CY1116976T1 - CRYSTALL 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-DIOXO-3,4-DIPPYPYRIMIDIN-1- (2H) -YL) -4-fluoro-3) -HYDROXY-4-METHYLTETRAHODROFURAN-2-YL) METHOXY) (FANOXY) PHOSPHORYL) AMINO) PROPANIC (S) -ISOPROPYL - Google Patents

CRYSTALL 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-DIOXO-3,4-DIPPYPYRIMIDIN-1- (2H) -YL) -4-fluoro-3) -HYDROXY-4-METHYLTETRAHODROFURAN-2-YL) METHOXY) (FANOXY) PHOSPHORYL) AMINO) PROPANIC (S) -ISOPROPYL

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Publication number
CY1116976T1
CY1116976T1 CY20151101059T CY151101059T CY1116976T1 CY 1116976 T1 CY1116976 T1 CY 1116976T1 CY 20151101059 T CY20151101059 T CY 20151101059T CY 151101059 T CY151101059 T CY 151101059T CY 1116976 T1 CY1116976 T1 CY 1116976T1
Authority
CY
Cyprus
Prior art keywords
methyltetrahodrofuran
fanoxy
dippypyrimidin
propanic
crystall
Prior art date
Application number
CY20151101059T
Other languages
Greek (el)
Inventor
Bruce S Ross
Michael Joseph Sofia
Ganapati Reddy Pamulapati
Suguna Rachakonda
Hai-Ren Zhang
Byoung-Kwon Chun
Peiyuan Wang
Original Assignee
Gilead Pharmasset Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/783,680 external-priority patent/US8642756B2/en
Priority claimed from EP11714465.9A external-priority patent/EP2552930B1/en
Application filed by Gilead Pharmasset Llc filed Critical Gilead Pharmasset Llc
Publication of CY1116976T1 publication Critical patent/CY1116976T1/en

Links

Abstract

Αποκαλύπτονται εις το παρόν φωσφοραμιδικά νουκλεοζιδίων και η χρήση αυτών ως παράγοντες για αγωγή ιικών παθήσεων. Αυτές οι ενώσεις είναι αναστολείς της εξαρτώμενης από RNA ιικής αντιγραφής RNA και είναι χρήσιμες ως αναστολείς της πολυμεράσης του NS5B του HCV, ως αναστολείς της αντιγραφής του HCV και για την αγωγή της λοίμωξης από ηπατίτιδα C σε θηλαστικά.The phosphoramid nucleoside nucleosides and their use as agents for the treatment of viral diseases are disclosed herein. These compounds are inhibitors of RNA-dependent viral RNA replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication, and for the treatment of hepatitis C infection in mammals.

CY20151101059T 2010-03-31 2015-11-24 CRYSTALL 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-DIOXO-3,4-DIPPYPYRIMIDIN-1- (2H) -YL) -4-fluoro-3) -HYDROXY-4-METHYLTETRAHODROFURAN-2-YL) METHOXY) (FANOXY) PHOSPHORYL) AMINO) PROPANIC (S) -ISOPROPYL CY1116976T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31951310A 2010-03-31 2010-03-31
US31954810A 2010-03-31 2010-03-31
US12/783,680 US8642756B2 (en) 2009-05-20 2010-05-20 Nucleoside phosphoramidates
EP11714465.9A EP2552930B1 (en) 2010-03-31 2011-03-31 Crystalline (s)-isopropyl 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Publications (1)

Publication Number Publication Date
CY1116976T1 true CY1116976T1 (en) 2017-04-05

Family

ID=58487029

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101059T CY1116976T1 (en) 2010-03-31 2015-11-24 CRYSTALL 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-DIOXO-3,4-DIPPYPYRIMIDIN-1- (2H) -YL) -4-fluoro-3) -HYDROXY-4-METHYLTETRAHODROFURAN-2-YL) METHOXY) (FANOXY) PHOSPHORYL) AMINO) PROPANIC (S) -ISOPROPYL

Country Status (1)

Country Link
CY (1) CY1116976T1 (en)

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