CY1117213T1 - PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE - Google Patents

PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE

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Publication number
CY1117213T1
CY1117213T1 CY20161100158T CY161100158T CY1117213T1 CY 1117213 T1 CY1117213 T1 CY 1117213T1 CY 20161100158 T CY20161100158 T CY 20161100158T CY 161100158 T CY161100158 T CY 161100158T CY 1117213 T1 CY1117213 T1 CY 1117213T1
Authority
CY
Cyprus
Prior art keywords
sap
human
preparation
modification
present
Prior art date
Application number
CY20161100158T
Other languages
Greek (el)
Inventor
W Scott Willett
Richard J Caimi
Original Assignee
Promedior Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10784210.6A external-priority patent/EP2438083B1/en
Application filed by Promedior Inc. filed Critical Promedior Inc.
Publication of CY1117213T1 publication Critical patent/CY1117213T1/en

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Abstract

Μία άποψη της παρούσας εφεύρεσης σχετίζεται με την απροσδόκητη ανακάλυψη ότι η τροποποίηση μιας δομής γλυκάνης σε ένα ανθρώπινο SAP πολυπεπτίδιο μπορεί να αυξήσει τη βιολογική δραστικότητα του SAP πολυπεπτιδίου σε σχέση με ένα αντίστοιχο δείγμα αγρίου-τύπου SAP απομονωμένου από ανθρώπινο ορό. Η γνωστοποίηση παρέχει τόσο παραλλαγμένα ανθρώπινα SAP πολυπεπτίδια όσο και μεθόδους για παρασκευή τους. Πιο συγκεκριμένα, η παρούσα εφεύρεση παρέχει μεθόδους και συνθέσεις για in vitro και in vivo προσθήκη, διαγραφή ή τροποποίηση καταλοίπων σακχάρου για να παραχθούν SAP πολυπεπτίδια, όπως ένα ανθρώπινο SAP πολυπεπτίδιο, τα οποία έχουν ένα επιθυμητό πρότυπο γλυκοζυλίωσης.One aspect of the present invention relates to the unexpected discovery that modification of a glucan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding wild-type SAP sample isolated from human serum. The disclosure provides both variants of human SAP polypeptides and methods for their preparation. More particularly, the present invention provides methods and compositions for in vitro and in vivo addition, deletion or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, which have a desired glycosylation pattern.

CY20161100158T 2009-06-04 2016-02-25 PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE CY1117213T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21793109A 2009-06-04 2009-06-04
EP10784210.6A EP2438083B1 (en) 2009-06-04 2010-06-04 Serum amyloid p derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
CY1117213T1 true CY1117213T1 (en) 2017-04-05

Family

ID=58487093

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100158T CY1117213T1 (en) 2009-06-04 2016-02-25 PRODUCTION OF AMOLEOID P RUM AND THEIR PREPARATION AND USE

Country Status (1)

Country Link
CY (1) CY1117213T1 (en)

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