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Priority claimed from EP10707783.6Aexternal-prioritypatent/EP2403605B1/en
Application filed by President And Fellows Of Harvard CollegefiledCriticalPresident And Fellows Of Harvard College
Publication of CY1116543T1publicationCriticalpatent/CY1116543T1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
Εκπονείται μέθοδος μείωσης συμπτώματος κλινικής διαταραχής που χαρακτηρίζεται από παρεκκλίνουσα αύξηση κυκλοφορούντος aP2 χορηγώντας σε υποκείμενο αναστολέα εκκρινόμενου aP2, έκκρισης aP2, ή παράγοντα παρεμπόδισης aP2 ορού. Για παράδειγμα, δυσανεξία γλυκόζης μειώνεται μετά από χορήγηση τέτοιου αναστολέα ή παράγοντα. Παραδειγματικές συνθέσεις αναστέλλουν κυτταρική έκκριση aP2 ή δεσμεύονται με aP2 στην κυκλοφορία, μειώνοντας κατ' αυτόν τον τρόπο το επίπεδο ή την δραστικότητα του aP2 σε αίμα ή ορό.A method of reducing the clinical disorder symptom characterized by aberrant circulating aP2 secretion is administered by administering a subject secreted aP2 inhibitor, aP2 secretion, or serum aP2 inhibitor. For example, glucose intolerance is reduced after administration of such an inhibitor or agent. Exemplary compositions inhibit aP2 cellular secretion or bind to aP2 in the circulation, thereby reducing the level or activity of aP2 in blood or serum.
CY20151100659T2009-03-052015-07-29
COMPOSITIONS INCLUDING aP2-SPECIAL ANTI-ORDER FOR THIS USE IN TREATMENT OF DIABETES, DYSANEXIA GLYPYKOSYOS
CY1116543T1
(en)
Compositions comprising an aP2-specific antibody or a fragment thereof for use in treating diabetes, glucose intolerance or obesity-induced insulin resistance
Activin-actrii antagonists, uses thereof for treating bone diseases and other disorders, and method for monitoring the effectiveness of treating or preventing a bone disease and other disorders