CY1116523T1 - PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE - Google Patents

PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE

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Publication number
CY1116523T1
CY1116523T1 CY20151100413T CY151100413T CY1116523T1 CY 1116523 T1 CY1116523 T1 CY 1116523T1 CY 20151100413 T CY20151100413 T CY 20151100413T CY 151100413 T CY151100413 T CY 151100413T CY 1116523 T1 CY1116523 T1 CY 1116523T1
Authority
CY
Cyprus
Prior art keywords
novel
compounds
phosphone
selection
manufacture
Prior art date
Application number
CY20151100413T
Other languages
Greek (el)
Inventor
Mark W Becker
Harlan H Chapman
Tomas Cihlar
Eugene J Eisenberg
Gong-Xin He
Michael R Kernan
William A Lee
Ernest J Prisbe
John C Rohloff
Mark L Sparacino
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01961695.2A external-priority patent/EP1301519B2/en
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CY1116523T1 publication Critical patent/CY1116523T1/en

Links

Abstract

Παρέχεται νέα μέθοδος για συστηματική εξέταση προφαρμάκων αναλόγων μεθοξυφωσφονικού νουκλεοτιδίου για να πιστοποιούνται προφάρμακα που στοχεύουν εκλεκτικώς επιθυμητούς ιστούς με αντι-ιική ή κατά του όγκου δραστικότητα. Η μέθοδος αυτή έχει οδηγήσει στην πιστοποίηση νέων δεικτών εστέρα-αμιδικών του ΡΜΡΑ για ρετροϊική ή ηπατοτροφικής-dna μόλυνσης θεραπεία, συμπεριλαμβανομένων ενώσεων της σύνταξης (5a) που έχουν ομάδες υποκαταστάτη όπως ορίζεται στο παρόν. Παρέχονται συνθέσεις αυτών των νέων ενώσεων σε φαρμακευτικώς αποδεκτά έκδοχα και χρήση αυτών στην θεραπεία και προφύλαξη. Επίσης, παρέχεται βελτιωμένη μέθοδος για την χρήση αλκοξειδίου μαγνησίου για την παρασκευή υλικών έναρξης και ενώσεων για χρήση στο παρόν.A novel method is provided for screening prodrug analogs of methoxyphosphonate nucleotide to identify prodrugs that target selectively desirable tissues with antiviral or antitumor activity. This method has led to the identification of novel PMPA ester-amide markers for retroviral or hepatotrophic-dna infection treatment, including compounds of the structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.

CY20151100413T 2000-07-21 2015-05-11 PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE CY1116523T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22002100A 2000-07-21 2000-07-21
EP01961695.2A EP1301519B2 (en) 2000-07-21 2001-07-20 Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same

Publications (1)

Publication Number Publication Date
CY1116523T1 true CY1116523T1 (en) 2016-12-14

Family

ID=58464055

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100413T CY1116523T1 (en) 2000-07-21 2015-05-11 PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE

Country Status (1)

Country Link
CY (1) CY1116523T1 (en)

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