CY1116839T1 - SYSTEM FOR CONFORMATION OF BONE DEVELOPMENT USING THIRD ELECTROMAGNETIC TREATMENT - Google Patents
SYSTEM FOR CONFORMATION OF BONE DEVELOPMENT USING THIRD ELECTROMAGNETIC TREATMENTInfo
- Publication number
- CY1116839T1 CY1116839T1 CY20151100887T CY151100887T CY1116839T1 CY 1116839 T1 CY1116839 T1 CY 1116839T1 CY 20151100887 T CY20151100887 T CY 20151100887T CY 151100887 T CY151100887 T CY 151100887T CY 1116839 T1 CY1116839 T1 CY 1116839T1
- Authority
- CY
- Cyprus
- Prior art keywords
- connective tissue
- cartilage
- growth
- repair
- bone
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
Προβλέπονται συνθέσεις και μέθοδοι για διαμόρφωση της αύξησης, της ανάπτυξης και της επιδιόρθωσης του οστού, του χόνδρου ή άλλου συνδετικού ιστού. Προβλέπονται συσκευές και κυματομορφές ερεθισμάτων για διαμόρφωση διαφορικά της συμπεριφοράς των οσετοβλαστών, των χονδροκυττάρων και άλλων κυττάρων συνδετικού ιστού για προαγωγή του πολλαπλασιασμού, της διαφοροποίησης, του σχηματισμού μήτρας (θεμέλιας ουσίας) ή της μεταλλοποίησης για εφαρμογές in vitro ή in vivo. Μπορεί να χρησιμοποιηθεί διέγερση των κυττάρων με συνεχή τρόπο και με τον τρόπο ριπής παλμών με σήματα ισορροπημένου φορτίου. Η αύξηση των οστών, του χόνδρου και άλλου συνδετικού ιστού διεγείρεται εν μέρει από την αποδέσμευση μονοξειδίου του αζώτου μέσω ηλεκτρικής διέγερσης και μπορεί να διαμορφωθεί μέσω της συν-χορήγησης από δότες NO και αναστολείς συνθάσης NO. Η αύξηση των οστών, του χόνδρου και άλλου συνδετικού ιστού διεγείρεται εν μέρει από την αποδέσμευση της ΒΜΡ-2 και της ΒΜΡ-7 σε απόκριση στην ηλεκτρική διέγερση για προαγωγή διαφοροποίησης των κυττάρων. Οι μέθοδοι και οι συσκευές που περιγράφονται είναι χρήσιμες στην προαγωγή της επιδιόρθωσης καταγμάτων των οστών, της επιδιόρθωσης χόνδρου και συνδετικού ιστού, καθώς επίσης και για την κατασκευή ιστών για μεταμόσχευση.Compositions and methods are provided to modulate the growth, development and repair of bone, cartilage or other connective tissue. Apparatus and stimulus waveforms are provided to modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation (maturation) or in vitro or in vitro applications. Stimulation of cells can be used in a continuous and pulsating fashion with balanced load signals. The growth of bone, cartilage and other connective tissue is partly stimulated by the release of nitric oxide by electrical stimulation and may be modulated by co-administration of NO donors and NO synthase inhibitors. The growth of bones, cartilage and other connective tissue is partly stimulated by the release of BMP-2 and BMP-7 in response to electrical stimulation to promote cell differentiation. The methods and apparatus described are useful in promoting bone fracture repair, cartilage and connective tissue repair, as well as in the manufacture of transplanted tissues.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68743005A | 2005-06-03 | 2005-06-03 | |
| US69349005A | 2005-06-23 | 2005-06-23 | |
| US79012806A | 2006-04-07 | 2006-04-07 | |
| EP06771526.8A EP1888162B1 (en) | 2005-06-03 | 2006-05-30 | System for modulating osteochondral development using pulsed electromagnetic field therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116839T1 true CY1116839T1 (en) | 2017-03-15 |
Family
ID=58459764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100887T CY1116839T1 (en) | 2005-06-03 | 2015-10-06 | SYSTEM FOR CONFORMATION OF BONE DEVELOPMENT USING THIRD ELECTROMAGNETIC TREATMENT |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1116839T1 (en) |
-
2015
- 2015-10-06 CY CY20151100887T patent/CY1116839T1/en unknown
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