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Priority claimed from EP10180484.7Aexternal-prioritypatent/EP2311432B1/en
Application filed by Dyax CorporationfiledCriticalDyax Corporation
Publication of CY1115911T1publicationCriticalpatent/CY1115911T1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
Ένα πολυπεπτίδιο που περιλαμβάνει την αλληλουχία αμινοξέων: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu Glu Phe lle Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (αμινοξέα 3-60 της SEQ ID NO:2), όπου το πολυπεπτίδιο καταστέλλει την καλλικρεΐνη (kallikrein).A polypeptide comprising the amino acid sequence: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu Glu Phe lle Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Met Cys Thr Arg Asp (amino acids 3-60 of SEQ ID NO: 2), where the polypeptide suppresses kallikrein.
CY20151100055T2002-06-072015-01-20
MODIFIED KUNITZ AREA POLYPTIPES AND USE IN REDUCING ISCHEMIA OR STARTING A SYSTEMATIC INFECTION INFECTION
CY1115911T1
(en)
Modified kunitz domain polypeptides and their use for reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure