 140 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 141 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 142 2-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 143 3-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 144 4-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 145 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 146 3-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 147 4-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 148 2-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 149 3-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub.5 150 4-Aze 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.5

• ·

151 cPr 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.6 152 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 153 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 154 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 155 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 156 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 157 3-Pyrd 3,4-diClPh WHAT simple custody 1 O ch ₂ ch ₂ sub.6 158 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 159 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 160 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 161 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 162 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 163 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.6 164 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.6 165 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.6 166 2-Pip 3,4-diClPh what simple custody 1 O ch ₂ ch ₂ sub.6 167 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 168 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 169 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 170 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.6 171 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 172 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 173 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 174 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6

> · 4 ·· ···

175 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch? ch ₂ sub.6 176 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 177 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 178 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 179 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 180 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.6 181 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 182 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 183 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 184 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 185 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 186 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 187 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 188 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 189 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 190 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 191 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 192 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 193 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 194 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 195 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 196 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 197 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 198 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7

199 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 200 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 201 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 202 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 203 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 204 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 205 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 206 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 207 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 208 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 209 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.7 210 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.7 211 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 212 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 213 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 214 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 215 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 216 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 217 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 218 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 219 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 220 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 8 221 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.8

222 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 223 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 224 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 225 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 226 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 227 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 228 4-Pip 3,4-diCIPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 229 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 230 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 231 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 232 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 8 233 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 234 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 235 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 236 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.8 237 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 238 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 239 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.8 240 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.8 241 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 242 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 243 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 244 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 245 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9

• 9 9

9 9 • 9 9

9 9 ···· · · · · ·

246 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 9 247 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 9 248 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 249 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 9 250 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 251 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 252 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 253 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 254 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 255 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 256 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 257 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 258 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 259 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 260 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 261 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 262 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 263 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 264 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 265 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 266 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 267 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9 268 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.9

9999 · ·

98 • 9 9 9

9 9 9

9 «· ··

269 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 270 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.9 271 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 272 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 273 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 274 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 275 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 276 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 277 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 278 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 279 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 280 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 281 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 10 282 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 283 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 284 4-OThi 3,4-diClPh what simple . custody 1 0 ch ₂ ch ₂ sub. 10 285 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 286 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 287 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 288 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 289 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 290 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 291 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10 292 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 10

• ·

99

9999 8 9

293 3-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 294 4-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 295 2-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 296 3-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 297 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 298 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 299 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 300 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 10 301 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 302 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 303 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 304 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 11 305 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 306 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 307 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub.l 1 308 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 11 309 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 11 310 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 11 311 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 11 312 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.l 1 313 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 11 314 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.l 1 315 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.l 1

·· 9

9999 9 9 ♦ 9 • 9 9 · ·

9 9 99 99

9 9 9 • 9 9 9

9 9

316 2-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 317 3-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 1 318 4-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 11 319 2-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 11 320 3-Mor 3,4-diCIPh WHAT simple custody 1 0 CH2CH2 sub. 11 321 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l 1 322 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l 1 323 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l 1 324 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.l 1 325 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 11 326 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 11 327 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 11 328 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 11 329 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.l 1 330 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 11 331 cPr 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 332 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 333 cPn 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 334 cHex 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 335 cHep 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 336 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 337 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 338 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12 339 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 12

φ · · · · · · φ φ φ φ φ · ·

340 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 341 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 342 4-00xa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 343 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 344 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 345 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 346 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 347 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 348 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 349 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 350 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 351 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 352 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 ο rn 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 354 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 355 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 356 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 357 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 358 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 12 359 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 360 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 12 361 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 362 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13

9 9 9 9 9 9 9 9 9 9 9

99

363 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 364 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 365 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 366 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 367 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 368 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 369 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 370 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 371 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 372 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 373 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 374 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 375 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 13 376 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 377 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 378 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 379 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 380 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 381 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 382 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 383 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 384 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 385 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13 386 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 13

• · 4 ** 44 4 * • ♦ 4

4

4 • · *

4 • »· · · 44 • 4 4 4

387 4-Piz 3.4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 13 388 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 13 389 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 13 390 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 13 391 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 392 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 393 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 394 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 395 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 396 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 397 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 14 398 4-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 399 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 400 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 401 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 402 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 403 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 404 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 405 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 406 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 407 3-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 408 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 409 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 410 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14

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411 4-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 412 2-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 413 3-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 414 4-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 415 2-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 416 3-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 417 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub. 14 418 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 14 419 3-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 420 4-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 14 421 cPr 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 422 cBu 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 423 cPn 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 424 cHex 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 425 cHep 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 426 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 427 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 428 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 429 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.15 430 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 431 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.15 432 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 433 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 434 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec

9 9 99 999 99 9 9 9 9 9 9 9 9 9 99 99 99 99 99

435 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 15 Dec 436 2-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 15 Dec 437 3-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 15 Dec 438 4-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 15 Dec 439 2-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.l 5 440 3-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 15 Dec 441 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 442 2-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 443 3-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 444 4-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 445 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 446 3-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 447 4-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 448 2-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 449 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 15 Dec 450 4-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 15 Dec 451 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 452 cBu 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 16 453 cPn 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 16 454 cHex 3,4-diClPh what simple custody 1 0 CH2CH2 sub.16 455 cHep 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 16 456 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 16 457 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 16

458 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 459 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 460 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 461 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 462 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 463 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 464 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 465 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 466 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 467 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 468 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 469 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 470 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 16 471 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.16 472 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 473 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 474 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 475 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 476 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 477 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 478 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 479 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 480 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 16 481 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17

482 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 483 cPn 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub. 17 484 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 485 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 486 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 487 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 488 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 489 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 490 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 491 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 492 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 493 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 494 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 495 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 496 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 497 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 498 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 499 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 500 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 501 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 502 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 503 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17 504 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 17

• · · · ··· ·

505 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 17 506 3-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 507 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 508 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 509 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 510 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 17 511 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 512 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 513 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 514 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 515 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 516 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 517 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 518 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 519 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 520 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 521 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 522 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 523 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 524 4-OThi 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub. 18 525 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 526 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub. 18 527 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 18 528 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.18

• ·

529 2-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 530 3-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 531 4-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 532 2-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 533 3-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 534 4-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 535 2-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub. 18 536 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 18 537 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 18 538 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 18 539 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 18 540 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 18 541 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 542 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 543 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 544 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 545 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 546 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 547 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 548 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 549 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 550 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 551 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec

• 99 99 ·· 99

99 9 9

998 9 · 9 9

99,999 99 9

9 · 999 9999

99 «9 9 · 99 99 99

552 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 553 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 554 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 555 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 556 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 557 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 558 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 559 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 560 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 561 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 562 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 563 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 564 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 565 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 566 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 567 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 568 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 569 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 570 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub. 19 Dec 571 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 572 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 573 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 574 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 575 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20

99 99 99 99 9 9 9 9 9 9 9 9 9 9 9 • 9 99 99 99 99

576 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.20 577 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.20 578 4-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.20 579 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 580 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 581 5-Thi 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.20 582 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 583 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 584 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 585 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 586 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 587 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 588 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 589 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 590 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 591 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.20 592 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 593 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 594 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 595 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 596 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 597 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.20 598 2-Aze 3,4-diClPh what simple vazba ..... 1 0 ch ₂ ch ₂ sub.20

• 9 99 99 99 99 99 99 99 99 99 9 9 9 9 9 9 9

599 3-Aze 3,4-diClPh WHAT simple custody 1 1 0 CH2CH2 sub.20 600 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.20 601 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 602 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 603 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 604 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 605 cHep 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.21 606 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 607 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.21 608 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 609 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 610 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 611 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 612 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.21 613 5-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 614 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 615 5-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 616 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 617 3-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 618 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 619 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 620 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 621 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21 622 2-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.21

· »•.............» »» »» »» »» »» »

623 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 624 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 625 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 626 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 627 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 628 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 629 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 630 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.21 631 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 632 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 633 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 634 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 635 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 636 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 637 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 638 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 639 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 640 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 641 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 642 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 643 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 644 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 645 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ | sub.22

• · · · · · · · ·

4 9 4 4 4 4 4 4 5 6 7 8 9 10 11 12 13 14

9 4 9 4 4 45

646 2-Pip 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.22 647 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 648 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 649 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 650 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 651 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 652 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 653 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 654 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 655 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.22 656 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 657 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 658 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 659 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 660 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.22 661 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 662 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 663 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 664 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 665 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 666 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 667 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 668 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 669 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23

tt · tt tt tt ttttt 0 ttttt tttt tttt tt ttt tttt ·· tttt

670 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 671 5-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.23 672 4-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.23 673 5-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.23 674 4-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.23 675 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 676 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 677 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 678 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 679 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 680 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 681 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 682 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 683 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 684 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 685 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 686 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 687 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.23 688 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 689 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 690 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.23 691 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.24 692 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.24

·· · · 44 «4»

4 4 4 4

445 44 4

43 4 4 4 * 4

44 44 44

4949 · ·

693 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 694 cHex 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.24 695 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 696 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 697 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 698 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.24 699 5-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 700 4-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 701 5-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 702 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.24 703 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.24 704 4-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 705 5-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 706 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.24 707 3-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 708 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 709 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 710 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 711 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 712 2-Thmor 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.24 713 3-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 714 4-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 715 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24 716 3-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.24

· 99 * · 99 99 99 99 99 99 99 99

· ♦ • *...... 99

717 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 718 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.24 719 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.24 720 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.24 721 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 722 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 723 cPn 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 724 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 725 cHep 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 726 2-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH0 sub.25 727 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 728 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 729 5-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 730 4-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 731 5-Thi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 732 4-OOxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 733 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 734 4-OThi 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 735 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.25 736 2-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 737 3-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 738 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.25 739 2-Mor 3,4-diClPh what simple 1 binding 1 0 CH2CH2 sub.25

φ φ φ · · · • • • • φ »φ φ φ φ

740 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub. 25 741 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 742 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 743 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 744 4-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 745 2-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 746 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 747 4-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 748 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 749 3-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 750 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.25 751 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 752 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 753 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 754 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 755 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 756 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 757 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 758 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 759 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 760 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 761 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 762 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26 763 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.26

9 · 9

9 9 9 9 9 9 9

9999 9 9 9 9 9 9 9 9 9

9 9 9 9 9

995 99 99 99 «·» »

764 4-OThi 3.4-diClPh WHAT simple custody 1 0 CH2CH2 sub.26 765 5-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.26 766 2-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.26 767 3-Pip 3.4-diClPh what simple custody 1 0 CH2CH2 sub.26 768 4-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.26 769 2-Mor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.26 770 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26 771 4-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26 772 2-Thmor 3.4-diClPh what simple custody 1 0 CH2CH2 sub.26 773 3-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26! 1 and 774 4-Thmor 3.4-diClPh what simple custody 1 0 CH2CH2 sub.26 775 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26 í and 776 3-Piz 3.4-diClPh what simple custody 1 0 CH2CH2 sub.26 í • 777 4-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26; and 778 2-Aze 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.26 i and 779 3-Aze 3.4-diClPh what simple custody 1 0 CH2CH2 sub.26! and 780 4-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub.26 i ΐ 781 cPr 3,4-diClPh what simple custody 1 0 CH2CH2 sub.27 782 cBu 3,4-diClPh what simple custody 1 0 CH2CH2 1 í sub.27 i 783 cPn 3,4-diClPh what simple custody 1 0 i CH2CH2 sub.27 1 784 cHex 3,4-diClPh what simple custody 1 0 í COTH and i sub.27 785 cHep 3,4-diClPh what simple 1 binding 1 0 CH9CH2 1 and sub.27 786 2-Pyrd 3,4-diClPh what | simple 1 binding 1 i ° i CH2CH2 j sub.27 AND

• ·· 99 99 99

9999 9 999

9999 99 99 999 99

9999 9999

9 99 99 99 99

787 3-Pyrd 3.4-diClPh WHAT simple custody 1 i 1 0 Haha sub.27 788 4-Oxa 3.4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 789 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 790 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 791 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 792 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 793 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 794 4-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.27 795 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 796 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 797 3-Pip 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 798 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 799 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 ί 800 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 801 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 802 2-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 803 3-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 804 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 805 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 806 3-Piz 3,4-diClPh 1 what simple custody 1 0 ch ₂ ch ₂ sub.27 807 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 808 2-Aze | 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 809 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27 810 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.27

»4 · · · · · · · · · · · · · · · · · · · 9 · 9

9 9 9 9 9

99 99 99 99

811 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 812 cBu 3.4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 813 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 814 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 815 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 816 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 817 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 818 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 819 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 820 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 821 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 822 4-OOxa 3,4-diClPh what simple custody 1 ⁰ ch ₂ ch ₂ sub.28 823 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 824 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 825 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 826 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.28 827 3-Pip 3,4-diClPh what simple custody 1 0 CH-> CH-> sub.28 828 4-Pip 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ 1 sub.28 829 2-Mor 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ i sub.28 830 3-Mor 3,4-diClPh WHAT simple custody 1 i ° CH ₂ CH ₂ sub.28 831 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.28 832 2-Thmor 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.28 833 3-Thmor 3,4-diClPh WHAT simple custody 1 0 i CH? CH? 1 sub.28

• • • 4 99 • 4444 44 44

4 4 4 4

4444 44 94

94

4 «

9 9

4 4

4 4 4

44

834 4-Thmor 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 835 2-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 836 3-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 837 4-Piz 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 838 2-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 839 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 840 4-Aze 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.28 841 cPr 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.29 842 cBu 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.29 843 cPn 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.29 844 cHex 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.29 845 1 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.29 i 846 and 2-Pyrd 3,4-diClPh what simple custody 1 ⁰ CH2CH2 sub.29 847 3-Pyrd 3,4-diClPh what simple custody 1 0 CH2CH2 sub.29 848 4-Oxa 3,4-diClPh what simple custody 1 0 CH2CH2 sub.29 849 5-Oxa 3,4-diClPh what simple i. 1 binding! i ⁰ CH2CH2 sub.29 850 4-Thi 3,4-diClPh what simple custody 1 and and θ CH2CH2 sub.29 851 5-Thi 3,4-diClPh what simple custody j 1 1 ⁰ CH2CH2 sub.29 852 4-OOxa 3,4-diClPh what simple ! custody 1 (0 i CH2CH2 sub.29 853 5-OOxa 3,4-diClPh what simple custody 1 Ϊ i 0 CH ₂ CH ₂ 1 i sub.29 854 4-OThi 3,4-diClPh what i simple ! custody 1 1 h ) CH2CH2 sub.29 855 5-OThi 3,4-diClPh what i simple j j binding i ! O CH2CH2 sub.29 856 2-Pip 3,4-diClPh what simple custody 1 CH2CH2 sub.29 857 3-Pip 3,4-diClPh what simple custody 1 CH2CH2 sub.29

9 9 · • «« «9 9 9 9 9 9

9 88 t

8 9 8 9 8

9 8 8 »

88

858 4-Pip 3.4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.29 859 2-Mor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 860 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 861 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 862 2-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 863 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 864 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 865 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 866 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 867 4-Piz 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 868 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 869 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 870 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.29 871 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 872 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 873 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 874 cHex 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 875 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 876 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 877 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 878 4-Oxa 3,4-diClPh what | simple 1 binding 1 0 ch ₂ ch ₂ sub.30 879 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 880 4-Thi 3,4-diClPh what and simple custody 1 0 1 CHoCHo and 1 sub.30

