CY1122679T1 - TETRACYCLINE SALTS - Google Patents

TETRACYCLINE SALTS

Info

Publication number
CY1122679T1
CY1122679T1 CY20201100166T CY201100166T CY1122679T1 CY 1122679 T1 CY1122679 T1 CY 1122679T1 CY 20201100166 T CY20201100166 T CY 20201100166T CY 201100166 T CY201100166 T CY 201100166T CY 1122679 T1 CY1122679 T1 CY 1122679T1
Authority
CY
Cyprus
Prior art keywords
tetracycline
salt
oxalate
maleate
lymecycline
Prior art date
Application number
CY20201100166T
Other languages
Greek (el)
Inventor
Luis Sobral
Livia SANTANA DE ARRUDA
Margarida FIGUEIREDO
Rafael ANTUNES
Ana Paula FILIPE
Original Assignee
Hovione Scientia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Scientia Limited filed Critical Hovione Scientia Limited
Publication of CY1122679T1 publication Critical patent/CY1122679T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs

Abstract

Παρέχεται ένα άλας τετρακυκλίνης, το οποίο περιλαμβάνει μια τετρακυκλίνη και ένα οργανικό οξύ, όπου το οργανικό οξύ είναι το οξαλικό οξύ ή το μηλεϊνικό οξύ. Η τετρακυκλίνη είναι κατά προτίμηση δοξυκυκλίνη, μινοκυκλίνη, σανκυκλίνη, λυμεκυκλίνη, τετρακυκλίνη ή δεμεκλοκυκλίνη, και τα προτιμώμενα άλατα περιλαμβάνουν μηλεϊνική οξυκυκλίνη, οξαλική μινοκυκλίνη, οξαλική τετρακυκλίνη, μηλεϊνική δεμεκλοκυκλίνη, οξαλική δεμεκλοκυκλίνη, μηλεϊνική σανκυκλίνη, μηλεϊνική λυμεκυκλίνη ή οξαλική λυμεκυκλίνη. Επίσης παρέχεται σύμφωνα με την εφεύρεση ένα φαρμακευτικό σκεύασμα, το οποίο περιλαμβάνει ένα άλας τετρακυκλίνης, καθώς και ένα ιατροτεχνολογικό προϊόν, το οποίο έχει επιστρωμένο επάνω του ένα άλας ή φαρμακευτικό σκεύασμα σύμφωνα με την εφεύρεση. Επίσης παρέχονται ένα άλας της εφεύρεσης ή ένα σκεύασμα της εφεύρεσης για χρήση ως φάρμακα, ιδιαίτερα για χρήση στην αντιμετώπιση ή την πρόληψη μιας φλεγμονής και/ή μιας λοίμωξης. Παρέχεται επίσης μια μέθοδος για την παρασκευή ενός άλατος τετρακυκλίνης, η οποία μέθοδος περιλαμβάνει την αντίδραση μιας βάσης τετρακυκλίνης με μια περίσσεια ενός οργανικού οξέος σε έναν διαλύτη.A tetracycline salt is provided, which comprises a tetracycline and an organic acid, wherein the organic acid is oxalic acid or maleic acid. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate or lymecycline oxalate. Also provided according to the invention is a pharmaceutical formulation, which includes a salt of tetracycline, as well as a medical technology product, which has a salt or pharmaceutical formulation according to the invention coated on it. Also provided is a salt of the invention or a formulation of the invention for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection. Also provided is a method for preparing a tetracycline salt, which method comprises reacting a tetracycline base with an excess of an organic acid in a solvent.

CY20201100166T 2015-11-24 2020-02-21 TETRACYCLINE SALTS CY1122679T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT108978A PT108978B (en) 2015-11-24 2015-11-24 TETRACYCLINE SALTS
PCT/GB2016/053695 WO2017089809A1 (en) 2015-11-24 2016-11-24 Salts of tetracyclines

Publications (1)

Publication Number Publication Date
CY1122679T1 true CY1122679T1 (en) 2021-03-12

Family

ID=57482470

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100166T CY1122679T1 (en) 2015-11-24 2020-02-21 TETRACYCLINE SALTS

Country Status (14)

Country Link
US (1) US10543298B2 (en)
EP (1) EP3365323B1 (en)
JP (1) JP6883578B2 (en)
CN (1) CN108602761B (en)
AU (1) AU2016358448B2 (en)
CA (1) CA3005806A1 (en)
CY (1) CY1122679T1 (en)
DK (1) DK3365323T3 (en)
ES (1) ES2775702T3 (en)
HU (1) HUE048839T2 (en)
IL (1) IL259572B (en)
PL (1) PL3365323T3 (en)
PT (1) PT108978B (en)
WO (1) WO2017089809A1 (en)

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IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
MX359879B (en) 2009-10-02 2018-10-12 Foamix Pharmaceuticals Ltd Topical tetracycline compositions.
PT108978B (en) 2015-11-24 2020-03-09 Hovione Farm S A TETRACYCLINE SALTS
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
AU2019248350B2 (en) * 2018-04-06 2023-07-27 Almirall, Llc Process for making sarecycline hydrochloride
CN110156624B (en) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 Method for synthesizing minocycline and derivatives thereof

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Also Published As

Publication number Publication date
CA3005806A1 (en) 2017-06-01
CN108602761B (en) 2021-11-02
IL259572A (en) 2018-07-31
US10543298B2 (en) 2020-01-28
HUE048839T2 (en) 2020-08-28
ES2775702T3 (en) 2020-07-28
PT108978B (en) 2020-03-09
AU2016358448B2 (en) 2020-07-16
JP6883578B2 (en) 2021-06-09
DK3365323T3 (en) 2020-04-06
JP2019503993A (en) 2019-02-14
PL3365323T3 (en) 2020-07-13
IL259572B (en) 2020-05-31
EP3365323A1 (en) 2018-08-29
CN108602761A (en) 2018-09-28
WO2017089809A1 (en) 2017-06-01
US20180344903A1 (en) 2018-12-06
EP3365323B1 (en) 2020-01-01
AU2016358448A1 (en) 2018-06-28
PT108978A (en) 2017-05-24

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