CY1115769T1 - ITCH REGULATORY ACTIVITY REGULATORS - Google Patents
ITCH REGULATORY ACTIVITY REGULATORSInfo
- Publication number
- CY1115769T1 CY1115769T1 CY20141100964T CY141100964T CY1115769T1 CY 1115769 T1 CY1115769 T1 CY 1115769T1 CY 20141100964 T CY20141100964 T CY 20141100964T CY 141100964 T CY141100964 T CY 141100964T CY 1115769 T1 CY1115769 T1 CY 1115769T1
- Authority
- CY
- Cyprus
- Prior art keywords
- itch
- relates
- regulating
- present
- stability
- Prior art date
Links
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με την ταυτοποίηση νέων στόχων φαρμάκου για θεραπεία διαταραχών οι οποίες περιλαμβάνουν τον καρκίνο. Ειδικότερα, η παρούσα εφεύρεση σχετίζεται με αναστολή της λιγάσης Ε3 ουβικουιτίνης, Itch, ως ένα μέσο για αντιμετώπιση διαταραχών. Επιπροσθέτως, η παρούσα εφεύρεση σχετίζεται με τη ρύθμιση p63 και p73 σταθερότητας σε κύτταρα. Ειδικότερα, η εφεύρεση σχετίζεται με τη διαμόρφωση της ρύθμισης p63 και p73 σταθερότητας σε κύτταρα μέσω διαμόρφωσης της έκφρασης ή της δραστικότητας της Itch. Επιπλέον, η εφεύρεση σχετίζεται με τη χρήση της Itch ως ένας στόχος για την ανάπτυξη παραγόντων ικανών να ρυθμίζουν p63 ή p73 σταθερότητα και ιδιαίτερα παραγόντων ικανών να ρυθμίζουν την αλληλεπίδραση της Itch και p63 ή p73. Τέτοιοι παράγοντες μπορεί να είναι χρήσιμοι σε θεραπευτικές εφαρμογές περιλαμβάνοντας αντιμετώπιση καρκίνου και ρύθμιση της διαφοροποίησης του δέρματος.The present invention relates to the identification of novel drug targets for the treatment of disorders including cancer. More particularly, the present invention relates to inhibition of the ubiquitin E3 ligase, Itch, as a means of treating disorders. In addition, the present invention relates to the regulation of p63 and p73 cell stability. More particularly, the invention relates to modulating p63 and p73 stability in cells by modulating Itch expression or activity. In addition, the invention relates to the use of Itch as a target for the development of agents capable of regulating p63 or p73 stability, and particularly of agents capable of regulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including treating cancer and regulating skin differentiation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0501202A GB0501202D0 (en) | 2005-01-20 | 2005-01-20 | Targets for therapy |
US64642505A | 2005-01-24 | 2005-01-24 | |
EP06703354.8A EP1838350B1 (en) | 2005-01-20 | 2006-01-19 | Modulators of itch ubiquitinase activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115769T1 true CY1115769T1 (en) | 2017-01-25 |
Family
ID=58457144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100964T CY1115769T1 (en) | 2005-01-20 | 2014-11-19 | ITCH REGULATORY ACTIVITY REGULATORS |
Country Status (1)
Country | Link |
---|---|
CY (1) | CY1115769T1 (en) |
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2014
- 2014-11-19 CY CY20141100964T patent/CY1115769T1/en unknown
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