CY1117377T1 - COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS - Google Patents

COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS

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Publication number
CY1117377T1
CY1117377T1 CY20161100178T CY161100178T CY1117377T1 CY 1117377 T1 CY1117377 T1 CY 1117377T1 CY 20161100178 T CY20161100178 T CY 20161100178T CY 161100178 T CY161100178 T CY 161100178T CY 1117377 T1 CY1117377 T1 CY 1117377T1
Authority
CY
Cyprus
Prior art keywords
pentostatin
production
heterocyclic
compositions
pentostatinine
Prior art date
Application number
CY20161100178T
Other languages
Greek (el)
Inventor
Pasit Phiasivongsa
Sanjeev Redkar
Original Assignee
Hospira UK Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04784157.2A external-priority patent/EP1670809B1/en
Application filed by Hospira UK Limited filed Critical Hospira UK Limited
Publication of CY1117377T1 publication Critical patent/CY1117377T1/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Εδώ παρέχονται μέθοδοι και συνθέσεις για την αποτελεσματική παρασκευή και παραγωγή πεντοστατίνης. Επίσης παρέχονται νέες πρόδρομες ενώσεις της πεντοστατίνης, ανάλογα και παράγωγα πεντοστατίνης. Σε μια άποψη της εφεύρεσης, παρέχεται μια μέθοδος για ολική χημική σύνθεση της πεντοστατίνης μέσω μιας οδού μεγέθυνσης ετεροκυκλικού δακτυλίου. Για παράδειγμα, ένα ετεροκυκλικό φαρμακευτικό ενδιάμεσο για φάρμακα όπως η πεντοστατίνη, π.χ., η πρόδρομη ένωση διαζεπινόνη, μπορεί να ληφθεί αποτελεσματικά μέσω μιας μεγέθυνσης δακτυλίου μιας δραστικής ομάδας Ο-C-N σε ένα παράγωγο υποξανθίνης ή 2'-δεοξυ-ινοσίνης. Οι μέθοδοι και συνθέσεις μπορούν επίσης να χρησιμοποιηθούν για την παρασκευή και παραγωγή ετεροκυκλικών ενώσεων διαφορετικών από πεντοστατίνη, ειδικότερα φαρμακευτικώς σημαντικών ετεροκυκλικών ενώσεων.Here are provided methods and compositions for the efficient preparation and production of pentostatin. Also provided are new pentostatin precursors, analogues and pentostatin derivatives. In one aspect of the invention, there is provided a method for total chemical synthesis of pentostatin via a heterocyclic ring magnification pathway. For example, a heterocyclic drug intermediate for drugs such as pentostatin, e.g., the diazepinone precursor, can be effectively obtained by a ring enlargement of an O-C-N functional group on a hypoxanthine or 2'-deoxyin derivative. The methods and compositions can also be used to prepare and produce heterocyclic compounds other than pentostatin, in particular pharmaceutically important heterocyclic compounds.

CY20161100178T 2003-09-15 2016-03-01 COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS CY1117377T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50323703A 2003-09-15 2003-09-15
EP04784157.2A EP1670809B1 (en) 2003-09-15 2004-09-15 Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives

Publications (1)

Publication Number Publication Date
CY1117377T1 true CY1117377T1 (en) 2017-04-26

Family

ID=58606618

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100178T CY1117377T1 (en) 2003-09-15 2016-03-01 COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS

Country Status (1)

Country Link
CY (1) CY1117377T1 (en)

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