• 9 9 * · ♦ »· ··

9 9 9 · 9 9 9 9 9 9 9

9999 9 · 99 99 99 · 9

9 9999 9999 «·» 9 90 99

881 5-Thi 2 AND 3.4-diClPh WHAT single J bond 1 1 1 0 CH2CH2 sub.30 882 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.30 883 5-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.30 884 4-OThi 3,4-diClPh WHAT simple custody and 1 0 ch ₂ ch ₂ sub.30 885 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 886 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 887 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 888 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.30 889 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 890 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 891 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 892 2-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 893 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 894 4-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 895 2-Piz 3,4-diClPh what simple custody 1 0 CH2CH2 sub.30 896 3-Piz 3.4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.30 897 4-Piz 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 898 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.30 899 3-Aze 3,4-diClPh what simple custody 1 0 CH2CH2 sub.30 1 900 4-Aze 3.4-diClPh what simple custody 1 0 CH2CH2 sub.30 901 cPr 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 902 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.31 903 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.31 904 cHex 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31

· »* * * • • • ···· · ·· · ··· · ·

100 ALIGN!

905 cHep 3,4-diCIPh WHAT simple custody 1 0 CH2CH2 sub.31 906 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 907 3-Pyrd 3.4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.31 908 4-Oxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 909 5-Oxa 3.4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.31 910 4-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 911 5-Thi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 912 4-OOxa 3.4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 913 5-OOxa 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 914 4-OThi 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 915 5-OThi 3,4-diClPh what simple custody 1 ⁰ CH2CH2 sub.31 916 2-Pip 3,4-diClPh what simple custody 1 0 CH ^ CH, sub.31 917 3-Pip 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.31 918 4-Pip 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 i 919 2-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 920 3-Mor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 921 4-Mor 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.31 922 2-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 1 ί 923 3-Thmor 3,4-diClPh what simple custody 1 0 i CH2CH2 sub.31 924 4-Thmor 3,4-diClPh what simple custody 1 0 CH2CH2 sub.31 925 2-Piz 3,4-diCIPh what simple custody 1 0 ! SMELL- and i sub.31 AND 926 3-Piz 3,4-diClPh what simple custody 1 0 | ch ₂ ch ₂ sub.31 927 4-Piz 3,4-diClPh i co 1 j simple 1 binding 1 i ⁰ i CI-TCI-l: 1 sub.31

101 • · • ··

928 2-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.31 929 3-Aze 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.31 930 4-Aze 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.31 931 cPr 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 932 cBu 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 933 cPn 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 934 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 935 cHep 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 936 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 937 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 938 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 939 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.32 940 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 941 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 942 4-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 943 5-OOxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 944 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 945 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 946 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 947 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 948 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 949 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 950 3-Mor 3,4-diClPh what simple custody' 1 0 ch ₂ ch ₂ sub.32 951 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32

102

952 2-Thmor 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.32 953 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 954 4-Thmor 3.4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 955 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 956 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 957 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 958 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 959 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 960 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.32 961 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.3 3 962 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 963 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 964 cHex 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 965 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 966 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 967 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 968 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 969 5-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 970 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 971 5-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 972 4-OOxa 3,4-diClPh what simple custody 1 0 CH7CH2 sub.33 973 5-OOxa 3,4-diClPh what simple custody 1 0 CH ₂ CH ₂ sub.33 974 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33

103 • ·

975 5-OThi 3,4-diClPh WHAT simple custody 1 0 CH ₂ CH ₂ sub.3 3 976 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 977 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 978 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 979 2-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 980 3-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 981 4-Mor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 982 2-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 983 3-Thmor 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 984 4-Thmor 3,4-diClPh WHAT simple __binding_ 1 0 ch ₂ ch ₂ sub.33 985 2-Piz 3,4-diClPh WHAT simple .binding ........... 1 0 ch ₂ ch ₂ sub.33 986 3-Piz 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.33 987 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 988 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.33 989 3-Aze 3,4-diClPh what simple .custody 1 0 ch ₂ ch ₂ sub.33 990 4-Aze 3,4-diCIPh what simple custody 1 0 ch ₂ ch ₂ sub.33 991 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 992 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 993 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 994 cHex 3,4-diClPh what simple .... weave 1 0 ch ₂ ch ₂ sub.34 995 cHep 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 996 2-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 997 3-Pyrd 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 998 4-Oxa 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 999 5-Oxa 3,4-diClPh what simple ... binding 1 0 ch ₂ ch ₂ sub.34 1000 4-Thi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34

• ·

104 • ·

• tttt tttt

1001 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1002 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1003 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1004 4-OThi 3,4-diClPh WHAT simple ‘Weave 1 0 ch ₂ ch ₂ sub.34 1005 5-OThi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1006 2-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1007 3-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1008 4-Pip 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.34 1009 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1010 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1011 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1012 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1013 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1014 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1015 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1016 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1017 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1018 2-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1019 3-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1020 4-Aze 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.34 1021 cPr 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1022 cBu 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1023 cPn 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35

• ·

105

1024 cHex 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1025 cHep 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.35 1026 2-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.35 1027 3-Pyrd 3,4-diClPh WHAT simple custody 1 0 CH2CH2 sub.35 1028 4-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1029 5-Oxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1030 4-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1031 5-Thi 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1032 4-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1033 5-OOxa 3,4-diClPh WHAT simple custody 1 0 ch ₂ ch ₂ sub.35 1034 4-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1035 5-OThi 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1036 2-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1037 3-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1038 4-Pip 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1039 2-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1040 3-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1041 4-Mor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1042 2-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1043 3-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1044 4-Thmor 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1045 2-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1046 3-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35 1047 4-Piz 3,4-diClPh what simple custody 1 0 ch ₂ ch ₂ sub.35

106

1048 2-Aze 3,4-diClPh WHAT simple custody 1 O CH ₂ CH ₂ sub.35 1049 3-Aze 3,4-diClPh WHAT simple custody 1 O ch ₂ ch ₂ sub.35 1050 4-Aze 3,4-diClPh WHAT simple custody 1 O ch ₂ ch ₂ sub.35 1051 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1052 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1053 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1054 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1055 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1056 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1057 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1058 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1059 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1060 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1061 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1062 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1063 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1064 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1065 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1066 2-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1067 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1068 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1069 2-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1070 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l

• 9 99 ·· ··

9 · 9 9 99 ·

9 9 9 9 9 9

99,999 99 9

9999 * 9999 * 9

107

1071 4-Mor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 1072 2-Thmor 3.4-diClPh what simple custody 2 O ch ₂ ch ₂ sub.l 1073 3-Thmor 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub.l 1074 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1075 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1076 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1077 4-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.l 1078 2-Aze 3,4-diClPh what simple custody 2 0 CH ₂ CH ₂ sub.l 1079 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1080 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1081 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1082 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1083 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1084 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1085 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1086 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1087 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1088 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1089 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1090 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1091 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1092 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1093 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 1094 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.2

108 • φ · φ · ♦ · ♦ · • · · · · · · · ···· · · · · ··· ··· ·· ·· ··

1095 5-OThi 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.2 1096 2-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.2 1097 3-Pip 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.2 1098 4-Pip 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.2 1099 2-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.2 1100 3-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.2 1101 4-Mor 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.2 1102 2-Thmor 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.2 1103 3-Thmor 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.2 1104 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 1105 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 1106 3-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.2 1107 4-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.2 1108 ' 2-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub.2 1109 3-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub.2 1110 4-Aze 3,4-diClPh what simple custody 2 0 CH ₂ CH ₂ sub.2 1111 cPr 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1112 cBu 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1113 cPn 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1114 cHex 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1115 cHep 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1116 2-Pyrd 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3 1117 3-Pyrd 3,4-diClPh what simple custody 2 0 CH2CH2 sub.3

9 «99

4 4

9 94

4 4

4 4

44 • *

4444

109

1118 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1119 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1120 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1121 ' 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1122 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1123 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1124 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1125 5-OThi 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.3 1126 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1127 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1128 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1129 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1130 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 1131 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1132 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1133 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1134 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1135 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1136 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1137 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1138 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1139 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1140 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 1141 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.4

44

4 4 4

4 4 4

4 4 4

4 4 4

44

44

4 4

4 44

4

110

9

1142 cBu 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1143 cPn 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1144 cHex 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1145 cHep 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1146 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1147 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.4 1148 4-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1149 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 1150 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1151 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1152 4-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1153 5-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1154 4-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1155 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1156 2-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1157 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1158 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1159 2-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1160 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1161 4-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1162 2-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1163 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4 1164 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.4

φ φ • φ φ φ φ φ φ φ

111 φ φ φ φ φ φ φ φ φ φ φ φ φ · φ φ φ • φ

Φφ φ ·

1165 2-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1166 3-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1167 4-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1168 2-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1169 3-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1170 4-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.4 1171 cPr 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1172 cBu 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1173 cPn 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1174 cHex 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.5 1175 cHep 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1176 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1177 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.5 1178 4-Oxa 3,4-diClPh what simple custody 2 0 -CH2CH2 sub.5 1179 5-Oxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1180 4-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1181 5-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1182 4-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1183 5-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1184 4-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1185 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1186 2-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1187 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5 1188 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.5

φφ φφ φφ φφ

1189 2-Mor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 5 1190 3-Mor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 1191 4-Mor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 1192 2-Thmor 3,4-diClPh WHAT simple ‘Weave 2 O ch ₂ ch ₂ sub.5 1193 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1194 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1195 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1196 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1197 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1198 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1199 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1200 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 1201 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1202 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1203 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1204 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1205 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1206 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1207 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1208 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1209 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1210 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1211 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6

• ·

113 99 99 9 9 9 9

9999 9 9 9 9 9 9 9 9 9 9 9 9 9 9

999 99 99 99 99

1212 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1213 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1214 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1215 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1216 2-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.6 1217 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1218 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1219 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1220 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1221 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1222 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1223 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1224 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 1225 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1226 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1227 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1228 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1229 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1230 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 1231 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1232 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1233 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1234 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1235 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7

• · · · φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ

114 φφ φφ

1236 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1237 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1238 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1239 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1240 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1241 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1242 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1243 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1244 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1245 5-OThi 3,4-diCIPh WHAT simple custody 2 0 CH2CH2 sub.7 1246 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1247 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1248 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1249 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1250 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1251 4-Mor 3,4-diCIPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1252 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1253 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1254 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1255 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1256 3-Piz 3,4-diCIPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1257 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 1258 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.7

115 tttt tttt ttt tttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt ttt · Tttttt tttttt · tttt ··

1259 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1260 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 1261 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1262 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1263 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1264 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1265 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1266 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1267 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1268 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1269 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1270 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1271 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1272 4-OOxa 3,4-diClPh what simple custody 2 0 / ch ₂ ch ₂ sub. 8 1273 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1274 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1275 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1276 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1277 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1278 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1279 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1280 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 1281 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8 1282 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 8

116 · 4 e <4 4 4 4 4 4 4 4 4 4 4 4 4

4444 t · · 4 · 4 * 4 4 * 4 4 * 4

1283 3-Thmor 3,4-diClPh WHAT simple binding. 2 O CH ₂ CH ₂ sub.8 1284 4-Thmor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 8 1285 2-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.8 1286 3-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.8 1287 4-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.8 1288 2-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.8 1289 3-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.8 1290 4-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.8 1291 cPr 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.9 1292 cBu 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.9 1293 cPn 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.9 1294 cHex 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.9 1295 cHep 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.9 1296 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1297 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1298 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1299 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1300 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 1301 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1302 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1303 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1304 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1305 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9

117

1306 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1307 3-Pip 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.9 1308 4-Pip 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.9 1309 2-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.9 1310 3-Mor 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.9 1311 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1312 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1313 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1314 4-Thmor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.9 1315 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1316 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1317 4-Piz 3,4-diCIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1318 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 1319 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 1320 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 1321 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1322 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1323 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1324 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1325 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1326 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1327 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1328 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1329 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10

• · • ·

118

1330 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 10 1331 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1332 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1333 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1334 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1335 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1336 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1337 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1338 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1339 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1340 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1341 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1342 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 1343 ' 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1344 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1345 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1346 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1347 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1348 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1349 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1350 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 1351 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 1352 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11

119

1353 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1354 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1355 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1356 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1357 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1358 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1359 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1360 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1361 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.11 1362 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 1363 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1364 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 1365 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1366 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1367 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 1368 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 1369 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 1370 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 1371 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 1372 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 1373 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 / 1374 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 1375 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 1376 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11

φφ φφ φφ • φ φ φ φ

120 • · · φ ·

1377 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1378 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1379 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1380 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 1381 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 1382 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 1383 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 1384 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 1385 cHep 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 12 1386 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1387 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1388 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1389 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1390 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1391 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1392 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1393 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1394 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1395 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1396 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1397 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1398 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 1399 ✓ 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12

121

1400 3-Mor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 12 1401 4-Mor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 12 1402 2-Thmor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 12 1403 3-Thmor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 12 1404 4-Thmor 3,4-diClPh WHAT simple custody 2 O CH ₂ CH ₂ sub. 12 1405 2-Piz 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1406 3-Piz 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1407 4-Piz 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1408 2-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1409 3-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1410 4-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 12 1411 cPr 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 1412 cBu 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 1413 cPn 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1414 cHex 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1415 cHep 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1416 2-Pyrd 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1417 3-Pyrd 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1418 4-Oxa 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1419 5-Oxa 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1420 4-Thi 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1421 5-Thi 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1422 4-00xa 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 13 1423 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13

122

1424 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1425 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1426 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1427 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3 1428 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1429 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1430 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1431 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1432 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1433 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1434 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 1435 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1436 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1437 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1438 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1439 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1440 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 1441 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 1442 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 1443 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 1444 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 1445 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 1446 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14

♦ 9 9 9999 9999 9 9 99

123 • 99 99 99

1447 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1448 4-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1449 5-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1450 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1451 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1452 4-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1453 5-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1454 4-OThi 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 14 1455 5-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1456 2-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1457 3-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1458 4-Pip 3,4-diCtPh WHAT simple custody 2 0 CH2CH2 sub. 14 1459 2-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 14 1460 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.14 1461 4-Mor 3,4-diCtPh what simple custody 2 0 CH2CH2 sub.14 1462 2-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1463 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.14 1464 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1465 2-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1466 3-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1467 4-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1468 2-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1469 3-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14 1470 4-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 14

· «► 1 • φ • ·

124 φ ► φ φ φ> φ φ φ

1471 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1472 cBu 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 15 Dec 1473 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1474 cHex 3,4-diClPh WHAT simple 'Binding 2 0 ch ₂ ch ₂ sub. 15 Dec 1475 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1476 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1477 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1478 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1479 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1480 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1481 5-Thi 3,4-diCIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1482 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1483 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1484 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1485 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 15 Dec 1486 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1487 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1488 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1489 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1490 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1491 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1492 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 1493 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec

125 • Φ »· • φ φ φ φ φ φ φ φ φ φ φ φ φ φ

1494 4-Thmor 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1495 2-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1496 3-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1497 4-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1498 2-Aze 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1499 3-Aze 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1500 4-Aze 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 15 Dec 1501 cPr 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 16 1502 cBu 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 16 1503 cPn 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 16 1504 cHex 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub. 16 1505 cHep 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 16 1506 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.16 1507 3-Pyrd 3,4-diClPh what simple custody 2 0 CH2CH2 sub.16 1508 4-Oxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1509 5-Oxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1510 4-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1511 5-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1512 4-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1513 5-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1514 4-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1515 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16 1516 2-Pip 3,4-diClPh what simple custody 2 0 CH ₂ CH ₂ sub. 16 1517 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 16

tttt ·· »· ··· 9 9 ··· 9 9 9 9 9 9 9 9

9 9 9 9 9 9 9

9999 99 99 999 99

9 9 9 9 9

999 99 99 99 99

126

1518 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1519 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1520 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1521 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1522 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1523 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1524 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1525 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1526 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1527 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1528 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1529 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 1530 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 1531 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1532 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1533 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1534 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1535 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1536 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1537 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1538 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1539 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1540 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17

