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Priority claimed from EP05775359Aexternal-prioritypatent/EP1773856B1/en
Application filed by Gilead Pharmasset LlcfiledCriticalGilead Pharmasset Llc
Publication of CY1113203T1publicationCriticalpatent/CY1113203T1/en
Η παρούσα εφεύρεση παρέχει (i) μια διαδικασία για παρασκευή ενός 2-δεοξυ-2-φθορο-2-μεθυλο-D-ριβολακτονικού παραγώγου, (ii) μετατροπή της λακτόνης προς νουκλεοζίτες με ισχυρή αντι-ΗCV δραστικότητα, και τα ανάλογα τους, και (iii) μια μέθοδο για παρασκευή των αντι-ΗCV νουκλεοζιτών που περιέχουν τους 2-δεοξυ-2-φθορο-2-C-μεθυλο-β-D-ριβοφουρανοζυλο νουκλεοζίτες από έναν προσχηματισμένο, κατά προτίμηση φυσικώς απαντώμενο, νουκλεοζίτη.The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribolactic derivative, (ii) conversion of lactone to nucleosides with potent anti-HCV activity, and the like, and (iii) a method for preparing the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally occurring, nucleoside.
CY20121100409T2004-07-212012-05-02
PREPARATION OF ALKYL-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives
CY1113203T1
(en)