CY1114697T1 - INTERFERENCE ALPHA PARTS AND THEIR USES - Google Patents
INTERFERENCE ALPHA PARTS AND THEIR USESInfo
- Publication number
- CY1114697T1 CY1114697T1 CY20131100171T CY131100171T CY1114697T1 CY 1114697 T1 CY1114697 T1 CY 1114697T1 CY 20131100171 T CY20131100171 T CY 20131100171T CY 131100171 T CY131100171 T CY 131100171T CY 1114697 T1 CY1114697 T1 CY 1114697T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ifn
- biological activity
- antibodies
- interferon
- monoclonal antibodies
- Prior art date
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει απομονωμένα μονοκλωνικά αντισώματα έναντι ιντερφερόνης-α, ιδίως ανθρώπινα μονοκλωνικά αντισώματα, τα οποία αναστέλλουν τη βιολογική ενεργότητα πολλαπλών υποτύπων ιντερφερόνης (IFN) α, χωρίς όμως να αναστέλλουν ουσιωδώς τη βιολογική ενεργότητα της IFN α 21 ή τη βιολογική ενεργότητα είτε της IFN β είτε της IFN ω. Επίσης παρέχονται ανοσοσυζεύγματα, διπλοειδικά μόρια και φαρμακευτικές συνθέσεις περιλαμβάνουσες τα αντισώματα της εφεύρεσης. Η εφεύρεση επίσης παρέχει μεθόδους για αναστολή της βιολογικής ενεργότητας της IFN α που κάνουν χρήση των αντισωμάτων της εφεύρεσης, καθώς και μεθόδους αγωγής πάθησης ή διαταραχών μεσολαβούμενων από IFN α, όπως αυτοάνοσων παθήσεων, απόρριψης μοσχεύματος και πάθησης μοσχεύματος έναντι ξενιστή, μέσω χορήγησης των αντισωμάτων της εφεύρεσης.The present invention provides isolated monoclonal antibodies to interferon-α, in particular human monoclonal antibodies, which inhibit the biological activity of multiple interferon (IFN) α subtypes, but do not substantially inhibit IFN α 21 biological activity or IFN biological activity. b or IFN h. Also provided are immunoconjugates, diploid molecules, and pharmaceutical compositions comprising the antibodies of the invention. The invention also provides methods for inhibiting the biological activity of IFN α using the antibodies of the invention, as well as methods for the treatment of disease or disorders mediated by IFN α, such as autoimmune diseases, graft rejection and graft-versus-host disease via the host. invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52875703A | 2003-12-10 | 2003-12-10 | |
| EP04814015A EP1711207B1 (en) | 2003-12-10 | 2004-12-10 | Interferon alpha antibodies and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114697T1 true CY1114697T1 (en) | 2016-10-05 |
Family
ID=58448807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100171T CY1114697T1 (en) | 2003-12-10 | 2013-02-22 | INTERFERENCE ALPHA PARTS AND THEIR USES |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1114697T1 (en) |
-
2013
- 2013-02-22 CY CY20131100171T patent/CY1114697T1/en unknown
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