φ ·

127

99

9 Φ Φ Φ • 9 · · • 9 9 9

9 9 9

ΦΦ ΦΦ

1541 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1542 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1543 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1544 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1545 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1546 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1547 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1548 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1549 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1550 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1551 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1552 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 1553 3-Thmor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 1554 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1555 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1556 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1557 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1558 2-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub. 17 1559 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1560 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 1561 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1562 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1563 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1564 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 8

128

9 ♦ · ·· 99 ·· • 9 9 9 9 9 9 9 9 9 9 • 99 9 9 99 9 9 9 • 999999

1565 cHep 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1566 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1567 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1568 4-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1569 5-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1570 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1571 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1572 4-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1573 5-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1574 4-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1575 5-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1576 2-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub. 18 1577 3-Pip 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 18 1578 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1579 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1580 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1581 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1582 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1583 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1584 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1585 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 1586 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.18 1587 4-Piz 3,4-diCIPh what simple typesetting - .. 2 0 ch ₂ ch ₂ sub. 18

·· ·· ·· ·· · * 9 9 99 9

9 9 9 9 9 9

99,999 99 9

99 9 9

99 99 99

129

1588 2-Aze 3,4-diClPh WHAT simple custody ² 1 O ch ₂ ch ₂ sub. 18 1589 3-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 1590 4-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 1591 cPr 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1592 cBu 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1593 cPn 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1594 cHex 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1595 cHep 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1596 2-Pyrd 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1597 3-Pyrd 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1598 4-Oxa 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1599 5-Oxa 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1600 4-Thi 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1601 5-Thi 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1602 4-OOxa 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1603 5-OOxa 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1604 4-OThi 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1605 5-OThi 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1606 2-Pip 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1607 3-Pip 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1608 4-Pip 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1609 2-Mor 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1610 3-Mor 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 1611 4-Mor 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub. 19 Dec

φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ • φ φ φ φ φ φ

130 φφφ

1612 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1613 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1614 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.19 1615 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1616 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1617 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1618 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1619 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1620 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 1621 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1622 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 20 May 1623 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1624 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1625 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1626 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1627 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1628 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1629 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1630 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1631 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1632 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1633 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1634 4-OThi 3,4-diClPh what simple vazha 2 0 ch ₂ ch ₂ sub.20

♦ · 9 9 9 9 9 9 9

131

9 9

9 9 ·

99

9 9 9

9 9

9 9

9 9

9 9 9

99

1635 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1636 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1637 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1638 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1639 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1640 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1641 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1642 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1643 3-Thmor 3,4-diCIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1644 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1645 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1646 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1647 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1648 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 1649 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1650 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 1651 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1652 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1653 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1654 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1655 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1656 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1657 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1658 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21

132 • * 99 94 * 4 99 * 9 4 9 9 ·

994 9,949 9,444 9

449999 49,944 4 9 9

4,9494,9444

4 9 4

1659 5-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.21 1660 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.21 1661 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.21 1662 4-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.21 1663 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1664 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1665 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1666 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1667 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1668 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1669 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1670 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1671 4-Mor 3,4-diCIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 1672 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1673 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1674 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1675 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1676 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1677 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1678 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1679 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1680 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 1681 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22

· E e * e e e e e e e e e e e e e e e e e e e e e e e · e e r ·· ·· * · ··

133

1682 cBu 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 1683 cPn 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 1684 cHex 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 1685 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1686 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1687 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1688 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1689 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1690 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1691 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1692 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1693 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1694 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1695 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1696 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1697 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1698 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1699 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1700 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1701 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1702 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1703 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.22 1704 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 1705 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.22

134

1706 3-Piz 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.22 1707 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1708 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1709 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1710 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 1711 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1712 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1713 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1714 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1715 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1716 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1717 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 1718 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1719 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1720 4-Thi 3,4-diCIPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1721 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1722 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1723 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1724 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1725 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1726 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1727 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 1728 4-Pip 3,4-diClPh what simple . custody 2 0 ch ₂ ch ₂ sub.23

135 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 99 99 99 99

1729 2-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1730 3-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1731 4-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1732 2-Thmor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1733 3-Thmor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1734 4-Thmor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1735 2-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1736 3-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1737 4-Piz 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1738 2-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1739 3-Aze 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.23 1740 4-Aze 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.23 1741 cPr 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.24 1742 cBu 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.24 1743 cPn 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1744 cHex 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1745 cHep 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1746 2-Pyrd 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1747 3-Pyrd 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1748 4-Oxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1749 5-Oxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1750 4-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1751 5-Thi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24 1752 4-OOxa 3,4-diClPh what simple custody 2 0 CH2CH2 sub.24

• »

136

1753 5-OOxa 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.24 1754 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1755 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1756 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1757 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1758 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1759 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1760 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1761 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1762 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1763 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 1764 4-Thmor 3,4-diClPh what simple i binding 2 0 ch ₂ ch ₂ sub.24 1765 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1766 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1767 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1768 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1769 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1770 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 1771 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1772 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1773 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1774 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1775 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25

137

1776 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1777 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1778 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1779 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1780 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1781 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1782 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1783 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1784 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1785 5-OThi 3,4-diCiPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1786 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1787 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1788 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 1789 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1790 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1791 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1792 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1793 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1794 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1795 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1796 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1797 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1798 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 1799 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.25

138

1800 4-Aze 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.25 1801 cPr 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 1802 cBu 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 1803 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1804 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1805 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1806 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1807 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1808 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1809 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1810 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1811 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1812 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1813 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1814 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1815 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1816 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1817 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1818 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1819 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1820 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1821 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 1822 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.26

9 ·

139

1823 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1824 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1825 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1826 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1827 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1828 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1829 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1830 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 1831 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1832 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1833 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1834 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1835 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1836 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1837 3-Pyrd 3,4-diClPh what simple custody simple custody 2 0 ch ₂ ch ₂ sub.27 1838 4-Oxa 3,4-diClPh what 2 0 ch ₂ ch ₂ sub.27 1839 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1840 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1841 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1842 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1843 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1844 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1845 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 1846 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.27

· · * * * * · <<<<<<<<<<<<< · · · · · · · · · · · · · · · · · · · ·

140

1847 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1848 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1849 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1850 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1851 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1852 2-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1853 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1854 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1855 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1856 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1857 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1858 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1859 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1860 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 1861 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1862 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1863 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1864 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1865 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1866 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1867 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1868 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1869 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28

• · * * * * * * * *

141 •

1870 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1871 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.28 1872 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1873 5-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1874 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1875 5-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1876 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1877 3-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1878 4-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1879 2-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1880 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1881 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 1882 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1883 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1884 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.28 1885 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1886 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1887 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1888 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1889 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1890 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 1891 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1892 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1893 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29

Φ φ φ · · · · φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ

142

1894 cHex 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 1895 cHep 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 1896 2-Pyrd 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 1897 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1898 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1899 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1900 4-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1901 5-Thi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1902 4-OOxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 1903 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1904 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1905 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1906 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1907 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1908 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1909 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1910 3-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1911 4-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1912 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1913 3-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1914 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1915 2-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 1916 3-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.29

»Φ

143:

φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ · · · φ φ φ φ · · · · · · •

1917 4-ζίζ 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.29 1918 2-Aze 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.29 1919 3-Aze 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.29 1920's 4-Aze 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.29 1921 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1922 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1923 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1924 cHex 3,4-diClPh WHAT simple custody 2 0 CH7CH2 sub.30 1925 cHep 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.30 1926 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1927 3-Pyrd 3,4-diCIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1928 4-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1929 5-Oxa 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1930 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1931 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1932 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1933 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1934 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1935 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1936 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1937 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1938 4-Pip 3,4-diClPh what simple custody 2 O ch ₂ ch ₂ sub.30 1939 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 1940 3-Mor 3,4-diClPh what simple 1 binding 2 0 ch ₂ ch ₂ sub.30

144 • 99 99 99 99 • 9 9 9 9 9 4 9 4 9 • 44 44 ·· 9 4 4 4

9499 9 4 ·· · 9 · 9 · 9 4 9 ·

9 4 9 · 4 · 99 49

1941 4-Mor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.30 1942 2-Thmor 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.30 1943 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1944 4-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1945 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1946 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1947 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1948 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1949 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1950 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 1951 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1952 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1953 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1954 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1955 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1956 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1957 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1958 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1959 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1960 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1961 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1962 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1963 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31

145 999 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 ·

999 99 99 99 99

1964 4-OThi 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1965 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.31 1966 2-Pip 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1967 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1968 4-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1969 2-Mor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1970 3-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1971 4-Mor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1972 2-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1973 3-Thmor 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1974 4-Thmor 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1975 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 1976 3-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.31 1977 4-Piz 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1978 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1979 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1980 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 1981 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1982 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1983 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1984 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1985 cHep 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1986 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 1987 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32

146 • 99 99 99 9 9 9 9 999 99 9

9 9 9 9 9

999 99 99 99 99

1988 4-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1989 5-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1990 4-Thi 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.32 1991 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1992 4-00xa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1993 5-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1994 4-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1995 5-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1996 2-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1997 3-Pip 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.32 1998 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 1999 2-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2000 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2001 4-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2002 2-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2003 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2004 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2005 2-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2006 3-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2007 4-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.32 2008 2-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 2009 3-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 2010 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.32

147 • 44 44 44 44

9 9 4 94 4 4 4 5

4444 44 44 494 44

4 4 4 4 4

44 44 94 44

2011 cPr 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.3 3 2012 cBu 3,4-diClPh WHAT simple custody 7 O CH2CH2 sub.33 11. Aug. 2013 cPn 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.33 11. Nov. 2014 cHex 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 11. Nov. 2015 cHep 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 17. Nov. 2016 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2017 3-Pyrd 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2018 4-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2019 5-Oxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2020 4-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2021 5-Thi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2022 4-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2023 5-OOxa 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2024 4-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2025 5-OThi 3,4-diClPh WHAT simple custody 2 0 CH2CH2 sub.33 2026 2-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2027 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2028 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2029 2-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2030 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2031 4-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2032 2-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2033 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33 2034 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.33

148 «ttt ttt tttt tttt tttt tttt tttt ttttttt ttttt tttttt ttttt ttttt tttt tttt tttt tttt

2035 2-Piz 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.33 2036 3-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.33 2037 4-Piz 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.33 2038 2-Aze 3,4-diClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.33 2039 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 2040 4-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 2041 cPr 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2042 cBu 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2043 cPn 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2044 cHex 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2045 cHep 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2046 2-Pyrd 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2047 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2048 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2049 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2050 4-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2051 5-Thi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2052 4-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2053 5-OOxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2054 4-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2055 5-OThi 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2056 2-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2057 3-Pip 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34

* »Φ · · φ •» φ φ φ φ φ φ »

• · · · φ · · φ · · · · φ φ φ * · · φ

149 • φ • Φ * • · φ φ φφφφ • φ φφφφ

2058 4-Pip 3,4-diClPh CC simple custody á ₂ C ch ₂ ch ₂ sub.34 2059 2-Mor 3,4-diClPh WHAT simple custody ^á 2 C ch ₂ ch ₂ sub.34 2060 3-Mor 3,4-diClPh WHAT simple. custody ^í 2 O ch ₂ ch ₂ sub.34 2061 4-Mor 3,4-diClPh WHAT simple; . 'Binding 2 O ch ₂ ch ₂ sub.34 2062 2-Thmor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 2063 3-Thmor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 2064 4-Thmor 3,4-diClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 2065 2-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2066 3-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2067 4-Piz 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2068 2-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2069 3-Aze 3,4-diClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 2070 4-Aze 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 2071 cPr 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2072 cBu 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2073 cPn 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2074 cHex 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2075 cHep 3,4-diCIPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2076 2-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2077 3-Pyrd 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2078 4-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2079 5-Oxa 3,4-diClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 2080 4-Thi 3,4-diClPh CO J simple custody 2 0 ch ₂ ch ₂ sub.35 2081 5-Thi 3,4-diClPh CO j simple custody 2 0 ch ₂ ch ₂ sub.35

150 • «» 9 9 · ·· ·· · 8 9 8 9 8 9 9 9

9 9 9 9 9 9 9

999 8999 8 9 8 9 9 9 9 8 9 9

9 9 9 · 8 9 9 9 9 • 99 9 88

2082 4-OOxa 3,4-diClPh WHAT simple custody 2 O CH2CH2 sub.35 2083 5-OOxa 3,4-diClPh what simple custody 2 O CH2CH2 sub.35 2084 4-OThi 3,4-diClPh what simple custody 2 O CH2CH2 sub.35 2085 5-OThi 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2086 2-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2087 3-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2088 4-Pip 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2089 2-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2090 3-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2091 4-Mor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2092 2-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2093 3-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2094 4-Thmor 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2095 2-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2096 3-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2097 4-Piz 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2098 2-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2099 3-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2100 4-Aze 3,4-diClPh what simple custody 2 0 CH2CH2 sub.35 2101 cPr 4-ClPh what simple custody 2 0 CH2CH2 sub.l 2102 cBu 4-ClPh what simple custody 2 0 CH2CH2 sub.l 2103 cPn 4-ClPh what simple custody 2 0 CH2CH2 sub.l 2104 cHex 4-ClPh what simple custody 2 0 CH2CH2 sub.l

• ·

151 • ·

2105 cHep 4-ClPh WHAT simple custody 2 O CH2CH2 sub.l 2106 2-Pyrd 4-ClPh WHAT simple custody 2 O CH2CH2 sub.l 2107 3-Pyrd 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 2108 4-Oxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 2109 5-Oxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 2110 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2111 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2112 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2113 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2114 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2115 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2116 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2117 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2118 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2119 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2120 3-Mor 4-ClPh what simple custody 2 0 ch? ch ₂ sub.l 2121 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2122 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2123 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2124 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2125 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2126 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2127 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 2128 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l

• · • ·

152

2129 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2130 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 2131 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2132 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2133 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2134 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub, 2 2135 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2136 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2137 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2138 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2139 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2140 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2141 5-Thi 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.2 2142 4-OOxa 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.2 2143 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2144 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2145 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2146 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2147 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2148 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2149 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2150 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2 2151 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.2

• ·

153

2152 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2153 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2154 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2155 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2156 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2157 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2158 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2159 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2160 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 2161 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2162 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2163 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2164 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2165 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2166 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2167 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2168 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2169 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2170 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2171 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2172 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2173 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2174 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2175 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3

154 ·· ··

2176 2-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.3 2177 3-Pip 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.3 2178 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2179 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2180 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2181 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2182 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2183 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2184 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2185 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2186 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2187 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2188 2-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.3 2189 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2190 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.3 2191 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2192 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2193 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2194 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2195 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2196 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2197 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4 2198 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.4

• ·

155

2199 5-Oxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2200 4-Thi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2201 5-Thi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2202 4-OOxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2203 5-OOxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2204 4-OThi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2205 5-OThi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2206 2-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2207 3-Pip 4-CiPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 2208 4-Pip 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2209 2-Mor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2210 3-Mor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2211 4-Mor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2212 2-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2213 3-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2214 4-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2215 2-Piz 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2216 3-Piz 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2217 4-Piz 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2218 2-Aze 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2219 3-Aze 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2220 4-Aze 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.4 2221 cPr 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.5 2222 cBu 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.5

