CY1113643T1 - KINOLINES AND THERAPEUTIC USE OF THESE - Google Patents
KINOLINES AND THERAPEUTIC USE OF THESEInfo
- Publication number
- CY1113643T1 CY1113643T1 CY20131100111T CY131100111T CY1113643T1 CY 1113643 T1 CY1113643 T1 CY 1113643T1 CY 20131100111 T CY20131100111 T CY 20131100111T CY 131100111 T CY131100111 T CY 131100111T CY 1113643 T1 CY1113643 T1 CY 1113643T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cycloalkyl
- heteroaryl
- aryl
- fluoroalkyl
- group
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ενώσεις του τύπου [1] είναι ανταγωνιστές, χρήσιμες στη θεραπεία καταστάσεων που έχουν φλεγμονώδες συστατικό, όπου τα: R1, R2, R3, R4 και R5 ανεξαρτήτως είναι υδρογόνο, C1-C6αλκύλ, C1-C6φθοροαλκύλ, κυκλοπροπύλ, αλογόνο, -S(O)nR6, -SO2NR7R8, -NR7R8, -NR7C(0)R6, -CO2R7, -C(O)NR7R8, -C(O)R6, -NO2, -CN ή μια ομάδα -OR9, όπου έκαστο R6 ανεξαρτήτως είναι C1-C6αλκύλ, C1-C6φθοροαλκύλ, κυκλοαλκύλ, αρύλ ή ετεροαρύλ, τα R7, R8 ανεξαρτήτως είναι C1-C6αλκύλ, C1-C6φθοροαλκύλ, κυκλοαλκύλ, κυκλοαλκυλ-(C1-C6αλκύλ)-, αρύλ, ετεροαρύλ ή υδρογόνο, το R9 είναι υδρογόνο, C1-C6αλκύλ, C1-C6φθοροαλκύλ, κυκλοαλκύλ, κυκλοαλκύλ-(C1-C6αλκύλ)- ή μια ομάδα -SO2R6, το Α είναι -CHR10-, -C(O)-, -S(O)n-, -Ο- ή -NR10- όπου το n είναι ακέραιος από 0-2 και το R10 είναι υδρογόνο, C1-C3αλκύλ ή C1-C6φθοροαλκύλ ομάδα, το Β είναι άμεσος δεσμός ή δισθενής ρίζα επιλεγόμενη από -CH2-, -CH2CH2-, -CHR11-, -CR11R12-, -CH2CHR11-, -CH2CR11R12-, -CHR11CHR12- και δισθενείς ρίζες του τύπου -(CR11 R12)p-Z- όπου το Ζ συνδέεται προς το δακτύλιο που φέρει τα R1, R2 και R3, όπου το R11 είναι C1-C3αλκύλ, κυκλοπροπύλ, C1-C6φθοροαλκύλ, το R12 είναι μεθύλ ή φθορομεθύλ, το p ανεξαρτήτως είναι 1 ή 2 και το Ζ είναι -Ο-, -ΝΗ- ή -S(O)n-, όπου το n είναι ακέραιος από 0-2, το Χ είναι καρβοξυλικού οξέος, τετραζολίου, 3-υδροξυϊσοξαζολίου, υδροξαμικού οξέος, φωσφινική, φωσφονική, φωσφοναμιδίου ή σουλφονικού οξέος ομάδα ή μια ομάδα του τύπου C(=0)NHSO2R6 ή SO2NHC( = 0)R6 και το Υ είναι αρύλ, ετεροαρύλ, αρυλ-συντηγμένη-ετεροκυκλοαλκύλ, ετεροαρυλ-συντηγμένη-κυκλοαλκύλ, ετεροαρύλ-συντηγμένη-ετεροκυκλοαλκύλ ή αρυλ-συντηγμένη-κυκλοαλκύλ ομάδα.Compounds of formula [1] are antagonists useful in the treatment of conditions having an inflammatory component, wherein: R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6alkyl, C1-C6fluoroalkyl, cyclopropyl, halogen, -S (O nR6, -SO2NR7R8, -NR7R8, -NR7C (0) R6, -CO2R7, -C (O) NR7R8, -C (O) R6, -NO2, -CN or a group -OR9, wherein each R6 is independently C1 -C6 alkyl, C1-C6 fluoroalkyl, cycloalkyl, aryl or heteroaryl, R7, R8 independently are C1-C6alkyl, C1-C6 fluoroalkyl, cycloalkyl, cycloalkyl- (C1-C6alkyl) -, aryl, heteroaryl, R or heteroaryl; -C6 alkyl, C1-C6 fluoroalkyl, cycloalkyl, cycloalkyl- (C1-C6alkyl) - or a group da -SO2R6, A is -CHR10-, -C (O) -, -S (O) n-, -O- or -NR10- where n is an integer of 0-2 and R10 is hydrogen, C1- A C3 alkyl or C1-C6 fluoroalkyl group, B is a direct bond or a divalent radical selected from -CH2-, -CH2CH2-, -CHR11-, -CR11R12-, -CH2CHR11-, -CH2CR11R12-, -CHR11CHR12- and divalent radicals. (CR11 R12) pZ- wherein Z is attached to the ring bearing R1, R2 and R3, wherein R11 is C1-C3 alkyl, cyclopropyl, C1-C6 fluoroalkyl, R12 is methyl or fluoromethyl, p is independently 1 or 2 and Z is -O-, -NH- or -S (O) n-, where n is an integer from 0-2, X is carboxylic acid, tetrazolium, 3-hydroxysoxy azole, hydroxamic acid, phosphinic, phosphonate, phosphonamide or sulfonic acid or a group of formula C (= 0) NHSO2R6 or SO2NHC (= 0) R6 and Y is aryl, heteroaryl, aryl-fused-heterocyclo-heterocyclo-heterocyclic cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl group.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US519969A | 2005-09-30 | 2005-09-30 | |
US610551A | 2006-05-26 | 2006-05-26 | |
EP06779591A EP1928457B1 (en) | 2005-09-30 | 2006-09-29 | Quinolines and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113643T1 true CY1113643T1 (en) | 2016-06-22 |
Family
ID=58448869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100111T CY1113643T1 (en) | 2005-09-30 | 2013-02-07 | KINOLINES AND THERAPEUTIC USE OF THESE |
Country Status (1)
Country | Link |
---|---|
CY (1) | CY1113643T1 (en) |
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2013
- 2013-02-07 CY CY20131100111T patent/CY1113643T1/en unknown
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