CY1114726T1 - TRP-P8 SMALL-MOTOR ACTIVITY REGULATORS - Google Patents

TRP-P8 SMALL-MOTOR ACTIVITY REGULATORS

Info

Publication number
CY1114726T1
CY1114726T1 CY20131101155T CY131101155T CY1114726T1 CY 1114726 T1 CY1114726 T1 CY 1114726T1 CY 20131101155 T CY20131101155 T CY 20131101155T CY 131101155 T CY131101155 T CY 131101155T CY 1114726 T1 CY1114726 T1 CY 1114726T1
Authority
CY
Cyprus
Prior art keywords
trp
methods
small molecule
small
motor activity
Prior art date
Application number
CY20131101155T
Other languages
Greek (el)
Inventor
Ofir Moreno
Sateesh Natarajan
David F Duncan
Original Assignee
Dendreon Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07750861.2A external-priority patent/EP1986622B1/en
Application filed by Dendreon Corporation filed Critical Dendreon Corporation
Publication of CY1114726T1 publication Critical patent/CY1114726T1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Παρεχόμενοι είναι μικρού-μορίου Τrp-p8 ρυθμιστές που συμπεριλαμβάνουν αγωνιστές Τrp-p8 και ανταγωνιστές Τrp-p8 και συνθέσεις που περιλαμβάνουν μικρού μορίου αγωνιστές Τrp-p8, καθώς επίσης μέθοδοι για πιστοποίηση και χαρακτηρισμό νέων μικρού-μορίου ρυθμιστών Τrp-p8 και μεθόδους για μείωση βιωσιμότητας ή/και παρεμπόδιση ανάπτυξης των κυττάρων που εκφράζουν Τrp-p8, μεθόδους ενεργοποίησης προκαλούμενης από Τrp-p8 εισροής κατιόντος, μέθοδοι για διέγερση απόπτωσης ή/και νέκρωσης και σχετικές μέθοδοι για τη θεραπεία ασθενειών που συμπεριλαμβάνουν καρκίνους, όπως καρκίνους πνεύμονα, μαστού, κόλου ή/και προστάτη, καθώς επίσης άλλες ασθένειες, όπως καλοήθη προστατική υπερπλασία που συνδυάζονται με έκφραση Τrp-p8.Provided are Trp-p8 small molecule regulators including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising Trp-p8 small molecule agonists, as well as methods for identifying and characterizing novel Trp-p8 small molecule regulators and methods for reduction. viability and / or inhibition of Trp-p8-expressing cells, Trp-p8-mediated activation methods, methods for stimulating apoptosis and / or necrosis, and related methods for the treatment of diseases including cancer such as lung, breast, colon and / or prostate cancers, as well as other diseases, such as benign prostatic hyperplasia associated with expression of Trp-p8.

CY20131101155T 2006-02-15 2013-12-20 TRP-P8 SMALL-MOTOR ACTIVITY REGULATORS CY1114726T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77343506A 2006-02-15 2006-02-15
EP07750861.2A EP1986622B1 (en) 2006-02-15 2007-02-15 Small-molecule modulators of trp-p8 activity

Publications (1)

Publication Number Publication Date
CY1114726T1 true CY1114726T1 (en) 2017-01-25

Family

ID=58456990

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101155T CY1114726T1 (en) 2006-02-15 2013-12-20 TRP-P8 SMALL-MOTOR ACTIVITY REGULATORS

Country Status (1)

Country Link
CY (1) CY1114726T1 (en)

Similar Documents

Publication Publication Date Title
CY1119901T1 (en) SUSPENSIONS OF STONES
EP1663962A4 (en) Compositions and methods for the treatment of disease associated with trp-p8 expression
CY1116847T1 (en) FGF-R4 Receptor Specific Antagonists
CY1122651T1 (en) METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO ANDROGEN RECEPTOR THERAPY
CY1119956T1 (en) MONOCLONIC ANTI-GT468 CANCER TREATMENTS
CY1123475T1 (en) LYSINE-1-SPECIFIC INHIBITORS
ATE538215T1 (en) EXPRESSION PROFILE OF PROSTATE CARCINOMA
CY1123666T1 (en) MEDICINAL COMPOUNDS
EA200801037A1 (en) PHOSPHATIDYLINOSITE-3-KINASE INHIBITORS AND METHODS OF THEIR APPLICATION
CY1121038T1 (en) BREAST CANCER TREATMENT
ECSP099523A (en) VEGF specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
BR112015009752A2 (en) antibody / drug conjugates and methods of use
CY1117687T1 (en) DOUBARCHYMKIN ADCS PROVING IMPROVED IN VIVO ANTI-FRAUD ACTIVITY
WO2007095340A3 (en) Small-molecule modulators of trp-p8 activity
CY1117319T1 (en) TRICYCLIC AMIN PRODUCTS AS PROTEIN TYSINE MUSCLE INSPECTORS
CL2008003846A1 (en) Use of compounds derived from 1,2,4-triazolo fused with heterocycles, which act as ligands of the androgen receptor (ar); compounds; Preparation process; Pharmaceutical composition and the use of said compounds for the treatment of prostate cancer.
EA201991622A1 (en) COMPLEX THERAPY FOR TREATMENT OF CANCER
CL2008000020A1 (en) Compounds derived from substituted 2,4-dianilinopyrimidines, protein kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment or prevention of inflammatory diseases, diabetes, and malignant tumors.
MX2017003246A (en) Macropinocytosing human anti-cd46 antibodies and targeted cancer therapeutics.
EA200701094A1 (en) IMPROVED TREATMENT OF CANCER WITH THE USE OF TLR3 AGONISTS
ECSP088823A (en) QUINAZOLINS FOR THE INHIBITION OF PDK1
BRPI0511975A (en) pyrazolopyrimidines
WO2005116259A3 (en) Use of gene expression profiling to predict survival in cancer patient
EA201290901A1 (en) PHYTOCANNABINOIDS FOR THE TREATMENT OF MALIGNANT TUMOR
CY1113637T1 (en) AMINO PYRAZOLIS UNION