156

2223 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2224 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2225 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2226 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2227 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2228 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2229 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2230 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2231 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2232 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2233 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2234 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2235 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2236 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2237 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2238 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2239 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2240 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2241 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2242 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2243 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2244 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5 2245 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.5

157

2246 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2247 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2248 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2249 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2250 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 2251 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2252 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 6 2253 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2254 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2255 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2256 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2257 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2258 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2259 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2260 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2261 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2262 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2263 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2264 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2265 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2266 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2267 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2268 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6 2269 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.6

158

2270 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2271 4-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2272 2-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2273 3-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2274 4-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2275 2-CAS 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2276 3-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2277 4-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.6 2278 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2279 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2280 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 2281 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2282 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 7 2283 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2284 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2285 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2286 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2287 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2288 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2289 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2290 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2291 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7 2292 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.7

159 • • • • • • • • • • • • 4 4 4 4 4 4 4 4

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• · · ···· · ·

160 9 9 9 9

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2317 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 2318 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 2319 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 2320 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 2321 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 2322 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2323 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2324 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2325 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2326 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2327 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2328 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2329 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2330 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2331 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2332 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2333 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2334 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2335 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2336 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2337 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2338 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8 2339 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.8

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2340 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 2341 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2342 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2343 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2344 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2345 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2346 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2347 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2348 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2349 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2350 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2351 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2352 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2353 5-OOxa 4-ClPh what simple custody 2 0 ^: ch ₂ ch ₂ sub.9 2354 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2355 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2356 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2357 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2358 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2359 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2360 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2361 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2362 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9 2363 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.9

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2364 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2365 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2366 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2367 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2368 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2369 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 2370 4-Aze 4-ClPh WHAT simple custody ? 0 ch ₂ ch ₂ sub.9 2371 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 2372 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2373 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2374 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2375 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2376 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2377 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2378 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2379 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2380 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2381 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2382 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2383 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2384 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2385 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 2386 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 10

163

2387 3-Pip 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2388 4-Pip 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2389 2-Mor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2390 3-Mor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2391 4-Mor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2392 2-Thmor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2393 3-Thmor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2394 4-Thmor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2395 2-Piz 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2396 3-Piz 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2397 4-Piz 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 10 2398 2-Aze 4-ClPh what simple custody 2 O CH2CH2 sub. 10 2399 3-Aze 4-ClPh what simple custody 2 O CH2CH2 sub.10 2400 4-Aze 4-ClPh what simple custody 2 0 . CH2CH2 sub. 10 2401 cPr 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2402 cBu 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub. 11 2403 cPn 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2404 cHex 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2405 cHep 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2406 2-Pyrd 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2407 3-Pyrd 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2408 4-Oxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2409 5-Oxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 11 2410 4-Thi 4-ClPh what simple custody 2 0 CH2CH2 sub. 11

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2411 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2412 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 2413 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 2414 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 2415 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 2416 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2417 3-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2418 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub, 11 2419 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2420 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2421 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 2422 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 2423 _ 3-Thmor 4-ClPh what simple custody n 0 ch ₂ ch ₂ sub. 11 2424 4-Thmor 4-ClPh what simple custody 0 ch ₂ ch ₂ sub.l 1 2425 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 2426 3-Piz 4-ClPh what simple custody 0 0 ch ₂ ch ₂ sub.l 1 2427 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 2428 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 2429 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 2430 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 2431 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.12 2432 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 2433 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 12

165 ·· · · · · · φ · φ · Φ · Φ · Φ · · · · · φ · · · · · φ · · · · · φ · · · · · Φ · φ · · · Φ · Φ · Φ · Φ · Φ · Φ · Φ · Φ

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2434 cHex 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2435 cHep 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2436 2-Pyrd 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2437 3-Pyrd 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2438 4-Oxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2439 5-Oxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2440 4-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2441 5-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2442 4-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.12 2443 5-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2444 4-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 12 2445 5-OThi 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2446 2-Pip 4-ClPh what simple custody O 0 CH2CH2 sub. 12 2447 3-Pip 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2448 4-Pip 4-ClPh what simple custody 0 0 CH2CH2 sub. 12 2449 2-Mor 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2450 3-Mor 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2451 4-Mor 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2452 2-Thmor 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2453 3-Thmor 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub. 12 2454 4-Thmor 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2455 2-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2456 3-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub. 12 2457 4-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub. 12

• 9 • 9

9

9 • 9

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166

2458 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 2459 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 2460 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 2461 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2462 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2463 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2464 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2465 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2466 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2467 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2468 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2469 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2470 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2471 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2472 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2473 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2474 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2475 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2476 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2477 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2478 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2479 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 2480 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 13

167

2481 4-Mor 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 13 2482 2-Thmor 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub. 13 2483 3-Thmor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 2484 4-Thmor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 2485 2-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 2486 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2487 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2488 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2489 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2490 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 2491 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2492 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2493 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2494 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2495 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2496 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2497 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2498 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2499 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2500 4-Thi 4-ClPh what single ² binding 2 0 ch ₂ ch ₂ sub. 14 2501 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2502 4-00xa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2503 5-00xa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2504 4-OThi 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub. 14

168

2505 5-OThi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 2506 2-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 2507 3-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 2508 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2509 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2510 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2511 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2512 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2513 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2514 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2515 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 2516 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2517 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2518 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2519 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2520 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 2521 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2522 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2523 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2524 cHex 4-CIPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2525 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2526 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2527 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec

φ φ · • • • • • • «φ

169 φ φ φ φ φ φ · · φ φ

2528 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2529 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2530 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2531 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2532 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2533 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2534 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2535 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2536 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2537 3-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2538 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2539 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2540 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 i 2541 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2542 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2543 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2544 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2545 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2546 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2547 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2548 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2549 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2550 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 2551 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16

• • • •

170 9 9 · · 9 · · 9 170 •

2552 cBu 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 16 2553 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2554 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2555 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2556 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub, 16 2557 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2558 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2559 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2560 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2561 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2562 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 2563 5-OOxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 16 2564 4-OThi 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub. 16 2565 5-OThi 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub. 16 2566 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2567 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2568 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2569 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2570 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2571 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2572 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2573 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 2574 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 16

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2575 2-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2576 3-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2577 4-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2578 2-Aze 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2579 3-Aze 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2580 4-Aze 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 16 2581 cPr 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 17 2582 cBu 4-ClPh WHAT simple custody 2 O CH2CH2 sub. 17 2583 · » cPn 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 17 2584 cHex 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 17 2585 cHep 4-ClPh WHAT simple custody 2 0 CH2CH2 sub. 17 2586 2-Pyrd 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.17 2587 3-Pyrd 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2588 4-Oxa 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub. 17 2589 5-Oxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2590 4-Thi 4-ClPh what simple custody 2 0 CH2CH2 sub.17 2591 5-Thi 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2592 4-OOxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2593 5-OOxa 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2594 4-OThi 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2595 5-OThi 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2596 2-Pip 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2597 3-Pip 4-ClPh what simple custody 2 0 CH2CH2 sub. 17 2598 4-Pip 4-ClPh what simple custody 2 0 CH2CH2 sub. 17

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4 9 4 9 4

2599 2-Mor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 2600 3-Mor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 2601 4-Mor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 2602 2-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub. 17 2603 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2604 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2605 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2606 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2607 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2608 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2609 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2610 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 2611 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2612 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2613 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2614 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2615 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2616 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2617 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2618 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2619 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2620 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2621 5-Thi 4-ClPh what simple -y.azba 2 0 ch ₂ ch ₂ sub. 18

173 • tttt tttt ·· · «tttttt tttt ·· • tt ···· tttttttt • •••• tt tttt tttttt tttt · • ···· tttttt · • tttt tt · tttt tttt

2622 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2623 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2624 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2625 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2626 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2627 3-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2628 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2629 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2630 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2631 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2632 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 2633 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2634 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2635 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2636 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2637 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2638 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2639 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2640 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 2641 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2642 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2643 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2644 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2645 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec

99 99 · 9 99 • 9 9 9999 9999

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174

2646 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2647 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2648 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2649 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2650 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2651 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2652 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2653 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2654 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2655 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2656 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2657 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2658 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2659 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2660 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2661 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2662 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2663 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.19 2664 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2665 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2666 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2667 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2668 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec

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2669 3-Aze 4-ClPh WHAT simple; custody ¹ 2 0 CH ₂ CH ₂ sub. 19 Dec 2670 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 2671 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2672 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2673 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2674 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2675 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2676 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2677 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2678 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2679 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2680 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2681 5-Thi 4-CIPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2682 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2683 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2684 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2685 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2686 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2687 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2688 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2689 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2690 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2691 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20 2692 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.20

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2693 3-Thmor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 2694 4-Thmor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 2695 2-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 2696 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2697 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2698 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2699 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2700 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 2701 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 2702 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 2703 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2704 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2705 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2706 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2707 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2708 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2709 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2710 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2711 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2712 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2713 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2714 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21 2715 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.21

* · ·· · * ·· ··

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2716 2-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2717 3-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2718 4-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2719 2-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2720 3-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2721 4-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2722 2-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2723 3-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2724 4-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2725 2-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2726 3-Piz 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.21 2727 4-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub.21 2728 2-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.21 2729 3-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.21 2730 4-Aze 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.21 2731 cPr 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.22 2732 cBu 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.22 2733 cPn 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.22 2734 cHex 4-ClPh what simple custody 2 0 CH2CH2 sub.22 2735 cHep 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.22 2736 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2737 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2738 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2739 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22

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178 • · ·

2740 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 2741 5-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2742 4-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2743 5-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2744 4-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2745 5-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2746 2-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2747 3-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2748 4-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2749 2-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2750 3-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.22 2751 4-Mor 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.22 2752 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2753 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2754 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2755 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2756 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2757 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2758 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2759 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2760 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.22 2761 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2762 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23

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179

2763 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2764 cHex 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 2765 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2766 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2767 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2768 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2769 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2770 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2771 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2772 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2773 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2774 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2775 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2776 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2777 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2778 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2779 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2780 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2781 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2782 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2783 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2784 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2785 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.23 2786 3-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub.23

· 99 · 99 • • • • • • • • • • • 99 9 9 9 9 9 9 9 9 9

999 9 9 9 9

9 9 9 9 9

999 · ·· · 99

180

2787 4-Piz 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.23 2788 2-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 2789 3-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 2790 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 2791 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2792 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2793 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2794 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2795 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2796 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2797 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 2798 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2799 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2800 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2801 5-Thi 4-CiPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2802 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2803 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2804 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2805 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2806 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2807 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2808 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2809 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24

181 • φ · φ · Φ φ φ φ β φ φ φ φ φ φ φ φ φ · · · · · · · · · φ φ · Φφ * · φφ

2810 3-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.24 2811 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2812 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2813 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2814 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2815 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2816 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2817 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2818 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2819 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2820 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.24 2821 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2822 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2823 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2824 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2825 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2826 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2827 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2828 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2829 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2830 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2831 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2832 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2833 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25

• • •

182

2834 4-OThi 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.25 2835 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 2836 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 2837 3-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.25 2838 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 2839 2-Mor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.25 2840 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 2841 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 2842 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2843 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2844 4-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.25 2845 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2846 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2847 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2848 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2849 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2850 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.25 2851 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 2852 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 2853 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 2854 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 2855 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26 2856 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.26

• · ·

183

2857 3-Pyrd 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.26 2858 4-Oxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2859 5-Oxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2860 4-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2861 5-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2862 4-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2863 5-OOxa 4-ClPh ' WHAT simple custody 2 0 CH2CH2 sub.26 2864 4-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2865 5-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2866 2-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2867 3-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2868 4-Pip 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2869 2-Mor 4-ClPh what simple custody 2 0 CH ₂ CH ₂ sub.26 2870 3-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2871 4-Mor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2872 2-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2873 3-Thmor 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.26 2874 4-Thmor 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2875 2-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2876 3-Piz 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2877 4-PIZ 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2878 2-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2879 3-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.26 2880 4-Aze 4-ClPh what simple custody 2 0 CH2CH2 sub.26

185 ··· * ·

2881 cPr 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.27 2882 cBu 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2883 cPn 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2884 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2885 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2886 2-Pyrd 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2887 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2888 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2889 5-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2890 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2891 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 2892 4-OOxa 4-ClPh what simple i binding 2 0 ch ₂ ch ₂ sub.27 2893 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2894 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2895 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2896 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2897 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2898 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2899 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2900 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2901 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2902 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27 2903 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.27

185

2904 4-Thmor 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.27 2905 2-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2906 3-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2907 4-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2908 2-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2909 3-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2910 4-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 2911 cPr 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.28 2912 cBu 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.28 2913 cPn 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.28 2914 cHex 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.28 2915 cHep 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.28 2916 2-Pyrd 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.28 2917 3-Pyrd 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.28 2918 4-Oxa 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.28 2919 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2920 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2921 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2922 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2923 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2924 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2925 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2926 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28 2927 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.28

186

2928 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 8 2929 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2930 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2931 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2932 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2933 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2934 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2935 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2936 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2937 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2938 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2939 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2940 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 2941 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2942 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2943 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2944 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2945 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2946 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2947 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2948 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2949 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.29 2950 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29

187 99 9 99 9 99 99 99 99 99 99 9 9 9 9999

999 9 99 ·· «9 ·»

2951 5-Thi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.29 2952 4-OOxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.29 2953 5-OOxa 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.29 2954 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2955 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2956 2-Pip 4-CIPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2957 3-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2958 4-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2959 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2960 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2961 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2962 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2963 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2964 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2965 2-Piz 4-CiPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2966 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2967 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2968 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2969 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2970 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 2971 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2972 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2973 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2974 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30

188 • · · 444 · ·

4 * 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4

2975 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2976 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2977 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2978 4-Oxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2979 5-Oxa 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.30 2980 4-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2981 5-Thi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2982 4-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2983 5-OOxa 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2984 4-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2985 5-OThi 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 2986 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2987 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2988 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2989 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2990 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2991 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2992 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2993 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2994 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2995 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2996 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2997 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30 2998 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.30

99 · ·

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9 9 9

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2999 3-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.3 0 3000 4-Aze 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.30 3001 cPr 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3002 cBu 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3003 cPn 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3004 cHex 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3005 cHep 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3006 2-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3007 3-Pyrd 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3008 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3009 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3010 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3011 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3012 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3013 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3014 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3015 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3016 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3017 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3018 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3019 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3020 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3021 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31 3022 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.31

190

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3023 3-Thmor 4-ClPh WHAT simple custody 2 O CH2CH2 sub.31 3024 4-Thmor 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3025 2-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3026 3-Piz 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3027 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3028 2-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3029 3-Aze 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 3030 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 3031 cPr 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3032 cBu 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 2 3033 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3034 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3035 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3036 2-Pyrd 4-ClPh what simple i binding 2 0 ch ₂ ch ₂ sub.32 3037 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3038 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3039 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3040 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3041 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3042 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3043 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3044 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3045 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32

9 99 99 99 99 • 9 9 9 9 9 9 9 9 9

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3046 2-Pip 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.32 3047 3-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.32 3048 4-Pip 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.32 3049 2-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3050 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3051 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3052 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3053 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3054 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 3055 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3056 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3057 4-Piz 4-ClPh what simple L binding 2 0 ch ₂ ch ₂ sub.32 3058 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3059 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3060 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.32 3061 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3062 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3063 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3064 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3065 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3066 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3067 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3068 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3069 5-Oxa 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.33

