CY1114818T1 - (E) -N-HYDROXY-3- (3-SULFAMOYL-FENYL) -ACRYLAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE - Google Patents
(E) -N-HYDROXY-3- (3-SULFAMOYL-FENYL) -ACRYLAMIDE COMPOUNDS AND THEIR THERAPEUTIC USEInfo
- Publication number
- CY1114818T1 CY1114818T1 CY20141100090T CY141100090T CY1114818T1 CY 1114818 T1 CY1114818 T1 CY 1114818T1 CY 20141100090 T CY20141100090 T CY 20141100090T CY 141100090 T CY141100090 T CY 141100090T CY 1114818 T1 CY1114818 T1 CY 1114818T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- aryl group
- fenyl
- sulfamoyl
- hydroxy
- Prior art date
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Αυτή η εφεύρεση αφορά ορισμένες δραστικές ενώσεις καρβαμικών οξέων οι οποίες αναστέλλουν την δραστηριότητα της HDAC και οι οποίες έχουν τον ακόλουθο χημικό τύπο: (I) το Α είναι μια αρυλομάδα · το Q1 είναι ένας ομοιοπολικός δεσμός ή μία καθοδηγητική αρυλομάδα · το J είναι μια σύνδεση σουλφοναμιδίου που επιλέγεται από: -S(=O)2NR1- και -NR1S(=O)2- · το R1 είναι ένα υποκατάστατο σουλφοναμιδομάδας · και, το Q1 είναι μια καθοδηγητική ομάδα οξέος · με την παραδοχή ότι εάν το J είναι -S(=O)2NR1-, τότε το Q1 είναι μια καθοδηγητική αρυλομάδα · και τα φαρμακευτικώς αποδεκτά άλατα, επιδιαλυτωμένα άλατα, αμίδια, εστέρες, αιθέρες, χημικώς προστατευμένες μορφές, και προφάρμακα εξ' αυτών. Η παρούσα εφεύρεση αφορά επίσης και φαρμακευτικές συνθέσεις περιλαμβάνοντας τέτοιες ενώσεις και την χρήση τέτοιων ενώσεων και συνθέσεων, αμφότερα in vitro και in vivo, για την αναστολή της HDAC, και, π.χ., για την αναστολή υπερπλαστικών καταστάσεων, όπως είναι ο καρκίνος και η ψωρίαση.This invention relates to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or a guide aryl group; J is a linkage; sulfonamide selected from: -S (= O) 2NR1- and -NR1S (= O) 2-; R1 is a sulfonamide substituent; and, Q1 is an acid guiding group; assuming that if J is -S (= O) 2NR1-, then Q1 is an aryl group; and the pharmaceutically acceptable salts solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds and compositions, both in vitro and in vivo, for inhibiting HDAC, and, for example, for inhibiting hyperplastic conditions, such as cancer, and psoriasis.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0023986.3A GB0023986D0 (en) | 2000-09-29 | 2000-09-29 | Therapeutic compounds |
| US29778401A | 2001-06-14 | 2001-06-14 | |
| US30813601A | 2001-07-30 | 2001-07-30 | |
| EP01970011.1A EP1328510B1 (en) | 2000-09-29 | 2001-09-27 | (e)-n-hydroxy-3-(3-sulfamoyl-phenyl)-acrylamide compounds and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114818T1 true CY1114818T1 (en) | 2016-12-14 |
Family
ID=58464036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100090T CY1114818T1 (en) | 2000-09-29 | 2014-02-05 | (E) -N-HYDROXY-3- (3-SULFAMOYL-FENYL) -ACRYLAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1114818T1 (en) |
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2014
- 2014-02-05 CY CY20141100090T patent/CY1114818T1/en unknown
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