CY1113602T1 - ANTI-HTNFSF13B COMPETITIVE ANTIBODIES - Google Patents
ANTI-HTNFSF13B COMPETITIVE ANTIBODIESInfo
- Publication number
- CY1113602T1 CY1113602T1 CY20121100901T CY121100901T CY1113602T1 CY 1113602 T1 CY1113602 T1 CY 1113602T1 CY 20121100901 T CY20121100901 T CY 20121100901T CY 121100901 T CY121100901 T CY 121100901T CY 1113602 T1 CY1113602 T1 CY 1113602T1
- Authority
- CY
- Cyprus
- Prior art keywords
- htnfsf13b
- tnfsf13b
- antibodies
- activity
- sec
- Prior art date
Links
Abstract
Φέρονται στο προσκήνιο μονοκλωνικά αντισώματα ανθρώπου τα οποία δεσμεύονται ειδικά σε πολυπεπτίδια TNFSF13b. Αυτά τα αντισώματα έχουν υψηλή συγγένεια για hTNFSF13b (π.χ. KD = 10-8 Μ ή μικρότερη), βραδεία ταχύτητα διάστασης από την ένωση τους με τα TNFSF13b (π.χ., Koff= 10-3 sec-1 ή μικρότερη) και εξουδετερώνουν τη δραστικότητα TNFSF13b in vitro και in vivo. Τα αντισώματα κατά την εφεύρεση είναι χρήσιμα σε μία υλοποίηση αναστολής της δραστικότητας των TNFSF13b σε άνθρωπο που πάσχει από διαταραχή στην οποία η δραστικότητα των hTNFSF13b είναι επιβλαβής. Στην εφεύρεση περικλείονται επίσης νουκλεϊκά οξέα που κωδικοποιούν τα αντισώματα κατά την παρούσα εφεύρεση, ως επίσης φορείς και ξενιστικά κύτταρα προς έκφραση αυτών.Human monoclonal antibodies that bind specifically to TNFSF13b polypeptides are brought to the forefront. These antibodies have a high affinity for hTNFSF13b (e.g. KD = 10-8 sec or less), slow dissociation rate from their association with TNFSF13b (e.g., Koff = 10-3 sec-1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies according to the invention are useful in an embodiment of inhibiting TNFSF13b activity in a human suffering from a disorder in which the activity of hTNFSF13b is harmful. Also included in the invention are nucleic acids encoding the antibodies according to the present invention, as well as vectors and host cells for expression thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31280801A | 2001-08-16 | 2001-08-16 | |
EP02756428A EP1432735B1 (en) | 2001-08-16 | 2002-08-15 | Antagonistic anti-htnfsf13b human antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113602T1 true CY1113602T1 (en) | 2016-06-22 |
Family
ID=58448919
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100901T CY1113602T1 (en) | 2001-08-16 | 2012-09-28 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
CY20151100041T CY1115966T1 (en) | 2001-08-16 | 2015-01-16 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100041T CY1115966T1 (en) | 2001-08-16 | 2015-01-16 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
Country Status (1)
Country | Link |
---|---|
CY (2) | CY1113602T1 (en) |
-
2012
- 2012-09-28 CY CY20121100901T patent/CY1113602T1/en unknown
-
2015
- 2015-01-16 CY CY20151100041T patent/CY1115966T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CY1115966T1 (en) | 2017-01-25 |
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