CY1113203T1 - PREPARATION OF ALKYL-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives - Google Patents

PREPARATION OF ALKYL-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives

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Publication number
CY1113203T1
CY1113203T1 CY20121100409T CY121100409T CY1113203T1 CY 1113203 T1 CY1113203 T1 CY 1113203T1 CY 20121100409 T CY20121100409 T CY 20121100409T CY 121100409 T CY121100409 T CY 121100409T CY 1113203 T1 CY1113203 T1 CY 1113203T1
Authority
CY
Cyprus
Prior art keywords
deoxy
fluoro
purines
derivatives
substituted
Prior art date
Application number
CY20121100409T
Other languages
Greek (el)
Inventor
Peiyuan Wang
Byoung-Kwon Chun
Junxing Shi
Jinfa Du
Wojciech Kolonia Wola Zaradzynski Stec
Jeremy Clark
Original Assignee
Gilead Pharmasset Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05775359A external-priority patent/EP1773856B1/en
Application filed by Gilead Pharmasset Llc filed Critical Gilead Pharmasset Llc
Publication of CY1113203T1 publication Critical patent/CY1113203T1/en

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Abstract

Η παρούσα εφεύρεση παρέχει (i) μια διαδικασία για παρασκευή ενός 2-δεοξυ-2-φθορο-2-μεθυλο-D-ριβολακτονικού παραγώγου, (ii) μετατροπή της λακτόνης προς νουκλεοζίτες με ισχυρή αντι-ΗCV δραστικότητα, και τα ανάλογα τους, και (iii) μια μέθοδο για παρασκευή των αντι-ΗCV νουκλεοζιτών που περιέχουν τους 2-δεοξυ-2-φθορο-2-C-μεθυλο-β-D-ριβοφουρανοζυλο νουκλεοζίτες από έναν προσχηματισμένο, κατά προτίμηση φυσικώς απαντώμενο, νουκλεοζίτη.The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribolactic derivative, (ii) conversion of lactone to nucleosides with potent anti-HCV activity, and the like, and (iii) a method for preparing the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally occurring, nucleoside.

CY20121100409T 2004-07-21 2012-05-02 PREPARATION OF ALKYL-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives CY1113203T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60832004P 2004-09-09 2004-09-09
EP05775359A EP1773856B1 (en) 2004-07-21 2005-07-21 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

Publications (1)

Publication Number Publication Date
CY1113203T1 true CY1113203T1 (en) 2016-04-13

Family

ID=55662392

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100409T CY1113203T1 (en) 2004-07-21 2012-05-02 PREPARATION OF ALKYL-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives

Country Status (1)

Country Link
CY (1) CY1113203T1 (en)

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