192 »9

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99

3070 4-Thi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.33 3071 5-Thi 4-ClPh WHAT simple custody 2 O CH ₂ CH ₂ sub.33 3072 4-OOxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.33 3073 5-OOxa 4-ClPh WHAT simple 'Binding 2 0 ch ₂ ch ₂ sub.33 3074 4-OThi 4-ClPh WHAT simple custody 2 0 CH2CH2 sub.33 3075 5-OThi 4-ClPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.33 3076 2-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 3077 3-Pip 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 3078 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3079 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3080 3-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3081 4-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3082 2-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3083 3-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3084 4-Thmor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3085 2-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3086 3-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3087 4-Piz 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3088 2-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3089 3-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3090 4-Aze 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.33 3091 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.34 3092 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.34

193

3093 cPn 4-ClPh WHAT simple custody * 2 O ch ₂ ch ₂ sub.34 3094 cHex 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3095 cHep 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3096 2-Pyrd 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3097 3-Pyrd 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3098 4-Oxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3099 5-Oxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3100 4-Thi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3101 5-Thi 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3102 4-OOxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3103 5-OOxa 4-ClPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 3104 4-OThi 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3105 5-OThi 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3106 2-Pip 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3107 3-Pip 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3108 4-Pip 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3109 2-Mor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3110 3-Mor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3111 4-Mor 4-CIPh what simple custody 2 O ch ₂ ch ₂ sub.34 3112 2-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3113 3-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3114 4-Thmor 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3115 2-Piz 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34 3116 3-Piz 4-ClPh what simple custody 2 O ch ₂ ch ₂ sub.34

• ·

194

3117 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 3118 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 3119 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 3120 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 3121 cPr 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3122 cBu 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3123 cPn 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3124 cHex 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3125 cHep 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3126 2-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3127 3-Pyrd 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3128 4-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3129 5-Oxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3130 4-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3131 5-Thi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3132 4-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3133 5-OOxa 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3134 4-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3135 5-OThi 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3136 2-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3137 3-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3138 4-Pip 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35 3139 2-Mor 4-ClPh what simple custody 2 0 ch ₂ ch ₂ sub.35

195

3140 3-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 5 3141 4-Mor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3142 2-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3143 3-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3144 4-Thmor 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3145 2-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3146 3-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3147 4-Piz 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3148 2-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3149 3-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3150 4-Aze 4-ClPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 3151 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3152 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3153 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3154 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3155 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3156 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3157 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3158 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3159 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3160 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3161 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3162 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3163 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l

196

3164 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3165 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3166 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3167 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3168 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3169 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3170 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3171 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3172 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3173 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3174 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3175 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 3176 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3177 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3178 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3179 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3180 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 3181 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3182 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3183 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3184 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3185 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3186 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2

• · · · · φ · ·

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197

3187 3-Pyrd 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.2 3188 4-Oxa 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.2 3189 5-Oxa 3,4-diFPh WHAT simple custody 2 O CH ₂ CH ₂ sub.2 3190 4-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.2 3191 5-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.2 3192 4-OOxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.2 3193 5-OOxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.2 3194 4-OThi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.2 3195 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3196 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3197 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3198 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3199 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3200 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 3201 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3202 2-Thmor 3,4-diFPh what simple custody 2 0 CH2CH2 sub.2 3203 3-Thmor 3,4-diFPh what simple custody 2 0 CH2CH2 sub.2 3204 4-Thmor 3,4-diFPh what simple custody 2 0 CH ₂ CH ₂ sub.2 3205 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3206 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3207 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3208 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3209 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2 3210 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.2

198 t · ·

3211 cPr 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3212 cBu 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3213 cPn 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.3 3214 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3215 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3216 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3217 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3218 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3219 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3220 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3221 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3222 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3223 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3224 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3225 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3226 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3227 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3228 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3229 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3230 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3231 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3232 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3 3233 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.3

♦ · ·

4

199 • t · ♦ * *

3234 4-Thmor 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3235 2-Piz 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3236 3-Piz 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3237 4-Piz 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3238 2-Aze 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3239 3-Aze 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.3 3240 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3241 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3242 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3243 cPn 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.4 3244 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3245 cHep 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.4 3246 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.4 3247 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.4 3248 4-Oxa 3,4-diFPh what simple custody 2 0 CH ₂ CH ₂ sub.4 3249 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3250 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3251 5-Thi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.4 3252 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3253 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3254 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3255 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3256 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3257 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4

200

3258 4-Pip 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 3259 2-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 3260 3-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.4 3261 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3262 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3263 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3264 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3265 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3266 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3267 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3268 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3269 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 3270 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.4 3271 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3272 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3273 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3274 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3275 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3276 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3277 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3278 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3279 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5 3280 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.5

201 φ · · φ »

3281 5-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3282 4-OOxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3283 5-OOxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3284 4-OThi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3285 5-OThi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3286 2-Pip 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3287 3-Pip 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3288 4-Pip 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3289 2-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3290 3-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3291 4-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3292 2-Thmor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3293 3-Thmor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3294 4-Thmor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.5 3295 2-Piz 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3296 3-Piz 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3297 4-Piz 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3298 2-Aze 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3299 3-Aze 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3300 4-Aze 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.5 3301 cPr 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.6 3302 cBu 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.6 3303 cPn 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.6 3304 cHex 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.6

202 »k k k k k k k k k k k k k k k k

3305 cHep 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.6 3306 2-Pyrd 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.6 3307 3-Pyrd 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.6 3308 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3309 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3310 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3311 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3312 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3313 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3314 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3315 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3316 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3317 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3318 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3319 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3320 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3321 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3322 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3323 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3324 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3325 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3326 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6 3327 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.6

·· ··

203

9 9 9 9 9 9 9 · · · t t t

9 9 9

9 9 9

3328 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 3329 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 3330 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 3331 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 7 3332 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 7 3333 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 7 3334 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3335 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3336 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3337 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3338 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3339 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3340 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3341 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3342 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3343 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3344 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3345 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3346 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3347 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3348 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3349 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3350 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7 3351 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.7

• 9 9 ·

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9 9

9 9 • · ·

3352 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3353 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3354 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3355 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3356 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3357 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3358 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3359 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3360 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 3361 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3362 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3363 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3364 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3365 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3366 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3367 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3368 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3369 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3370 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3371 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3372 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3373 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3374 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8

• tt tttt tt · «• · I tt · <

• · · · ···

205 • · tttt · tt tttttt *

3375 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 3376 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3377 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3378 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3379 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3380 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3381 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3382 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3383 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3384 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3385 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3386 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3387 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3388 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 3389 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3390 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.8 3391 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3392 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3393 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3394 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3395 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3396 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3397 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3398 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9

44 ·· ♦ ♦ *

206 • · · · ···

4 4 4 4 4 4

3399 5-Oxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.9 3400 4-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.9 3401 5-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.9 3402 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3403 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3404 4-OThi 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.9 3405 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3406 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3407 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3408 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3409 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3410 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3411 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 3412 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3413 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3414 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3415 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3416 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3417 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3418 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3419 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3420 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.9 3421 cPr 3,4-diFPh what simple ... binding. 2 0 ch ₂ ch ₂ sub. 10

207 • · ΦΦΦ®

4 • Φ • 4 · ♦ 4 4 Φ Φ

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3422 cBu 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 10 3423 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3424 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3425 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3426 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3427 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3428 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3429 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3430 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3431 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3432 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3433 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3434 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.10 3435 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.10 3436 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3437 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3438 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3439 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3440 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3441 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3442 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3443 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3444 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 3445 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 10

4

4 4

44

208 • 4 ···· · 9 • 44

4 4

9 4 ·

3446 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3447 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3448 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3449 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3450 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 3451 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3452 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3453 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3454 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3455 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3456 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3457 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3458 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3459 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3460 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3461 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3462 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3463 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 3464 4-OThi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub. 11 3465 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 3466 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 3467 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 3468 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1

9 • 99 • · 9 9

4 99

9 9 9

99

209 • * • 9 · «9 9 • 4949 9 • 4

9 9

3469 2-Mor 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 11 3470 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3471 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3472 2-Thmor 3,4-diFPh WHAT simple ......... weave_____ 2 0 ch ₂ ch ₂ sub. 11 3473 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3474 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3475 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3476 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 3477 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3478 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3479 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3480 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 3481 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3482 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3483 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3484 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3485 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3486 2-Pyrd 3,4-diFPh what simple ...... weave 2 0 ch ₂ ch ₂ sub. 12 3487 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3488 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3489 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3490 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3491 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3492 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3493 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3494 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3495 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3496 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3497 3-Pip 3,4-diFPh what simple ....... binding ...... 2 0 ch ₂ ch ₂ sub. 12 3498 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 3499 2-Mor 3,4-diFPh what simple custody. 2 0 ch ₂ ch ₂ sub. 12

210 ·· # · · «** ** ** ** · ·

3500 3-Mor 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 12 3501 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.12 3502 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3503 3-Thmor 3,4-diFPh WHAT simple .custody........ 2 0 ch ₂ ch ₂ sub. 12 3504 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3505 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3506 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3507 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3508 2-Aze 3,4-diFPh WHAT simple ..custody.... 2 0 ch ₂ ch ₂ sub. 12 3509 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 3510 4-Aze 3,4-diFPh what simple va ....... 2 0 ch ₂ ch ₂ sub. 12 3511 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3512 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3513 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3514 cHex 3,4-diFPh what simple ........ weave ... 2 0 ch ₂ ch ₂ sub. 13 3515 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3516 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3517 3-Pyrd 3,4-diFPh what single binding ... 2 0 ch ₂ ch ₂ sub. 13 3518 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3519 5-Oxa 3,4-diFPh what single ........ binding. ... 2 0 ch ₂ ch ₂ sub.13 3520 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3521 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3522 4-OOxa 3,4-diFPh what simple .. binding ......... 2 0 ch ₂ ch ₂ sub. 13 3523 5-OOxa 3,4-diFPh what simple binding 2 0 ch ₂ ch ₂ sub. 13

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• · Φ »

211 «φ

Φ · Φ · φφ φ

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3524 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3525 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3526 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3527 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3528 4-Pip 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 13 3529 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3530 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3531 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3532 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3533 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3534 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3535 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3536 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3537 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 3538 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3539 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3540 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 3541 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3542 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3543 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3544 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3545 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3546 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3547 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14

·· ·· ->

• · ·!

• · · · · · · · · · · · · ·

212 • · ······

3548 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3549 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3550 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3551 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3552 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3553 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3554 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3555 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3556 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3557 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3558 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3559 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3560 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 3561 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3562 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3563 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3564 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3565 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3566 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3567 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3568 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3569 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 3570 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 14

* ·

213

3571 cPr 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.15 3572 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3573 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3574 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3575 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3576 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3577 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3578 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3579 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3580 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3581 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3582 4-OOxa 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 15 Dec 3583 5-OOxa 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 15 Dec 3584 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3585 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3586 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3587 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.15 3588 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3589 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3590 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3591 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3592 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3593 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3594 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec

• 9

214 9999 9 9 9 9 9 9 9 9

999999 99 999 99 9

9 9 9 9 9

9 9 9 9 9

3595 2-Piz 3,4-diFPh WHAT simple custody 2 O CH ₂ CH ₂ sub. 15 Dec 3596 3-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 15 Dec 3597 4-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 15 Dec 3598 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3599 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 3600 4-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 15 Dec 3601 cPr 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 16 3602 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3603 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3604 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3605 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3606 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3607 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3608 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3609 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3610 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3611 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3612 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3613 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3614 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3615 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3616 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 3617 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 16

215

3618 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3619 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.16 3620 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3621 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.16 3622 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3623 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3624 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3625 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3626 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3627 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3628 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3629 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3630 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 3631 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3632 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3633 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3634 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3635 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3636 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3637 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3638 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3639 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3640 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3641 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.17

• · • · ····

216

3642 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3643 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3644 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3645 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3646 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3647 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3648 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3649 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3650 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3651 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3652 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 3653 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3654 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3655 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3656 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3657 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3658 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3659 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3660 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 3661 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3662 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3663 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3664 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18

• ·

217

3665 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3666 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3667 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3668 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3669 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3670 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3671 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3672 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3673 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3674 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3675 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3676 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3677 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3678 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 3679 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3680 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3681 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3682 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3683 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3684 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.18 3685 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3686 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3687 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 3688 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 18

• 9

218 4 4 4 9 9 9 9 9 9 4 9

3689 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 3690 4-Aze 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.l 8 3691 cPr 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 3692 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3693 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3694 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3695 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3696 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3697 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3698 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3699 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3700 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3701 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3702 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3703 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3704 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3705 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3706 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3707 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3708 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3709 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3710 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 3711 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec

219 t t ♦ ♦ t t t t t 219 · · · · · · · · · ·

3712 2-Thmor 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 19 Dec 3713 3-Thmor 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 19 Dec 3714 4-Thmor 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 19 Dec 3715 2-Piz 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub. 19 Dec 3716 3-Piz 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 19 Dec 3717 4-Piz 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 19 Dec 3718 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.19 3719 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 3720 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.19 3721 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3722 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3723 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3724 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3725 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3726 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3727 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3728 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3729 5-Oxa 3,4-diFPh what simple custody 2 0 CH2CH2 sub.20 3730 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3731 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3732 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3733 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3734 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3735 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20

220 φ • φ φ φ • · · · · »· · · · · φ φ φ φ φ φ · · · · · φ φ φ φ φ φ φ φ φ φ φ

3736 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3737 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3738 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3739 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3740 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3741 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3742 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3743 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3744 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3745 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3746 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3747 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3748 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3749 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.20 3750 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 3751 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3752 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3753 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3754 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3755 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3756 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3757 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3758 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21

221 221 9 9 9 9 9 9 9 9

9 · · ·

99 99 99 99

3759 5-Oxa 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.21 3760 4-Thi 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.21 3761 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3762 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3763 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3764 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3765 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3766 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3767 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3768 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3769 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3770 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3771 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3772 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 3773 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3774 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3775 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3776 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3777 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3778 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3779 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3780 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.21 3781 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3782 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22

222 • 9 99 99 99 99 • 9 · 9 9 9

999 99 99 9499

999 99 99 994 44 9

9,999,999

999 99 99 99 99

3783 cPn 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.22 3784 cHex 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.22 3785 cHep 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 3786 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3787 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3788 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3789 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3790 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3791 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3792 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3793 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3794 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3795 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3796 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3797 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3798 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3799 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3800 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3801 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3802 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3803 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3804 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22 3805 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.22

223 9 9 9 9

9999 99 99 999 99

9 9 9 9 9

9 9 9 9 9 9 9 9 99

3806 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 3807 4-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 3808 2-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 3809 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 3810 4-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 3811 cPr 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3812 cBu 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3813 cPn 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3814 cHex 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3815 cHep 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3816 2-Pyrd 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3817 3-Pyrd 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3818 4-Oxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3819 5-Oxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 3820 4-Thi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3821 5-Thi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3822 4-OOxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3823 5-OOxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3824 4-OThi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3825 5-OThi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3826 2-Pip 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3827 3-Pip 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3828 4-Pip 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.23 3829 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.23

224 • t »t * · * 49 * ♦ 9 4 · · · · · · · · · · · · ·

4 4 4 4 9 4

448 4 49 49 49 4 9

3830 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3831 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3832 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3833 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3834 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3835 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3836 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3837 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3838 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3839 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3840 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 3841 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3842 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3843 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3844 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3845 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3846 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3847 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3848 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3849 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3850 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3851 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3852 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24

