CY1116637T1 - IGF-1 Fusion Polypeptides And Their Therapeutic Uses - Google Patents

IGF-1 Fusion Polypeptides And Their Therapeutic Uses

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Publication number
CY1116637T1
CY1116637T1 CY20151100727T CY151100727T CY1116637T1 CY 1116637 T1 CY1116637 T1 CY 1116637T1 CY 20151100727 T CY20151100727 T CY 20151100727T CY 151100727 T CY151100727 T CY 151100727T CY 1116637 T1 CY1116637 T1 CY 1116637T1
Authority
CY
Cyprus
Prior art keywords
igf1
igf
component
fusion polypeptides
therapeutic uses
Prior art date
Application number
CY20151100727T
Other languages
Greek (el)
Inventor
David J Glass
George D Yancopoulos
Thomas J Daly
Nicholas J Papadopoulos
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10007017.6A external-priority patent/EP2241575B1/en
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY1116637T1 publication Critical patent/CY1116637T1/en

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Abstract

Πρωτεΐνη σύντηξης που περιλαμβάνει τουλάχιστον ένα IGF1 παραλλακτικό συστατικό και ένα συστατικό σύντηξης (F) και προαιρετικά μια αλληλουχία σήμα που δεικνύει βελτιωμένη σταθερότητα σε σχέση προς το φυσικό IGF1 ή IGF2 πολυπεπτίδιο. Το συστατικό σύντηξης (F) μπορεί να είναι ένα πολυμεριστικό συστατικό, συνδετήρας στοχοθέτησης ή άλλη δραστική ή θεραπευτική ένωση. Παραλλαγές IGF1 δείχθηκαν να έχουν βελτιωμένη ικανότητα να διεγείρουν υπερτροφία σκελετικού μυός σε σχέση προς φυσικό IGF1.A fusion protein comprising at least one IGF1 variant and a fusion component (F) and optionally a signal sequence indicating improved stability over the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a polymerizing component, targeting ligand or other active or therapeutic compound. IGF1 variants have been shown to have an enhanced ability to stimulate skeletal muscle hypertrophy relative to native IGF1.

CY20151100727T 2005-01-07 2015-08-20 IGF-1 Fusion Polypeptides And Their Therapeutic Uses CY1116637T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64222905A 2005-01-07 2005-01-07
US65658305A 2005-02-25 2005-02-25
EP10007017.6A EP2241575B1 (en) 2005-01-07 2006-01-06 IGF-1 fusion polypeptides and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
CY1116637T1 true CY1116637T1 (en) 2017-03-15

Family

ID=58448902

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111100980T CY1113656T1 (en) 2005-01-07 2011-10-14 IGF-1 Fusion Polypeptides And Their Therapeutic Uses
CY20151100727T CY1116637T1 (en) 2005-01-07 2015-08-20 IGF-1 Fusion Polypeptides And Their Therapeutic Uses

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20111100980T CY1113656T1 (en) 2005-01-07 2011-10-14 IGF-1 Fusion Polypeptides And Their Therapeutic Uses

Country Status (1)

Country Link
CY (2) CY1113656T1 (en)

Also Published As

Publication number Publication date
CY1113656T1 (en) 2016-06-22

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