CY1117213T1 - PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE - Google Patents
PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USEInfo
- Publication number
- CY1117213T1 CY1117213T1 CY20161100158T CY161100158T CY1117213T1 CY 1117213 T1 CY1117213 T1 CY 1117213T1 CY 20161100158 T CY20161100158 T CY 20161100158T CY 161100158 T CY161100158 T CY 161100158T CY 1117213 T1 CY1117213 T1 CY 1117213T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sap
- human
- preparation
- modification
- present
- Prior art date
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- Peptides Or Proteins (AREA)
Abstract
Μία άποψη της παρούσας εφεύρεσης σχετίζεται με την απροσδόκητη ανακάλυψη ότι η τροποποίηση μιας δομής γλυκάνης σε ένα ανθρώπινο SAP πολυπεπτίδιο μπορεί να αυξήσει τη βιολογική δραστικότητα του SAP πολυπεπτιδίου σε σχέση με ένα αντίστοιχο δείγμα αγρίου-τύπου SAP απομονωμένου από ανθρώπινο ορό. Η γνωστοποίηση παρέχει τόσο παραλλαγμένα ανθρώπινα SAP πολυπεπτίδια όσο και μεθόδους για παρασκευή τους. Πιο συγκεκριμένα, η παρούσα εφεύρεση παρέχει μεθόδους και συνθέσεις για in vitro και in vivo προσθήκη, διαγραφή ή τροποποίηση καταλοίπων σακχάρου για να παραχθούν SAP πολυπεπτίδια, όπως ένα ανθρώπινο SAP πολυπεπτίδιο, τα οποία έχουν ένα επιθυμητό πρότυπο γλυκοζυλίωσης.One aspect of the present invention relates to the unexpected discovery that modification of a glucan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding wild-type SAP sample isolated from human serum. The disclosure provides both variants of human SAP polypeptides and methods for their preparation. More particularly, the present invention provides methods and compositions for in vitro and in vivo addition, deletion or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, which have a desired glycosylation pattern.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21793109A | 2009-06-04 | 2009-06-04 | |
EP10784210.6A EP2438083B1 (en) | 2009-06-04 | 2010-06-04 | Serum amyloid p derivatives and their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117213T1 true CY1117213T1 (en) | 2017-04-05 |
Family
ID=58487093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100158T CY1117213T1 (en) | 2009-06-04 | 2016-02-25 | PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE |
Country Status (1)
Country | Link |
---|---|
CY (1) | CY1117213T1 (en) |
-
2016
- 2016-02-25 CY CY20161100158T patent/CY1117213T1/en unknown
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