225 • · »8 9 8

9 9 9 9 9 9 9

8 8 8 9

987 9 * · *>

• 9

8 9

8 8 · 9

9 9

9 · «9

3853 5-OOxa 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.24 3854 4-OThi 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.24 3855 5-OThi 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.24 3856 2-Pip 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.24 3857 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3858 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3859 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3860 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3861 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3862 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3863 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3864 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3865 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3866 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.24 3867 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3868 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3869 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3870 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.24 3871 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3872 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3873 cPn 3,4-diFPh what simple custody 2 0 CH2CH2 sub.25 3874 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3875 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3876 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25

• · · φ · · · · · · · · · ·

226

3877 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3878 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3879 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3880 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3881 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3882 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3883 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3884 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3885 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3886 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3887 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3888 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3889 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3890 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 3891 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3892 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3893 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3894 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3895 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3896 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3897 4-Piz 3,4-diFPh what simple custody 2 0 CH2CH2 sub.25 3898 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25 3899 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.25

227

3900 4-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.25 3901 cPr 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 3902 cBu 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 3903 cPn 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 3904 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3905 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3906 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3907 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3908 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3909 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3910 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3911 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3912 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3913 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3914 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3915 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3916 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3917 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3918 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3919 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3920 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3921 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3922 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3923 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26

228 • ·

3924 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3925 2-Piz 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.26 3926 3-Piz 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.26 3927 4-Piz 3,4-diFPh WHAT simple 'Binding 2 0 CH ₂ CH ₂ sub.26 3928 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3929 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.26 3930 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 3931 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3932 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3933 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3934 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3935 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3936 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3937 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3938 4-Oxa 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.27 3939 5-Oxa 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.27 3940 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3941 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3942 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3943 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3944 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3945 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27 3946 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.27

4

229 • ·

3947 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3948 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3949 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3950 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3951 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3952 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3953 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3954 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3955 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3956 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3957 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3958 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3959 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3960 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 3961 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3962 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3963 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3964 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3965 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3966 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3967 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3968 4-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3969 5-Oxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3970 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28

• ·

230

3971 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3972 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3973 5-OOxa 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.28 3974 4-OThi 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.28 3975 5-OThi 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.28 3976 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3977 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3978 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3979 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3980 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3981 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3982 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3983 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3984 4-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3985 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3986 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3987 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 3988 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3989 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3990 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.28 3991 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 3992 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 3993 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29

231 ·· •♦ · 9 • 9

3994 cHex 3,4-diFPh WHAT simple custody 2 O CH2CH2 sub.29 3995 cHep 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 3996 2-Pyrd 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 3997 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 3998 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 3999 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4000 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4001 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4002 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4003 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4004 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4005 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4006 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 4007 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4008 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4009 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4010 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4011 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4012 2-Thmor 3,4-diFPh what simple custody 2 0 CH2CH2 sub.29 4013 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4014 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4015 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4016 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29 4017 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.29

• ·

232

4018 2-Aze 3,4-diFPh WHAT simple custody 2 O CH ₂ CH ₂ sub, 29 4019 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 4020 4-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 4021 cPr 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4022 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4023 cPn 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4024 cHex 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4025 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4026 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4027 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4028 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4029 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.30 4030 4-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4031 5-Thi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4032 4-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4033 5-OOxa 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4034 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4035 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4036 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4037 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4038 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4039 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30 4040 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.30

99

9 9 9

9 9 9 • 9 · 9 9

99 · 9 9

9 99

233

4041 4-Mor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4042 2-Thmor 3,4-diFPh WHAT simple custody 2 O CH ₂ CH ₂ sub.3 0 4043 3-Thmor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4044 4-Thmor 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4045 2-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4046 3-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4047 4-Piz 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4048 2-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4049 3-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4050 4-Aze 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.30 4051 cPr 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4052 cBu 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4053 cPn 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4054 cHex 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4055 cHep 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4056 2-Pyrd 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4057 3-Pyrd 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4058 4-Oxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4059 5-Oxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4060 4-Thi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4061 5-Thi 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4062 4-OOxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4063 5-OOxa 3,4-diFPh what simple custody 2 O ch ₂ ch ₂ sub.31 4064 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31

234 9 9 9 9 9 9

9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 99 99 99

4065 5-OThi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4066 2-Pip 3,4-diFPh what simple custody 2 O CH ₂ CH ₂ sub.31 4067 3-Pip 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.31 4068 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4069 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4070 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4071 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4072 2-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4073 3-Thmor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 4074 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4075 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4076 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4077 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4078 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4079 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4080 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.31 4081 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4082 cBu 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4083 cPn 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4084 cHex 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4085 cHep 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4086 2-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4087 3-Pyrd 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32

φ »» »» »• • • • • • φ φ φ φ φ

Φ φ φ φ · · · φ φ φ φ φ φ

235 φφ φφφφφ · · φ φφφφφφφ ·φφφφφφ

4088 4-Oxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.32 4089 5-Oxa 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.32 4090 4-Thi 3,4-diFPh WHAT simple custody 2 O ch ₂ ch ₂ sub.32 4091 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4092 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4093 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4094 4-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4095 5-OThi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4096 2-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4097 3-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4098 4-Pip 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4099 2-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4100 3-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4101 4-Mor 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 4102 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4103 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4104 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4105 2-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4106 3-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4107 4-Piz 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4108 2-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4109 3-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4110 4-Aze 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.32 4111 cPr 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33

• 9 ·· · «· ♦ ·

9 9 • 9

4994

236 4 9 9

94 ··

4112 cBu 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 3 4113 cPn 3,4-diFPh WHAT simple custody 2 0 CH2CH2 sub.3 3 4114 cHex 3,4-diFPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.33 4115 cHep 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4116 2-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4117 3-Pyrd 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4118 4-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4119 5-Oxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4120 4-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4121 5-Thi 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4122 4-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4123 5-OOxa 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4124 4-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4125 5-OThi 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4126 2-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4127 3-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4128 4-Pip 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4129 2-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4130 3-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4131 4-Mor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4132 2-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4133 3-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33 4134 4-Thmor 3,4-diFPh what simple custody 2 0 ch ₂ ch ₂ sub.33

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237 ··

4135 2-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4136 3-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4137 4-Piz 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4138 2-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4139 3-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4140 4-Aze 3,4-diFPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 4141 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4142 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4143 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4144 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4145 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4146 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4147 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4148 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4149 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4150 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4151 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4152 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4153 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4154 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4155 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4156 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4157 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 4158 4-Pip 4-FPh what simple custody 2 ⁰ ch ₂ ch ₂ sub.34

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4159 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4160 3-Mor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.34 4161 4-Mor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.34 4162 2-Thmor 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.34 4163 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4164 4-Thmor 4-FPh WHAT simple custody 2 O CH2CH2 sub.34 4165 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4166 3-Piz 4-FPh WHAT simple custody 2 0 CH2CH2 sub.34 4167 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4168 2-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.34 4169 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4170 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 4171 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4172 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4173 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4174 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4175 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4176 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4177 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4178 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4179 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4180 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4181 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35

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4182 4-OOxa 4-FPh WHAT simple custody 2 0 CH2CH2 sub.35 4183 5-OOxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.35 4184 4-OThi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.35 4185 5-OThi 4-FPh WHAT simple 'Binding 2 O ch ₂ ch ₂ sub.35 4186 2-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.35 4187 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4188 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4189 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4190 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4191 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4192 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4193 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4194 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4195 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 4196 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 4197 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 4198 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 4199 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 4200 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 4201 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4202 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4203 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4204 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4205 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l

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240 tttt · tttttt · ttt

4206 2-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 4207 3-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 4208 4-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.l 4209 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4210 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4211 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4212 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4213 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4214 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4215 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4216 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4217 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4218 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4219 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4220 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4221 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4222 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4223 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4224 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4225 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4226 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4227 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 4228 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l

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4229 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4230 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 4231 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4232 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4233 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4234 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4235 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4236 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4237 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4238 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4239 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4240 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4241 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4242 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4243 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4244 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4245 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4246 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4247 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2 4248 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2 4249 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2 4250 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2 4251 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2 4252 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.2

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242

4253 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4254 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4255 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4256 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4257 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4258 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4259 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4260 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.2 4261 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4262 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4263 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4264 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4265 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4266 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4267 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4268 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4269 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4270 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4271 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4272 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4273 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4274 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3 4275 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.3

• • •

243

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4276 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4277 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4278 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4279 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4280 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4281 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4282 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4283 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4284 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4285 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4286 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4287 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4288 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4289 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4290 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 4291 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4292 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4293 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4294 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4295 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4296 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4297 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4298 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4299 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4

• ·

244

4300 4-Thi 4-FPh WHAT simple custody 2 O CH2CH2 sub.4 4301 5-Thi 4-FPh WHAT simple custody 2 O CH2CH2 sub.4 4302 4-OOxa 4-FPh WHAT simple custody 2 O CH2CH2 sub.4 4303 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4304 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4305 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4306 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4307 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4308 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4309 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4310 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4311 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4312 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.4 4313 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4314 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4315 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4316 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4317 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4318 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4319 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4320 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.4 4321 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4322 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5

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4323 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4324 cHex 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.5 4325 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4326 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4327 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4328 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4329 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4330 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4331 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4332 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4333 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4334 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4335 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4336 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4337 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4338 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4339 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4340 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4341 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4342 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4343 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4344 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4345 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5 4346 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.5

· · · · · · · · · · · · · · · · · · · · · · · · · · · ·

246

4347 4-ζίζ 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4348 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4349 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4350 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.5 4351 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4352 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4353 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4354 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4355 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4356 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4357 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4358 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4359 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4360 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4361 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4362 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4363 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4364 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4365 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4366 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4367 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4368 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6 4369 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.6

247

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999 · 9 · 9 ·

99 99 9999

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4370 3-Mor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.6 4371 4-Mor 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 6 4372 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4373 3-Thmor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.6 4374 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4375 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4376 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4377 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4378 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4379 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4380 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.6 4381 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4382 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4383 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4384 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4385 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4386 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4387 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4388 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4389 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4390 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4391 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4392 4-OOxa 4-FPh what simple custody 2 0 CH2CH2 sub.7 4393 5-OOxa 4-FPh what simple custody 2 0 CH ₂ CH ₂ sub.7

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4394 4-OThi 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub.7 4395 5-OThi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.7 4396 2-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.7 4397 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4398 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4399 2-Mor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.7 4400 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4401 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4402 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4403 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4404 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4405 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4406 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4407 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.7 4408 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4409 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4410 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.7 4411 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4412 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4413 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4414 cHex 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.8 4415 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4416 2-Pyrd 4-FPh what simple 1 binding 2 0 ch ₂ ch ₂ sub.8

• ·

249 9 9 9 99 9 9 9 9

9999 99 99 999 99 9 · · · · · · · · · · · ·

999 99 99 99 99

4417 3-Pyrd 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 8 4418 4-Oxa 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 8 4419 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 4420 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4421 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 8 4422 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4423 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4424 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4425 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4426 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4427 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.8 4428 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4429 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4430 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4431 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4432 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4433 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4434 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4435 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4436 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4437 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4438 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4439 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8 4440 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.8

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250 • • ΦΦΦ φ • • φ φ · φ φ φ φ φ φ φ φ φ φ φ φ

4441 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 9 4442 cBu 4-FPh WHAT simple custody 2 0 CH2CH2 sub.9 4443 cPn 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 9 4444 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4445 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4446 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4447 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4448 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4449 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4450 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4451 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4452 4-OOxa 4-FPh WHAT simple custody 2 0 CH2CH2 sub.9 4453 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4454 4-OThi 4-FPh WHAT simple custody 2 0 CH2CH2 sub.9 4455 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4456 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4457 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4458 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4459 2-Mor 4-FPh what simple custody 2 0 CH2CH2 sub.9 4460 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4461 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4462 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9 4463 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.9

251 tttt tttt tttt tttt • tttt tttttttt tttttttt tttttt tttt tttt tttttttt • tttttttt tttt tttt tttttt tttt tt tt · · · * ttttttt • tttt tt tttt tttt tttt tttt

4464 4-Thmor 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.9 4465 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4466 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4467 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4468 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4469 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4470 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.9 4471 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.10 4472 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4473 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4474 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.10 4475 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4476 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4477 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4478 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4479 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4480 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4481 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4482 4-00xa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4483 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.10 4484 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.10 4485 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4486 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10 4487 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 10

252 • 99 99 99 09

9 9 4 0 9 4 0 9 1

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4488 4-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 10 4489 2-Mor 4-FPh WHAT simple custody 2 O CH2CH2 sub. 10 4490 3-Mor 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub. 10 4491 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4492 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4493 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4494 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4495 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4496 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4497 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4498 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4499 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4500 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 10 4501 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4502 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4503 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4504 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4505 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 4506 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 4507 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1 4508 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 4509 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 11 4510 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.l 1

253

4511 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4512 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4513 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4514 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4515 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4516 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4517 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4518 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4519 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4520 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4521 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4522 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4523 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4524 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l1 4525 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4526 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.11 4527 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.11 4528 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.l 1 4529 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4530 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 11 4531 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4532 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4533 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4534 cHex 4-FPh what simple 1 binding 2 0 ch ₂ ch ₂ sub. 12

254

4535 cHep 4-FPh WHAT simple custody 2 0 CH2CH2 sub. 12 4536 2-Pyrd 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 12 4537 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4538 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4539 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4540 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4541 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4542 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4543 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4544 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4545 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4546 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4547 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4548 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4549 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4550 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4551 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4552 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4553 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4554 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4555 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4556 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12 4557 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 12

• · · · · · · · · · · · · · · · · · · · · · · · · · ·

255

4558 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4559 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4560 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 12 4561 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4562 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4563 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4564 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4565 cHep 4-FPh WHAT simple custody 2 0 CH2CH2 sub. 13 4566 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4567 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4568 4-Oxa 4-FPh WHAT simple custody 2 0 CH2CH2 sub. 13 4569 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4570 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4571 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4572 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4573 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4574 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4575 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4576 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4577 3-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 13 4578 4-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 13 4579 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4580 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13 4581 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 13

256

4582 2-Thmor 4-FPh WHAT simple custody 2 O CH2CH2 sub. 13 4583 3-Thmor 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub. 13 4584 4-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 4585 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4586 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4587 4-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 13 4588 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4589 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4590 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 13 4591 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4592 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4593 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4594 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4595 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4596 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4597 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4598 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4599 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4600 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4601 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4602 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4603 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4604 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14

• ······················· · 9 · · · · · · · · · · · ·

257

4605 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4606 2-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 4607 3-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 4608 4-Pip 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 14 4609 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4610 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4611 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4612 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4613 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4614 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4615 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4616 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4617 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4618 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 14 4619 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4620 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 14 4621 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4622 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4623 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4624 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4625 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4626 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4627 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4628 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec

258 • φ · Φ • · · · · · φ · · · φ φ • • • • · · · · · · · · · · ·

4629 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4630 4-Thi 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 15 Dec 4631 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4632 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4633 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4634 4-OThi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 15 Dec 4635 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4636 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4637 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4638 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4639 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4640 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4641 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4642 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4643 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4644 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4645 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4646 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4647 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4648 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4649 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4650 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 15 Dec 4651 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16

259 • · 9

9 9 99 9 9 9

999 9 99 ·

989 99 9

9 9 9 9 9 • 9 99 99 99

4652 cBu 4-FPh WHAT simple custody 2 0 CH2CH2 sub. 16 4653 cPn 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 16 4654 cHex 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub. 16 4655 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4656 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4657 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4658 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4659 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4660 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4661 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4662 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4663 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4664 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4665 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4666 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4667 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4668 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4669 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4670 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4671 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4672 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4673 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16 4674 4-Thmor 4-FPh what simple custody 2 0 CH2CH2 sub. 16 4675 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 16

