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Priority claimed from EP05818254.4Aexternal-prioritypatent/EP1771482B1/en
Application filed by Genentech, Inc.filedCriticalGenentech, Inc.
Publication of CY1115644T1publicationCriticalpatent/CY1115644T1/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
Αποκαλύπτεται σύνθεση που περιλαμβάνει κύριο είδος αντισώματος αντι-HER2 το οποίο δεσμεύεται με την περιοχή II του HER2, και παραλλαγή αλληλουχίας αμινοξέων αυτού που περιλαμβάνει αμινοτελική προέκταση οδηγού. Αποκαλύπτονται επίσης φαρμακευτικά σκευάσματα που περιλαμβάνουν την σύνθεση, και θεραπευτικές χρήσεις για την σύνθεση.A composition comprising a major species of anti-HER2 antibody that binds to domain II of HER2 is disclosed, and an amino acid sequence variant thereof comprising an N-terminal leader extension. Also disclosed are pharmaceutical preparations comprising the composition, and therapeutic uses for the composition.
ANTIBODY CONJUGATE - ASSOCIATED MOLECULA DIRECTED TO THE PROTEIN TIROSINA QUINASA 7 (PTK 7), PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, NUCLEIC ACID, EXPRESSION FACTOR AND RELATED HUMAN CELL AND ITS USE TO PREPARE A MEDICATION