CY1115263T1 - ALKALINE PHOSPHATEASE TARGETED TO BONE, KITS AND METHODS OF USE - Google Patents

ALKALINE PHOSPHATEASE TARGETED TO BONE, KITS AND METHODS OF USE

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Publication number
CY1115263T1
CY1115263T1 CY20141100418T CY141100418T CY1115263T1 CY 1115263 T1 CY1115263 T1 CY 1115263T1 CY 20141100418 T CY20141100418 T CY 20141100418T CY 141100418 T CY141100418 T CY 141100418T CY 1115263 T1 CY1115263 T1 CY 1115263T1
Authority
CY
Cyprus
Prior art keywords
amino acid
kits
bone
methods
targeted
Prior art date
Application number
CY20141100418T
Other languages
Greek (el)
Inventor
Philippe Crine
Guy Boileau
Thomas P Loisel
Isabelle Lemire
Pierre Leonard
Robert Heft
Hal Landy
Original Assignee
Alexion Pharma Holding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11004496.3A external-priority patent/EP2368999B1/en
Application filed by Alexion Pharma Holding filed Critical Alexion Pharma Holding
Publication of CY1115263T1 publication Critical patent/CY1115263T1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Μία αλκαλική φωσφατάση στοχευμένη στα οστά που περιλαμβάνει ένα πολυπεπτίδιο που έχει τη δομή: Z-sALP-Y-αποστάτης-X-Wn-V, όπου το sALP είναι η εξωκυτταρική περιοχή της αλκαλικής φωσφατάσης• όπου το V είναι απόν ή είναι ή είναι μία ακολουθία αμινοξέων τουλάχιστον ενός αμινοξέος• το Χ είναι απόν ή είναι μία ακολουθία αμινοξέων τουλάχιστον ενός αμινοξέος• Υ είναι απόν ή είναι μία ακολουθία αμινοξέων τουλάχιστον ενός αμινοξέος• Ζ είναι απόν ή είναι μία ακολουθία αμινοξέων τουλάχιστον ενός αμινοξέος• και το Wn είναι ένα πολυασπαρτικό ή ένα πολυγλουταμικό όπου n = 10 ως 16. Κιτ και μέθοδοι χρήσης αυτών.A bone-targeted alkaline phosphatase comprising a polypeptide having the structure: Z-sALP-Y-spacer-X-Wn-V, where sALP is the extracellular domain of alkaline phosphatase; wherein V is absent or is or is one amino acid sequence of at least one amino acid • X is absent or is an amino acid sequence of at least one amino acid • Y is absent or is an amino acid sequence of at least one amino acid • Z is absent or is an amino acid sequence of at least one amino acid or Wn and is Wn; a polyglot k where n = 10 to 16. Kits and methods for their use.

CY20141100418T 2007-05-11 2014-06-11 ALKALINE PHOSPHATEASE TARGETED TO BONE, KITS AND METHODS OF USE CY1115263T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91758907A 2007-05-11 2007-05-11
EP11004496.3A EP2368999B1 (en) 2007-05-11 2008-05-12 Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (1)

Publication Number Publication Date
CY1115263T1 true CY1115263T1 (en) 2016-08-31

Family

ID=58436525

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100418T CY1115263T1 (en) 2007-05-11 2014-06-11 ALKALINE PHOSPHATEASE TARGETED TO BONE, KITS AND METHODS OF USE

Country Status (1)

Country Link
CY (1) CY1115263T1 (en)

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