260 • φ φ φ φ · · φ · · φ φ · φ φ φ φ φ

4676 3-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 16 4677 4-ζίζ 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4678 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4679 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4680 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 16 4681 cPr 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4682 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4683 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4684 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4685 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4686 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4687 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4688 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4689 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4690 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4691 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4692 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4693 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4694 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4695 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4696 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4697 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17 4698 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 17

9 «» 9 • 9

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9 9 9

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4699 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 17 4700 3-Mor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4701 4-Mor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4702 2-Thmor 4-FPh WHAT simple 'Binding 2 O ch ₂ ch ₂ sub. 17 4703 3-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4704 4-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4705 2-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4706 3-Piz 4-FPh WHAT simple custody 2 O CH2CH2 sub. 17 4707 4-Piz 4-FPh WHAT simple custody 2 O CH2CH2 sub. 17 4708 2-Aze 4-FPh WHAT simple custody 2 O CH2CH2 sub. 17 4709 3-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4710 4-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 17 4711 cPr 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 4712 cBu 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 18 4713 cPn 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 18 4714 cHex 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 18 4715 cHep 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.18 4716 2-Pyrd 4-FPh what simple custody 2 O ch ₂ ch ₂ sub. 18 4717 3-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 4718 4-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 4719 5-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 4720 4-Thi 4-FPh WHAT simple custody 2 0 CH2CH2 sub. 18 4721 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4722 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18

9 ····

262 ························· · 9 9 • 9 9 9

4723 5-OOxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 18 4724 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4725 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4726 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4727 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4728 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4729 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4730 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4731 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 18 4732 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4733 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4734 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4735 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4736 3-Piz 4-FPh what single _L bond 2 0 ch ₂ ch ₂ sub. 18 4737 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4738 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4739 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4740 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 18 4741 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4742 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4743 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4744 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4745 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec

• ·

263

4746 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4747 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4748 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4749 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4750 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4751 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4752 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4753 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4754 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4755 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4756 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4757 3-Pip 4-FPh WHAT simple i binding 2 0 ch ₂ ch ₂ sub. 19 Dec 4758 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4759 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4760 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4761 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4762 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4763 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4764 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4765 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4766 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4767 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4768 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec 4769 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub. 19 Dec

• · · · · · · · · ·

264 • ··

4770 4-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub. 19 Dec 4771 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4772 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4773 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4774 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4775 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4776 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4777 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4778 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4779 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4780 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4781 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4782 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.20 4783 5-OOxa 4-FPh what simple i binding 2 0 ch ₂ ch ₂ sub.20 4784 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4785 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4786 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4787 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4788 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4789 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4790 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4791 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20 4792 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.20

• ·

265 ··· · ·· ··

4793 3-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4794 4-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4795 2-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4796 3-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4797 4-Piz 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4798 2-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4799 3-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4800 4-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.20 4801 cPr 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.21 4802 cBu 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.21 4803 cPn 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.21 4804 cHex 4-FPh WHAT simple I binding 2 O ch ₂ ch ₂ sub.21 4805 cHep 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.21 4806 2-Pyrd 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4807 3-Pyrd 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4808 4-Oxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4809 5-Oxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4810 4-Thi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4811 5-Thi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4812 4-OOxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4813 5-OOxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4814 4-OThi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4815 5-OThi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4816 2-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21

266

4817 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4818 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4819 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4820 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4821 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.21 4822 2-Thmor 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.21 4823 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4824 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4825 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4826 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4827 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4828 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4829 3-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.21 4830 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.21 4831 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4832 cBu 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.22 4833 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4834 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4835 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4836 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4837 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4838 4-Oxa 4-FPh WHAT simple custody 2 0 CH2CH2 sub.22 4839 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22

267

4840 4-Thi 4-FPh WHAT simple custody 2 0 CH2CH2 sub.22 4841 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4842 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4843 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4844 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4845 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4846 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4847 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4848 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4849 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4850 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4851 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4852 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4853 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4854 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.22 4855 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4856 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4857 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4858 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4859 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4860 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.22 4861 cPr 4-FPh what simple custody 2 0 CH2CH2 sub.23 4862 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4863 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23

268

4864 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4865 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4866 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4867 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4868 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4869 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4870 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4871 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4872 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4873 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4874 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4875 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4876 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.23 4877 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4878 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4879 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4880 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4881 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4882 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4883 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4884 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4885 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23 4886 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.23

· «<<<<<<<<<<<< 9 9 9 9 9 9

269

4887 4-Piz 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub.23 4888 2-Aze 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub.23 4889 3-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 4890 4-Aze 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.23 4891 cPr 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4892 cBu 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4893 cPn 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4894 cHex 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4895 cHep 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4896 2-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4897 3-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4898 4-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.24 4899 5-Oxa 4-FPh WHAT simple custody 2 O CH2CH2 sub.24 4900 4-Thi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4901 5-Thi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4902 4-OOxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4903 5-OOxa 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4904 4-OThi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4905 5-OThi 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4906 2-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4907 3-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4908 4-Pip 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4909 2-Mor 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24 4910 3-Mor 4-FPh what simple custody 2 O ch ₂ ch ₂ sub.24

»· ·· ·· ··

9 9 9 9 8 9 9 9 9 9 9

9 9 9 9 9 9

99 99 89 ···· ·

270

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φ 99 99 99 99

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271

4934 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4935 5-OThi 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4936 2-Pip 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4937 3-Pip 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4938 4-Pip 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4939 2-Mor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4940 3-Mor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.25 4941 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4942 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4943 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4944 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4945 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4946 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.25 4947 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.25 4948 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.25 4949 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.25 4950 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.25 4951 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4952 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4953 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4954 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4955 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4956 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4957 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26

272 9 9 9 9 9

9 9 9 99

9999 99 99 999 99

9 9 9 9 9

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4958 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4959 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4960 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4961 5-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4962 4-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4963 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4964 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4965 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4966 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4967 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4968 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4969 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4970 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.26 4971 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4972 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4973 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4974 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4975 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4976 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4977 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4978 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4979 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26 4980 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.26

273 • 9 9 99 9 9 9 9

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4981 cPr 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4982 cBu 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4983 cPn 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4984 cHex 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4985 cHep 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4986 2-Pyrd 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 4987 3-Pyrd 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4988 4-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4989 5-Oxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4990 4-Thi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4991 5-Thi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4992 4-OOxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4993 5-OOxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4994 4-OThi 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.27 4995 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 4996 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 4997 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 4998 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 4999 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 5000 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 5001 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 5002 2-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 5003 3-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.27 5004 4-Thmor 4-FPh what simple custody 2 0 CH2CH2 sub.27

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5005 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.27 5006 3-Piz 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 5007 4-Piz 4-FPh WHAT simple custody 2 O CH2CH2 sub.27 5008 2-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.27 5009 3-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.27 5010 4-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.27 5011 cPr 4-FPh WHAT simple custody 2 0 CH2CH2 sub.28 5012 cBu 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.28 5013 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.28 5014 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5015 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5016 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5017 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5018 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5019 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5020 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5021 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5022 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5023 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5024 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5025 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5026 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28 5027 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.28

• φ

275 φ · · · • · · · · φ φ φ φ φ φ φ φ φ φ φ φ φ

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276 * 9 9 9 t · · · · **

5052 4-OOxa 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.29 5053 5-OOxa 4-FPh WHAT simple custody 2 O CH2CH2 sub.29 5054 4-OThi 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub.29 5055 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5056 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5057 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5058 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5059 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5060 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5061 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5062 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5063 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5064 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.29 5065 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5066 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5067 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5068 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5069 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5070 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.29 5071 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.30 5072 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.30 5073 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.30 5074 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.30

277 • 9 99 99 φφ * 9 φ 9 9 9 9 «999 • 9» 9 9 9 * «999 • 9999« 9 99 999 99 · · 9 · 9 9 9999

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278

5099 3-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.30 5100 4-Aze 4-FPh WHAT simple custody 2 0 CH2CH2 sub.30 5101 cPr 4-FPh WHAT simple custody 2 0 CH2CH2 sub.31 5102 cBu 4-FPh WHAT simple custody 2 0 CH2CH2 sub.31 5103 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5104 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5105 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5106 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5107 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5108 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5109 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5110 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5111 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5112 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5113 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5114 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5115 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5116 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5117 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5118 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5119 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5120 3-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31 5121 4-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.31

• · • ·

279

5122 2-Thmor 4-FPh WHAT simple custody 2 0 CH2CH2 sub.31 5123 3-Thmor 4-FPh WHAT simple custody 2 0 CH ₂ CH ₂ sub.31 5124 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5125 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5126 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5127 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5128 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5129 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5130 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.31 5131 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5132 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5133 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5134 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5135 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5136 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5137 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5138 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5139 5-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5140 4-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5141 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5142 4-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5143 5-OOxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5144 4-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5145 5-OThi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32

* φ • φ

280

5146 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5147 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5148 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5149 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5150 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5151 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5152 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5153 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5154 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5155 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5156 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5157 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5158 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.32 5159 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5160 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.32 5161 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5162 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5163 cPn 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5164 cHex 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5165 cHep 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5166 2-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5167 3-Pyrd 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5168 4-Oxa 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33

281 • 9

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5169 5-Oxa 4-FPh WHAT simple custody 2 0 CH2CH2 sub.33 5170 4-Thi 4-FPh WHAT simple custody 2 0 CH2CH2 sub.33 5171 5-Thi 4-FPh WHAT simple custody 2 0 CH2CH2 sub.33 5172 4-OOxa 4-FPh WHAT simple 'Binding 2 0 ch ₂ ch ₂ sub.33 5173 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5174 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5175 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5176 2-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5177 3-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5178 4-Pip 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5179 2-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5180 3-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5181 4-Mor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5182 2-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5183 3-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.33 5184 4-Thmor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5185 2-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5186 3-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5187 4-Piz 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5188 2-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5189 3-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5190 4-Aze 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.33 5191 cPr 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34 5192 cBu 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.34

282 • 9 · · · ·

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283 • 9 9 9 9 9 9 9 9 9 9 9 9

999999 9 9 999 99 9 9999

9999 9999

5216 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 5217 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 5218 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 5219 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 5220 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.34 5221 cPr 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub. 3 5 5222 cBu 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5223 cPn 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.3 5 5224 cHex 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5225 cHep 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5226 2-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5227 3-Pyrd 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5228 4-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5229 5-Oxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5230 4-Thi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5231 5-Thi 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 5232 4-00xa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5233 5-OOxa 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5234 4-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5235 5-OThi 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5236 2-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 5237 3-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 5238 4-Pip 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35 5239 2-Mor 4-FPh what simple custody 2 0 ch ₂ ch ₂ sub.35

• · · · ···

284

5240 3-Mor 4-FPh WHAT simple custody 2 O CH ₂ CH ₂ sub, 35 5241 4-Mor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.35 5242 2-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.3 5 5243 3-Thmor 4-FPh WHAT simple custody 2 O ch ₂ ch ₂ sub.35 5244 4-Thmor 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5245 2-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5246 3-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5247 4-Piz 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5248 2-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5249 3-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35 5250 4-Aze 4-FPh WHAT simple custody 2 0 ch ₂ ch ₂ sub.35

Among the compounds listed above, preferred compounds are numbered 1 to 180, 631 to 1230, 1681 to 2100, 3151 to 3330 and 3781 to 4200. More preferred compounds are numbered 1051 to 1230, 1681 to 2100 and 3871 to 3874, Most preferred compounds are numbered 1051 to 1054 , 1081 to 1084, 1111 to 1114, 1141 to 1144, 1171 to 1174, 1201 to 1204, 1921 to 1924, 1951 to 1954 and 3871 to 3874.

The present invention is further illustrated by a reference example.

Reference Example Reference Example 1

2 - [(2 R) - (3,4-dichlorophenyl) morpholin-2-yl] ethanol

Dioxane solution of hydrogen chloride (4 mol / l; 500 ml) containing

2- [4-tert-butoxycarbonyl- (2R) - (3,4-dichlorophenyl) morpholin-2-yl] ethyl tert-butyldimethylsilyl ether (38.6 g; 78.7 mmol) was stirred at 60 ° C for 3 hours. The solvent was distilled off under reduced pressure. The residue was dissolved in hydrochloric acid (1 mol / L) and the solution was washed with diethyl ether. The aqueous layer was basified with aqueous sodium hydroxide (2M) and then extracted with dichloromethane. After washing the organic layer with saturated

285

99 9 9

9% aqueous sodium chloride solution, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixture of n-hexane (210 mL) and ethyl acetate (175 mL) to give the title compound (18.0 g, 83%) as a white crystalline solid.

Melting point: 90 - 91 ° C [α] D ²⁴ + 19.2 ° (c = 0.51, methanol)

IR spectrum ν max cm ^-1 (KBr): 3261, 3098, 2940, 1471, 1085, 1047.

MS spectrum (EI) m / z: 275 (M);

Formulation example

Formulation Example 1 - Powder

The powder can be obtained by mixing the compound of Example 1 (5 g), lactose (895 g) and corn starch (100 g) in a mixer.

Formulation Example 2 - Granules

Granules can be prepared by mixing the compound of Example 2 (5 g), lactose (865 g) and lower substituted hydroxypropylcellulose (100 g), adding 300 g of a 10% aqueous hydroxypropylcellulose solution to this mixture, kneading the mixture, granulating the kneaded mass using an extruder granulator and then drying the granular product.

Formulation Example 3 - Capsules

Capsules can be obtained by mixing the compound of Example 3 (5 g), lactose (115 g), corn starch (58 g) and magnesium stearate (2 g) in a V-mixer, and then filling the resulting mixture into capsules # 3 of 180 mg portions. .

Formulation Example 4 - Tablets

Tablets can be obtained by mixing the compound of Example 4 (5 g), lactose (90 g), corn starch (34 g), crystalline cellulose (20 g) and magnesium stearate (1 g) in a mixer and then tabletting the resulting mixture using a tabletting machine.

Test example

Test Example 1 - NK 1 receptor binding assay

a) Preparation of the crude fraction from the lung membrane

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The crude azure fraction was prepared from the lungs of male Hartley guinea pigs. The guinea pigs were killed by chloroform and bled from the cava abdominalis and the lung tissue was immediately removed.

The extracted lungs were embedded with buffer (1) (50 mmol / l Tris-HCl, pH 7.4), finely sliced in this solution and then homogenized in buffer (2) (buffer (1) containing 120 mmol / l chloride) sodium chloride and 5 mmol / l potassium chloride) using a Polytron homogenizer.

The tissue mass was removed from the homogenate by filtration through a nylon mesh (50 µm) and the supernatant was centrifuged (30,000 xg, 30 min, 4 ° C).

The resulting pellet was resuspended in ice buffer (3) (buffer solution (1) containing 10 mmol / l EDTA and 300 mmol / l potassium chloride), allowed to stand for 60 min at 4 ° C and then washed twice followed by centrifugation (30000 xg , 15 min, 4 ° C).

The crude film fraction was stored at -80 ° C before use. b) Receptor Binding Assay

The pulmonary membrane (250 μΐ) crude fraction solution was added to a stirred solution (250 μΐ) of test compound and [ ³ H] -Substance P (total concentration 1 nmol / l) (50 mmol / l Tris-HCl; pH 7.4 6 mmol / l manganese chloride; 800 pg / ml BSA; 8 pg / ml chymostatin; 8 pg / ml leupeptin; 80 pg / ml bacitracin, 20 pg / ml phosphoramidone) followed by 30 min incubation at room temperature.

