CY1116022T1 - Monoclonal antibodies that block TON B7H6 and their uses - Google Patents

Monoclonal antibodies that block TON B7H6 and their uses

Info

Publication number
CY1116022T1
CY1116022T1 CY20141101046T CY141101046T CY1116022T1 CY 1116022 T1 CY1116022 T1 CY 1116022T1 CY 20141101046 T CY20141101046 T CY 20141101046T CY 141101046 T CY141101046 T CY 141101046T CY 1116022 T1 CY1116022 T1 CY 1116022T1
Authority
CY
Cyprus
Prior art keywords
monoclonal antibodies
antibodies
antibody
disclosed
expressing cells
Prior art date
Application number
CY20141101046T
Other languages
Greek (el)
Inventor
Michel Pierres
Eric Vivier
Myriam Baratin
Original Assignee
Institut National De La Sante Et De La Recherche Medicale (Inserm)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10813116.0A external-priority patent/EP2510011B2/en
Application filed by Institut National De La Sante Et De La Recherche Medicale (Inserm) filed Critical Institut National De La Sante Et De La Recherche Medicale (Inserm)
Publication of CY1116022T1 publication Critical patent/CY1116022T1/en

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Αποκαλύπτονται μονοκλωνικά αντισώματα τα οποία δεσμεύονται επιλεκτικά στον Β7Η6, μέλος της Β7-οικογένειας, συμπεριλαμβανομένων αντισωμάτων ικανών να αναστείλουν την αλληλεπίδραση του Β7Η6 με ΝΚp30. Επίσης αποκαλύπτονται συζεύγματα αντισώματος αντι-Β7Η6 φαρμακευτικής ουσίας που περιλαμβάνουν μονοκλωνικά αντίσωμα αντι-Β7Η6 συζευγμένο σε θεραπευτικό παράγοντα. Τα αντισώματα αντι-Β7Η6 και τα συζεύγματα αντισώματος-φαρμακευτικής ουσίας είναι χρήσιμα σε μεθόδους για άσκηση θεραπευτικών επιδράσεων έναντι κυττάρων εκφραζόντων τον Β7Η6, καθώς και σε διαγνωστικές μεθόδους για την ανίχνευση του Β7Η6 ή κυττάρων εκφραζόντων τον Β7Η6.Monoclonal antibodies that specifically bind to B7H6, a member of the B7 family, are disclosed, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody drug conjugates comprising anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. Anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6 expressing cells, as well as in diagnostic methods for detecting B7H6 or B7 expressing cells.

CY20141101046T 2009-12-09 2014-12-16 Monoclonal antibodies that block TON B7H6 and their uses CY1116022T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28501809A 2009-12-09 2009-12-09
EP10813116.0A EP2510011B2 (en) 2009-12-09 2010-12-08 Monoclonal antibodies that bind b7h6 and uses thereof

Publications (1)

Publication Number Publication Date
CY1116022T1 true CY1116022T1 (en) 2017-01-25

Family

ID=58457241

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141101046T CY1116022T1 (en) 2009-12-09 2014-12-16 Monoclonal antibodies that block TON B7H6 and their uses

Country Status (1)

Country Link
CY (1) CY1116022T1 (en)

Similar Documents

Publication Publication Date Title
IN2012DN04908A (en)
CY1121546T1 (en) HUMANIZED ANTIBODIES AGAINST LIV-1 AND THE USE OF THEMSELVES IN CANCER TREATMENT
CY1122210T1 (en) HUMAN ANTI-SOD1 ANTIBODIES
CY1121818T1 (en) PYRROLOBENZODIAZEPINES AND THEIR CONJUGATIONS
CY1122155T1 (en) CONJUGATION COMPOUNDS INCLUDING MODIFIED CYSTEINE ANTIBODIES
UA111341C2 (en) Conjugates of amatoxin with improved linkers
CY1122091T1 (en) CD37-BINDING MOLECULES AND IMMUNOCONJUGUES THEREOF
CY1121860T1 (en) SYNTHETIC INTERMEDIATES FOR THE PREPARATION OF OLIGOSACCHARIDE-PROTEIN CONJUGATES
EA201070463A1 (en) COMBINED THERAPY WITH THE USE OF ANTIBODY AND MEDICINE CONJUGATES
CY1117236T1 (en) MONOCLONIC ANTIBODIES AGAINST GLYPICAN-3
CY1118668T1 (en) Immunoconjugates Against Folic Acid Receptors 1 and their uses
CY1116488T1 (en) ANTI-PERPETIN antibodies
CY1119209T1 (en) BRUTON TYROSINE KINASE INHIBITORS
TR201900176T4 (en) Anti-TROP2 antibody-drug conjugate.
NZ703581A (en) Anti-cd70 antibody drug conjugates
CY1118933T1 (en) ANTI-CXCR1 COMPOSITIONS AND METHODS
PH12015500977A1 (en) Anti-il-13 receptor alpha 2 antibodies and antibody-drug conjugates
MX2016003744A (en) Tem8 antibodies and their use.
NO20083891L (en) Anti-5T4 antibodies and uses thereof
NZ610239A (en) Cross-linkers and their uses
MY170719A (en) Antibody-drug conjugates
NZ712035A (en) Pyrrolobenzodiazepines and conjugates thereof
PH12016501995A1 (en) Tubulysin derivatives
EA200800952A1 (en) CONJUGATES ANTIBODY-DRUG AND METHODS OF APPLICATION
MA35928B1 (en) Combined antibody therapy for human csf -1r and its uses