CY1114016T1 - Συνδυασμος δυο βιοδραστικων περιοχων της ορμονης προ-οπιομελανοκορτινη - Google Patents

Συνδυασμος δυο βιοδραστικων περιοχων της ορμονης προ-οπιομελανοκορτινη

Info

Publication number
CY1114016T1
CY1114016T1 CY20121100950T CY121100950T CY1114016T1 CY 1114016 T1 CY1114016 T1 CY 1114016T1 CY 20121100950 T CY20121100950 T CY 20121100950T CY 121100950 T CY121100950 T CY 121100950T CY 1114016 T1 CY1114016 T1 CY 1114016T1
Authority
CY
Cyprus
Prior art keywords
sequences
yggfm
sysmehfrwgkpv
komet
pro
Prior art date
Application number
CY20121100950T
Other languages
English (en)
Inventor
Zlatko Ademovic
Nikola Stambuk
Pasko Konjevoda
Darko Mikus
Original Assignee
Zlatko Ademovic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zlatko Ademovic filed Critical Zlatko Ademovic
Publication of CY1114016T1 publication Critical patent/CY1114016T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34—Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Χρησιμοποιείται υπολογιστική ανάλυση, προκειμένου να ορισθούν επαναλαμβανόμενες και βιοδραστικές περιοχές της προ-οπιομελανοκορτίνης SYSMEHFRWGKPV και YGGFM. Χρησιμοποιείται το μοντέλο κυτταροπροστασίας γαστρικών αλλοιώσεων, οι οποίες προκαλούνται με αιθανόλη, προκειμένου να αποδειχθούν τα πρόσθετα κυτταροπροστατευτικά αποτελέσματα του συνδυασμού των αλληλουχιών SYSMEHFRWGKPV και YGGFM εν συγκρίσει προς τις ξεχωριστές αλληλουχίες πεπτιδίων. Ο συνδυασμών των δύο αλλουλουχιών SYSMEHFRWGKPV και YGGFM χαρακτηρίζεται ΚΟΜΕΤ και κατοχυρώνεται δια Διπλώματος Ευρεσιτεχνίας. Ο σκοπός της χορήγησης ΚΟΜΕΤ είναι να ληφθούν καλύτερα και ισχυρότερα φαρμακολογικά αποτελέσματα στη συστημική και τοπική τροποποίηση της φλεγμονής και της επούλωσης της πληγής. Πρόσθετοι συντακτικοί τύποι, οι οποίοι παριστούν διαφορετικούς συνδυασμούς και των δύο αλληλουχιών ορίζονται επίσης ως: ΚΟΜΕΤ-1 με την αλληλουχία YGGFMSYSMEHFRWGKPVYGGFM, ΚΟΜΕΤ-2 με την αλληλουχία YGGFMSYSMEHFRWGKPV και ΚΟΜΕΤ-3 με την αλληλουχία SYSMEHFRWGKPVYGGFM.
CY20121100950T 2001-10-18 2012-10-12 Συνδυασμος δυο βιοδραστικων περιοχων της ορμονης προ-οπιομελανοκορτινη CY1114016T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BA010898 2001-10-18
EP01988010A EP1435999B1 (en) 2001-10-18 2001-11-29 Combination of two bioactive regions of pro-opiomelanocortin hormone

Publications (1)

Publication Number Publication Date
CY1114016T1 true CY1114016T1 (el) 2016-07-27

Family

ID=3839672

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100950T CY1114016T1 (el) 2001-10-18 2012-10-12 Συνδυασμος δυο βιοδραστικων περιοχων της ορμονης προ-οπιομελανοκορτινη

Country Status (15)

Country Link
US (1) US7544653B2 (el)
EP (1) EP1435999B1 (el)
JP (1) JP2005508356A (el)
CN (1) CN1321687C (el)
AU (1) AU2002240733B2 (el)
BR (1) BR0117155A (el)
CA (1) CA2462713C (el)
CY (1) CY1114016T1 (el)
DK (1) DK1435999T3 (el)
ES (1) ES2391551T3 (el)
MX (1) MXPA04003504A (el)
NO (1) NO20042001L (el)
PT (1) PT1435999E (el)
RU (1) RU2297238C2 (el)
WO (1) WO2003033017A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2857588B1 (fr) * 2003-07-17 2007-11-30 Oreal Utilisation de beta-endorphine, d'agents exercant une activite beta-endorphine-like en cosmetique et dermatologie
AU2011265315B2 (en) * 2004-05-12 2014-08-28 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods related to the treatment of neurodegenerative and inflammatory conditions
WO2010054446A1 (en) 2008-11-11 2010-05-20 Ademovic Zlatko Combination of two or more peptides in a single stable lyophilized pharmaceutical compound
WO2015033175A1 (en) 2013-09-06 2015-03-12 Zlatko Ademovic Combination of pro-opiomelanocortin endogenous peptides in autoimmune disease treatment
US10644009B2 (en) 2017-12-21 2020-05-05 Renesas Electronics Corporation Semiconductor memory device
CN109824772B (zh) * 2019-02-28 2022-07-29 海南大学 一组提高血清糖皮质激素水平的基因重组人促皮质素前体及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864250B1 (en) * 1997-08-22 2005-03-08 Kaken Pharmaceutical Co., Ltd. N-acylated lipophilic amino acid derivatives
WO2000004873A1 (en) * 1998-07-22 2000-02-03 Smith & Nephew Plc Dermatological compositions for the treatment of scars
CA2623458A1 (en) * 1999-05-17 2000-11-23 Conjuchem Biotechnologies Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components

Also Published As

Publication number Publication date
AU2002240733B2 (en) 2009-04-09
NO20042001L (no) 2004-05-14
BR0117155A (pt) 2004-10-26
CN1321687C (zh) 2007-06-20
MXPA04003504A (es) 2005-06-20
RU2297238C2 (ru) 2007-04-20
US20050014696A1 (en) 2005-01-20
PT1435999E (pt) 2012-10-24
EP1435999B1 (en) 2012-07-18
JP2005508356A (ja) 2005-03-31
CA2462713A1 (en) 2003-04-24
CA2462713C (en) 2014-03-18
EP1435999A1 (en) 2004-07-14
US7544653B2 (en) 2009-06-09
CN1558772A (zh) 2004-12-29
RU2004114992A (ru) 2005-04-20
WO2003033017A1 (en) 2003-04-24
DK1435999T3 (da) 2012-10-22
ES2391551T3 (es) 2012-11-27

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