After the reaction, the membrane component was recovered on a GF / B glass fiber filter (Whatman Co.) using an automatic filter device (Brandel Co).

The glass filter was used after it had been pretreated for 4 hours in a 0.1% polyethyleneimine solution to avoid non-specific binding as much as possible.

The filter containing the recovered membrane component was transferred to a plastic mini-vial containing a picoflow (4 ml) and radioactivity was measured using a liquid scintillation counter (Beckman Co., LSC3500) to determine 50% drug binding concentration (IC 50).

The IC 50 values of the compounds of the present invention were 1000 ng / ml or more.

Test Example 2 - NK ₂ receptor binding assay

a) Preparation of the crude fraction from the lung membrane

The crude azure fraction was prepared from the lungs of male Hartley guinea pigs. The guinea pigs were killed by chloroform and bled from the cava abdominalis and the lung tissue was immediately removed.

The contents, excretions and lining were scraped off with a slide and the lung tissue removed was finely sliced in buffer (1) (50 mmol / l Tris-HCl, pH 7.4) and then homogenized

287 ♦ · «* * * * * * * * * * * * * * * * * * * * * • · · · · · · · · · · · · · · · ·.

in buffer solution (2) (buffer solution (1) containing 120 mmol / l sodium chloride and 5 mmol / l potassium chloride) using a Polytron homogenizer.

The tissue mass was removed from the homogenate by filtration through a nylon mesh (50 µm) and the supernatant was centrifuged (30,000 xg, 30 min, 4 ° C).

The resulting pellet was resuspended in ice-cold buffer (3) (buffer (1) containing 10 mmol / l EDTA and 300 mmol / l potassium chloride), allowed to stand for 60 min at 4 ° C and then washed twice followed by centrifugation (30000 xg) , 15 min, 4 ° C).

The crude film fraction was stored at -80 ° C before use. b) Receptor Binding Assay

The crude lung tissue fraction (250 μΐ) solution was added to a stirred solution (250 μL) of test compound and [ ³ H] -SR-48968 (Amasham Co., total concentration 1 nmol / L) (50 mmol / L Tris- HCl; pH 7.4; 6 mmol / L manganese chloride; 800 pg / ml BSA; 8 pg / ml chymostatin; 8 pg / ml leupeptin; 80 pg / ml bacitracin, 20 pg / ml phosphoramidone) followed by 30 min incubation at room temperature.

After the reaction, the membrane component was recovered on a GF / B glass fiber filter (Whatman Co.) using an automatic filter device (Brandel Co.).

The glass filter was used after it had been pretreated for 4 hours in a 10% polyethyleneimine solution to avoid non-specific binding as much as possible.

The filter containing the recovered membrane component was transferred to a plastic mini-vial containing a picoflow (4 ml) and radioactivity was measured using a liquid scintillation counter (Beckman Co., LSC3500) to determine 50% drug binding concentration (IC 50).

Table 2 NK ₂ Receptor Binding Assay Results

Test compound IC ₅₀ o (ng / ml) Example 1 compound 0.94 Example 2 compound 0.76 Example 3 compound 0.91 Compound B 6.2

As can be seen from Table 2, the compounds of the present invention show potent binding activity to the NK ₂ receptor.

* ·

288 990 9 9 9 9 9 0 0 9 9 9 9 9 9 9 0

499 9 44 99

Industrial Applicability:

The compound of the present invention has excellent NK ₂ - selective antagonistic action and low toxicity and can therefore be useful as a drug. For example, it may be useful as a preventive and therapeutic agent for diseases of the central nervous system, such as anxiety, depression, psychosis, and schizophrenia; neurodegenerative diseases such as AIDS dementia, Alzheimer's senile dementia, Alzeimer disease, Down's syndrome, demyelinating diseases, amyotrophic lateral sclerosis, neuropathy, peripheral neuropathy and neuralgia; respiratory diseases such as chronic obstructive pulmonary disease, bronchitis, pneumonia, bronchoconstriction, asthma and cough; inflammatory diseases such as inflammatory bowel disease, psoriasis, fibrosis, bone and joint inflammation, degenerative arthritis and rheumatoid arthritis; eczema; allergic diseases such as runny nose; hypersensitivity diseases such as hypersensitivity to grapevines; ophthalmological diseases such as conjunctivitis, conjunctivitis, spring catarrh, destruction of the blood-eye barrier caused by various inflammatory eye diseases, increased intraocular pressure and miosis; skin diseases such as contact dermatitis, atopic dermatitis, urticaria and other eczematic dermatitis; dependencies such as alcohol dependence; somatic diseases caused by stress; involved in reflex dystrophy, such as shoulder-hand syndrome; dysthymia; undesirable immune responses, such as transplant defensive reactions, immunopotentiation-related diseases such as systemic lupus erythematosus or immunosuppression; digestive diseases such as diseases caused by abnormalities of the nerves regulating organs, colitis, ulcerative colitis and Crohn's disease; vomiting, such as vomiting caused by adverse effects of X-rays and chemotherapy, poisons, toxins, pregnancy, vestibular disorders, postoperative disease, gastrointestinal occlusion, decreased gastrointestinal activity, physical pain, migraine, increased intracranial pressure, decreased intracranial pressure or various drugs; bladder diseases such as cystitis and urinary incontinence; eosinophilia caused by collagen disease, scleroderma or Fasciola hepatica infection; diseases caused by abnormal blood flow due to vascular enlargement or narrowing of blood vessels, such as angina, migraine and Reynauds disease; and pain or pain signals such as migraine, headache and toothache; and temporary sleep breathing.

Claims (35)

PATENT CLAIMS 1. A compound of formula I: 289 q> In ZooO ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 ·· · · · N-GR ² ^ N — A — B — R ¹ or R ¹ 0) where R ¹ represents a C 3 -C 7 cycloalkyl group, a three to seven membered saturated heterocyclic group, a C 3 -C 7 cycloalkyl group substituted with 1 to 3 substituents selected from group A and B substituents, or a three to seven membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents, R ² represents an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from group A substituents, or a heteroaryl group substituted with 1 to 3 substituents selected from group A substituents, A represents a methylene group, a carbonyl group or a sulfonyl group, B represents a single bond, a C1-C4 alkylene group or a C2-C4 alkenylene group, D represents an oxygen or sulfur atom, G represents a C 1 -C 4 alkylene group or a C 2 -C 4 alkenylene group, L is -N (R ³ ) - or -C (R ⁴ ) (R ⁵ ) wherein R ³ represents an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from group A substituents, or a heteroaryl group substituted with 1 to 3 substituents selected from group A substituents, R ⁴ represents a hydrogen atom, an aryl group, a heteroaryl group, an aryl group substituted with 1 to 3 substituents selected from the group A substituents, a heteroaryl group substituted with 1 to 3 substituents selected from the group consisting of: Φ 290 φ φ φ φ φ φ φ φ φ φ φ φ · φ φ ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze ze a group A substituent and a group B substituent, or a three to seven membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents, R ⁵ represents lower alkyl, amino, acylamino, lower acylaminoalkyl, acylamino in which the nitrogen atom is substituted by lower alkyl, hydroxy, lower hydroxyalkyl in which the oxygen atom is optionally substituted by arylalkyl, lower alkoxy or - CO-R ⁶ wherein R ⁶ is lower alkyl, lower alkoxy, aminozbytek, aryl substituted by 1 to 3 substituents selected from substituent group A or a heteroaryl group substituted with 1 to 3 substituents selected from substituent group A or R ⁴ and R ⁵ together with the carbon atom to which they are attached form a C 5 -C 8 cycloalkane ring, a C 5 -C 8 cycloalkene ring, or a five to eight membered saturated heterocyclic ring; either of these rings may be optionally substituted with 1 or 2 substituents selected from group A substituents and group B substituents and may optionally be fused with an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents, or a 1-substituted heteroaryl ring up to 3 substituents selected from substituents of group A, R ⁷ represents a lower alkyl group, Z represents two hydrogen atoms or an oxygen atom, n represents 0,1 or 2; or a pharmaceutically acceptable salt, ester or other derivative thereof. Group A substituents: halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups, lower alkoxycarbonyl groups, carboxyl groups, hydroxy groups, lower aliphatic acyl groups, lower aliphatic acylamino groups, amino and cyano groups, Group B substituents: oxo and thiol groups; and as substituents on the nitrogen atom, lower alkyl, aryl and alkylaryl groups, which may be optionally 291 • 9 9 4 * 4 4 44 4 9 4 9 9444 substituted with a substituent selected from the substituents of group A, lower alkanesulfonyl and acyl. A compound according to claim 1, wherein R ¹ is a C ₃ -C ₆ cycloalkyl group, a five or six membered saturated heterocyclic group, a C ₃ -C ₆ cycloalkyl group substituted with 1 to 3 substituents selected from substituents of group A and substituents of group B, or five or a six-membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents; or a pharmaceutically acceptable salt, ester or other derivative thereof. The compound of claim 1, wherein R ¹ is a C ₃ -C 6 cycloalkyl group, a five or six membered saturated heterocyclic group, or a five or six membered saturated heterocyclic group substituted with 1 or 2 substituents selected from group A substituents and group B substituents; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 3, wherein R ² is an aryl group, or an aryl group substituted with 1 to 3 substituents selected from substituents of group A; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 3, wherein R ² is an aryl group substituted with 1 to 3 halogen atoms; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 5, wherein A is a methylene or carbonyl group; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 5, wherein A is a carbonyl group and Z is two hydrogen atoms, or wherein A is a methylene group and Z is an oxygen atom; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 5, wherein A is a carbonyl group; or a pharmaceutically acceptable salt, ester or other derivative thereof. • 9 • · OOO · 9999 · 9 · · 9 · 9 9 ZZZÁ. 9 · «999 9 9 l · * · * · 9 99 9« A compound according to any one of claims 1 to 8, wherein B is a single bond; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 9, wherein D is an oxygen atom; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 10, wherein G is a C 1 -C 4 alkylene group; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 10, wherein G is a C 2 -C 3 alkylene group; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 12, wherein R ³ is a heteroaryl group, or an aryl group substituted with 1 to 3 substituents selected from substituents of group A; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 13, wherein L is a group of the formula -C (R ⁴ ) (R ⁵ ) -; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 13, wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a C 5 -C 8 cycloalkane ring, a C 5 -C 8 cycloalkene ring, or a five to eight membered saturated heterocyclic ring; either of these rings may be optionally substituted with 1 or 2 substituents selected from group A substituents and group B substituents and may optionally be fused with an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents, or a 1-substituted heteroaryl ring up to 3 substituents selected from substituents of group A; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 13, wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a C 5 -C 6 cycloalkane ring, a C 5 -C 6 cycloalkene ring, or a five or six membered saturated heterocyclic ring; either of these rings may be optionally substituted with 1 or 2 substituents selected from substituents of group A and 293 9 9 9 9 9,9999 • · 999 · 9 9 9 9 9 9 9 9 9 9 9 9 9 • »9 100 9 · · «· 9 9 9 9 * 9 9 9 9 9 9 9 99 99 substituents of group B and may optionally be fused with an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents or a heteroaryl ring substituted with 1 to 3 substituents selected from group A substituents; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 13, wherein R ⁴ and R ⁵ together with the carbon atom to which they are attached form a cyclopentane ring, a cyclopentene ring, a tetrahydrothiophene ring, a tetrahydrothiophenesulfoxide ring, a tetrahydrothiophenesulfone ring or a piperidine ring; either of these rings may be optionally substituted with 1 or 2 substituents selected from group A substituents and group B substituents and may optionally be fused with an aryl ring, a heteroaryl ring, an aryl ring substituted with 1 to 3 substituents selected from group A substituents, or a 1-substituted heteroaryl ring or 3 substituents selected from substituents of group A; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 17, wherein Z is two hydrogen atoms; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 18, wherein n is 0 or 1; or a pharmaceutically acceptable salt, ester or other derivative thereof. A compound according to any one of claims 1 to 18, wherein n is 1; or a pharmaceutically acceptable salt, ester or other derivative thereof. The compound of claim 1, or a pharmaceutically acceptable salt, ester or other derivative thereof, wherein the compound is one of the following: 1- {2 - ((2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 '-piperidine] - (2') - oxide, 1- {2 - ((2 H) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophene-1 (377), 4'-piperidine ] - (25) -oxide, 1- {2 - ((2 H) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (37 L), 4 '-piperidine] - (2, S) -oxide, 294 · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ΦΦΦΦ · {φ l •φ •----- 1- (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2? -Oxide) , 1- {2 - ((2 R) - (3,4-difluorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 '-piperidine] - (2S) -oxide, 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4 ' -piperidine] - (2S-oxide, 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [benzo [c] thiophen-1 (3 H), 4'-piperidine] - (2 S) -oxide, 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl ] ethyl} spiro [benzo [c] thiophene-1 (3 //) 4 ^5-piperidin] - (2o ⁷⁾ -oxide, 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indan-1,4'-piperidine ], 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [((2, S) -hydroxy) indane-1,4 ' -piperidine], 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl] spiro [((2 R) -hydroxy) indan-1, 4'-piperidine], 1- {2 - [(2 H) - (3,4-dichlorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 H) -hydroxy) indan-1] 4'-piperidin], 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indane -1,4'-piperidine], 1- {2 - [(2 R) - (3,4-Difluorophenyl) -4- (cyclobutanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 R) -hydroxy) indane-1,4'-piperidine ], 1- {2 - [(2 R) - (3,4-Difluorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} spiro [((2 S) -hydroxy) indan-1, 4'-piperidine], 1- {2 - [(2 R) - (3,4-difluorophenyl) -4- (cyclohexanecarbonyl) morpholin-2-yl] ethyl] spiro [((2 R) -hydroxy) indane- 1,4'-piperidine], 1- {2 - [(2 R) - (3,4-dichlorophenyl) -4- (cyclopropanecarbonyl) morpholin-2-yl] ethyl} -4-phenylpiperidine-4-carboxamide, and 1- {2 - [(2R) - (3,4-dichlorophenyl) -4- (cyclopentanecarbonyl) morpholin-2-yl] ethyl} -4- (2-pyridyl) piperidine-4-carboxamide. «9 9 · · 9 9 9 9 9 • 9 99 295 99 9 9 9 9 9999 9 9 99 9 • 9 9 9 9 9 A pharmaceutical composition comprising, as an active ingredient, a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. A preventive or therapeutic agent for asthma and / or bronchitis, characterized in that it contains as active ingredient a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. A preventive or therapeutic agent for rhinitis comprising as an active ingredient a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. A preventive or therapeutic agent against allergic disease comprising as an active ingredient a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. A preventive or therapeutic preparation for urinary incontinence, characterized in that it contains as active ingredient a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. Use of a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof, for the manufacture of a pharmaceutical composition. Use of a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof, for the manufacture of a preventive or therapeutic composition against asthma and / or bronchitis. The use of a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof, for the manufacture of a preventive or therapeutic agent against rhinitis. 296 • φ · · • • • • • • • φ φ φ · · · · · · φ φ φ φ φ φ Use of a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof, for the manufacture of a preventive or therapeutic agent against allergic disease. Use of a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof, for the manufacture of a preventive or therapeutic preparation for urinary incontinence. A method for preventing or treating asthma and / or bronchitis, comprising administering a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. A method of preventing or treating a cold, comprising administering a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester or other derivative thereof. 34. A method of preventing or treating an allergic disease comprising administering a compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt, ester, or other derivative thereof. A method of preventing or treating urinary incontinence, comprising administering a compound of any one of claims 1 to 21, a pharmaceutically acceptable salt, ester, or other derivative thereof.