CY1114349T1 - Concentrated imidazole derivatives for inhibiting aldosterone and aromatics synthesis - Google Patents
Concentrated imidazole derivatives for inhibiting aldosterone and aromatics synthesisInfo
- Publication number
- CY1114349T1 CY1114349T1 CY20131100532T CY131100532T CY1114349T1 CY 1114349 T1 CY1114349 T1 CY 1114349T1 CY 20131100532 T CY20131100532 T CY 20131100532T CY 131100532 T CY131100532 T CY 131100532T CY 1114349 T1 CY1114349 T1 CY 1114349T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compound
- aldosterone
- disease
- aromatase
- restenosis
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
H παρούσα εφεύρεση παρέχει μία ένωση με τον τύπο (Ι). Η εν λόγω ένωση είναι ένας αναστολέας της συνθάσης της αλδοστερόνης και της αρωματάσης, και επομένως είναι δυνατό να χρησιμοποιηθεί για τη θεραπευτική αντιμετώπιση μίας διαταραχής ή μίας νόσου στην οποία διαμεσολαβεί η συνθάση της αλδοστερόνης ή η αρωματάση. Συνεπώς η ένωση με τον τύπο Ι είναι δυνατό να χρησιμοποιηθεί για τη θεραπευτική αντιμετώπιση της υποκαλιαιμίας, της υπέρτασης, της συμφορητικής καρδιακής ανεπάρκειας, της κολπικής μαρμαρυγής, της νεφρικής ανεπάρκειας, ιδιαίτερα, της χρόνιας νεφρικής ανεπάρκειας, της επαναστένωσης, της αθηρωσκλήρυνσης, του συνδρόμου Χ, της παχυσαρκίας, της νεφροπάθειας, μετά από έμφραγμα του μυοκαρδίου, της στεφανιαίας νόσου, της φλεγμονής, του αυξημένου σχηματισμού κολλαγόνου, της ίνωση όπως η ίνωση της καρδιάς ή του μυοκαρδίου, της αναδιαμόρφωσης μετά από υπέρταση και δυσλειτουργία του ενδοθηλίου, της γυναικομαστίας, της οστεοπόρωσης, του καρκίνου του προστάτη, της ενδομητρίωσης, των ινώματων της μήτρας, της δυσλειτουργικής αιμορραγίας της μήτρας, της υπερπλασίας του ενδομητρίου, του συνδρόμου των πολυκυστικών ωοθηκών, της στειρότητα, της ινωκυστικής νόσου του μαστού, του καρκίνου του μαστού και της ινωκυστικής μαστοπάθειας. Τέλος η παρούσα εφεύρεση παρέχει επίσης μία φαρμακευτική σύνθεση.The present invention provides a compound of formula (I). This compound is an aldosterone and aromatase synthase inhibitor, and can therefore be used to treat a disorder or disorder mediated by aldosterone synthase or aromatase. Therefore the compound of formula I can be used for the treatment of hypokalaemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, restenosis, , obesity, kidney disease, after myocardial infarction, coronary heart disease, inflammation, increased collagen formation, fibrosis such as fibrosis of the heart or myocardium, remodeling after hypertension and dysfunction of endothelium, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian syndrome, striatum , Breast Cancer and Fibrotic Breast Disease. Finally, the present invention also provides a pharmaceutical composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71144205A | 2005-08-25 | 2005-08-25 | |
| EP06789951.8A EP1919916B8 (en) | 2005-08-25 | 2006-08-23 | Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114349T1 true CY1114349T1 (en) | 2016-08-31 |
Family
ID=58436509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100532T CY1114349T1 (en) | 2005-08-25 | 2013-07-02 | Concentrated imidazole derivatives for inhibiting aldosterone and aromatics synthesis |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1114349T1 (en) |
-
2013
- 2013-07-02 CY CY20131100532T patent/CY1114349T1/en unknown
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