CY1115769T1 - ITCH REGULATORY ACTIVITY REGULATORS - Google Patents

ITCH REGULATORY ACTIVITY REGULATORS

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Publication number
CY1115769T1
CY1115769T1 CY20141100964T CY141100964T CY1115769T1 CY 1115769 T1 CY1115769 T1 CY 1115769T1 CY 20141100964 T CY20141100964 T CY 20141100964T CY 141100964 T CY141100964 T CY 141100964T CY 1115769 T1 CY1115769 T1 CY 1115769T1
Authority
CY
Cyprus
Prior art keywords
itch
relates
regulating
present
stability
Prior art date
Application number
CY20141100964T
Other languages
Greek (el)
Inventor
Gennaro Melino
Mario Rossi
Paolo Salomoni
Original Assignee
Ryboquin Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0501202A external-priority patent/GB0501202D0/en
Priority claimed from EP06703354.8A external-priority patent/EP1838350B1/en
Application filed by Ryboquin Company Limited filed Critical Ryboquin Company Limited
Publication of CY1115769T1 publication Critical patent/CY1115769T1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με την ταυτοποίηση νέων στόχων φαρμάκου για θεραπεία διαταραχών οι οποίες περιλαμβάνουν τον καρκίνο. Ειδικότερα, η παρούσα εφεύρεση σχετίζεται με αναστολή της λιγάσης Ε3 ουβικουιτίνης, Itch, ως ένα μέσο για αντιμετώπιση διαταραχών. Επιπροσθέτως, η παρούσα εφεύρεση σχετίζεται με τη ρύθμιση p63 και p73 σταθερότητας σε κύτταρα. Ειδικότερα, η εφεύρεση σχετίζεται με τη διαμόρφωση της ρύθμισης p63 και p73 σταθερότητας σε κύτταρα μέσω διαμόρφωσης της έκφρασης ή της δραστικότητας της Itch. Επιπλέον, η εφεύρεση σχετίζεται με τη χρήση της Itch ως ένας στόχος για την ανάπτυξη παραγόντων ικανών να ρυθμίζουν p63 ή p73 σταθερότητα και ιδιαίτερα παραγόντων ικανών να ρυθμίζουν την αλληλεπίδραση της Itch και p63 ή p73. Τέτοιοι παράγοντες μπορεί να είναι χρήσιμοι σε θεραπευτικές εφαρμογές περιλαμβάνοντας αντιμετώπιση καρκίνου και ρύθμιση της διαφοροποίησης του δέρματος.The present invention relates to the identification of novel drug targets for the treatment of disorders including cancer. More particularly, the present invention relates to inhibition of the ubiquitin E3 ligase, Itch, as a means of treating disorders. In addition, the present invention relates to the regulation of p63 and p73 cell stability. More particularly, the invention relates to modulating p63 and p73 stability in cells by modulating Itch expression or activity. In addition, the invention relates to the use of Itch as a target for the development of agents capable of regulating p63 or p73 stability, and particularly of agents capable of regulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including treating cancer and regulating skin differentiation.

CY20141100964T 2005-01-20 2014-11-19 ITCH REGULATORY ACTIVITY REGULATORS CY1115769T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0501202A GB0501202D0 (en) 2005-01-20 2005-01-20 Targets for therapy
US64642505A 2005-01-24 2005-01-24
EP06703354.8A EP1838350B1 (en) 2005-01-20 2006-01-19 Modulators of itch ubiquitinase activity

Publications (1)

Publication Number Publication Date
CY1115769T1 true CY1115769T1 (en) 2017-01-25

Family

ID=58457144

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100964T CY1115769T1 (en) 2005-01-20 2014-11-19 ITCH REGULATORY ACTIVITY REGULATORS

Country Status (1)

Country Link
CY (1) CY1115769T1 (en)

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